Quantikine Immunoassay Control Set 1064 for Human HS CTLA-4

• Reactivity: Hu
• Applications: Ctrl
• Conjugate: Unconjugated

Quantikine Immunoassay Control Set 1064 for Human HS CTLA-4 Summary

• Additional Information: For use with catalog number HSCT40
• Source: N/A
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details

Applications/Dilutions

• Dilutions:
  • Control

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Quantikine Immunoassay Control Set 1064 for Human HS CTLA-4

• CD
• CD152 antigen
• CD152
• CD152IDDM12
• CD28
• celiac disease 3
• CELIAC3
• CTLA4
• CTLA-4
• cytotoxic T-lymphocyte antigen 4
• cytotoxic T-lymphocyte protein 4
• Cytotoxic T-lymphocyte-associated antigen 4
• cytotoxic T-lymphocyte-associated protein 4
• cytotoxic T-lymphocyte-associated serine esterase-4
• GRD4
• GSE
• ICOS
• ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4

Background

CTLA-4/CD152 (Cytotoxic T-Lymphocyte Antigen 4) is a transmembrane T cell inhibitory molecule that is expressed as a covalent homodimer. CTLA-4 is recruited from intracellular vesicles to the immunological synapse beginning 1-2 days after T cell activation. It forms a linear lattice with B7-1 on APC, inducing negative regulatory signals and ending CD28-dependent T cell activation. Mice deleted for CTLA-4 develop lethal autoimmune reactions due to continued T cell activation and poor control by regulatory T cells which constitutively express CTLA-4.