PDZD2/PDZK3 Antibody

Product Discontinued

PDZD2/PDZK3 Antibody Summary

• Immunogen: The antiserum was produced against synthesized peptide derived from human PDZD2. The immunogen region is: N-terminal.
• Specificity: PDZD2 Antibody detects endogenous levels of total PDZD2 protein.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PDZD2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:5000
  • Immunocytochemistry/ Immunofluorescence 1:100-1:500
  • Immunohistochemistry 1:50-1:100
  • Immunohistochemistry-Paraffin 1:50-1:100
• Theoretical MW: 301 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human,Mouse, Rat

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (without Mg2+ and Ca2+, pH 7.4), 0.15M NaCl and 50% Glycerol
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PDZD2/PDZK3 Antibody

• Activated in prostate cancer protein
• AIPC
• AIPCPAPIN
• KIAA0300
• KIAA0300PDZ domain-containing protein 3
• Papin
• PDZ domain containing 2
• PDZ domain containing 3
• PDZ domain-containing protein 2
• PDZD2
• PDZK3
• Pin1

Background

GenBank Accession Number - NP_055837. Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. Two transcript variants encoding different isoforms have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PDZD2
• Uniprot:
  • O15018(Human)