PAR/pADPr Antibody [Unconjugated]

Product Discontinued

PAR/pADPr Antibody [Unconjugated] Summary

• Source: N/A
• Isotype: IgG
• Host: Rabbit

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PAR/pADPr Antibody [Unconjugated]

• pADPr
• PAR
• Poly(ADP-ribose)

Background

PARP [Poly(ADP-ribose) Polymerase], also known as ADPRT and PPOL, is a 118-kDa enzyme that uses NAD as a substrate to catalyze the covalent transfer of ADP-ribose to a variety of nuclear protein acceptors. ADP ribosyltransferase is required for cellular repair, and PARP expression is induced by single-strand breaks in DNA. PARP is proteolytically cleaved by Caspase-3 into two fragments of 89- and 24-kDa in one of the hallmark events of apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PAR/pADPr Antibody (4336-BPC-100)(26)

Publications using 4336-BPC-100

• Elfar, GA;Aning, O;Ngai, TW;Yeo, P;Chan, JWK;Sim, SH;Goh, L;Yuan, J;Phua, CZJ;Yeo, JZZ;Mak, SY;Goh, BKP;Chow, PK;Tam, WL;Ho, YS;Cheok, CF; p53-dependent crosstalk between DNA replication integrity and redox metabolism mediated through a NRF2-PARP1 axis Nucleic acids research 2024-09-24 [PMID: 39315696] (Western Blot, Human)
• Kamaletdinova, T;Zong, W;Urbánek, P;Wang, S;Sannai, M;Grigaravi?ius, P;Sun, W;Fanaei-Kahrani, Z;Mangerich, A;Hottiger, MO;Li, T;Wang, ZQ; Poly(ADP-Ribose) Polymerase-1 Lacking Enzymatic Activity Is Not Compatible with Mouse Development Cells 2023-08-16 [PMID: 37626888] (ICC, Western Blot, Mouse)
• Fontana, P;Buch-Larsen, SC;Suyari, O;Smith, R;Suskiewicz, MJ;Schützenhofer, K;Ariza, A;Rack, JGM;Nielsen, ML;Ahel, I; Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling Nature communications 2023-06-02 [PMID: 37268618] (Western Blot, Drosophila melanogaster)
• Eleazer, R;De Silva, K;Andreeva, K;Jenkins, Z;Osmani, N;Rouchka, EC;Fondufe-Mittendorf, Y; PARP1 Regulates Circular RNA Biogenesis though Control of Transcriptional Dynamics Cells 2023-04-14 [PMID: 37190069] (Western Blot, Drosophila melanogaster)
• AS Singatulin, MV Sukhanova, B Desforges, V Joshi, D Pastré, OI Lavrik PARP1 Activation Controls Stress Granule Assembly after Oxidative Stress and DNA Damage Cells, 2022-12-05;11(23):. 2022-12-05 [PMID: 36497190] (ICC, Human)
• EA Matveeva, H Dhahri, Y Fondufe-Mi PARP1's Involvement in RNA Polymerase II Elongation: Pausing and Releasing Regulation through the Integrator and Super Elongation Complex Cells, 2022-10-12;11(20):. 2022-10-12 [PMID: 36291070] (Western Blot, Drosophila)
• SS Santos, MKC Brunialti, LOCP Rodrigues, AMA Liberatore, IHJ Koh, V Martins, FG Soriano, C Szabo, R Salomão Effects of the PARP Inhibitor Olaparib on the Response of Human Peripheral Blood Leukocytes to Bacterial Challenge or Oxidative Stress Biomolecules, 2022-06-04;12(6):. 2022-06-04 [PMID: 35740913] (Western Blot, Human)
• M Stanzione, J Zhong, E Wong, TJ LaSalle, JF Wise, A Simoneau, DT Myers, S Phat, M Sade-Feldm, MS Lawrence, MK Hadden, L Zou, AF Farago, NJ Dyson, BJ Drapkin Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer Science Advances, 2022-05-13;8(19):eabn1229. 2022-05-13 [PMID: 35559669] (Western Blot, Xenograft)
• C Tian, Y Wei, J Li, Z Huang, Q Wang, Y Lin, X Lv, Y Chen, Y Fan, P Sun, R Xiang, A Chang, S Yang A Novel CDK4/6 and PARP Dual Inhibitor ZC-22 Effectively Suppresses Tumor Growth and Improves the Response to Cisplatin Treatment in Breast and Ovarian Cancer International Journal of Molecular Sciences, 2022-03-07;23(5):. 2022-03-07 [PMID: 35270034]
• AP Lombard, CM Armstrong, LS D'Abronzo, S Ning, AR Leslie, M Sharifi, W Lou, CP Evans, M Dall'Era, HW Chen, X Chen, AC Gao Olaparib Induced Senescence is Bypassed through G2/M Checkpoint Override in Olaparib Resistant Prostate Cancer Molecular Cancer Therapeutics, 2022-04-01;0(0):. 2022-04-01 [PMID: 35086956] (Western Blot, Human)
• KL Cooper, LB Volk, DR Dominguez, AD Duran, KJ Ke Jian Li, LG Hudson Contribution of NADPH oxidase to the retention of UVR-induced DNA damage by arsenic Toxicology and Applied Pharmacology, 2021-11-16;434(0):115799. 2021-11-16 [PMID: 34798142] (ELISA Detection, Human)
• M Kirtay, J Sell, C Marx, H Haselmann, M Ceanga, ZW Zhou, V Rahmati, J Kirkpatric, K Buder, P Grigaravic, A Ori, C Geis, ZQ Wang ATR regulates neuronal activity by modulating presynaptic firing Nature Communications, 2021-07-01;12(1):4067. 2021-07-01 [PMID: 34210973] (Western Blot, Mouse)
• Z Zhou, F Huang, I Shrivastav, R Zhu, A Luo, M Hottiger, I Bahar, Z Liu, M Cristofani, Y Wan New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy EMBO Mol Med, 2020-11-24;12(12):e12391. 2020-11-24 [PMID: 33231937] (IHC, Mouse)
• HD Chen, N Guo, SS Song, CH Chen, ZH Miao, JX He Novel mutations in BRCA2 intron 11 and overexpression of COX-2 and BIRC3 mediate cellular resistance to PARP inhibitors Am J Cancer Res, 2020-09-01;10(9):2813-2831. 2020-09-01 [PMID: 33042619] (Western Blot, Human)
• EF Fang, Y Hou, S Lautrup, MB Jensen, B Yang, T SenGupta, D Caponio, R Khezri, TG Demarest, Y Aman, D Figueroa, M Morevati, HJ Lee, H Kato, H Kassahun, JH Lee, D Filippelli, MN Okur, A Mangerich, DL Croteau, Y Maezawa, CA Lyssiotis, J Tao, K Yokote, TE Rusten, MP Mattson, H Jasper, H Nilsen, VA Bohr NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome Nat Commun, 2019-11-21;10(1):5284. 2019-11-21 [PMID: 31754102] (Western Blot, Human)
• W Jdey, M Kozlak, S Alekseev, S Thierry, P Lascaux, PM Girard, F Bono, M Dutreix AsiDNA Treatment Induces Cumulative Antitumor Efficacy with a Low Probability of Acquired Resistance Neoplasia, 2019-07-27;21(9):863-871. 2019-07-27 [PMID: 31362243] (ELISA Detection, Human)
• S Lodovichi, A Mercatanti, T Cervelli, A Galli Computational analysis of data from a genome-wide screening identifies new PARP1 functional interactors as potential therapeutic targets Oncotarget, 2019-04-12;10(28):2722-2737. 2019-04-12 [PMID: 31105872] (Western Blot, Human)
• LD Ordonez, T Hay, R McEwen, UM Polanska, A Hughes, O Delpuech, E Cadogan, S Powell, J Dry, G Tornillo, L Silcock, E Leo, MJ O'Connor, AR Clarke, MJ Smalley Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours Oncotarget, 2019-04-05;10(27):2586-2606. 2019-04-05 [PMID: 31080552] (Western Blot, Mouse)
• AS Singatulin, L Hamon, MV Sukhanova, B Desforges, V Joshi, A Bouhss, OI Lavrik, D Pastré PARP-1 Activation Directs FUS to DNA Damage Sites to Form PARG-Reversible Compartments Enriched in Damaged DNA Cell Rep, 2019-05-07;27(6):1809-1821.e5. 2019-05-07 [PMID: 31067465] (ICC, Human)
• EA Matveeva, LF Mathbout, YN Fondufe-Mi PARP1 is a versatile factor in the regulation of mRNA stability and decay Sci Rep, 2019-03-06;9(1):3722. 2019-03-06 [PMID: 30842529] (Western Blot, Drosophila melanogaster)
• G Ngo, S Hyatt, J Grimstead, R Jones, E Hendrickso, C Pepper, D Baird PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation Oncotarget, 2018-12-25;9(101):37549-37563. 2018-12-25 [PMID: 30680069] (Western Blot, Human)
• R Wang, J Wang, T Dong, J Shen, X Gao, J Zhou Naringenin has a chemoprotective effect in MDA-MB-231 breast cancer cells via inhibition of caspase-3 and -9 activities Oncol Lett, 2018-11-15;17(1):1217-1222. 2018-11-15 [PMID: 30655887] (Western Blot, Human)
• Q Li, Y Jiao, Y Yu, G Wang, Y Yu Hydrogen?rich medium alleviates high glucose?induced oxidative stress and parthanatos in rat Schwann cells in�vitro Mol Med Rep, 2018-11-08;0(0):. 2018-11-08 [PMID: 30431142] (Western Blot, Rat)
• Murai J, Huang S, Renaud A, Zhang Y, Ji J, Takeda S, Morris J, Teicher B, Doroshow J, Pommier Y Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib. Mol Cancer Ther, 2013-12-19;13(2):433-43. 2013-12-19 [PMID: 24356813] (Western Blot, Chicken)
• Cheng H, Zhang Z, Borczuk A, Powell C, Balajee A, Lieberman H, Halmos B PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells. Carcinogenesis, 2012-12-28;34(4):739-49. 2012-12-28 [PMID: 23275151] (Western Blot, Human)
• Murai J, Huang S, Das B, Renaud A, Zhang Y, Doroshow J, Ji J, Takeda S, Pommier Y Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors. Cancer Res, 2012-11-01;72(21):5588-99. 2012-11-01 [PMID: 23118055] (Western Blot, Chicken, Human)