Recombinant Human TGF-alpha Protein, CF

• Reactivity: Hu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Human TGF-alpha Protein, CF Summary

• Details of Functionality: Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. Marquardt, H. et al. (1984) Science 223:1079. The ED₅₀ for this effect is 0.0300-0.300 ng/mL.
• Source: E. coli-derived human TGF-alpha protein
  Val40-Ala89
• Accession #: P01135
• N-terminal Sequence: Val40
• Protein/Peptide Type: Recombinant Proteins
• Gene: TGFA
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 6 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile 10 mM Acetic Acid.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human TGF-alpha Protein, CF

• protransforming growth factor alpha
• TFGA
• TGFA
• TGFalpha
• TGF-alpha
• transforming growth factor, alpha
• transforming growth factor-alpha

Background

TGF-alpha was originally isolated from the conditioned media of oncogenically transformed cells as an EGF-like bioactivity. TGF-alpha is a member of the EGF family of cytokines that are synthesized as transmembrane precursors and are characterized by the presence of one or several EGF structural units in their extracellular domain. The soluble forms of these cytokines are released from the transmembrane protein by proteolytic cleavage. Membrane-bound proTGF-alpha is biologically active and seems to play a role in mediation of cell-cell adhesion and in juxtacrine stimulation of adjacent cells. Expression of TGF-alpha is widespread in tumors and transformed cells. TGF-alpha is also expressed in normal tissues during embryogenesis and in adult tissues, including pituitary, brain, keratinocytes and macrophages. Mature TGF-alpha  shows approximately 93% amino acid sequence identity with mouse or rat TGF-alpha and is not species specific in its biological effects.

TGF-alpha binds to the EGF receptor and activates the receptor tyrosine kinase. Accordingly, TGF-alpha shows a similar potency to EGF as a mitogen for fibroblasts and as an inducer of epithelial development in vivo. TGF-alpha is reportedly more potent than EGF as an angiogenic factor in vivo and as a stimulator for keratinocyte migration. The EGF receptor gene represents the cellular homologue of the avian v-erb-B oncogene.

Publications for TGF-alpha (239-A)(61)

Publications using 239-A

• Soares De Oliveira, L;Kaserman, JE;Van Der Spek, AH;Lee, NJ;Undeutsch, HJ;Werder, RB;Wilson, AA;Hollenberg, AN; Thyroid hormone receptor beta (THR?1) is the major regulator of T3 action in human iPSC-derived hepatocytes Molecular metabolism 2024-10-29 [PMID: 39481850] (Bioassay, Human)
• Priego, N;de Pablos-Aragoneses, A;Perea-García, M;Pieri, V;Hernandez-Oliver, C;Alvaro-Espinosa, L;Rojas, A;Sanchez, O;Steindl, A;Caleiras, E;Garcia, F;Garcia-Martin, S;Grana-Castro, O;Garcia-Mulero, S;Serrano, D;Velasco-Beltran, P;Jimenez-Lasheras, B;Egia-Mendikute, L;Rupp, L;Stammberger, A;Meinhardt, M;Chaachou-Charradi, A;Martínez-Saez, E;Bertero, L;Cassoni, P;Mangherini, L;Pellerino, A;Ruda, R;Soffietti, R;Al-Shahrour, F;Saftig, P;Sanz-Pamplona, R;Schmitz, M;Crocker, SJ;Calvo, A;Palazon, A;Group, R;Valiente, M; TIMP1 mediates astrocyte-dependent local immunosuppression in brain metastasis acting on infiltrating CD8+ T cells Cancer discovery 2024-10-02 [PMID: 39354883] (Bioassay, Mouse)
• Wirth, D;Özdemir, E;Hristova, K; Quantification of ligand and mutation-induced bias in EGFR phosphorylation in direct response to ligand binding Nature communications 2023-11-21 [PMID: 37989743] (Bioassay, Chinese Hamster)
• Kamentseva, RS;Kharchenko, MV;Gabdrahmanova, GV;Kotov, MA;Kosheverova, VV;Kornilova, ES; EGF, TGF-? and Amphiregulin Differently Regulate Endometrium-Derived Mesenchymal Stromal/Stem Cells International journal of molecular sciences 2023-08-29 [PMID: 37686213] (Bioassay, Human)
• VanSlyke, JK;Boswell, BA;Musil, LS; ErbBs in Lens Cell Fibrosis and Secondary Cataract Investigative ophthalmology & visual science 2023-07-03 [PMID: 37418274] (Bioassay, Avian - Chicken)
• Takada, H;Sasagawa, Y;Yoshimura, M;Tanaka, K;Iwayama, Y;Hayashi, T;Isomura-Matoba, A;Nikaido, I;Kurisaki, A; Single-cell transcriptomics uncovers EGFR signaling-mediated gastric progenitor cell differentiation in stomach homeostasis Nature communications 2023-06-29 [PMID: 37386010] (Bioassay, Mouse)
• Y Wang, Q Zheng, Z Sun, C Wang, J Cen, X Zhang, Y Jin, B Wu, T Yan, Z Wang, Q Gu, X Lv, J Nan, Z Wu, W Sun, G Pan, L Zhang, L Hui, X Cai Reversal of liver failure using a bioartificial liver device implanted with clinical-grade human-induced hepatocytes Cell Stem Cell, 2023-04-13;0(0):. 2023-04-13 [PMID: 37059100] (Human)
• JE Kaserman, RB Werder, F Wang, T Matte, MI Higgins, M Dodge, J Lindstrom-, P Bawa, A Hinds, E Bullitt, IS Caballero, X Shi, RE Gerszten, N Brunetti-P, M Liesa, C Villacorta, AN Hollenberg, DN Kotton, AA Wilson Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity Cell Reports, 2022-12-06;41(10):111775. 2022-12-06 [PMID: 36476855] (Bioassay, Human)
• S Gnosa, L Puig-Blasc, KB Piotrowski, ML Freiberg, S Savickas, DH Madsen, U Auf dem Ke, P Kronqvist, M Kveiborg ADAM17-mediated EGFR ligand shedding directs macrophage promoted cancer cell invasion JCI Insight, 2022-09-22;0(0):. 2022-09-22 [PMID: 35998057] (Stimulation, Human)
• C Monteiro, L Miarka, M Perea-Garc, N Priego, P García-Góm, L Álvaro-Esp, A de Pablos-, N Yebra, D Retana, P Baena, C Fustero-To, O Graña-Cast, K Troulé, E Caleiras, P Tezanos, P Muela, E Cintado, JL Trejo, JM Sepúlveda, P González-L, L Jiménez-Ro, LM Moreno, O Esteban, Á Pérez-Núñe, A Hernández-, J Mazarico G, I Ferrer, R Suárez, EM Garrido-Ma, L Paz-Ares, C Dalmasso, E Cohen-Jona, A Siegfried, A Hegarty, S Keelan, D Varešlija, LS Young, M Mohme, Y Goy, H Wikman, J Fernández-, G Blasco, L Alcázar, C Cabañuz, SI Grivenniko, A Ianus, N Shemesh, CC Faria, R Lee, P Lorigan, E Le Rhun, M Weller, R Soffietti, L Bertero, U Ricardi, J Bosch-Barr, E Sais, E Teixidor, A Hernández-, A Calvo, J Aristu, SM Martin, A Gonzalez, O Adler, N Erez, RENACER, M Valiente Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism Nature Medicine, 2022-04-11;28(4):752-765. 2022-04-11 [PMID: 35411077] (Bioassay, Human)
• C Hu, CA Leche, A Kiyatkin, Z Yu, SE Stayrook, KM Ferguson, MA Lemmon Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias Nature, 2022-02-09;602(7897):518-522. 2022-02-09 [PMID: 35140400] (Bioassay, Human)
• S Steiner, GM Seleznik, T Reding, M Stopic, D Lenggenhag, E Ten Buren, D Eshmuminov, K Endhardt, C Hagedorn, AM Heidenblut, A Bratus-Neu, J Grossmann, C Trachsel, KS Jabbar, SA Hahn, JV Berg, R Graf, A Gupta De novo expression of gastrokines in pancreatic precursor lesions impede the development of pancreatic cancer Oncogene, 2022-01-26;0(0):. 2022-01-26 [PMID: 35082384] (Bioassay, Mouse)
• R Matsushima, N Yamada, Y Hattori, Y Hosokawa, J Tachi, T Hori, O Kozawa SERMs (selective estrogen receptor modulator), acting as estrogen receptor beta agonists in hepatocellular carcinoma cells, inhibit the transforming growth factor-alpha-induced migration via specific inhibition of AKT signaling pathway PLoS ONE, 2022-01-10;17(1):e0262485. 2022-01-10 [PMID: 35007301] (Bioassay, Human)
• IT Stancil, JE Michalski, D Davis-Hall, HW Chu, JA Park, CM Magin, IV Yang, BJ Smith, E Dobrinskik, DA Schwartz Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional Nature Communications, 2021-07-27;12(1):4566. 2021-07-27 [PMID: 34315881] (Bioassay, Human)
• J Sugita, K Fujiu, Y Nakayama, T Matsubara, J Matsuda, T Oshima, Y Liu, Y Maru, E Hasumi, T Kojima, H Seno, K Asano, A Ishijima, N Tomii, M Yamazaki, F Kudo, I Sakuma, R Nagai, I Manabe, I Komuro Cardiac macrophages prevent sudden death during heart stress Nature Communications, 2021-03-26;12(1):1910. 2021-03-26 [PMID: 33771995] (Bioassay, Human)
• K Nomi, R Hayashi, Y Ishikawa, Y Kobayashi, T Katayama, AJ Quantock, K Nishida Generation of functional conjunctival epithelium, including goblet cells, from human iPSCs Cell Reports, 2021-02-02;34(5):108715. 2021-02-02 [PMID: 33535050] (Bioassay, Human)
• S Feng, J Wu, WL Qiu, L Yang, X Deng, Y Zhou, Y Chen, X Li, L Yu, H Li, ZR Xu, Y Xiao, X Ren, L Zhang, C Wang, Z Sun, J Wang, X Ding, Y Chen, P Gadue, G Pan, M Ogawa, S Ogawa, J Na, P Zhang, L Hui, H Yin, L Chen, CR Xu, X Cheng Large-scale Generation of Functional and Transplantable Hepatocytes and Cholangiocytes from Human Endoderm Stem Cells Cell Reports, 2020-12-08;33(10):108455. 2020-12-08 [PMID: 33296648] (Bioassay, Human)
• K Kobayashi, R Matsushima, N Yamada, S Migita, T Hioki, D Mizutani, O Kozawa Heat shock protein 70 positively regulates transforming growth factor-&amp;alpha-induced hepatocellular carcinoma cell migration via the AKT signaling pathway Heliyon, 2020-09-23;6(9):e05002. 2020-09-23 [PMID: 33005803] (Bioassay, Human)
• S Liu, Y Wang, Y Han, W Xia, L Zhang, S Xu, H Ju, X Zhang, G Ren, L Liu, W Ye, Z Zhang, J Hu EREG-driven oncogenesis of Head and Neck Squamous Cell Carcinoma exhibits higher sensitivity to Erlotinib therapy Theranostics, 2020-08-25;10(23):10589-10605. 2020-08-25 [PMID: 32929368] (Bioassay, Human)
• N Yamada, R Matsushima, O Kozawa Quercetin suppresses the migration of hepatocellular carcinoma cells stimulated by hepatocyte growth factor or transforming growth factor-&amp;alpha: Attenuation of AKT signaling pathway Arch. Biochem. Biophys., 2020-02-04;682(0):108296. 2020-02-04 [PMID: 32032576] (Bioassay, Human)
• L Yammine, A Zablocki, W Baron, F Terzi, M Gallazzini Lipocalin-2 Regulates Epidermal Growth Factor Receptor Intracellular Trafficking Cell Rep, 2019-11-12;29(7):2067-2077.e6. 2019-11-12 [PMID: 31722218] (Cell Culture, Human)
• K Yoshioka, K Uchikura, T Suda, S Matoba Production of piglets from in�vitro-produced blastocysts by ultrasound-guided ovum pick-up from live donors Theriogenology, 2019-09-12;141(0):113-119. 2019-09-12 [PMID: 31536860] (Bioassay, Porcine)
• J Peterson, B Lin, CM Barrios-Ca, DB Herrick, EH Holbrook, W Jang, JH Coleman, JE Schwob Activating a Reserve Neural Stem Cell Population In�Vitro Enables Engraftment and Multipotency after Transplantation Stem Cell Reports, 2019-03-28;0(0):. 2019-03-28 [PMID: 30930245] (Stimulation, Human)
• Y Li, H Li, Y Duan, X Cai, D You, F Zhou, C Yang, X Tuo, Z Liu Blockage of TGF-? Induced by Spherical Silica Nanoparticles Inhibits Epithelial-Mesenchymal Transition and Proliferation of Human Lung Epithelial Cells Biomed Res Int, 2019-02-18;2019(0):8231267. 2019-02-18 [PMID: 30906781] (Bioassay, Human)
• N Priego, L Zhu, C Monteiro, M Mulders, D Wasilewski, W Bindeman, L Doglio, L Martínez, E Martínez-S, SRY Cajal, D Megías, E Hernández-, C Blanco-Apa, L Martínez, E Zarzuela, J Muñoz, C Fustero-To, E Pineiro, A Hernández-, L Bertero, V Poli, M Sánchez-Ma, JA Menendez, R Soffietti, J Bosch-Barr, M Valiente STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis Nat. Med., 2018-06-11;0(0):. 2018-06-11 [PMID: 29892069] (Bioassay, Human)
• LJ Martin, SB Smith, A Khoutorsky, CA Magnussen, A Samoshkin, RE Sorge, C Cho, N Yosefpour, S Sivaselvac, S Tohyama, T Cole, TM Khuong, E Mir, DG Gibson, JS Wieskopf, SG Sotocinal, JS Austin, CB Meloto, JH Gitt, C Gkogkas, N Sonenberg, JD Greenspan, RB Fillingim, R Ohrbach, GD Slade, C Knott, R Dubner, AG Nackley, A Ribeiro-da, GG Neely, W Maixner, DV Zaykin, JS Mogil, L Diatchenko Epiregulin and EGFR interactions are involved in pain processing J. Clin. Invest., 2017-08-07;0(0):. 2017-08-07 [PMID: 28783046] (In Vivo, Mouse)
• Nadia B. Hassounah, Martha Nunez, Colleen Fordyce, Denise Roe, Ray Nagle, Thomas Bunch et al. Inhibition of Ciliogenesis Promotes Hedgehog Signaling, Tumorigenesis, and Metastasis in Breast Cancer Molecular Cancer Research 2017-10-01 [PMID: 28611083] (Bioassay, Human, Mouse)
• TS Lau, LK Chan, EC Wong, CW Hui, K Sneddon, TH Cheung, SF Yim, JH Lee, CS Yeung, TK Chung, J Kwong A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNF?-TGF?-EGFR Oncogene, 2017-02-06;0(0):. 2017-02-06 [PMID: 28166193] (Bioassay, Human)
• EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis initiation Proc. Natl. Acad. Sci. U.S.A., 2016-11-28;113(50):14360-14365. 2016-11-28 [PMID: 27911782] (Bioassay, Mouse)
• R Matsushima, H Toyoda, T Nagasawa, E Yasuda, N Chiba, S Okuda, A Maeda, Y Kaneoka, T Kumada, O Kozawa Phosphorylated Heat Shock Protein 20 (HSPB6) Regulates Transforming Growth Factor-?-Induced Migration and Invasion of Hepatocellular Carcinoma Cells PLoS ONE, 2016-04-05;11(4):e0151907. 2016-04-05 [PMID: 27046040] (Bioassay, Human)
• Negative regulation of the hepatic fibrogenic response by suppressor of cytokine signaling 1 Cytokine, 2015-12-31;82(0):58-69. 2015-12-31 [PMID: 26748724] (Bioassay, Mouse)
• Zhang C, Spevak W, Zhang Y, Burton E, Ma Y, Habets G, Zhang J, Lin J, Ewing T, Matusow B, Tsang G, Marimuthu A, Cho H, Wu G, Wang W, Fong D, Nguyen H, Shi S, Womack P, Nespi M, Shellooe R, Carias H, Powell B, Light E, Sanftner L, Walters J, Tsai J, West B, Visor G, Rezaei H, Lin P, Nolop K, Ibrahim P, Hirth P, Bollag G RAF inhibitors that evade paradoxical MAPK pathway activation. Nature, 2015-10-14;526(7574):583-6. 2015-10-14 [PMID: 26466569] (Bioassay, Mouse)
• Sundnes O, Pietka W, Loos T, Sponheim J, Rankin A, Pflanz S, Bertelsen V, Sitek J, Hol J, Haraldsen G, Khnykin D Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences. J Invest Dermatol, 2015-03-04;135(7):1771-80. 2015-03-04 [PMID: 25739051] (Bioassay, Human)
• Harada M, Kamimura D, Arima Y, Kohsaka H, Nakatsuji Y, Nishida M, Atsumi T, Meng J, Bando H, Singh R, Sabharwal L, Jiang J, Kumai N, Miyasaka N, Sakoda S, Yamauchi-Takihara K, Ogura H, Hirano T, Murakami M Temporal expression of growth factors triggered by epiregulin regulates inflammation development. J Immunol, 2015-01-02;194(3):1039-46. 2015-01-02 [PMID: 25556244] (Bioassay, Mouse)
• Klijn C, Durinck S, Stawiski E, Haverty P, Jiang Z, Liu H, Degenhardt J, Mayba O, Gnad F, Liu J, Pau G, Reeder J, Cao Y, Mukhyala K, Selvaraj S, Yu M, Zynda G, Brauer M, Wu T, Gentleman R, Manning G, Yauch R, Bourgon R, Stokoe D, Modrusan Z, Neve R, de Sauvage F, Settleman J, Seshagiri S, Zhang Z A comprehensive transcriptional portrait of human cancer cell lines. Nat Biotechnol, 2014-12-08;33(3):306-12. 2014-12-08 [PMID: 25485619] (Bioassay, Human)
• Eresheim , Christin, Leeb , Christia, Buchegger , Patricia, Nimpf , Johannes Signaling by the extracellular matrix protein Reelin promotes granulosa cell proliferation in the chicken follicle. J Biol Chem, 2014-02-26;289(14):10182-91. 2014-02-26 [PMID: 24573679] (Bioassay, Chicken)
• Desai , Tushar J, Brownfield , Douglas, Krasnow , Mark A Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature, 2014-02-05;507(7491):190-4. 2014-02-05 [PMID: 24499815] (Bioassay, Mouse)
• Huang , Sarah X, Islam , Mohammad, O'Neill , John, Hu , Zheng, Yang , Yong-Gua, Chen , Ya-Wen, Mumau , Melanie, Green , Michael, Vunjak-Novakovic , Gordana, Bhattacharya , Jahar, Snoeck , Hans-Wil Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol, 2013-12-01;32(1):84-91. 2013-12-01 [PMID: 24291815] (Bioassay, Human)
• Meijer I, Kerperien J, Sotoca A, van Zoelen E, van Leeuwen J The Usp8 deubiquitination enzyme is post-translationally modified by tyrosine and serine phosphorylation. Cell Signal, 2013-01-17;25(4):919-30. 2013-01-17 [PMID: 23333852] (Bioassay, Human)
• Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)
• Kim S, Lewis C, Nadel JA Epidermal growth factor receptor reactivation induced by E-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (NCI-H292) cells. Exp. Cell Res., 2011-09-07;317(18):2650-60. 2011-09-07 [PMID: 21925169] (Bioassay, Human)
• Tsai SY, Bouwman BA, Ang YS, Kim SJ, Lee DF, Lemischka IR, Rendl M Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells. Stem Cells, 2011-06-01;29(6):964-71. 2011-06-01 [PMID: 21563278] (Bioassay, Mouse)
• Kim S, Lewis C, Nadel JA CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells. J. Immunol., 2011-02-07;186(6):3392-400. 2011-02-07 [PMID: 21300824] (Bioassay, Human)
• Park JA, Drazen JM, Tschumperlin DJ The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress. J. Biol. Chem., 2010-07-22;285(39):29817-25. 2010-07-22 [PMID: 20650887] (Bioassay, Human)
• Gudjonsson JE, Johnston A, Stoll SW Evidence for altered Wnt signaling in psoriatic skin. J. Invest. Dermatol., 2010-04-08;130(7):1849-59. 2010-04-08 [PMID: 20376066] (Bioassay, Human)
• Gleason D, Fallon JH, Guerra M, Liu JC, Bryant PJ Ependymal stem cells divide asymmetrically and transfer progeny into the subventricular zone when activated by injury. Neuroscience, 2008-07-11;156(1):81-8. 2008-07-11 [PMID: 18682279] (In Vivo, Rat)
• Sasaki T, Nakamura T, Rebhun RB, Cheng H, Hale KS, Tsan RZ, Fidler IJ, Langley RR Modification of the primary tumor microenvironment by transforming growth factor alpha-epidermal growth factor receptor signaling promotes metastasis in an orthotopic colon cancer model. Am. J. Pathol., 2008-07-01;173(1):205-16. 2008-07-01 [PMID: 18583324] (Bioassay, Human)
• Gonzalez RM, Seurynck-Servoss SL, Crowley SA Development and validation of sandwich ELISA microarrays with minimal assay interference. J. Proteome Res., 2008-04-19;7(6):2406-14. 2008-04-19 [PMID: 18422355] (ELISA (Standard))
• Garcia B, Neninger E, de la Torre A, Leonard I, Martinez R, Viada C, Gonzalez G, Mazorra Z, Lage A, Crombet T Effective inhibition of the epidermal growth factor/epidermal growth factor receptor binding by anti-epidermal growth factor antibodies is related to better survival in advanced non-small-cell lung cancer patients treated with the epidermal growth factor cancer vaccine. Clin. Cancer Res., 2008-02-01;14(3):840-6. 2008-02-01 [PMID: 18245547] (ELISA Developmet, Human)
• Zhu J, Jia X, Xiao G, Kang Y, Partridge NC, Qin L EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases. J. Biol. Chem., 2007-07-17;282(37):26656-64. 2007-07-17 [PMID: 17636266] (Bioassay, Mouse)
• Wolff GS, Chiang PJ, Smith SM, Romero R, Armant DR Epidermal growth factor-like growth factors prevent apoptosis of alcohol-exposed human placental cytotrophoblast cells. Biol. Reprod., 2007-03-28;77(1):53-60. 2007-03-28 [PMID: 17392498] (Bioassay, Human)
• Zhou BB, Peyton M, He B, Liu C, Girard L, Caudler E, Lo Y, Baribaud F, Mikami I, Reguart N, Yang G, Li Y, Yao W, Vaddi K, Gazdar AF, Friedman SM, Jablons DM, Newton RC, Fridman JS, Minna JD, Scherle PA Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell, 2006-07-01;10(1):39-50. 2006-07-01 [PMID: 16843264] (Bioassay, Human)
• Li Y, Fan J, Chen M, Li W, Woodley DT Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration. J. Invest. Dermatol., 2006-05-11;126(9):2096-105. 2006-05-11 [PMID: 16691197] (Bioassay, Human)
• Rhodes KE, Raivich G, Fawcett JW The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines. Neuroscience, 2006-04-21;140(1):87-100. 2006-04-21 [PMID: 16631314] (In Vivo, Rat)
• Baginski TK, Dabbagh K, Satjawatcharaphong C, Swinney DC Cigarette smoke synergistically enhances respiratory mucin induction by proinflammatory stimuli. Am. J. Respir. Cell Mol. Biol., 2006-03-16;35(2):165-74. 2006-03-16 [PMID: 16543607] (Bioassay, Human)
• Armant DR, Kilburn BA, Petkova A, Edwin SS, Duniec-Dmuchowski ZM, Edwards HJ, Romero R, Leach RE Human trophoblast survival at low oxygen concentrations requires metalloproteinase-mediated shedding of heparin-binding EGF-like growth factor. Development, 2006-01-11;133(4):751-9. 2006-01-11 [PMID: 16407398] (Bioassay, Human)
• Schmidt-Ott KM, Yang J, Chen X, Wang H, Paragas N, Mori K, Li JY, Lu B, Costantini F, Schiffer M, Bottinger E, Barasch J Novel regulators of kidney development from the tips of the ureteric bud. J. Am. Soc. Nephrol., 2005-05-25;16(7):1993-2002. 2005-05-25 [PMID: 15917337] (Bioassay, Rat)
• Beer HD, Bittner M, Niklaus G, Munding C, Max N, Goppelt A, Werner S The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. Oncogene, 2005-08-11;24(34):5269-77. 2005-08-11 [PMID: 15806171] (Bioassay, Human)
• Snodgrass-Belt P, Gilbert JL, Davis FC Central administration of transforming growth factor-alpha and neuregulin-1 suppress active behaviors and cause weight loss in hamsters. Brain Res., 2005-03-21;1038(2):171-82. 2005-03-21 [PMID: 15757633] (In Vivo, Hamster)
• Nagineni CN, Kutty V, Detrick B, Hooks JJ Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta. J. Cell. Physiol., 2005-04-01;203(1):35-43. 2005-04-01 [PMID: 15368539] (Bioassay, Human)
• Leach RE, Kilburn B, Wang J, Liu Z, Romero R, Armant DR Heparin-binding EGF-like growth factor regulates human extravillous cytotrophoblast development during conversion to the invasive phenotype. Dev. Biol., 2004-02-15;266(2):223-37. 2004-02-15 [PMID: 14738873] (Bioassay, Human)

Bioinformatics

• Gene Symbol: TGFA
• Uniprot:
  • P01135()