Recombinant Human M-CSF Protein

Recombinant human M-CSF (Catalog # 216-MC) has a molecular weight (MW) of 39.2 kDa as analyzed by SEC-MALS, suggesting that this protein is a homodimer. MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation).

Recombinant Human M-CSF (Catalog # 216-MC) stimulates cell proliferation of the M‑NFS‑60 mouse myelogenous leukemia lymphoblast cell line in a dose-dependent manner. The ED50 for this effect is 0.5-1.5 ng/mL.

1 μg/lane of Recombinant Human M-CSF was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing bands at 19 kDa and 35 kDa, respectively.

• Reactivity: Hu
• Applications: Bioactivity

Recombinant Human M-CSF Protein Summary

• Additional Information: Analyzed by SEC-MALS,
• Details of Functionality: Measured in a cell proliferation assay using M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells. Nakoinz, I. et al. (1990) J. Immunol. 145:860. The ED₅₀ for this effect is 0.5-1.5 ng/mL.
• Source: E. coli-derived human M-CSF protein
  Glu33-Ser190, with an N-terminal Met
• Accession #: NP_757350
• N-terminal Sequence: Met
• Structure / Form: Disulfide-linked homodimer
• Protein/Peptide Type: Recombinant Proteins
• Gene: CSF1
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 18.5 kDa (monomer).
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 37 kDa, non-reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 50-500 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human M-CSF Protein

• colony stimulating factor 1 (macrophage)
• CSF1
• CSF-1
• Lanimostim
• macrophage colony stimulating factor
• macrophage colony-stimulating factor 1
• MCSF
• M-CSF
• MCSFlanimostim
• MGC31930

Background

M-CSF, also known as CSF-1, is a four-alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation (1-3). M-CSF is also essential for the survival and proliferation of osteoclast progenitors (1, 4). M-CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis (2, 3). M-CSF increases during pregnancy to support implantation and growth of the decidua and placenta (5). Sources of M-CSF include fibroblasts, activated macrophages, endometrial secretory epithelium, bone marrow stromal cells and activated endothelial cells (1-5). The M-CSF receptor (c-fms) transduces its pleotropic effects and mediates its endocytosis. M-CSF mRNAs of various sizes occur (3-9). Full length human M-CSF transcripts encode a 522 amino acid (aa) type I transmembrane (TM) protein with a 464 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. Differential processing produces two proteolytically cleaved, secreted dimers. One is an N- and O- glycosylated 86 kDa dimer, while the other is modified by both glycosylation and chondroitin-sulfate proteoglycan (PG) to generate a 200 kDa subunit. Although PG-modified M-CSF can circulate, it may be immobilized by attachment to type V collagen (8). Shorter transcripts encode
M‑CSF that lacks cleavage and PG sites and produces an N-glycosylated 68 kDa TM dimer and a slowly produced 44 kDa secreted dimer (7). Although forms may vary in activity and half-life, all contain the N‑terminal 150 aa portion that is necessary and sufficient for interaction with the M-CSF receptor (10, 11). The first 223 aa of mature human M-CSF shares 88%, 86%, 81% and 74% aa identity with corresponding regions of dog, cow, mouse and rat M‑CSF, respectively (12, 13). Human M-CSF is active in the mouse, but mouse M-CSF is reported to be species-specific.

1. Pixley, F.J. and E.R. Stanley (2004) Trends Cell Biol. 14:628.
2. Chitu, V. and E.R. Stanley (2006) Curr. Opin. Immunol. 18:39.
3. Fixe, P. and V. Praloran (1997) Eur. Cytokine Netw. 8:125.
4. Ryan, G.R. et al. (2001) Blood 98:74.
5. Makrigiannakis, A. et al. (2006) Trends Endocrinol. Metab. 17:178.
6. Nandi, S. et al. (2006) Blood 107:786.
7. Rettenmier, C.W. and M.F. Roussel (1988) Mol. Cell Biol. 8:5026.
8. Suzu, S. et al. (1992) J. Biol. Chem. 267:16812.
9. Manos, M.M. (1988) Mol. Cell. Biol. 8:5035.
10. Koths, K. (1997) Mol. Reprod. Dev. 46:31.
11. Jang, M-H. et al. (2006) J. Immunol. 177:4055.
12. Kawasaki, E.S. et al. (1985) Science 230: 291.
13. Wong, G.G. et al. (1987) Science 235:1504.

Publications for M-CSF (216-MC)(252)

Publications using 216-MC

• Yamashita, Y;Hayashi, M;Liu, A;Sasaki, F;Tsuchiya, Y;Takayanagi, H;Saito, M;Nakashima, T; Fam102a translocates Runx2 and Rbpjl to facilitate Osterix expression and bone formation Nature communications 2025-01-02 [PMID: 39747056] (Bioassay, Transgenic Mouse)
• Pickering, S;Wilson, H;Bravo, E;Perera, MR;Seow, J;Graham, C;Almeida, N;Fotopoulos, L;Williams, T;Moitra, A;Winstone, H;Nissen, TAD;Galão, RP;Snell, LB;Doores, KJ;Malim, MH;Neil, SJD; Antibodies to the RBD of SARS-CoV-2 spike mediate productive infection of primary human macrophages Nature communications 2024-12-30 [PMID: 39737903] (Bioassay, Human)
• Ding, D;Liu, G;Yan, J;Zhang, Q;Meng, F;Wang, L; Curcumin alleviates osteoarthritis in mice by suppressing osteoclastogenesis in subchondral bone via inhibiting NF-?B/JNK signaling pathway PloS one 2024-09-05 [PMID: 39236007] (Bioassay, Mouse)
• Berrocal-Rubio, MA;Pawer, YDJ;Dinevska, M;De Paoli-Iseppi, R;Widodo, SS;Gleeson, J;Rajab, N;De Nardo, W;Hallab, J;Li, A;Mantamadiotis, T;Clark, MB;Wells, CA; Discovery of NRG1-VII: the myeloid-derived class of NRG1 BMC genomics 2024-08-29 [PMID: 39210279] (Bioassay, Human)
• Arias, AA;Neehus, AL;Ogishi, M;Meynier, V;Krebs, A;Lazarov, T;Lee, AM;Arango-Franco, CA;Yang, R;Orrego, J;Corcini Berndt, M;Rojas, J;Li, H;Rinchai, D;Erazo-Borrás, L;Han, JE;Pillay, B;Ponsin, K;Chaldebas, M;Philippot, Q;Bohlen, J;Rosain, J;Le Voyer, T;Janotte, T;Amarajeeva, K;Soudée, C;Brollo, M;Wiegmann, K;Marquant, Q;Seeleuthner, Y;Lee, D;Lainé, C;Kloos, D;Bailey, R;Bastard, P;Keating, N;Rapaport, F;Khan, T;Moncada-Vélez, M;Carmona, MC;Obando, C;Alvarez, J;Cataño, JC;Martínez-Rosado, LL;Sanchez, JP;Tejada-Giraldo, M;L'Honneur, AS;Agudelo, ML;Perez-Zapata, LJ;Arboleda, DM;Alzate, JF;Cabarcas, F;Zuluaga, A;Pelham, SJ;Ensser, A;Schmidt, M;Velásquez-Lopera, MM;Jouanguy, E;Puel, A;Krönke, M;Ghirardello, S;Borghesi, A;Pahari, S;Boisson, B;Pittaluga, S;Ma, CS;Emile, JF;Notarangelo, LD;Tangye, SG;Marr, N;Lachmann, N;Salvator, H;Schlesinger, LS;Zhang, P;Glickman, MS;Nathan, CF;Geissmann, F;Abel, L;Franco, JL;Bustamante, J;Casanova, JL;Boisson-Dupuis, S; Tuberculosis in otherwise healthy adults with inherited TNF deficiency Nature 2024-08-28 [PMID: 39198650] (Bioassay, Human)
• Kent, GM;Atkins, MH;Lung, B;Nikitina, A;Fernandes, IM;Kwan, JJ;Andrews, TS;MacParland, SA;Keller, GM;Gage, BK; Human liver sinusoidal endothelial cells support the development of functional human pluripotent stem cell-derived Kupffer cells Cell reports 2024-08-14 [PMID: 39146183] (Bioassay, Human)
• Dias, J;Cattin, A;Bendoumou, M;Dutilleul, A;Lodge, R;Goulet, J;Fert, A;Marchand, L;Salinas, T;Yoka, C;Gabriel, E;Caballero, R;Routy, J;Cohen, É;Lint, C;Ancu?a, P; Retinoic acid enhances HIV-1 reverse transcription and transcription in macrophages via mTOR-modulated mechanisms Cell Reports 2024-06-28 [PMID: 38943643] (Bioassay, Human)
• Landau, S;Zhao, Y;Hamidzada, H;Kent, GM;Okhovatian, S;Lu, RXZ;Liu, C;Wagner, KT;Cheung, K;Shawky, SA;Vosoughi, D;Beroncal, EL;Fernandes, I;Cummins, CL;Andreazza, AC;Keller, GM;Epelman, S;Radisic, M; Primitive macrophages enable long-term vascularization of human heart-on-a-chip platforms Cell stem cell 2024-06-20 [PMID: 38908380] (Bioassay, Human)
• Deng, M;Odhiambo, WO;Qin, M;To, TT;Brewer, GM;Kheshvadjian, AR;Cheng, C;Agak, GW; Analysis of Intracellular Communication Reveals Consistent Gene Changes Associated with Early-Stage Acne Skin Research square 2024-05-29 [PMID: 38854033] (Bioassay, Human)
• Verma, S;Das, M;Sharma, RD;Yadav, V;Thakur, S;Sharma, P;Marzuki, M;Foo, S;Piperno, GM;Khan, MZ;Mathew, B;Bajpai, M;Maras, JS;Howland, S;Sarkar, S;Benvenuti, F;Singh, A;Nandicoori, V;Singhal, A;Kumar, D; A mitochondrial quality control mechanism reverses the phagosome maturation arrest caused by Mycobacterium tuberculosis bioRxiv : the preprint server for biology 2023-12-01 [PMID: 38076943] (Bioassay, Human)
• Múnera, JO;Kechele, DO;Bouffi, C;Qu, N;Jing, R;Maity, P;Enriquez, JR;Han, L;Campbell, I;Mahe, MM;McCauley, HA;Zhang, X;Sundaram, N;Hudson, JR;Zarsozo-Lacoste, A;Pradhan, S;Tominaga, K;Sanchez, JG;Weiss, AA;Chatuvedi, P;Spence, JR;Hachimi, M;North, T;Daley, GQ;Mayhew, CN;Hu, YC;Takebe, T;Helmrath, MA;Wells, JM; Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon Cell stem cell 2023-11-02 [PMID: 37922878] (Differentiation)
• Katagata, M;Okayama, H;Nakajima, S;Saito, K;Sato, T;Sakuma, M;Fukai, S;Endo, E;Sakamoto, W;Saito, M;Saze, Z;Momma, T;Mimura, K;Kono, K; TIM-3 Expression and M2 Polarization of Macrophages in the TGF?-Activated Tumor Microenvironment in Colorectal Cancer Cancers 2023-10-11 [PMID: 37894310] (Cell Culture, Human)
• Alexander, ET;Fahey, E;Phanstiel, O;Gilmour, SK; Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice Biomedicines 2023-10-05 [PMID: 37893077] (Bioassay, Mouse, Transgenic Mouse)
• Tang, Y;Yang, K;Liu, Q;Ma, Y;Zhu, H;Tang, K;Geng, C;Xie, J;Zhuo, D;Wu, W;Jin, L;Xiao, W;Wang, J;Zhu, Q;Liu, J; Preosteoclast plays a pathogenic role in syndesmophyte formation of ankylosing spondylitis through the secreted PDGFB - GRB2/ERK/RUNX2 pathway Arthritis research & therapy 2023-10-05 [PMID: 37798786] (Bioassay, Human)
• Makis Tzioras, Michael J.D. Daniels, Caitlin Davies, Paul Baxter, Declan King, Sean McKay et al. Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8 Cell Reports Medicine 2023-09-19 [PMID: 37652017] (Bioassay, Human)
• Duran-Castells, C;Prats, A;Oriol-Tordera, B;Llano, A;Galvez, C;Martinez-Picado, J;Ballana, E;Garcia-Vidal, E;Clotet, B;Muñoz-Moreno, JA;Hanke, T;Moltó, J;Mothe, B;Brander, C;Ruiz-Riol, M; Plasma proteomic profiling identifies CD33 as a marker of HIV control in natural infection and after therapeutic vaccination EBioMedicine 2023-07-26 [PMID: 37506557] (Bioassay, Human)
• Tesfaye, RA;Lavaud, M;Charrier, C;Brounais-Le Royer, B;Cartron, PF;Verrecchia, F;Baud'huin, M;Lamoureux, F;Georges, S;Ory, B; Tracking Targets of Dynamic Super-Enhancers in Vitro to Better Characterize Osteoclastogenesis and to Evaluate the Effect of Diuron on the Maturation of Human Bone Cells Environmental health perspectives 2023-06-01 [PMID: 37307168] (Bioassay, Human)
• L Chen, C Yu, Y Xiong, K Chen, P Liu, AC Panayi, X Xiao, Q Feng, B Mi, G Liu Multifunctional hydrogel enhances bone regeneration through sustained release of Stromal Cell-Derived Factor-1alpha and exosomes Bioactive materials, 2022-08-12;25(0):460-471. 2022-08-12 [PMID: 37056272] (Bioassay, Mouse)
• W Wang, PV Taufalele, M Millet, K Homsy, K Smart, ED Berestesky, CT Schunk, MM Rowe, F Bordeleau, CA Reinhart-K Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENA Cell Reports, 2023-04-05;42(4):112338. 2023-04-05 [PMID: 37027295] (Bioassay, Mouse)
• G Yi, F Yang, A Labani-Mot, JD Moreira, D Ansari, JA Bohorquez, S Patel, F Spagnolo, J Florence, A Vankayalap, R Vankayalap, JJDJ Dennehy, B Samten Bacteriophage therapy for the treatment of Mycobacterium tuberculosis infections in humanized mice bioRxiv : the preprint server for biology, 2023-02-21;0(0):. 2023-02-21 [PMID: 36747734] (Bioassay, Human)
• L Feige, T Kozaki, G Dias de Me, V Guillemot, F Larrous, F Ginhoux, H Bourhy Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses Viruses, 2022-12-29;15(1):. 2022-12-29 [PMID: 36680128] (Bioassay, Human)
• Y Kitamura, YI Koma, K Tanigawa, S Tsukamoto, Y Azumi, S Miyako, S Urakami, T Kodama, M Nishio, M Shigeoka, Y Kakeji, H Yokozaki Roles of IL-7R Induced by Interactions between Cancer Cells and Macrophages in the Progression of Esophageal Squamous Cell Carcinoma Cancers, 2023-01-06;15(2):. 2023-01-06 [PMID: 36672342] (Bioassay, Human)
• J Pape, D Bakkalci, RA Hosni, BS Simpson, K Heikinheim, S Fedele, U Cheema RANKL neutralisation prevents osteoclast activation in a human in vitro ameloblastoma-bone model Journal of tissue engineering, 2022-12-24;13(0):2041731422114. 2022-12-24 [PMID: 36582941] (Cell Culture, Human)
• C Bratengeie, AD Bakker, A Liszka, J Schilcher, A Fahlgren The release of osteoclast-stimulating factors on supraphysiological loading by osteoprogenitors coincides with expression of genes associated with inflammation and cytoskeletal arrangement Scientific Reports, 2022-12-14;12(1):21578. 2022-12-14 [PMID: 36517534] (Differentiation, Differentiation, Human)
• R Boland, MT Heemskerk, G Forn-Cuní, CJ Korbee, KV Walburg, JJ Esselink, C Carvalho D, AM de Waal, DCM van der Ho, E van der Sa, AS de Ries, J Xie, HP Spaink, M van der Va, MC Haks, AH Meijer, THM Ottenhoff Repurposing Tamoxifen as Potential Host-Directed Therapeutic for Tuberculosis MBio, 2022-12-07;0(0):e0302422. 2022-12-07 [PMID: 36475748] (Cell Culture, Human)
• Y Hou, D Wei, Z Zhang, H Guo, S Li, J Zhang, P Zhang, L Zhang, Y Zhao FABP5 controls macrophage alternative activation and allergic asthma by selectively programming long-chain unsaturated fatty acid metabolism Cell Reports, 2022-11-15;41(7):111668. 2022-11-15 [PMID: 36384126] (Bioassay, Human)
• D Ding, L Wang, J Yan, Y Zhou, G Feng, L Ma, Y Yang, X Pei, Q Jin Zoledronic acid generates a spatiotemporal effect to attenuate osteoarthritis by inhibiting potential Wnt5a-associated abnormal subchondral bone resorption PLoS ONE, 2022-07-28;17(7):e0271485. 2022-07-28 [PMID: 35900969] (Bioassay, Rat)
• KE Nilsen, A Skjesol, J Frengen Ko, T Espevik, J Stenvik, M Yurchenko TIRAP/Mal Positively Regulates TLR8-Mediated Signaling via IRF5 in Human Cells Oncogene, 2022-06-22;10(7):. 2022-06-22 [PMID: 35884781] (Bioassay, Human)
• AM Soileau, CN Quick, CE Moeller, JC Schaumburg, SS Withers The Effect of Arginase on Canine T-Lymphocyte Functions and its Modulation by All-Trans Retinoid Acid (ATRA) in Canine Monocyte-Derived Macrophages Oncogene, 2022-07-21;9(7):. 2022-07-21 [PMID: 35878391] (Bioassay, Canine)
• S Lin, A Zhang, L Yuan, Y Wang, C Zhang, J Jiang, H Xu, H Yuan, H Yao, Q Zhang, Y Zhang, M Lou, P Wang, ZN Zhang, B Luan Targeting parvalbumin promotes M2 macrophage polarization and energy expenditure in mice Nature Communications, 2022-06-08;13(1):3301. 2022-06-08 [PMID: 35676256] (Bioassay, Human)
• N Rigamonti, N Veitonmäki, C Domke, S Barsin, S Jetzer, O Abdelmotal, R Bessey, T Lekishvili, F Malvezzi, M Gachechila, M Béhé, V Levitsky, PA Trail A multispecific anti-CD40 DARPin� construct induces tumor-selective CD40 activation and tumor regression Cancer Immunology Research, 2022-05-03;0(0):. 2022-05-03 [PMID: 35319751] (Bioassay, Mouse)
• X Wang, Y Chen, B Lan, Y Wang, W Lin, X Jiang, J Ye, B Shang, C Feng, J Liu, J Zhai, M Xu, Q Li, L Lin, M Hu, F Zheng, L Chen, C Shao, Y Wang, Y Shi Heterogeneity of tyrosine-based melanin anabolism regulates pulmonary and cerebral organotropic colonization microenvironment of melanoma cells Theranostics, 2022-01-31;12(5):2063-2079. 2022-01-31 [PMID: 35265199] (Bioassay, Human)
• P Gao, H Liu, H Huang, Y Sun, B Jia, B Hou, X Zhou, W Strober, F Zhang The Crohn Disease-associated ATG16L1T300A polymorphism regulates inflammatory responses by modulating TLR- and NLR-mediated signaling Autophagy, 2022-02-27;0(0):1-15. 2022-02-27 [PMID: 35220902] (Bioassay, Human)
• R Liu, Y Zhong, R Chen, S Chen, Y Huang, H Liu Bacterial infections exacerbate myeloma bone disease Journal of Translational Medicine, 2022-01-06;20(1):16. 2022-01-06 [PMID: 34991592] (Bioassay, Human)
• PL Chi, CC Cheng, CC Hung, MT Wang, HY Liu, MW Ke, MC Shen, KC Lin, SH Kuo, PP Hsieh, SR Wann, WC Huang MMP-10 from M1 macrophages promotes pulmonary vascular remodeling and pulmonary arterial hypertension International journal of biological sciences, 2022-01-01;18(1):331-348. 2022-01-01 [PMID: 34975336] (Bioassay, Human)
• H Guo, D Ding, L Wang, J Yan, L Ma, Q Jin Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-kappaB/ERK signaling pathway PLoS ONE, 2021-12-16;16(12):e0261127. 2021-12-16 [PMID: 34914744] (Bioassay, Mouse)
• Q Xu, P Zhan, X Li, F Mo, H Xu, Y Liu, Q Lai, B Zhang, M Dai, X Liu Bisphosphonate-enoxacin inhibit osteoclast formation and function by abrogating RANKL-induced JNK signalling pathways during osteoporosis treatment Journal of Cellular and Molecular Medicine, 2021-10-15;0(0):. 2021-10-15 [PMID: 34651433] (Cell Culture, Mouse)
• M Zhao, Y Zhang, X Yang, J Jin, Z Shen, X Feng, T Zou, L Deng, D Cheng, X Zhang, C Qin, C Niu, Z Ye, X Zhang, J He, C Hou, G Li, G Han, Q Cheng, Q Wang, L Wei, J Dong, J Zhang Myeloid neddylation targets IRF7 and promotes host innate immunity against RNA viruses PloS Pathogens, 2021-09-10;17(9):e1009901. 2021-09-10 [PMID: 34506605] (Bioassay, Mouse)
• Yang Shi, Prabhakar Sairam Andhey, Christina Ising, Kairuo Wang, Lisa L. Snipes, Kevin Boyer et al. Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms Neuron 2021-08-01 [PMID: 34157306] (Bioassay, Transgenic Mouse)
• D Zhang, J Huang, F Wang, H Ding, Y Cui, Y Yang, J Xu, H Luo, Y Gao, L Pan, Y Wu, Y Gong, L Xie, Z Liu, Y Qu, L Zhang, W Liu, W Zhang, S Zhao, Q Yi, T Niu, Y Zheng BMI1 regulates multiple myeloma-associated macrophage&#039;s pro-myeloma functions Cell Death & Disease, 2021-05-15;12(5):495. 2021-05-15 [PMID: 33993198] (Bioassay, Human)
• M Zelic, F Pontarelli, L Woodworth, C Zhu, A Mahan, Y Ren, M LaMorte, R Gruber, A Keane, P Loring, L Guo, TH Xia, B Zhang, P Orning, E Lien, A Degterev, T Hammond, D Ofengeim RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis Cell Reports, 2021-05-11;35(6):109112. 2021-05-11 [PMID: 33979622] (Bioassay, Human)
• R Song, Y Gao, I Dozmorov, V Malladi, I Saha, MM McDaniel, S Parameswar, C Liang, C Arana, B Zhang, B Wakeland, J Zhou, MT Weirauch, LC Kottyan, EK Wakeland, C Pasare IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility Cell Reports, 2021-03-23;34(12):108891. 2021-03-23 [PMID: 33761354] (Bioassay, Human)
• MS Phuong, RE Hernandez, DJ Wolter, LR Hoffman, S Sad Impairment in inflammasome signaling by the chronic Pseudomonas aeruginosa isolates from cystic fibrosis patients results in an increase in inflammatory response Cell Death & Disease, 2021-03-04;12(3):241. 2021-03-04 [PMID: 33664232] (Bioassay, Human)
• Z Zhou, A Xu, J Teng, F Wang, Y Tan, H Liu, X Cheng, Y Su, H Shi, Q Hu, H Chi, J Li, J Hou, Y Sun, C Yang, J Ye Anti-Tyro3 IgG Associates with Disease Activity and Reduces Efferocytosis of Macrophages in New-Onset Systemic Lupus Erythematosus J Immunol Res, 2020-11-10;2020(0):2180708. 2020-11-10 [PMID: 33224991] (Cell Culture, Human)
• Obst J, Simon E, Martin-Estebane M, Pipi E, Barkwill L, Gonzalez-Rivera I, Buchanan F, Prescott A, Faust D, Fox S, Brownlees J, Taylor D, Perry V, Nuthall H, Atkinson P, Karran E, Routledge C, Gomez-Nicola D Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration. Front Immunol, 2020-10-08;11(0):579000. 2020-10-08 [PMID: 33162994] (Cell Culture, Mouse)
• S Saha, E Profumo, AR Togna, R Riganò, L Saso, B Buttari Lupeol Counteracts the Proinflammatory Signalling Triggered in Macrophages by 7-Keto-Cholesterol: New Perspectives in the Therapy of Atherosclerosis Oxid Med Cell Longev, 2020-09-27;2020(0):1232816. 2020-09-27 [PMID: 33062133] (Bioassay, Human)
• D Olagnier, E Farahani, J Thyrsted, J Blay-Cadan, A Herengt, M Idorn, A Hait, B Hernaez, A Knudsen, MB Iversen, M Schilling, SE Jørgensen, M Thomsen, LS Reinert, M Lappe, HD Hoang, VH Gilchrist, AL Hansen, R Ottosen, CG Nielsen, C Møller, D van der Ho, S Peri, S Balachandr, J Huang, M Jakobsen, EB Svenningse, TB Poulsen, L Bartsch, AL Thielke, Y Luo, T Alain, J Rehwinkel, A Alcamí, J Hiscott, TH Mogensen, SR Paludan, CK Holm SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate Nat Commun, 2020-10-02;11(1):4938. 2020-10-02 [PMID: 33009401] (Cell Culture, Human)
• FM Davis, LC Tsoi, R Wasikowski, A denDekker, A Joshi, C Wilke, H Deng, S Wolf, A Obi, S Huang, AC Billi, S Robinson, J Lipinski, WJ Melvin, CO Audu, S Weidinger, SL Kunkel, A Smith, JE Gudjonsson, BB Moore, KA Gallagher Epigenetic regulation of the PGE2 pathway modulates macrophage phenotype in normal and pathologic wound repair JCI Insight, 2020-09-03;5(17):. 2020-09-03 [PMID: 32879137] (Cell Culture, Human)
• F Duan, L Guo, L Yang, Y Han, A Thakur, BE Nilsson-Pa, P Wang, Z Zhang, CY Ma, X Zhou, T Han, T Zhang, X Wang, D Xu, X Duan, J Xiang, HF Tse, C Liao, W Luo, FP Huang, YW Chen, T Evans, RE Schwartz, B tenOever, DD Ho, S Chen, Q Lian, HJ Chen Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2 Res Sq, 2020-09-15;0(0):. 2020-09-15 [PMID: 32839764] (Bioassay, Human)
• G Camilli, M Bohm, AC Piffer, R Lavenir, DL Williams, B Neven, G Grateau, S Georgin-La, J Quintin &amp;beta-Glucan-induced reprogramming of human macrophages inhibits NLRP3 inflammasome activation in cryopyrinopathies J. Clin. Invest., 2020-09-01;0(0):. 2020-09-01 [PMID: 32716363] (Cell Culture, Human)
• KJ Gregory, SM Morin, A Kubosiak, J Ser-Dolans, B Schalet, DJ Jerry, SS Schneider The use of patient-derived breast tissue explants to study macrophage polarization and the effects of environmental chemical exposure Immunol. Cell Biol., 2020-09-09;0(0):. 2020-09-09 [PMID: 32713010] (Cell Culture, Human)
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• Liu Z, Xu J, Li H, Zheng Y, He J, Liu H, Zhong Y, Lu Y, Hong B, Zhang M, Lin P, Du J, Hou J, Qian J, Kwak L, Yi Q, Yang J Bone marrow stromal cells derived MCP-1 reverses the inhibitory effects of multiple myeloma cells on osteoclastogenesis by upregulating the RANK expression. PLoS ONE, 2013-12-10;8(12):e82453. 2013-12-10 [PMID: 24340030] (Bioassay, Human)
• Spurrell , Emma, Gangeswaran , Rathi, Wang , Pengju, Cao , Fengyu, Gao , Dongling, Feng , Baisui, Wold , William, Tollefson , Ann, Lemoine , Nicholas, Wang , Yaohe STAT1 interaction with E3-14.7K in monocytes affects the efficacy of oncolytic adenovirus. J Virol, 2013-12-11;88(4):2291-300. 2013-12-11 [PMID: 24335311] (Bioassay, Human)
• Vatter H, Brinton M Differential responses of disease-resistant and disease-susceptible primate macrophages and myeloid dendritic cells to simian hemorrhagic fever virus infection. J Virol, 2013-12-11;88(4):2095-106. 2013-12-11 [PMID: 24335289] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque), Primate - Papio anubis (Olive Baboon))
• Engstrom A, Erlandsson A, Delbro D, Wijkander J Conditioned media from macrophages of M1, but not M2 phenotype, inhibit the proliferation of the colon cancer cell lines HT-29 and CACO-2. Int J Oncol, 2013-12-02;44(2):385-92. 2013-12-02 [PMID: 24296981] (Bioassay, Human)
• Haselow K, Bode J, Wammers M, Ehlting C, Keitel V, Kleinebrecht L, Schupp A, Haussinger D, Graf D Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages. J Leukoc Biol, 2013-08-29;94(6):1253-64. 2013-08-29 [PMID: 23990628] (Bioassay, Human)
• Chen C, Cheng P, Xie H, Zhou H, Wu X, Liao E, Luo X MiR-503 regulates osteoclastogenesis via targeting RANK. J Bone Miner Res, 2014-02-01;29(2):338-47. 2014-02-01 [PMID: 23821519] (Bioassay, Human)
• He W, Mazumder A, Wilder T, Cronstein B Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma. FASEB J, 2013-05-16;27(9):3446-54. 2013-05-16 [PMID: 23682121] (Bioassay, Human)
• Veitonmaki N, Hansson M, Zhan F, Sundberg A, Lofstedt T, Ljungars A, Li Z, Martinsson-Niskanen T, Zeng M, Yang Y, Danielsson L, Kovacek M, Lundqvist A, Martensson L, Teige I, Tricot G, Frendeus B A human ICAM-1 antibody isolated by a function-first approach has potent macrophage-dependent antimyeloma activity in vivo. Cancer Cell, 2013-04-15;23(4):502-15. 2013-04-15 [PMID: 23597564] (Bioassay, Human)
• Deschaseaux F, Gaillard J, Langonne A, Chauveau C, Naji A, Bouacida A, Rosset P, Heymann D, De Pinieux G, Rouas-Freiss N, Sensebe L Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue. FASEB J, 2013-04-16;27(8):2977-87. 2013-04-16 [PMID: 23592762] (Bioassay, Human)
• Yoneno K, Hisamatsu T, Shimamura K, Kamada N, Ichikawa R, Kitazume M, Mori M, Uo M, Namikawa Y, Matsuoka K, Sato T, Koganei K, Sugita A, Kanai T, Hibi T TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn&#039;s disease. Immunology, 2013-05-01;139(1):19-29. 2013-05-01 [PMID: 23566200] (Bioassay, Human)
• Choi H, Kang H, Jung E, Kim T, Lin J, Lee S Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis. Cell Res, 2013-03-12;23(4):524-36. 2013-03-12 [PMID: 23478294] (Bioassay, Mouse)
• van der Kraan A, Chai R, Singh P, Lang B, Xu J, Gillespie M, Price J, Quinn J HSP90 inhibitors enhance differentiation and MITF (microphthalmia transcription factor) activity in osteoclast progenitors. Biochem J, 2013-04-15;451(2):235-44. 2013-04-15 [PMID: 23379601] (Bioassay, Mouse)
• Johnston A, Xing X, Swindell W, Kochkodan J, Riblett M, Nair R, Stuart P, Ding J, Voorhees J, Elder J, Gudjonsson J Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis. Hum Mol Genet, 2013-01-31;22(9):1807-15. 2013-01-31 [PMID: 23376980] (Bioassay, Human)
• Logan J, Sophocleous A, Marino S, Muir M, Brunton V, Idris A Selective tyrosine kinase inhibition of insulin-like growth factor-1 receptor inhibits human and mouse breast cancer-induced bone cell activity, bone remodeling, and osteolysis. J Bone Miner Res, 2013-05-01;28(5):1229-42. 2013-05-01 [PMID: 23239200] (Bioassay, Mouse)
• Wu M, Chen S, Yang A, Lin W, Lin Y, Chen N, Tsai I, Li L, Hsieh S CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages. Blood, 2012-11-14;121(1):95-106. 2012-11-14 [PMID: 23152543] (Bioassay, Human)
• Macrophages induce differentiation of plasma cells through CXCL10/IP-10. J. Exp. Med., 2012-09-17;209(10):1813-23. 2012-09-17 [PMID: 22987802] (Bioassay, Human)
• Raposo RA, Trudgian DC, Thomas B, van Wilgenburg B, Cowley SA, James W Protein kinase C and NF-kappaB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection. J. Immunol., 2011-06-10;187(2):748-59. 2011-06-10 [PMID: 21666058] (Bioassay, Human)
• Lan X, Xu J, Kiyota T, Peng H, Zheng JC, Ikezu T HIV-1 reduces Abeta-degrading enzymatic activities in primary human mononuclear phagocytes. J. Immunol., 2011-05-06;186(12):6925-32. 2011-05-06 [PMID: 21551363] (Bioassay, Human)
• Knowles HJ, Cleton-Jansen AM, Korsching E, Athanasou NA Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4. FASEB J., 2010-07-28;24(12):4648-59. 2010-07-28 [PMID: 20667978] (Bioassay, Human)
• Gupta N, Barhanpurkar AP, Tomar GB IL-3 inhibits human osteoclastogenesis and bone resorption through downregulation of c-Fms and diverts the cells to dendritic cell lineage. J. Immunol., 2010-07-19;185(4):2261-72. 2010-07-19 [PMID: 20644169] (Bioassay, Human)
• Schipper HS, De Jager W, van Dijk ME, Meerding J, Zelissen PM, Adan RA, Prakken BJ, Kalkhoven E A multiplex immunoassay for human adipokine profiling. Clin. Chem., 2010-06-08;56(0):1320. 2010-06-08 [PMID: 20530731] (ELISA (Standard))
• Soe K, Delaisse JM Glucocorticoids maintain human osteoclasts in the active mode of their resorption cycle. J. Bone Miner. Res., 2010-10-01;25(10):2184-92. 2010-10-01 [PMID: 20499345] (Bioassay, Human)
• Lamprecht B, Walter K, Kreher S, Kumar R, Hummel M, Lenze D, Kochert K, Bouhlel MA, Richter J, Soler E, Stadhouders R, Johrens K, Wurster KD, Callen DF, Harte MF, Giefing M, Barlow R, Stein H, Anagnostopoulos I, Janz M, Cockerill PN, Siebert R, Dorken B, Bonifer C, Mathas S Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma. Nat. Med., 2010-05-02;16(5):571-9. 2010-05-02 [PMID: 20436485] (Bioassay, Human)
• Tso GH, Law HK, Tu W Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells. Stem Cells, 2010-05-01;28(5):939-54. 2010-05-01 [PMID: 20222014] (Bioassay, Human)
• Mengshol JA, Golden-Mason L, Arikawa T A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection. PLoS ONE, 2010-03-04;5(3):e9504. 2010-03-04 [PMID: 20209097] (Bioassay, Human)
• Costa-Rodrigues J, Teixeira CA, Sampaio P, Fernandes MH Characterisation of the osteoclastogenic potential of human osteoblastic and fibroblastic conditioned media. J. Cell. Biochem., 2010-01-01;109(1):205-16. 2010-01-01 [PMID: 19911374] (Bioassay, Human)
• Colucci S, Brunetti G, Mori G, Oranger A, Centonze M, Mori C, Cantatore FP, Tamma R, Rizzi R, Liso V, Zallone A, Grano M Soluble decoy receptor 3 modulates the survival and formation of osteoclasts from multiple myeloma bone disease patients. Leukemia, 2009-07-09;23(11):2139-46. 2009-07-09 [PMID: 19587706] (Bioassay, Human)
• Pytlik R, Stehlik D, Soukup T, Kalbacova M, Rypacek F, Trc T, Mulinkova K, Michnova P, Kideryova L, Zivny J, Klener P, Vesela R, Trneny M, Klener P The cultivation of human multipotent mesenchymal stromal cells in clinical grade medium for bone tissue engineering. Biomaterials, 2009-04-10;30(20):3415-27. 2009-04-10 [PMID: 19362364] (Bioassay, Human)
• Irie N, Takada Y, Watanabe Y, Matsuzaki Y, Naruse C, Asano M, Iwakura Y, Suda T, Matsuo K Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis. J. Biol. Chem., 2009-03-19;284(21):14637-44. 2009-03-19 [PMID: 19299512] (Bioassay, Mouse)
• Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts. Bone, 2009-03-02;44(6):1143-50. 2009-03-02 [PMID: 19264156] (Cell Culture, Human)
• Mizutani K, Sud S, Pienta KJ Prostate cancer promotes CD11b positive cells to differentiate into osteoclasts. J. Cell. Biochem., 2009-03-01;106(4):563-9. 2009-03-01 [PMID: 19170075] (Bioassay, Human)
• Mabilleau G, Sabokbar A Interleukin-32 promotes osteoclast differentiation but not osteoclast activation. PLoS ONE, 2009-01-12;4(1):e4173. 2009-01-12 [PMID: 19137064] (Bioassay, Human)
• Chen H, Campbell RA, Chang Y, Li M, Wang CS, Li J, Sanchez E, Share M, Steinberg J, Berenson A, Shalitin D, Zeng Z, Gui D, Perez-Pinera P, Berenson RJ, Said J, Bonavida B, Deuel TF, Berenson JR Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis. Blood, 2008-12-05;113(9):1992-2002. 2008-12-05 [PMID: 19060246] (Bioassay, Human)
• Kwan Tat S, Pelletier JP, Amiable N, Boileau C, Lajeunesse D, Duval N, Martel-Pelletier J Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts. Arthritis Rheum., 2008-12-01;58(12):3820-30. 2008-12-01 [PMID: 19035475] (Bioassay, Human)
• Savage ND, De Boer T, Walburg KV, Joosten SA, van Meijgaarden K, Geluk A, Ottenhoff TH Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1. J. Immunol., 2008-08-01;181(3):2220-6. 2008-08-01 [PMID: 18641362] (Bioassay, Human)
• Breitkreutz I, Raab MS, Vallet S, Hideshima T, Raje N, Mitsiades C, Chauhan D, Okawa Y, Munshi NC, Richardson PG, Anderson KC Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma. Leukemia, 2008-07-03;22(10):1925-32. 2008-07-03 [PMID: 18596740] (Bioassay, Human)
• Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M Isolation and characterization of CD146+ multipotent mesenchymal stromal cells. Exp. Hematol., 2008-05-27;36(8):1035-46. 2008-05-27 [PMID: 18504067] (Bioassay, Human)
• Ishitsuka K, Hideshima T, Neri P, Vallet S, Shiraishi N, Okawa Y, Shen Z, Raje N, Kiziltepe T, Ocio EM, Chauhan D, Tassone P, Munshi N, Campbell RM, Dios AD, Shih C, Starling JJ, Tamura K, Anderson KC p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications. Br. J. Haematol., 2008-04-07;141(5):598-606. 2008-04-07 [PMID: 18397345] (Bioassay, Human)
• Boissy P, Andersen TL, Lund T, Kupisiewicz K, Plesner T, Delaisse JM Pulse treatment with the proteasome inhibitor bortezomib inhibits osteoclast resorptive activity in clinically relevant conditions. Leuk. Res., 2008-04-18;32(11):1661-8. 2008-04-18 [PMID: 18394701] (Bioassay, Human)
• Clerin V, Shih HH, Deng N, Hebert G, Resmini C, Shields KM, Feldman JL, Winkler A, Albert L, Maganti V, Wong A, Paulsen JE, Keith JC, Vlasuk GP, Pittman DD Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis. Atherosclerosis, 2008-02-21;0(0):. 2008-02-21 [PMID: 18377911] (Bioassay, Human)
• Chamoux E, Houde N, L'Eriger K, Roux S Osteoprotegerin decreases human osteoclast apoptosis by inhibiting the TRAIL pathway. J. Cell. Physiol., 2008-08-01;216(2):536-42. 2008-08-01 [PMID: 18338379] (Bioassay, Human)
• Wolk K, Witte K, Witte E, Proesch S, Schulze-Tanzil G, Nasilowska K, Thilo J, Asadullah K, Sterry W, Volk HD, Sabat R Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes. J. Leukoc. Biol., 2008-02-15;83(5):1181-93. 2008-02-15 [PMID: 18281438] (Bioassay, Human)
• Breitkreutz I, Raab MS, Vallet S, Hideshima T, Raje N, Chauhan D, Munshi NC, Richardson PG, Anderson KC Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma. Br. J. Haematol., 2007-10-01;139(1):55-63. 2007-10-01 [PMID: 17854307] (Bioassay, Human)
• Colucci S, Brunetti G, Cantatore FP, Oranger A, Mori G, Quarta L, Cirulli N, Mancini L, Corrado A, Grassi FR, Grano M Lymphocytes and synovial fluid fibroblasts support osteoclastogenesis through RANKL, TNFalpha, and IL-7 in an in vitro model derived from human psoriatic arthritis. J. Pathol., 2007-05-01;212(1):47-55. 2007-05-01 [PMID: 17370327] (Bioassay, Human)
• Tang CH, Hsu TL, Lin WW, Lai MZ, Yang RS, Hsieh SL, Fu WM Attenuation of bone mass and increase of osteoclast formation in decoy receptor 3 transgenic mice. J. Biol. Chem., 2006-11-10;282(4):2346-54. 2006-11-10 [PMID: 17099218] (Bioassay, Mouse)
• Edwards JR, Sun SG, Locklin R, Shipman CM, Adamopoulos IE, Athanasou NA, Sabokbar A LIGHT (TNFSF14), a novel mediator of bone resorption, is elevated in rheumatoid arthritis. Arthritis Rheum., 2006-05-01;54(5):1451-62. 2006-05-01 [PMID: 16649193] (Bioassay, Human)
• de Vries TJ, Schoenmaker T, Wattanaroonwong N, van den Hoonaard M, Nieuwenhuijse A, Beertsen W, Everts V Gingival fibroblasts are better at inhibiting osteoclast formation than periodontal ligament fibroblasts. J. Cell. Biochem., 2006-05-15;98(2):370-82. 2006-05-15 [PMID: 16440316] (Bioassay, Human)
• Mortara L, Ploquin MJ, Faye A, Scott-Algara D, Vaslin B, Butor C, Hosmalin A, Barre-Sinoussi F, Diop OM, Muller-Trutwin MC Phenotype and function of myeloid dendritic cells derived from African green monkey blood monocytes. J. Immunol. Methods, 2005-11-21;308(1):138-55. 2005-11-21 [PMID: 16325847] (Bioassay, Primate - Chlorocebus pygerythrus (Vervet Monkey))
• Roux S, Lambert-Comeau P, Saint-Pierre C, Lepine M, Sawan B, Parent JL Death receptors, Fas and TRAIL receptors, are involved in human osteoclast apoptosis. Biochem. Biophys. Res. Commun., 2005-07-22;333(1):42-50. 2005-07-22 [PMID: 15936719] (Bioassay, Human)
• Wei S, Kitaura H, Zhou P, Ross FP, Teitelbaum SL IL-1 mediates TNF-induced osteoclastogenesis. J. Clin. Invest., 2005-02-01;115(2):282-90. 2005-02-01 [PMID: 15668736] (Bioassay, Human, Mouse)
• Sharif MN, Tassiulas I, Hu Y, Mecklenbrauker I, Tarakhovsky A, Ivashkiv LB IFN-alpha priming results in a gain of proinflammatory function by IL-10: implications for systemic lupus erythematosus pathogenesis. J. Immunol., 2004-05-15;172(10):6476-81. 2004-05-15 [PMID: 15128840] (Bioassay, Human)
• Gough PJ, Garton KJ, Wille PT, Rychlewski M, Dempsey PJ, Raines EW A disintegrin and metalloproteinase 10-mediated cleavage and shedding regulates the cell surface expression of CXC chemokine ligand 16. J. Immunol., 2004-03-15;172(6):3678-85. 2004-03-15 [PMID: 15004171] (Bioassay, Mouse)
• Herrero C, Hu X, Li WP, Samuels S, Sharif MN, Kotenko S, Ivashkiv LB Reprogramming of IL-10 activity and signaling by IFN-gamma. J. Immunol., 2003-11-15;171(10):5034-41. 2003-11-15 [PMID: 14607900] (Bioassay, Human)

Bioinformatics

• Gene Symbol: CSF1
• Uniprot:
  • NP_757350()