Recombinant Human SCF Protein

• Reactivity: Hu
• Applications: Bioactivity

Recombinant Human SCF Protein Summary

• Details of Functionality: Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED₅₀ for this effect is 1‑5 ng/mL.
• Source: E. coli-derived human SCF/c-kit Ligand protein
  Glu26-Ala189, with an N-terminal Met
• Accession #: P21583.1
• N-terminal Sequence: Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: KITLG
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Endotoxin Note: <1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 19 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 17-18 kDa, under reducing condtitions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Reconstitution Instructions: Reconstitute at 100-200 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human SCF Protein

• c-kit Ligand
• DCUA
• DFNA69
• DKFZp686F2250
• familial progressive hyperpigmentation 2
• FPH2
• FPHH
• KIT ligand
• Kitl
• KITLG
• KL-1
• Mast cell growth factor
• MGF
• MGFSHEP7
• SCF
• SCFStem cell factor
• SFc-Kit ligand
• SHEP7
• SLF
• steel factor

Background

What is Stem cell factor?

Stem cell factor (SCF) is a potent hematopoietic growth factor required in regulating both embryonic and adult hematopoiesis. SCF protein promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors (1 7). SCF is a primary growth and activation factor for mast cells and eosinophils (8). And SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels (9). Stem cell factor is an important cytokine for ex vivo clinical applications. Along with other cytokines, SCF is used in the culture and expansion of hematopoietic stem cells (HSCs) as well as for proliferation and differentiation of both myeloid and erythroid progenitor cells.

Mature stem cell factor consists of a 189 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane domain, and a 36 aa cytoplasmic tail (10). The ECD shows both N linked and O-linked glycosylation (11). SCF protein exists in two forms, a membrane-bound form and a proteolytically processed soluble form that lacks the transmembrane domain and cytoplasmic tail. The soluble form is created by proteolytic cleavage at two alternate sites in the extracellular juxtamembrane region releasing a 25 kDa soluble SCF protein which is comparable to the only form produced by Steel-dickie mutant mice (12, 13). There is also an alternately spliced isoform of human SCF that lacks 28 amino acids that encompasses the primary proteolytic recognition site (14). This form cannot be cleaved and is only membrane bound.

SCF binds to C-kit (CD117). C-kit is expressed on many different cell types including HSCs, mast cells, germ cells, and melanocytes. Binding of SCF to C-kit induces receptor dimerization and autophosphorylation of tyrosine residues in the cytoplasmic domain (15). Tyrosine phosphorylation initiates multiple signaling pathways including RAS, PI3 kinase, Src, and JAK/STAT. Stem cell factor is highly conserved among mammals. Human SCF protein shares 79% 87% aa sequence identity with dog, cat, mouse, and rat SCF. Rat SCF is active on mouse and human cells, but human SCF is only weakly active on mouse cells (10).

1. Ashman, L.K. (1999) Int. J. Biochem. Cell Biol. 31:1037. 
2. Sette, C. et al. (2000) Int. J. Dev. Biol. 44:599. 
3. Yoshida, H. et al. (2001) J. Invest. Dermatol. Symp. Proc. 6:1. 
4. Erlandsson, A. et al. (2004) Exp. Cell Res. 301:201. 
5. Kapur, R. et al. (2002) Blood 100:1287. 
6. Wang, C.-H. et al. (2007) Arterioscler. Thromb. Vasc. Biol. 27:540. 
7. Bashamboo, A. et al. (2006) J. Cell Sci. 119:3039. 
8. Reber, L. et al. (2006) Eur. J. Pharmacol. 533:327.
9. Kanellakis, P. et al. (2006) Cardiovasc. Res. 70:117.
10. Martin, F.H. et al. (1990) Cell 63:203.
11. Arakawa, T. et al. (1991) J. Biol. Chem. 266:18942.
12. Majumdar, M.K. et al. (1994) J. Biol. Chem. 269:1237.
13. Brannan, C.I. et al. (1991) Proc. Natl. Acad. Sci. 88:4671.
14. Anderson, D.M. et al. (1991) Cell Growth Differ. 2:373.
15. Lemmon, M.A. et al. (1997) J. Biol. Chem. 272:6311.

Publications for SCF/c-kit Ligand (255-SC)(205)

Publications using 255-SC

• Kok, LML;Helwegen, K;Coveña, NF;Heine, VM; Human pluripotent stem cell-derived microglia shape neuronal morphology and enhance network activity in vitro Journal of neuroscience methods 2024-12-24 [PMID: 39724963] (Bioassay, Human)
• Yoo, SP;Yuan, X;Engstrom, C;Chang, P;Li, S;Lathrop, L;Lagosh, J;Seet, C;Kohn, DB;Crooks, GM; Stage-specific CAR-mediated signaling generates naïve-like, TCR-null CAR T cells from induced pluripotent stem cells bioRxiv : the preprint server for biology 2024-11-28 [PMID: 39651198] (Bioassay, Human)
• Demirci, S;Zeng, J;Palchaudhuri, R;Wu, C;Abraham, DM;Hayal, TB;Essawi, K;Nguyen, MA;Stasula, U;Chu, R;Leonard, A;Porter, SN;Khan, MBN;Hinojosa, G;Uchida, N;Hong, S;Lazzarotto, CR;Neri, NR;da Silva, LF;Pellin, D;Verma, A;Lanieri, L;Bhat, A;Hammond, K;Tate, T;Maitland, SA;Sheikhsaran, F;Bonifacino, AC;Krouse, AE;Linde, NS;Engels, T;Golomb, J;Tsai, SQ;Pruett-Miller, SM;Scadden, DT;Dunbar, CE;Wolfe, SA;Donahue, RE;Olson, LM;Bauer, DE;Tisdale, JF; BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate Cell stem cell 2024-12-05 [PMID: 39642886] (Bioassay, Mouse, Rhesus Macaque)
• Kent, GM;Atkins, MH;Lung, B;Nikitina, A;Fernandes, IM;Kwan, JJ;Andrews, TS;MacParland, SA;Keller, GM;Gage, BK; Human liver sinusoidal endothelial cells support the development of functional human pluripotent stem cell-derived Kupffer cells Cell reports 2024-08-14 [PMID: 39146183] (Bioassay, Human)
• Abello, J;Yin, Y;Zhao, Y;Maurer, J;Lee, J;Bodell, C;Clevenger, AJ;Burton, Z;Goeckel, ME;Lin, M;Grainger, S;Halabi, CM;Raghavan, SA;Sah, R;Stratman, AN; Endothelial cell Piezo1 promotes vascular smooth muscle cell differentiation on large arteries bioRxiv : the preprint server for biology 2024-06-12 [PMID: 38915529] (Bioassay, Human)
• Landau, S;Zhao, Y;Hamidzada, H;Kent, GM;Okhovatian, S;Lu, RXZ;Liu, C;Wagner, KT;Cheung, K;Shawky, SA;Vosoughi, D;Beroncal, EL;Fernandes, I;Cummins, CL;Andreazza, AC;Keller, GM;Epelman, S;Radisic, M; Primitive macrophages enable long-term vascularization of human heart-on-a-chip platforms Cell stem cell 2024-06-20 [PMID: 38908380] (Bioassay, Human)
• Johnson, D;Colijn, S;Richee, J;Yano, J;Burns, M;Davis, AE;Pham, VN;Saric, A;Jain, A;Yin, Y;Castranova, D;Melani, M;Fujita, M;Grainger, S;Bonifacino, JS;Weinstein, BM;Stratman, AN; Regulation of angiogenesis by endocytic trafficking mediated by cytoplasmic dynein 1 light intermediate chain 1 bioRxiv : the preprint server for biology 2024-04-01 [PMID: 38903077] (Bioassay, Human)
• Kim, J;Diaz, LF;Miller, MJ;Leadem, B;Krivega, I;Dean, A; An enhancer RNA recruits KMT2A to regulate transcription of Myb Cell reports 2024-06-17 [PMID: 38889007] (Mouse)
• Khan, F;Lin, Y;Ali, H;Pang, L;Dunterman, M;Hsu, WH;Frenis, K;Grant Rowe, R;Wainwright, DA;McCortney, K;Billingham, LK;Miska, J;Horbinski, C;Lesniak, MS;Chen, P; Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression Nature communications 2024-03-05 [PMID: 38443336] (Bioassay, Mouse)
• Hwang, YS;Seita, Y;Blanco, MA;Sasaki, K; CRISPR loss of function screening to identify genes involved in human primordial germ cell-like cell development PLoS genetics 2023-12-01 [PMID: 38091369] (Cell Culture, Human)
• Chen, P;Khan, F;Lin, Y;Ali, H;Pang, L;Dunterman, M;Hsu, WH;Frenis, K;Rowe, RG;Wainwright, D;McCortney, K;Billingham, L;Miska, J;Horbinski, C;Lesniak, M; LDHA-regulated tumor-macrophage symbiosis promotes glioblastoma progression Research square 2023-10-05 [PMID: 37886538] (Bioassay, Human, Mouse)
• Alimohammadi, S;Masuda-Kuroki, K;Szöll?si, AG;Di Nardo, A; Factors Influencing Marker Expressions of Cultured Human Cord Blood-Derived Mast Cells International journal of molecular sciences 2023-10-04 [PMID: 37834338] (Bioassay, Human)
• Goeckel, ME;Lee, J;Levitas, A;Colijn, S;Mun, G;Burton, Z;Chintalapati, B;Yin, Y;Abello, J;Stratman, A; CXCR3-CXCL11 signaling restricts angiogenesis and promotes pericyte recruitment bioRxiv : the preprint server for biology 2023-09-17 [PMID: 37745440] (Cell Culture, Human)
• Fei-Man Hsu, Qiu Ya Wu, Emily B. Fabyanic, Alex Wei, Hao Wu, Amander T. Clark TET1 facilitates specification of early human lineages including germ cells iScience 2023-07-21 [PMID: 37456839] (Bioassay, Human)
• Mayuranathan, T;Newby, GA;Feng, R;Yao, Y;Mayberry, KD;Lazzarotto, CR;Li, Y;Levine, RM;Nimmagadda, N;Dempsey, E;Kang, G;Porter, SN;Doerfler, PA;Zhang, J;Jang, Y;Chen, J;Bell, HW;Crossley, M;Bhoopalan, SV;Sharma, A;Tisdale, JF;Pruett-Miller, SM;Cheng, Y;Tsai, SQ;Liu, DR;Weiss, MJ;Yen, JS; Potent and uniform fetal hemoglobin induction via base editing Nature genetics 2023-07-03 [PMID: 37400614] (Cell Culture, Human)
• A Gehrlein, V Udayar, N Anastasi, ML Morella, I Ruf, D Brugger, S von der Ma, R Thoma, A Rufer, D Heer, N Pfahler, A Jochner, J Niewoehner, L Wolf, M Fueth, M Ebeling, R Villaseñor, Y Zhu, MC Deen, X Shan, Z Ehsaei, V Taylor, E Sidransky, DJ Vocadlo, PO Freskgård, R Jagasia Targeting neuronal lysosomal dysfunction caused by beta-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct Nature Communications, 2023-04-12;14(1):2057. 2023-04-12 [PMID: 37045813] (Bioassay, Human)
• AA Almad, L Garcia, A Takanohash, A Gagne, W Yang, J Ann McGuir, D French, A Vanderver Generation of three induced Pluripotent Stem Cell lines from individuals with Hypomyelination with Atrophy of Basal Ganglia and Cerebellum caused by a c.745G&gt;A (p.D249N) autosomal dominant mutation in TUBB4A Stem Cell Research, 2023-03-26;69(0):103083. 2023-03-26 [PMID: 37003180] (Bioassay, Human)
• S Li, CS Wang, A Montel-Hag, HC Chen, S Lopez, O Zhou, K Dai, S Tsai, W Satyadi, C Botero, C Wong, D Casero, GM Crooks, CS Seet Strength of CAR signaling determines T�cell versus ILC differentiation from pluripotent stem cells Cell Reports, 2023-03-11;42(3):112241. 2023-03-11 [PMID: 36906850] (Bioassay, Human)
• Y Fan, J Hackland, A Baggiolini, LY Hung, H Zhao, P Zumbo, P Oberst, AP Minotti, E Hergenrede, S Najjar, Z Huang, NM Cruz, A Zhong, M Sidharta, T Zhou, E de Stanchi, D Betel, RM White, M Gershon, KG Margolis, L Studer hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung&#039;s disease Cell Stem Cell, 2023;30(3):264-282.e9. 2023 [PMID: 36868194] (Bioassay, Human)
• Y Fan, J Hackland, A Baggiolini, LY Hung, H Zhao, P Zumbo, P Oberst, AP Minotti, E Hergenrede, S Najjar, Z Huang, NM Cruz, A Zhong, M Sidharta, T Zhou, E de Stanchi, D Betel, RM White, M Gershon, KG Margolis, L Studer hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung&#039;s disease Cell Stem Cell, 2023-03-02;30(3):264-282.e9. 2023-03-02 [PMID: 36868194] (Bioassay, Human)
• L Feige, T Kozaki, G Dias de Me, V Guillemot, F Larrous, F Ginhoux, H Bourhy Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses Viruses, 2022-12-29;15(1):. 2022-12-29 [PMID: 36680128] (Bioassay, Human)
• JP Borges, RSR Sætra, A Volchuk, M Bugge, P Devant, B Sporsheim, BR Kilburn, CL Evavold, JC Kagan, NM Goldenberg, TH Flo, BE Steinberg Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death Elife, 2022-12-05;11(0):. 2022-12-05 [PMID: 36468682] (Cell Culture, Mouse)
• PY Su, W Lee, J Zernant, SH Tsang, T Nagasaki, B Corneo, R Allikmets Establishment of the iPSC line CUIMCi005-A from a patient with Stargardt disease for retinal organoid culture Oncogene, 2022-11-14;65(0):102973. 2022-11-14 [PMID: 36455383] (Bioassay, Human)
• X Liu, N Sato, T Yabushita, J Li, Y Jia, M Tamura, S Asada, T Fujino, T Fukushima, T Yonezawa, Y Tanaka, T Fukuyama, A Tsuchiya, S Shikata, H Iwamura, C Kinouchi, K Komatsu, S Yamasaki, T Shibata, AT Sasaki, J Schibler, M Wunderlich, E O'Brien, B Mizukawa, JC Mulloy, Y Sugiura, H Takizawa, T Shibata, K Miyake, T Kitamura, S Goyama IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia Embo Molecular Medicine, 2022-12-01;0(0):e15631. 2022-12-01 [PMID: 36453131] (Cell Culture, Human)
• Kunitomi A, Hirohata R, Arreola V, Osawa M, Kato T, Nomura M, Kawaguchi J, Hara H, Kusano K, Takashima Y, Takahashi K, Fukuda K, Takasu N, Yamanaka S Improved Sendai viral system for reprogramming to naive pluripotency. Cell Rep Methods, 2022-10-17;2(11):100317. 2022-10-17 [PMID: 36447645] (Bioassay, Human)
• Z Li, F Fang, Y Long, Q Zhao, X Wang, Z Ye, T Meng, X Gu, W Xiang, C Xiong, H Li The balance between NANOG and SOX17 mediated by TET proteins regulates specification of human primordial germ cell fate Cell & bioscience, 2022-11-04;12(1):181. 2022-11-04 [PMID: 36333732] (Bioassay, Human)
• JC Huang, SC Chen, WA Chang, WW Hung, PH Wu, LY Wu, JM Chang, YL Hsu, YC Tsai KITLG Promotes Glomerular Endothelial Cell Injury in Diabetic Nephropathy by an Autocrine Effect International Journal of Molecular Sciences, 2022-10-03;23(19):. 2022-10-03 [PMID: 36233032] (Cell Culture, Human)
• R Feng, T Mayuranath, P Huang, PA Doerfler, Y Li, Y Yao, J Zhang, LE Palmer, K Mayberry, GE Christakop, P Xu, C Li, Y Cheng, GA Blobel, MC Simon, MJ Weiss Activation of gamma-globin expression by hypoxia-inducible factor 1alpha Nature, 2022-10-12;0(0):. 2022-10-12 [PMID: 36224385] (Bioassay, Human)
• N Vilaplana-, V Cuminetti, R Almaghrabi, G Papatzikas, AK Rout, M Jeeves, E González, Y Alyahyawi, A Cunningham, A Erdem, F Schnütgen, M Raghavan, S Potluri, JB Cazier, JJ Schuringa, MAC Reed, L Arranz, UL Günther, P Garcia Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells Elife, 2022-09-02;11(0):. 2022-09-02 [PMID: 36052997] (Bioassay, Human)
• YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells Science Advances, 2022-08-24;8(34):eabn5522. 2022-08-24 [PMID: 36001668] (Bioassay, Human)
• R Jing, I Scarfo, MA Najia, E Lummertz d, A Han, M Sanborn, T Bingham, C Kubaczka, DK Jha, M Falchetti, TM Schlaeger, TE North, MV Maus, GQ Daley EZH1 repression generates mature iPSC-derived CAR T�cells with enhanced antitumor activity Cell Stem Cell, 2022-08-04;29(8):1181-1196.e6. 2022-08-04 [PMID: 35931029] (Bioassay, Human)
• D Ávila-Gonz, W Portillo, CP Barragán-Á, G Hernandez-, E Flores-Gar, A Molina-Her, NE Díaz-Martí, NF Díaz The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells Elife, 2022-07-11;11(0):. 2022-07-11 [PMID: 35815953] (Bioassay, Human)
• L Liu, A Vujovic, NP Deshpande, S Sathe, G Anande, HTT Chen, J Xu, MD Minden, GW Yeo, A Unnikrishn, KJ Hope, Y Lu The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors Nature Communications, 2022-07-04;13(1):3833. 2022-07-04 [PMID: 35781533] (Bioassay, Human)
• J Skokowa, B Hernandez, M Coles, M Ritter, M Nasri, J Haaf, N Aghaallaei, Y Xu, P Mir, AC Krahl, KW Rogers, K Maksymenko, B Bajoghli, K Welte, AN Lupas, P Müller, M ElGamacy A topological refactoring design strategy yields highly stable granulopoietic proteins Nature Communications, 2022-05-26;13(1):2948. 2022-05-26 [PMID: 35618709] (Bioassay, Human)
• JH Hong, JH Kim, KW Kang, BH Lee, Y Park, BS Kim Generation of a human induced pluripotent stem cell line KUMi006 from a patient with multiple myeloma Stem Cell Research, 2022-03-28;61(0):102767. 2022-03-28 [PMID: 35397398] (Bioassay, Human)
• Y Liu, Y Liu, Y Jia, J Lv, D Sun, Y Yin, N Liu, B Su, G Sun Generation of an induced pluripotent stem cell (iPSC) line from a diabetic patient with glucagon receptor (GCGR) p.W83X mutation Stem Cell Research, 2022-03-11;61(0):102745. 2022-03-11 [PMID: 35381520] (Bioassay, Human)
• G Iannello, A Patel, D Sirabella, B Corneo, VV Thaker Derivation and characterization of the induced pluripotent stem cell line CUIMCi004-A from a patient with a novel frameshift variant in exon 18a of OCRL Stem Cell Research, 2021-12-23;59(0):102635. 2021-12-23 [PMID: 35074682] (Bioassay, Human)
• M Sone, S Nakamura, S Umeda, H Ginya, M Oshima, MA Kanashiro, SK Paul, K Hashimoto, E Nakamura, Y Harada, K Tsujimura, A Saraya, T Yamaguchi, N Sugimoto, A Sawaguchi, A Iwama, K Eto, N Takayama Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs Stem Cell Reports, 2021-12-02;0(0):. 2021-12-02 [PMID: 34861163] (Bioassay, Human)
• AF de Souza, FF Bressan, NCG Pieri, RC Botigelli, T Revay, SK Haddad, DT Covas, ES Ramos, WA King, FV Meirelles Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients Cells, 2021-11-10;10(11):. 2021-11-10 [PMID: 34831322] (Bioassay, Human)
• SS Sahoo, VB Pastor, C Goodings, RK Voss, EJ Kozyra, A Szvetnik, P Noellke, M Dworzak, J Starý, F Locatelli, R Masetti, M Schmugge, B De Moerloo, A Catala, K Kállay, D Turkiewicz, H Hasle, J Buechner, K Jahnukaine, M Ussowicz, S Polychrono, OP Smith, O Fabri, S Barzilai, V de Haas, I Baumann, S Schwarz-Fu, European W, MR Niewisch, MG Sauer, B Burkhardt, P Lang, P Bader, R Beier, I Müller, MH Albert, R Meisel, A Schulz, G Cario, PK Panda, J Wehrle, S Hirabayash, M Derecka, R Durruthy-D, G Göhring, A Yoshimi-No, M Ku, D Lebrecht, M Erlacher, C Flotho, B Strahm, CM Niemeyer, MW Wlodarski Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes Nature Medicine, 2021-10-07;27(10):1806-1817. 2021-10-07 [PMID: 34621053] (Bioassay, Human)
• S Yu, C Di, S Chen, M Guo, J Yan, Z Zhu, L Liu, R Feng, Y Xie, R Zhang, J Chen, M Wang, D Wei, H Fang, T Yin, J Huang, S Chen, H Lu, J Zhu, J Qu Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2pos subjects Cell Research, 2021-09-24;0(0):. 2021-09-24 [PMID: 34561618] (Bioassay, Human)
• Sudo K, Yamazaki S, Wilkinson A, Nakauchi H, Nakamura Y Polyvinyl alcohol hydrolysis rate and molecular weight influence human and murine HSC activity ex vivo. Stem Cell Res, 2021-09-03;56(0):102531. 2021-09-03 [PMID: 34509158] (Bioassay, Human)
• GB Schwartz, H Kubo, MM Laronda Generation of two human induced pluripotent stem cell lines from a patient with complete androgen insensitivity syndrome with a hemizygous single nucleotide variant in the androgen receptor (AR) gene Stem Cell Research, 2021-06-30;55(0):102441. 2021-06-30 [PMID: 34233262] (Bioassay, Human)
• H Kato, Y Maezawa, Y Ouchi, N Takayama, M Sone, K Sone, A Takada-Wat, K Tsujimura, M Koshizaka, S Nagasawa, H Saitoh, M Ohtaka, M Nakanishi, H Tahara, A Shimamoto, A Iwama, K Eto, K Yokote Generation of disease-specific and CRISPR/Cas9-mediated gene-corrected iPS cells from a patient with adult progeria Werner syndrome Stem Cell Research, 2021-04-23;53(0):102360. 2021-04-23 [PMID: 34087989] (Cell Culture, Human)
• GA Newby, JS Yen, KJ Woodard, T Mayuranath, CR Lazzarotto, Y Li, H Sheppard-T, SN Porter, Y Yao, K Mayberry, KA Everette, Y Jang, CJ Podracky, E Thaman, C Lechauve, A Sharma, JM Henderson, MF Richter, KT Zhao, SM Miller, T Wang, LW Koblan, AP McCaffrey, JF Tisdale, TA Kalfa, SM Pruett-Mil, SQ Tsai, MJ Weiss, DR Liu Base editing of haematopoietic stem cells rescues sickle cell disease in mice Nature, 2021-06-02;0(0):. 2021-06-02 [PMID: 34079130] (Bioassay, Human)
• JC Reid, D Golubeva, AL Boyd, CG Hollands, C Henly, L Orlando, A Leber, J Hébert, F Morabito, G Cutrona, L Agnelli, M Gentile, M Ferrarini, A Neri, B Leber, M Bhatia Human pluripotent stem cells identify molecular targets of trisomy 12 in chronic lymphocytic leukemia patients Cell Reports, 2021-03-16;34(11):108845. 2021-03-16 [PMID: 33730576] (Bioassay, Human)
• W Yuan, Z Yao, V Veerapandi, X Yang, X Wang, D Chen, L Ma, C Li, Y Zheng, F Luo, XY Zhao The histone demethylase KDM2B regulates human primordial germ cell-like cells specification International journal of biological sciences, 2021-01-01;17(2):527-538. 2021-01-01 [PMID: 33613110] (Bioassay, Human)
• T Wang, AR Pine, AG Kotini, H Yuan, L Zamparo, DT Starczynow, C Leslie, EP Papapetrou Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets Cell Stem Cell, 2021-02-10;0(0):. 2021-02-10 [PMID: 33571445] (Bioassay, Human)
• Q Jiang, J Isquith, L Ladel, A Mark, F Holm, C Mason, Y He, P Mondala, I Oliver, J Pham, W Ma, E Reynoso, S Ali, IJ Morris, R Diep, C Nasamran, G Xu, R Sasik, SB Rosenthal, A Birmingham, S Coso, G Pineda, L Crews, ME Donohoe, JC Venter, T Whisenant, RA Mesa, LB Alexandrov, KM Fisch, C Jamieson Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution Cell Reports, 2021-01-26;34(4):108670. 2021-01-26 [PMID: 33503434] (Bioassay, Human)
• S Iriguchi, Y Yasui, Y Kawai, S Arima, M Kunitomo, T Sato, T Ueda, A Minagawa, Y Mishima, N Yanagawa, Y Baba, Y Miyake, K Nakayama, M Takiguchi, T Shinohara, T Nakatsura, M Yasukawa, Y Kassai, A Hayashi, S Kaneko A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy Nature Communications, 2021-01-18;12(1):430. 2021-01-18 [PMID: 33462228] (Bioassay, Human)
• YS Hwang, S Suzuki, Y Seita, J Ito, Y Sakata, H Aso, K Sato, BP Hermann, K Sasaki Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells Nat Commun, 2020-11-09;11(1):5656. 2020-11-09 [PMID: 33168808] (Cell Culture, Human)
• H Zhu, RH Blum, D Bernareggi, EH Ask, Z Wu, HJ Hoel, Z Meng, C Wu, KL Guan, KJ Malmberg, DS Kaufman Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In�Vivo Persistence and Enhances Anti-tumor Activity Cell Stem Cell, 2020-06-11;0(0):. 2020-06-11 [PMID: 32531207] (Bioassay, Human)
• J Wesely, AG Kotini, F Izzo, H Luo, H Yuan, J Sun, M Georgomano, A Zviran, AG Deslaurier, N Dusaj, SD Nimer, C Leslie, DA Landau, MG Kharas, EP Papapetrou Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells Cell Rep, 2020-06-02;31(9):107688. 2020-06-02 [PMID: 32492433] (Cell Culture, Human)
• P Norbnop, P Ingrungrua, N Israsena, K Suphapeeti, V Shotelersu Generation and characterization of HLA-universal platelets derived from induced pluripotent stem cells Sci Rep, 2020-05-21;10(1):8472. 2020-05-21 [PMID: 32439978] (Cell Culture, Human)
• S Demirci, B Gudmundsdo, Q Li, JJ Haro-Mora, T Nassehi, C Drysdale, M Yapundich, J Gamer, F Seifuddin, JF Tisdale, N Uchida &amp;betaT87Q-Globin Gene Therapy Reduces Sickle Hemoglobin Production, Allowing for Ex�Vivo Anti-sickling Activity in Human Erythroid Cells Mol Ther Methods Clin Dev, 2020-04-18;17(0):912-921. 2020-04-18 [PMID: 32405513] (Cell Culture, Human)
• C Yamashiro, K Sasaki, S Yokobayash, Y Kojima, M Saitou Generation of human oogonia from induced pluripotent stem cells in culture Nat Protoc, 2020-03-30;15(4):1560-1583. 2020-03-30 [PMID: 32231324] (Bioassay, Human)
• A Leonard, M Yapundich, T Nassehi, J Gamer, CM Drysdale, JJ Haro-Mora, S Demirci, MM Hsieh, N Uchida, JF Tisdale Low-Dose Busulfan Reduces Human CD34+ Cell Doses Required for Engraftment in c-kit Mutant Immunodeficient Mice Mol Ther Methods Clin Dev, 2019-11-11;15(0):430-437. 2019-11-11 [PMID: 31890735] (Bioassay, Human)
• D Suzuki, C Flahou, N Yoshikawa, I Stirblyte, Y Hayashi, A Sawaguchi, M Akasaka, S Nakamura, N Higashi, H Xu, T Matsumoto, K Fujio, MG Manz, A Hotta, H Takizawa, K Eto, N Sugimoto iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity Stem Cell Reports, 2019-12-26;0(0):. 2019-12-26 [PMID: 31883921] (Bioassay, Human)
• Z Li, F Fang, Q Zhao, H Li, C Xiong Supplementation of vitamin C promotes early germ cell specification from human embryonic stem cells Stem Cell Res Ther, 2019-11-15;10(1):324. 2019-11-15 [PMID: 31730021] (Cell Culture, Human)
• JP Ruiz, G Chen, JJ Haro Mora, K Keyvanfar, C Liu, J Zou, J Beers, H Bloomer, H Qanash, N Uchida, JF Tisdale, M Boehm, A Larochelle Robust generation of erythroid and multilineage hematopoietic progenitors from human iPSCs using a scalable monolayer culture system Stem Cell Res, 2019-10-15;41(0):101600. 2019-10-15 [PMID: 31710911] (Cell Culture, Mouse)
• T Ikuno, S Ito, T Inoue Human induced pluripotent stem cell-derived mast cells useful for in vitro mast cell activation assay exhibiting phenotypes and morphological characteristics of human mast cells J Toxicol Sci, 2019-01-01;44(11):789-797. 2019-01-01 [PMID: 31708535] (Cell Culture, Human)
• J Chagraoui, B Lehnertz, S Girard, JF Spinella, I Fares, E Tomellini, N Mayotte, S Corneau, T MacRae, L Simon, G Sauvageau UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal PLoS ONE, 2019-11-08;14(11):e0224900. 2019-11-08 [PMID: 31703090] (Cell Culture, Human)
• J Grajcarek, J Monlong, Y Nishinaka-, M Nakamura, M Nagai, S Matsuo, D Lougheed, H Sakurai, MK Saito, G Bourque, K Woltjen Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations Nat Commun, 2019-10-24;10(1):4856. 2019-10-24 [PMID: 31649251] (Bioassay, Human)
• WR Proto, SV Siegel, S Dankwa, W Liu, A Kemp, S Marsden, ZA Zenonos, S Unwin, PM Sharp, GJ Wright, BH Hahn, MT Duraisingh, JC Rayner Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand Nat Commun, 2019-10-04;10(1):4512. 2019-10-04 [PMID: 31586047] (Cell Culture, Human)
• N Uchida, MM Hsieh, L Raines, JJ Haro-Mora, S Demirci, AC Bonifacino, AE Krouse, ME Metzger, RE Donahue, JF Tisdale Development of a forward-oriented therapeutic lentiviral vector for hemoglobin disorders Nat Commun, 2019-10-02;10(1):4479. 2019-10-02 [PMID: 31578323] (Cell Culture, Human)
• GL Rogers, HY Chen, H Morales, PM Cannon Homologous Recombination-Based Genome Editing by Clade F AAVs Is Inefficient in the Absence of a Targeted DNA Break Mol. Ther., 2019-09-09;27(10):1726-1736. 2019-09-09 [PMID: 31540849] (Bioassay, Human)
• M Ly, S Rentas, A Vujovic, N Wong, S Moreira, J Xu, N Holzapfel, S Bhatia, D Tran, MD Minden, JS Draper, KJ Hope Diminished AHR signaling drives human acute myeloid leukemia stem cell maintenance Cancer Res., 2019-09-13;0(0):. 2019-09-13 [PMID: 31519687] (Bioassay, Human)
• MD McKenzie, M Ghisi, EP Oxley, S Ngo, L Cimmino, C Esnault, R Liu, JM Salmon, CC Bell, N Ahmed, M Erlichster, MT Witkowski, GJ Liu, M Chopin, A Dakic, E Simankowic, G Pomilio, T Vu, P Krsmanovic, S Su, L Tian, TM Baldwin, DA Zalcenstei, L DiRago, S Wang, D Metcalf, RW Johnstone, BA Croker, GI Lancaster, AJ Murphy, SH Naik, SL Nutt, V Pospisil, T Schroeder, M Wall, MA Dawson, AH Wei, H de Thé, ME Ritchie, J Zuber, RA Dickins Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia Cell Stem Cell, 2019-08-01;25(2):258-272.e9. 2019-08-01 [PMID: 31374198] (Cell Culture, Human)
• MA Kinney, LT Vo, JM Frame, J Barragan, AJ Conway, S Li, KK Wong, JJ Collins, P Cahan, TE North, DA Lauffenbur, GQ Daley A systems biology pipeline identifies regulatory networks for stem cell engineering Nat. Biotechnol., 2019-07-01;37(7):810-818. 2019-07-01 [PMID: 31267104] (Cell Culture, Human)
• Ohta R, Sugimura R, Niwa A, Saito M Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition. J Vis Exp, 2019-06-16;0(148):. 2019-06-16 [PMID: 31259914] (Bioassay, Human)
• M Nasri, M Ritter, P Mir, B Dannenmann, N Aghaallaei, D Amend, V Makaryan, Y Xu, B Fletcher, R Bernhard, I Steiert, K Hahnel, J Berger, I Koch, B Sailer, K Hipp, C Zeidler, M Klimiankou, B Bajoghli, DC Dale, K Welte, J Skokowa CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients Haematologica, 2019-06-27;0(0):. 2019-06-27 [PMID: 31248972] (Bioassay, Human)
• YL Chang, Z Wang, S Igawa, JE Choi, T Werbel, A Di Nardo Lipocalin 2: A New Antimicrobial in Mast Cells Int J Mol Sci, 2019-05-14;20(10):. 2019-05-14 [PMID: 31091692] (Cell Culture, Human)
• B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, JJ Kwan, KR Brown, E Titus, M Atkins, KSK Chan, L Munsie, A Habsid, H Han, M Kennedy, B Cohen, G Keller, J Moffat Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies Cell Rep, 2019-04-09;27(2):599-615.e12. 2019-04-09 [PMID: 30970261] (Differentiation, Differentiation, Human)
• A Tobío, G Bandara, DA Morris, DK Kim, MP O'Connell, HD Komarow, MC Carter, D Smrz, DD Metcalfe, A Olivera Oncogenic D816V-KIT signaling in mast cells causes persistent IL-6 production Haematologica, 2019-04-04;0(0):. 2019-04-04 [PMID: 30948489] (Bioassay, Human)
• AK Seneviratn, M Xu, JJA Henao, VA Fajardo, Z Hao, V Voisin, GW Xu, R Hurren, S Kim, N MacLean, X Wang, M Gronda, D Jeyaraju, Y Jitkova, T Ketela, M Mullokando, D Sharon, G Thomas, R Chouinard-, JR Hawley, C Schafer, HL Yau, Z Khuchua, A Aman, R Al-Awar, A Gross, SM Claypool, R Bazinet, M Lupien, S Chan, DD De Carvalh, MD Minden, GD Bader, KD Stark, P LeBlanc, AD Schimmer The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids Cell Stem Cell, 2019-03-28;0(0):. 2019-03-28 [PMID: 30930145] (Bioassay, Human)
• T Hochdörfer, C Winkler, K Pardali, J Mjösberg Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells Eur. J. Immunol., 2019-03-28;0(0):. 2019-03-28 [PMID: 30892687] (Bioassay, Human)
• H Xu, B Wang, M Ono, A Kagita, K Fujii, N Sasakawa, T Ueda, P Gee, M Nishikawa, M Nomura, F Kitaoka, T Takahashi, K Okita, Y Yoshida, S Kaneko, A Hotta Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility Cell Stem Cell, 2019-03-07;0(0):. 2019-03-07 [PMID: 30853558] (Bioassay, Human)
• M Suga, T Kondo, K Imamura, R Shibukawa, Y Okanishi, Y Sagara, K Tsukita, T Enami, M Furujo, K Saijo, Y Nakamura, M Osawa, MK Saito, S Yamanaka, H Inoue Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I Stem Cell Res, 2019-02-12;36(0):101406. 2019-02-12 [PMID: 30849633] (Bioassay, Human)
• N Uchida, T Nassehi, CM Drysdale, J Gamer, M Yapundich, S Demirci, JJ Haro-Mora, A Leonard, MM Hsieh, JF Tisdale High-Efficiency Lentiviral Transduction of Human CD34+ Cells in High-Density Culture with Poloxamer and Prostaglandin E2 Mol Ther Methods Clin Dev, 2019-01-25;13(0):187-196. 2019-01-25 [PMID: 30788387] (Bioassay, Human)
• X Wang, T Liao, C Wan, X Yang, J Zhao, R Fu, Z Yao, Y Huang, Y Shi, G Chang, Y Zheng, F Luo, Z Liu, Y Wang, X Mao, XY Zhao Efficient generation of human primordial germ cell-like cells from pluripotent stem cells in a methylcellulose-based 3D system at large scale PeerJ, 2019-01-09;6(0):e6143. 2019-01-09 [PMID: 30643676] (Bioassay, Human)
• P Potirat, M Wattanapan, V Viprakasit, P Kheolamai, S Issaragris An integration-free iPSC line (MUSIi008-A) derived from a patient with severe hemolytic anemia carrying compound heterozygote mutations in KLF1 gene for disease modeling Stem Cell Res, 2018-12-14;34(0):101344. 2018-12-14 [PMID: 30605837] (Bioassay, Human)
• S Poldee, C Metheetrai, S Nugoolsuks, J Frayne, K Trakarnsan Optimization of an erythroid culture system to reduce the cost of in vitro production of red blood cells MethodsX, 2018-11-30;5(0):1626-1632. 2018-11-30 [PMID: 30560064] (Bioassay, Human)
• A Minagawa, T Yoshikawa, M Yasukawa, A Hotta, M Kunitomo, S Iriguchi, M Takiguchi, Y Kassai, E Imai, Y Yasui, Y Kawai, R Zhang, Y Uemura, H Miyoshi, M Nakanishi, A Watanabe, A Hayashi, K Kawana, T Fujii, T Nakatsura, S Kaneko Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy Cell Stem Cell, 2018-11-15;0(0):. 2018-11-15 [PMID: 30449714] (Bioassay, Human)
• Park S, Mostoslavsky G Generation of Human Induced Pluripotent Stem Cells Using a Defined, Feeder-Free Reprogramming System. Curr Protoc Stem Cell Biol, 2018-05-04;45(1):e48. 2018-05-04 [PMID: 30040234] (Bioassay, Human)
• A Camgoz, M Paszkowski, S Satpathy, M Wermke, MV Hamann, M von Bonin, C Choudhary, S Knapp, F Buchholz STK3 is a therapeutic target for a subset of acute myeloid leukemias Oncotarget, 2018-05-22;9(39):25458-25473. 2018-05-22 [PMID: 29876001] (Bioassay, Human)
• N Ueda, Y Uemura, R Zhang, S Kitayama, S Iriguchi, Y Kawai, Y Yasui, M Tatsumi, T Ueda, TY Liu, Y Mizoro, C Okada, A Watanabe, M Nakanishi, S Senju, Y Nishimura, K Kuzushima, H Kiyoi, T Naoe, S Kaneko Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response Stem Cell Reports, 2018-05-24;0(0):. 2018-05-24 [PMID: 29805109] (Bioassay, Human)
• P Shen, S Yang, H Sun, G Li, B Wu, F Ji, T Sun, D Zhou SCF/c-KIT Signaling Increased Mucin2 Production by Maintaining Atoh1 Expression in Mucinous Colorectal Adenocarcinoma Int J Mol Sci, 2018-05-22;19(5):. 2018-05-22 [PMID: 29786668] (Bioassay, Human)
• MC Allenby, A Tahlawi, JCF Morais, K Li, N Panoskalts, A Mantalaris Ceramic Hollow Fibre Constructs for Continuous Perfusion and Cell Harvest from 3D Hematopoietic Organoids Stem Cells Int, 2018-04-02;2018(0):6230214. 2018-04-02 [PMID: 29760729] (Bioassay, Human)
• M Cesana, MH Guo, D Cacchiarel, L Wahlster, J Barragan, S Doulatov, LT Vo, B Salvatori, C Trapnell, K Clement, P Cahan, KM Tsanov, PM Sousa, B Tazon-Vega, A Bolondi, FM Giorgi, A Califano, JL Rinn, A Meissner, JN Hirschhorn, GQ Daley A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development Cell Stem Cell, 2018-04-05;22(4):575-588.e7. 2018-04-05 [PMID: 29625070] (Bioassay, Human)
• S Kotha, S Sun, A Adams, B Hayes, KT Phong, R Nagao, JA Reems, D Gao, B Torok-Stor, JA López, Y Zheng Microvasculature-directed thrombopoiesis in a 3D in vitro marrow microenvironment PLoS ONE, 2018-04-04;13(4):e0195082. 2018-04-04 [PMID: 29617409] (Bioassay, Human)
• SY Han, EM Lee, HS Choi, BH Chun, EJ Baek The effects of plasma gelsolin on human erythroblast maturation for erythrocyte production Stem Cell Res, 2018-03-05;29(0):64-75. 2018-03-05 [PMID: 29597129] (Bioassay, Human)
• CM Ferrer, M Alders, AV Postma, S Park, MA Klein, M Cetinbas, E Pajkrt, A Glas, S van Koning, VM Christoffe, MMAM Mannens, L Knegt, JP Etchegaray, RI Sadreyev, JM Denu, G Mostoslavs, MC van Maarle, R Mostoslavs An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality Genes Dev., 2018-03-19;32(5):373-388. 2018-03-19 [PMID: 29555651] (Bioassay, Human)
• S Zheng, E Papalexi, A Butler, W Stephenson, R Satija Molecular transitions in early progenitors during human cord blood hematopoiesis Mol. Syst. Biol., 2018-03-15;14(3):e8041. 2018-03-15 [PMID: 29545397] (Bioassay, Human)
• K Schmitt, P Charlins, M Veselinovi, L Kinner-Bib, S Hu, J Curlin, L Remling-Mu, KE Olson, T Aboellail, R Akkina Zika viral infection and neutralizing human antibody response in a BLT humanized mouse model Virology, 2018-01-06;515(0):235-242. 2018-01-06 [PMID: 29310105] (Bioassay, Human)
• M Carretta, AZ Brouwers-V, M Bosman, SJ Horton, JHA Martens, E Vellenga, JJ Schuringa BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells PLoS ONE, 2017-12-14;12(12):e0189102. 2017-12-14 [PMID: 29240787] (Bioassay, Human)
• YE Bar-Ephrai, F Cornelisse, N Papazian, T Konijn, RM Hoogenboez, MA Sanders, BA Westerman, M Gönültas, J Kwekkeboom, JMM Den Haan, RM Reijmers, RE Mebius, T Cupedo Cross-Tissue Transcriptomic Analysis of Human Secondary Lymphoid Organ-Residing ILC3s Reveals a Quiescent State in the Absence of Inflammation Cell Rep, 2017-10-17;21(3):823-833. 2017-10-17 [PMID: 29045847] (Bioassay, Human)
• S Radecke, K Schwarz, F Radecke Genome-wide Mapping of Off-Target Events in Single-Stranded Oligodeoxynucleotide-Mediated Gene Repair Experiments Mol. Ther., 2017-09-15;26(1):115-131. 2017-09-15 [PMID: 28988714] (Bioassay, Human)
• NJ Palpant, Y Wang, B Hadland, RJ Zaunbreche, M Redd, D Jones, L Pabon, R Jain, J Epstein, WL Ruzzo, Y Zheng, I Bernstein, A Margolin, CE Murry Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis Cell Rep, 2017-08-15;20(7):1597-1608. 2017-08-15 [PMID: 28813672] (Bioassay, Human)
• L Butcher, M Ahluwalia, T Örd, J Johnston, RH Morris, E Kiss-Toth, T Örd, JD Erusalimsk Evidence for a role of TRIB3 in the regulation of megakaryocytopoiesis Sci Rep, 2017-07-27;7(1):6684. 2017-07-27 [PMID: 28751721] (Bioassay, Human)
• J Helft, F Anjos-Afon, AG van der Ve, P Chakravart, D Bonnet, C Reis E Sou Dendritic Cell Lineage Potential in Human Early Hematopoietic Progenitors Cell Rep, 2017-07-18;20(3):529-537. 2017-07-18 [PMID: 28723558] (Bioassay, Human)
• E Varga, C Nemes, I Bock, Z Táncos, S Berzsenyi, G Lévay, V Román, J Kobolák, A Dinnyés Establishment of an induced pluripotent stem cell (iPSC) line from a 9-year old male with autism spectrum disorder (ASD) Stem Cell Res, 2017-03-18;21(0):19-22. 2017-03-18 [PMID: 28677532] (Bioassay, Human)
• J Huang, A Khan, BC Au, DL Barber, L López-Vásq, NL Prokopishy, M Boutin, M Rothe, JW Rip, M Abaoui, MS Nagree, S Dworski, A Schambach, A Keating, ML West, J Klassen, PV Turner, S Sirrs, CA Rupar, C Auray-Blai, R Foley, JA Medin Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34(+) Cells for Correction of Fabry Disease Mol Ther Methods Clin Dev, 2017-05-12;5(0):241-258. 2017-05-12 [PMID: 28603745] (Bioassay, Human)
• W Jeong, S Jung, FW Bazer, J Kim Stem Cell Factor-Induced AKT Cell Signaling Pathway: Effects on Porcine Trophectoderm and Uterine Luminal Epithelial Cells Gen. Comp. Endocrinol., 2017-05-24;0(0):. 2017-05-24 [PMID: 28551414] (Bioassay, Human)
• H Zhao, S Gulesseria, MC Malinao, S Kumar-Gane, J Song, MS Chang, MM Williams, Z Zeng, M Mattie, BA Mendelsohn, DR Stover, F Doñate A Potential Mechanism for ADC-Induced Neutropenia: Role of Neutrophils in Their Own Demise Mol. Cancer Ther., 2017-05-18;0(0):. 2017-05-18 [PMID: 28522588] (Bioassay, Human)
• S Liu, Z Ye, Y Gao, C He, DW Williams, A Moliterno, J Spivak, H Huang, L Cheng Generation of human iPSCs from an essential thrombocythemia patient carrying a V501L mutation in the MPL gene Stem Cell Res, 2016-12-11;18(0):57-59. 2016-12-11 [PMID: 28395806] (Bioassay, Human)
• K Trakarnsan, RE Griffiths, MC Wilson, A Blair, TJ Satchwell, M Meinders, N Cogan, S Kupzig, R Kurita, Y Nakamura, AM Toye, DJ Anstee, J Frayne An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells Nat Commun, 2017-03-14;8(0):14750. 2017-03-14 [PMID: 28290447] (Bioassay, Human)
• AG Kotini, CJ Chang, A Chow, H Yuan, TC Ho, T Wang, S Vora, A Solovyov, C Husser, M Olszewska, J Teruya-Fel, D Perumal, VM Klimek, A Spyridonid, RK Rampal, L Silverman, EP Reddy, E Papaemmanu, S Parekh, BD Greenbaum, CS Leslie, MG Kharas, EP Papapetrou Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia Cell Stem Cell, 2017-02-16;0(0):. 2017-02-16 [PMID: 28215825] (Bioassay, Human)
• I Baccelli, J Krosl, G Boucher, I Boivin, VP Lavallée, J Hébert, S Lemieux, A Marinier, G Sauvageau A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens Blood Cancer J, 2017-02-17;7(2):e529. 2017-02-17 [PMID: 28211886] (Bioassay, Human)
• AJ Garton, S Seibel, L Lopresti-M, L Crew, N Janson, S Mandiyan, ES Trombetta, S Pankratz, TM LaVallee, R Gedrich Anti-KIT Monoclonal Antibody Treatment Enhances the Anti-Tumor Activity of Immune Checkpoint Inhibitors by Reversing Tumor-Induced Immunosuppression Mol. Cancer Ther, 2017-01-30;0(0):. 2017-01-30 [PMID: 28138031] (Bioassay, Human, Mouse)
• Ivan Carcamo-Or Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity Cell Stem Cell, 2016-12-22;0(0):. 2016-12-22 [PMID: 28017796] (Bioassay, Human)
• Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease JCI Insight, 2016-12-08;1(20):e87446. 2016-12-08 [PMID: 27942582] (Bioassay, Human)
• Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML Mol Ther Methods Clin Dev, 2016-12-07;3(0):16074. 2016-12-07 [PMID: 27933304] (Bioassay, Human)
• Amber N Stratman Mural-Endothelial cell-cell interactions stabilize the developing zebrafish dorsal aorta Development, 2016-12-02;0(0):. 2016-12-02 [PMID: 27913637] (Bioassay, Human)
• Thomas Müller Differentiation of induced pluripotent stem cell-derived neutrophil granulocytes from common marmoset monkey (Callithrix jacchus) Transfusion, 2016-11-25;0(0):. 2016-11-25 [PMID: 27888517] (Bioassay, Human)
• Effect of high-dose plerixafor on CD34+ cells mobilization in healthy stem-cell donors: results of a randomized crossover trial Haematologica, 2016-10-20;0(0):. 2016-10-20 [PMID: 27846612] (Bioassay, Human)
• Robust reprogramming of Ataxia-Telangiectasia patient and carrier erythroid cells to induced pluripotent stem cells Stem Cell Res, 2016-08-12;17(2):296-305. 2016-08-12 [PMID: 27596957] (Bioassay, Human)
• Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway Cell Biosci, 2016-08-30;6(1):50. 2016-08-30 [PMID: 27583127] (Bioassay, Human)
• Functional IL-33 receptors are expressed in early progenitor stages of allergy-related granulocytes Immunology, 2016-09-30;0(0):. 2016-09-30 [PMID: 27568595] (Bioassay, Human)
• Efficient regeneration of Human V?24(+) invariant NKT cells and their anti-tumor activity in vivo Stem Cells, 2016-08-01;0(0):. 2016-08-01 [PMID: 27422351] (Bioassay, Human)
• Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells Nature, 2016-04-28;532(7600):508-11. 2016-04-28 [PMID: 27121842] (Bioassay, Human)
• Decitabine enhances anti-CD33 monoclonal antibody BI 836858-mediated natural killer ADCC against AML blasts Blood, 2016-03-24;127(23):2879-89. 2016-03-24 [PMID: 27013443] (Bioassay, Human)
• Hermanson D, Bendzick L, Pribyl L, McCullar V, Vogel R, Miller J, Geller M, Kaufman D Induced Pluripotent Stem Cell-Derived Natural Killer Cells for Treatment of Ovarian Cancer. Stem Cells, 2015-12-06;34(1):93-101. 2015-12-06 [PMID: 26503833] (Bioassay, Human)
• Kitajima K, Nakajima M, Kanokoda M, Kyba M, Dandapat A, Tolar J, Saito M, Toyoda M, Umezawa A, Hara T GSK3beta inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells. Exp Hematol, 2015-10-23;44(1):68-74.e10. 2015-10-23 [PMID: 26477526] (Bioassay, Human)
• Breton G, Lee J, Liu K, Nussenzweig M Defining human dendritic cell progenitors by multiparametric flow cytometry. Nat Protoc, 2015-08-20;10(9):1407-22. 2015-08-20 [PMID: 26292072] (Bioassay, Human)
• Jiang X, Lim C, Li Z, Lee P, Yatim S, Guan P, Li J, Zhou J, Pan J, Chng W, Chai C, Yu Q Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML). PLoS ONE, 2015-04-30;10(4):e0122983. 2015-04-30 [PMID: 25928216] (Bioassay, Human)
• Patterson , Scott D, Rossi , John M, Paweletz , Katherin, Fitzpatrick , V Dan, Begley , C Glenn, Busse , Leigh, Elliott , Steve, McCaffery , Ian Functional EpoR pathway utilization is not detected in primary tumor cells isolated from human breast, non-small cell lung, colorectal, and ovarian tumor tissues. PLoS ONE, 2015-03-25;10(3):e0122149. 2015-03-25 [PMID: 25807104] (Bioassay, Human)
• Lamikanra A, Merryweather-Clarke A, Tipping A, Roberts D Distinct mechanisms of inadequate erythropoiesis induced by tumor necrosis factor alpha or malarial pigment. PLoS ONE, 2015-03-17;10(3):e0119836. 2015-03-17 [PMID: 25781011] (Bioassay, Human)
• Lee J, Graham M, Collins T, Lee J, Hong S, McNicol A, Shapovalova Z, Bhatia M Reversible lineage-specific priming of human embryonic stem cells can be exploited to optimize the yield of differentiated cells. Stem Cells, 2015-04-01;33(4):1142-52. 2015-04-01 [PMID: 25639500] (Bioassay, Human)
• Purushothaman P, Thakker S, Verma S Transcriptome analysis of Kaposi&#039;s sarcoma-associated herpesvirus during de novo primary infection of human B and endothelial cells. J Virol, 2014-12-31;89(6):3093-111. 2014-12-31 [PMID: 25552714] (Bioassay, Human)
• Kim H, Yun J, Shin T, Lee S, Lee B, Yu K, Seo Y, Lee S, Kang T, Choi S, Seo K, Kang K Human umbilical cord blood mesenchymal stem cell-derived PGE2 and TGF-beta1 alleviate atopic dermatitis by reducing mast cell degranulation. Stem Cells, 2015-04-01;33(4):1254-66. 2015-04-01 [PMID: 25522163] (Bioassay, Human)
• Song B, Fan Y, He W, Zhu D, Niu X, Wang D, Ou Z, Luo M, Sun X Improved hematopoietic differentiation efficiency of gene-corrected beta-thalassemia induced pluripotent stem cells by CRISPR/Cas9 system. Stem Cells Dev, 2015-02-05;24(9):1053-65. 2015-02-05 [PMID: 25517294] (Bioassay, Human)
• Gallagher K, Joshi A, Carson W, Schaller M, Allen R, Mukerjee S, Kittan N, Feldman E, Henke P, Hogaboam C, Burant C, Kunkel S Epigenetic changes in bone marrow progenitor cells influence the inflammatory phenotype and alter wound healing in type 2 diabetes. Diabetes, 2014-11-03;64(4):1420-30. 2014-11-03 [PMID: 25368099] (Bioassay, Human)
• Barese C, Felizardo T, Sellers S, Keyvanfar K, Di Stasi A, Metzger M, Krouse A, Donahue R, Spencer D, Dunbar C Regulated apoptosis of genetically modified hematopoietic stem and progenitor cells via an inducible caspase-9 suicide gene in rhesus macaques. Stem Cells, 2015-01-01;33(1):91-100. 2015-01-01 [PMID: 25330775] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))
• Shen S, Xu N, Klamer G, Ko K, Khoo M, Ma D, Moore J, O'Brien T, Dolnikov A Small-molecule inhibitor of glycogen synthase kinase 3beta 6-Bromoindirubin-3-oxime inhibits hematopoietic regeneration in stem cell recipient mice. Stem Cells Dev, 2014-12-09;24(6):724-36. 2014-12-09 [PMID: 25329250] (Bioassay, Human)
• Kazuki , Yasuhiro, Yakura , Yuwna, Abe , Satoshi, Osaki , Mitsuhik, Kajitani , Naoyo, Kazuki , Kanako, Takehara , Shoko, Honma , Kazuhisa, Suemori , Hirofumi, Yamazaki , Satoshi, Sakuma , Tetsushi, Toki , Tsutomu, Shimizu , Ritsuko, Nakauchi , Hiromits, Yamamoto , Takashi, Oshimura , Mitsuo Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies. Sci Rep, 2014-08-27;4(0):6136. 2014-08-27 [PMID: 25159877] (Bioassay, Human)
• Dighe N, Khoury M, Mattar C, Chong M, Choolani M, Chen J, Antoniou M, Chan J Long-term reproducible expression in human fetal liver hematopoietic stem cells with a UCOE-based lentiviral vector. PLoS ONE, 2014-08-12;9(8):e104805. 2014-08-12 [PMID: 25118036] (Bioassay, Human)
• Rosen , David B, Leung , Ling Y, Louie , Brent, Cordeiro , James A, Conroy , Andrew, Shapira , Iuliana, Fields , Scott Z, Cesano , Alessand, Hawtin , Rachael Quantitative measurement of alterations in DNA damage repair (DDR) pathways using single cell network profiling (SCNP). J Transl Med, 2014-06-25;12(0):184. 2014-06-25 [PMID: 24965603] (Bioassay, Human)
• Smith , Laura J, Ul-Hasan , Taihra, Carvaines , Sarah K, Van Vliet , Kim, Yang , Ethel, Wong , Kamehame, Agbandje-McKenna , Mavis, Chatterjee , Saswati Gene transfer properties and structural modeling of human stem cell-derived AAV. Mol Ther, 2014-06-13;22(9):1625-34. 2014-06-13 [PMID: 24925207] (Bioassay, Human)
• Horwitz , Mitchell, Chao , Nelson J, Rizzieri , David A, Long , Gwynn D, Sullivan , Keith M, Gasparetto , Cristina, Chute , John P, Morris , Ashley, McDonald , Carolyn, Waters-Pick , Barbara, Stiff , Patrick, Wease , Steven, Peled , Amnon, Snyder , David, Cohen , Einat Ga, Shoham , Hadas, Landau , Efrat, Friend , Etty, Peleg , Iddo, Aschengrau , Dorit, Yackoubov , Dima, Kurtzberg , Joanne, Peled , Tony Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment. J Clin Invest, 2014-06-09;124(7):3121-8. 2014-06-09 [PMID: 24911148] (Bioassay, Human)
• Khoo M, Carlin S, Lutherborrow M, Jayaswal V, Ma D, Moore J Gene profiling reveals association between altered Wnt signaling and loss of T-cell potential with age in human hematopoietic stem cells. Aging Cell, 2014-05-30;13(4):744-54. 2014-05-30 [PMID: 24889652] (Bioassay, Human)
• Jitkova , Yulia, Gronda , Marcela, Hurren , Rose, Wang , Xiaoming, Goard , Carolyn, Jhas , Bozhena, Schimmer , Aaron D A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity. PLoS ONE, 2014-05-28;9(5):e95281. 2014-05-28 [PMID: 24871339] (Bioassay, Human)
• Yang C, French A, Goh P, Pagnamenta A, Mettananda S, Taylor J, Knight S, Nathwani A, Roberts D, Watt S, Carpenter L Human induced pluripotent stem cell derived erythroblasts can undergo definitive erythropoiesis and co-express gamma and beta globins. Br J Haematol, 2014-05-16;166(3):435-48. 2014-05-16 [PMID: 24837254] (Bioassay, Human)
• Muench M, Beyer A, Fomin M, Thakker R, Mulvaney U, Nakamura M, Suemizu H, Barcena A The adult livers of immunodeficient mice support human hematopoiesis: evidence for a hepatic mast cell population that develops early in human ontogeny. PLoS ONE, 2014-05-12;9(5):e97312. 2014-05-12 [PMID: 24819392] (Bioassay, Human)
• Chaurasia P, Gajzer D, Schaniel C, D'Souza S, Hoffman R Epigenetic reprogramming induces the expansion of cord blood stem cells. J Clin Invest, 2014-04-24;124(6):2378-95. 2014-04-24 [PMID: 24762436] (Bioassay, Human)
• Wu C, Li B, Lu R, Koelle S, Yang Y, Jares A, Krouse A, Metzger M, Liang F, Lore K, Wu C, Donahue R, Chen I, Weissman I, Dunbar C Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells. Cell Stem Cell, 2014-04-03;14(4):486-99. 2014-04-03 [PMID: 24702997] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))
• Williams M, Yousafzai Y, Cox C, Blair A, Carmody R, Sai S, Chapman K, McAndrew R, Thomas A, Spence A, Gibson B, Graham G, Halsey C Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia. Blood, 2014-04-03;123(20):3116-27. 2014-04-03 [PMID: 24700781] (Bioassay, Human)
• Levescot A, Flamant S, Basbous S, Jacomet F, Feraud O, Anne Bourgeois E, Bonnet M, Giraud C, Roy L, Barra A, Chomel J, Turhan A, Guilhot F, Girard J, Gombert J, Herbelin A BCR-ABL-induced deregulation of the IL-33/ST2 pathway in CD34+ progenitors from chronic myeloid leukemia patients. Cancer Res, 2014-03-27;74(10):2669-76. 2014-03-27 [PMID: 24675360] (Bioassay, Human)
• Vannucchi , A M, Rotunno , G, Bartalucci , N, Raugei , G, Carrai , V, Balliu , M, Mannarelli , C, Pacilli , A, Calabresi , L, Fjerza , R, Pieri , L, Bosi , A, Manfredini , R, Guglielmelli , P Calreticulin mutation-specific immunostaining in myeloproliferative neoplasms: pathogenetic insight and diagnostic value. Leukemia, 2014-03-12;28(9):1811-8. 2014-03-12 [PMID: 24618731] (Bioassay, Human)
• Reynolds , C, Roderick , J E, LaBelle , J L, Bird , G, Mathieu , R, Bodaar , K, Colon , D, Pyati , U, Stevenson , K E, Qi , J, Harris , M, Silverman , L B, Sallan , S E, Bradner , J E, Neuberg , D S, Look , A T, Walensky , L D, Kelliher , M A, Gutierrez , A Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia. Leukemia, 2014-02-20;28(9):1819-27. 2014-02-20 [PMID: 24552990] (Bioassay, Human)
• Nakamura S, Takayama N, Hirata S, Seo H, Endo H, Ochi K, Fujita K, Koike T, Harimoto K, Dohda T, Watanabe A, Okita K, Takahashi N, Sawaguchi A, Yamanaka S, Nakauchi H, Nishimura S, Eto K Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells. Cell Stem Cell, 2014-02-13;14(4):535-48. 2014-02-13 [PMID: 24529595] (Bioassay, Human)
• Jensen B, Frandsen P, Raaby E, Schiotz P, Skov P, Poulsen L Molecular and stimulus-response profiles illustrate heterogeneity between peripheral and cord blood-derived human mast cells. J Leukoc Biol, 2014-02-03;95(6):893-901. 2014-02-03 [PMID: 24493825] (Bioassay, Human)
• Kamat V, Paluru P, Myint M, French D, Gadue P, Diamond S MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells. Stem Cells, 2014-05-01;32(5):1337-46. 2014-05-01 [PMID: 24446170] (Bioassay, Human)
• Smith A, Bowers S, Stratman A, Davis G Hematopoietic stem cell cytokines and fibroblast growth factor-2 stimulate human endothelial cell-pericyte tube co-assembly in 3D fibrin matrices under serum-free defined conditions. PLoS ONE, 2013-12-31;8(12):e85147. 2013-12-31 [PMID: 24391990] (Bioassay, Human)
• Klimenkova O, Ellerbeck W, Klimiankou M, Unalan M, Kandabarau S, Gigina A, Hussein K, Zeidler C, Welte K, Skokowa J A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation. Blood, 2013-12-18;123(8):1239-49. 2013-12-18 [PMID: 24352879] (Bioassay, Human)
• Tolar J, McGrath J, Xia L, Riddle M, Lees C, Eide C, Keene D, Liu L, Osborn M, Lund T, Blazar B, Wagner J Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa. J Invest Dermatol, 2013-12-06;134(5):1246-54. 2013-12-06 [PMID: 24317394] (Bioassay, Human)
• Sjeklocha L, Wong P, Belcher J, Vercellotti G, Steer C beta-Globin sleeping beauty transposon reduces red blood cell sickling in a patient-derived CD34(+)-based in vitro model. PLoS ONE, 2013-11-18;8(11):e80403. 2013-11-18 [PMID: 24260386] (Bioassay, Cell Culture, Human)
• Uchida N, Weitzel R, Evans M, Green R, Bonifacino A, Krouse A, Metzger M, Hsieh M, Donahue R, Tisdale J Evaluation of engraftment and immunological tolerance after reduced intensity conditioning in a rhesus hematopoietic stem cell gene therapy model. Gene Ther, 2013-11-21;21(2):148-57. 2013-11-21 [PMID: 24257347] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))
• Csaszar , Elizabet, Wang , Weijia, Usenko , Tatiana, Qiao , Wenlian, Delaney , Colleen, Bernstein , Irwin D, Zandstra , Peter W Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signaling. Blood, 2013-11-15;123(5):650-8. 2013-11-15 [PMID: 24243972] (Bioassay, Human)
• Doulatov S, Vo L, Chou S, Kim P, Arora N, Li H, Hadland B, Bernstein I, Collins J, Zon L, Daley G Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors. Cell Stem Cell, 2013-10-03;13(4):459-70. 2013-10-03 [PMID: 24094326] (Bioassay, Human)
• Morishima , Tatsuya, Watanabe , Ken-ichi, Niwa , Akira, Hirai , Hideyo, Saida , Satoshi, Tanaka , Takayuki, Kato , Itaru, Umeda , Katsutsu, Hiramatsu , Hidefumi, Saito , Megumu K, Matsubara , Kousaku, Adachi , Souichi, Kobayashi , Masao, Nakahata , Tatsutos, Heike , Toshio Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis. Haematologica, 2013-08-23;99(1):19-27. 2013-08-23 [PMID: 23975175] (Bioassay, Human)
• Bachet J, Tabone-Eglinger S, Dessaux S, Besse A, Brahimi-Adouane S, Emile J, Blay J, Alberti L Gene expression patterns of hemizygous and heterozygous KIT mutations suggest distinct oncogenic pathways: a study in NIH3T3 cell lines and GIST samples. PLoS ONE, 2013-04-12;8(4):e61103. 2013-04-12 [PMID: 23593401] (Bioassay, Mouse)
• Yu , Jianhua, Peng , Yong, Wu , Lai-Chu, Xie , Zhiliang, Deng , Youcai, Hughes , Tiffany, He , Shun, Mo , XiaoKui, Chiu , Ming, Wang , Qi-En, He , Xiaoming, Liu , Shujun, Grever , Michael, Chan , Kenneth, Liu , Zhongfa Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia. PLoS ONE, 2013-02-13;8(2):e55934. 2013-02-13 [PMID: 23457487] (Bioassay, Human)
• Farrer R, Farrer J, DeVries G Platelet-derived growth factor-BB activates calcium/calmodulin-dependent and -independent mechanisms that mediate Akt phosphorylation in the neurofibromin-deficient human Schwann cell line ST88-14. J Biol Chem, 2013-03-01;288(16):11066-73. 2013-03-01 [PMID: 23457304] (Bioassay, Human)
• Giannoni F, Hardee C, Wherley J, Gschweng E, Senadheera S, Kaufman M, Chan R, Bahner I, Gersuk V, Wang X, Gjertson D, Baltimore D, Witte O, Economou J, Ribas A, Kohn D Allelic exclusion and peripheral reconstitution by TCR transgenic T cells arising from transduced human hematopoietic stem/progenitor cells. Mol Ther, 2013-02-05;21(5):1044-54. 2013-02-05 [PMID: 23380815] (Bioassay, Human)
• Lee M, Prasain N, Chae H, Kim Y, Mantel C, Yoder M, Broxmeyer H Epigenetic regulation of NANOG by miR-302 cluster-MBD2 completes induced pluripotent stem cell reprogramming. Stem Cells, 2013-04-01;31(4):666-81. 2013-04-01 [PMID: 23255147] (Bioassay, Human)
• Todd J, Scurr L, Becker T, Kefford R, Rizos H The MAPK pathway functions as a redundant survival signal that reinforces the PI3K cascade in c-Kit mutant melanoma. Oncogene, 2012-12-17;33(2):236-45. 2012-12-17 [PMID: 23246970] (Bioassay, Human)
• Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in Acute Myeloid Leukaemia. BMC Cancer, 2012-09-26;12(0):431. 2012-09-26 [PMID: 23013471] (Bioassay, Human)
• Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms. Blood Cancer J, 2012-09-07;2(0):e87. 2012-09-07 [PMID: 22961059] (Bioassay, Human)
• Li Q, Ramirez-Bergeron D, Dunwoodie S, Yang Y Cited2 gene controls pluripotency and cardiomyocyte differentiation of murine embryonic stem cells through Oct4 gene. J Biol Chem, 2012-07-03;287(34):29088-100. 2012-07-03 [PMID: 22761414] (Bioassay, Human)
• Ichii , Michiko, Frank , Mark Bar, Iozzo , Renato V, Kincade , Paul W The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells. Blood, 2011-11-23;119(7):1683-92. 2011-11-23 [PMID: 22117039] (Bioassay, Human, Mouse)
• Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells. Gene Ther, 2011-11-10;19(10):1035-40. 2011-11-10 [PMID: 22071967] (Bioassay, Human)
• Torrano V, Procter J, Cardus P ETV6-RUNX1 promotes survival of early B lineage progenitor cells via a dysregulated erythropoietin receptor. Blood, 2011-09-07;118(18):4910-8. 2011-09-07 [PMID: 21900195] (Bioassay, Human)
• Niwa A, Heike T, Umeda K A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors. PLoS ONE, 2011-07-27;6(7):e22261. 2011-07-27 [PMID: 21818303] (Bioassay, Human)
• Uchida N, Hsieh MM, Hayakawa J, Madison C, Washington KN, Tisdale JF Optimal conditions for lentiviral transduction of engrafting human CD34+ cells. Gene Ther., 2011-05-05;18(11):1078-86. 2011-05-05 [PMID: 21544097] (Bioassay, Human)
• Tolar J, Park I, Xia L, Lees C, Peacock B, Webber B, McElmurry R, Eide C, Orchard P, Kyba M, Osborn M, Lund T, Wagner J, Daley G, Blazar B Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome). Blood, 2010-10-29;117(3):839-47. 2010-10-29 [PMID: 21037085] (Bioassay, Human)
• Kirouac DC, Ito C, Csaszar E, Roch A, Yu M, Sykes EA, Bader GD, Zandstra PW Dynamic interaction networks in a hierarchically organized tissue. Mol. Syst. Biol., 2010-10-05;6(0):417. 2010-10-05 [PMID: 20924352] (Bioassay, Human)
• Stratman AN, Malotte KM, Mahan RD, Davis MJ, Davis GE Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation. Blood, 2009-10-12;114(24):5091-101. 2009-10-12 [PMID: 19822899] (Bioassay, Human)
• Duraisingham SS, Hornig J, Gotch F, Patterson S TLR-stimulated CD34 stem cell-derived human skin-like and monocyte-derived dendritic cells fail to induce Th17 polarization of naive T cells but do stimulate Th1 and Th17 memory responses. J. Immunol., 2009-07-22;183(4):2242-51. 2009-07-22 [PMID: 19625644] (Bioassay, Human)
• Margulis A, Nocka KH, Brennan AM, Deng B, Fleming M, Goldman SJ, Kasaian MT Mast cell-dependent contraction of human airway smooth muscle cell-containing collagen gels: influence of cytokines, matrix metalloproteases, and serine proteases. J. Immunol., 2009-07-10;183(3):1739-50. 2009-07-10 [PMID: 19592653] (Bioassay, Human)
• Ye L, Chang JC, Lin C, Sun X, Yu J, Kan YW Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases. Proc. Natl. Acad. Sci. U.S.A., 2009-05-29;106(24):9826-30. 2009-05-29 [PMID: 19482945] (Bioassay, Human)
• Aerbajinai W, Zhu J, Kumkhaek C, Chin K, Rodgers GP SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII. Blood, 2009-04-28;114(1):187-94. 2009-04-28 [PMID: 19401563] (Bioassay, Human)
• Margulis A, Nocka KH, Wood NL, Wolf SF, Goldman SJ, Kasaian MT MMP dependence of fibroblast contraction and collagen production induced by human mast cell activation in a three-dimensional collagen lattice. Am. J. Physiol. Lung Cell Mol. Physiol., 2008-12-05;296(2):L236-47. 2008-12-05 [PMID: 19060229] (Bioassay, Human)
• Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A, Berger P, Ito A, Brightling CE, Bradding P Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. J. Immunol., 2008-08-15;181(4):2772-80. 2008-08-15 [PMID: 18684968] (Bioassay, Human)
• Kobune M, Kawano Y, Takahashi S, Takada K, Murase K, Iyama S, Sato T, Takimoto R, Niitsu Y, Kato J Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-) cells. Exp. Hematol., 2008-06-17;36(9):1121-31. 2008-06-17 [PMID: 18562079] (Bioassay, Human)
• Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M Isolation and characterization of CD146+ multipotent mesenchymal stromal cells. Exp. Hematol., 2008-05-27;36(8):1035-46. 2008-05-27 [PMID: 18504067] (Bioassay, Human)
• McCullar V, Oostendorp R, Panoskaltsis-Mortari A, Yun G, Lutz CT, Wagner JE, Miller JS Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15. Exp. Hematol., 2008-03-04;36(5):598-608. 2008-03-04 [PMID: 18295962] (Bioassay, Human)
• Gunetti M, Ferrero I, Rustichelli D, Berger M, Gammaitoni L, Timeus F, Piacibello W, Aglietta M, Fagioli F Refreezing of cord blood hematopoietic stem cells for allogenic transplantation: in vitro and in vivo validation of a clinical phase I/II protocol in European and Italian Good Manufacturing Practice conditions. Exp. Hematol., 2008-02-01;36(2):235-43. 2008-02-01 [PMID: 18206730] (Bioassay, Human)
• Bogatkevich GS, Ludwicka-Bradley A, Highland KB, Hant F, Nietert PJ, Singleton CB, Feghali-Bostwick CA, Silver RM Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis. Arthritis Rheum., 2007-07-01;56(7):2432-42. 2007-07-01 [PMID: 17599773] (Bioassay, Human)
• Riccioni R, Diverio D, Mariani G, Buffolino S, Riti V, Saulle E, Petrucci E, Cedrone M, Lo-Coco F, Foa R, Peschle C, Testa U Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts. Stem Cells, 2007-04-19;25(8):1862-71. 2007-04-19 [PMID: 17446561] (Bioassay, Human)
• Srivastava AS, Nedelcu E, Esmaeli-Azad B, Mishra R, Carrier E Thrombopoietin enhances generation of CD34+ cells from human embryonic stem cells. Stem Cells, 2007-03-22;25(6):1456-61. 2007-03-22 [PMID: 17379761] (Bioassay, Human)
• Dentelli P, Rosso A, Balsamo A, Colmenares Benedetto S, Zeoli A, Pegoraro M, Camussi G, Pegoraro L, Brizzi MF C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium. Blood, 2007-02-08;109(10):4264-71. 2007-02-08 [PMID: 17289809] (Bioassay, Human)
• Hiroyama T, Miharada K, Aoki N, Fujioka T, Sudo K, Danjo I, Nagasawa T, Nakamura Y Long-lasting in vitro hematopoiesis derived from primate embryonic stem cells. Exp. Hematol., 2006-06-01;34(6):760-9. 2006-06-01 [PMID: 16728281] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• Yu H, Fang D, Kumar SM, Li L, Nguyen TK, Acs G, Herlyn M, Xu X Isolation of a novel population of multipotent adult stem cells from human hair follicles. Am. J. Pathol., 2006-06-01;168(6):1879-88. 2006-06-01 [PMID: 16723703] (Bioassay, Human)
• Kahl CA, Tarantal AF, Lee CI, Jimenez DF, Choi C, Pepper K, Petersen D, Fletcher MD, Leapley AC, Fisher J, Burns TS, Ultsch MN, Dorey FJ, Kohn DB Effects of busulfan dose escalation on engraftment of infant rhesus monkey hematopoietic stem cells after gene marking by a lentiviral vector. Exp. Hematol., 2006-03-01;34(3):369-81. 2006-03-01 [PMID: 16543071] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))
• Gemelli C, Montanari M, Tenedini E, Zanocco Marani T, Vignudelli T, Siena M, Zini R, Salati S, Tagliafico E, Manfredini R, Grande A, Ferrari S Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells. Cell Death Differ., 2006-02-03;13(10):1686-96. 2006-02-03 [PMID: 16456583] (Bioassay, Human)
• Hsieh FH, Sharma P, Gibbons A, Goggans T, Erzurum SC, Haque SJ Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells. Proc. Natl. Acad. Sci. U.S.A., 2005-09-26;102(40):14380-5. 2005-09-26 [PMID: 16186496] (Bioassay, Human)
• Hanley MB, Napolitano LA, McCune JM Growth hormone-induced stimulation of multilineage human hematopoiesis. Stem Cells, 2005-06-13;23(8):1170-9. 2005-06-13 [PMID: 15955828] (Bioassay, Human)
• Femenia F, Arock M, Leriche L, Delouis C, Millet G, Ben Hamouda N, Cote M, Alliot A, Lilin T, Pinton A, Iannucceli N, Parodi AL, Boireau P Establishment and characterization of continuous hematopoietic progenitors-derived pig normal mast cell lines. Life Sci., 2005-07-01;77(7):808-23. 2005-07-01 [PMID: 15896811] (Bioassay, Porcine)
• Wang J, Roy SK Growth differentiation factor-9 and stem cell factor promote primordial follicle formation in the hamster: modulation by follicle-stimulating hormone. Biol. Reprod., 2003-10-29;70(3):577-85. 2003-10-29 [PMID: 14585807] (Bioassay, Hamster)
• Manz MG, 107325, Miyamoto T, Akashi K, Weissman IL Prospective isolation of human clonogenic common myeloid progenitors. Ultra-Sensitive and Semi-Quantitative Vertical Flow Assay for the Rapid Detection of Interleukin-6 in Inflammatory Diseases, 2002-08-22;99(18):11872-7. 2002-08-22 [PMID: 12193648] (Bioassay, Human)
• Da Silva CA, 2019, Kassel O, Mathieu E, Massard G, Gasser B, Frossard N Inhibition by glucocorticoids of the interleukin-1beta-enhanced expression of the mast cell growth factor SCF. 2002-04-01;135(7):1634-40. 2002-04-01 [PMID: 11934803] (ELISA (Standard))
• Shih CC, Hu MC, Hu J A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells. Blood, 2000-03-15;95(6):1957-66. 2000-03-15 [PMID: 10706861] (Bioassay, Human)
• Gomez-Navarro J, ¯&h~²@á, Contreras JL, Arafat W, Jiang XL, Krisky D, Oligino T, Marconi P, Hubbard B, Glorioso JC, Curiel DT, Thomas JM Genetically modified CD34+ cells as cellular vehicles for gene delivery into areas of angiogenesis in a rhesus model. 2000-01-01;7(1):43-52. 2000-01-01 [PMID: 10680015] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))
• Drouet M, 49153, Mathieu J, Grenier N, Multon E, Sotto JJ, Herodin F The reduction of in vitro radiation-induced Fas-related apoptosis in CD34+ progenitor cells by SCF, FLT-3 ligand, TPO, and IL-3 in combination resulted in CD34+ cell proliferation and differentiation. Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance, 1999-01-01;17(5):273-85. 1999-01-01 [PMID: 10527462] (Bioassay, Primate - Papio anubis (Olive Baboon))
• Barcena A, Park SW, Banapour B, Muench MO, Mechetner E Expression of Fas/CD95 and Bcl-2 by primitive hematopoietic progenitors freshly isolated from human fetal liver. Blood, 1996-09-15;88(6):2013-25. 1996-09-15 [PMID: 8822920] (Bioassay, Human)

Bioinformatics

• Gene Symbol: KITLG
• Uniprot:
  • P21583.1()