Pet1 Antibody

Product Discontinued

Pet1 Antibody Summary

• Immunogen: FEV (NP_059991, 31 a.a. ~ 131 a.a) partial recombinant protein with GST tag.PSWGPLSPAVQKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQG
• Specificity: FEV - FEV (ETS oncogene family)
• Clonality: Polyclonal
• Host: Mouse
• Gene: FEV
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot 1:500
• Application Notes: The quality control of this antibody is limited to Western blot on the immunizing protein. It has also been used for ELISA. Abnova's recommended working dilutions for western analysis are as follows: 1:500 dilution for ascites 1:1000 for purified Ig 1:500

Reactivity Notes

Human. Other species not tested.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Unpurified antisera so the specific antibody concentration is unknown. Contains 50% glycerol.
• Preservative: No Preservative
• Purity: Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Pet1 Antibody

• FEV (ETS oncogene family)
• FEV (fifth Ewing variant)
• Fifth Ewing variant protein
• HSRNAFEV
• PC12 ETS domain-containing transcription factor 1
• PC12 ETS factor 1
• PET1
• Pet-1
• protein FEV

Background

This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Pet1 Antibody (H00054738-A01)(1)

Publication using H00054738-A01

• Garcia-Manteiga JM, Bonfiglio S, Folladori L et al. REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation. Front Cell Neurosci 2015-01-01 [PMID: 26617488] (WB)

Bioinformatics

• Gene Symbol: FEV
• Entrez:
  • 54738(Human)
• OMIM:
  • 607150(Human)
• Uniprot:
  • NP_059991(Human)