Recombinant Human IFN-alpha 2 (alpha 2b) Protein

• Reactivity: Hu

Recombinant Human IFN-alpha 2 (alpha 2b) Protein Summary

• Protein/Peptide Type: Recombinant Proteins
• Gene: IFNA2

Applications/Dilutions

Publications

Read Publications using 11105-1 in the following applications: Bioassay 6 publications Cell Culture 2 publications

Packaging, Storage & Formulations

• Storage: Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IFN-alpha 2 (alpha 2b) Protein

• alpha-2a interferon
• Ifa2
• IFNA
• IFNA2
• IFNA2a
• IFNA2b
• IFNA2c
• IFNAA
• IFNalpha 2
• IFN-alpha 2
• IFN-alpha-2
• IFN-alphaA
• INFA2
• interferon alpha 2b
• interferon alpha A
• interferon alpha-2
• Interferon alpha-A
• interferon, alpha 2
• LeIF A
• MGC125764
• MGC125765

Background

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

Publications for IFN-alpha 2 (11105-1)(8)

Publications using 11105-1

• Scott, HC;Draganov, SD;Yu, Z;Kessler, BM;Pinto-Fernández, A; Targeted Mass Spectrometry Reveals Interferon-Dependent Eicosanoid and Fatty Acid Alterations in Chronic Myeloid Leukaemia International journal of molecular sciences 2023-10-24 [PMID: 37958498] (Bioassay, Human)
• I Pietrafort, A Butera, L Gaddini, A Mennella, R Palazzo, D Campanile, K Stefananto, V Riccieri, R Lande, L Frasca CXCL4-RNA Complexes Circulate in Systemic Sclerosis and Amplify Inflammatory/Pro-Fibrotic Responses by Myeloid Dendritic Cells International Journal of Molecular Sciences, 2022-12-30;24(1):. 2022-12-30 [PMID: 36614095] (Cell Culture, Human)
• C Wilkinson, J Kyle, M Irimpen, S Stuart, S Mohandass, A Sheperd, KJ Smith, MJ Mullin Improved yield of recombinant human IFN-alpha2b from mammalian cells using heterologous signal peptide approach Protein Expression and Purification, 2022-06-02;198(0):106125. 2022-06-02 [PMID: 35659600] (Bioassay, Human)
• AM Kell, EA Hemann, JB Turnbull, M Gale RIG-I-like receptor activation drives type I IFN and antiviral signaling to limit�Hantaan orthohantavirus replication PLoS Pathog., 2020-04-24;16(4):e1008483. 2020-04-24 [PMID: 32330200] (Cell Culture, Human)
• C He, X Lv, C Huang, PC Angeletti, G Hua, J Dong, J Zhou, Z Wang, B Ma, X Chen, PF Lambert, BR Rueda, JS Davis, C Wang A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis Cell Rep, 2019-03-05;26(10):2636-2650.e5. 2019-03-05 [PMID: 30840887] (Bioassay, Human)
• Abdel-Mohsen M, Deng X, Danesh A, Liegler T, Jacobs E, Rauch A, Ledergerber B, Norris P, Gunthard H, Wong J, Pillai S Role of microRNA modulation in the interferon-alpha/ribavirin suppression of HIV-1 in vivo. PLoS ONE, 2014-10-02;9(10):e109220. 2014-10-02 [PMID: 25275557] (Bioassay, Human)
• Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)
• Lee PY, Li Y, Richards HB, Chan FS, Zhuang H, Narain S, Butfiloski EJ, Sobel ES, Reeves WH, Segal MS Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus. Arthritis Rheum., 2007-11-01;56(11):3759-69. 2007-11-01 [PMID: 17968925] (Bioassay, Human)

Bioinformatics

• Gene Symbol: IFNA2