Recombinant Human VEGF 165 Protein, CF

Recombinant Human VEGF165(Catalog # 293-VE/CF) stimulates proliferation in HUVEC human umbilical vein endothelial cells. The ED50 is 1.50‑12.0 ng/mL.

Recombinant Human VEGF165(Catalog # 293-VE/CF) stimulates proliferation in HUVEC human umbilical vein endothelial cells. The ED50 is 1.50‑12.0 ng/mL.

1 μg/lane of Recombinant Human VEGF165 was resolved by SDS-PAGE with silver staining, under reducing (R) and non-reducing (NR) conditions, showing major bands at 20-22 kDa and 39-42 kDa, respectively. Multiple bands in gel are due to glycosylation.

• Reactivity: Hu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Human VEGF 165 Protein, CF Summary

• Details of Functionality: Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. Conn, G. et al. (1990) Proc. Natl. Acad. Sci. USA 87:1323. The ED₅₀ for this effect is 1.50-12.0 ng/mL.
• Source: Spodoptera frugiperda, Sf 21 (baculovirus)-derived human VEGF protein
  Ala27-Arg191
• Accession #: NP_001165097
• N-terminal Sequence: Ala27
• Structure / Form: Disulfide-linked homodimer
• Protein/Peptide Type: Recombinant Proteins
• Gene: VEGFA
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Endotoxin Note: <0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 19.2 kDa (monomer).
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 20-22 kDa, under reducing conditions.
  39-42 kDa, under non-reducing conditions.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with trehalose.
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Reconstitution Instructions: Reconstitute at 100-500 μg/mL in sterile 4 mM HCl.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human VEGF 165 Protein, CF

• MVCD1
• VAS
• vascular endothelial growth factor A
• Vascular permeability factor
• Vasculotropin
• VEGF
• VEGFA
• VEGF-A
• VEGFMGC70609
• VPF
• VPFvascular endothelial growth factor

Background

Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult (1-3). It is a member of the PDGF family that is characterized by the presence of eight conserved cysteine residues and a cystine knot structure (4). Humans express alternately spliced isoforms of 121, 145, 165, 183, 189, and 206 amino acids (aa) in length (4). VEGF₁₆₅ appears to be the most abundant and potent isoform, followed by VEGF₁₂₁ and VEGF₁₈₉ (3, 4). Isoforms other than VEGF₁₂₁ contain basic heparin-binding regions and are not freely diffusible (4). Human VEGF₁₆₅ shares 88% aa sequence identity with corresponding regions of mouse and rat, 96% with porcine, 95% with canine, and 93% with feline, equine and bovine VEGF, respectively. VEGF binds the type I transmembrane receptor tyrosine kinases VEGF R1 (also called Flt-1) and VEGF R2 (Flk-1/KDR) on endothelial cells (4). Although VEGF affinity is highest for binding to VEGF R1, VEGF R2 appears to be the primary mediator of VEGF angiogenic activity (3, 4). VEGF₁₆₅ binds the semaphorin receptor, Neuropilin-1 and promotes complex formation with VEGF R2 (5). VEGF is required during embryogenesis to regulate the proliferation, migration, and survival of endothelial cells (3, 4). In adults, VEGF functions mainly in wound healing and the female reproductive cycle (3). Pathologically, it is involved in tumor angiogenesis and vascular leakage (6, 7). Circulating VEGF levels correlate with disease activity in autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (8). VEGF is induced by hypoxia and cytokines such as IL-1, IL-6, IL-8, oncostatin M and TNF-alpha (3, 4, 9).

Due to its role in angiogenesis of blood vessels, tumor and stroma cells use VEGF to stimulate formation of blood vessels and the proliferation and survival of endothelial cells. Specific immunotherapies targeting the VEGF signaling pathway include the recombinant antibody against VEGF (Bevacizumab), antibodies targeting the main VEGF receptor (VEGFR2), and small molecule inhibitors against VEGF receptor tyrosine kinases (10). Immune checkpoint inhibitors are an important tool in cancer therapies as tumor cells can hijack immune checkpoint signals to evade detection by immune cells. In addition to stimulating the formation of tumor blood vessels, VEGF has immunosuppressive effects by acting on dendritic cells to block their antigen-presenting and T cell stimulatory functions. Targeting VEGF in combination with other immune checkpoint ligands or receptors may prove more effective in immunotherapy approaches to certain cancer types (11). Because of its role in the formation of blood vessels, VEGF is also an important factor in skeletal development where blood supply and vascularization are crucial. This has made VEGF an important molecule in regenerative studies for bone repair as sustained release of VEGF has been shown to improve the efficiency of bone regeneration (12).

In differentiation protocols for stems cells, VEGF is a commonly added growth factor for the transformation of induced pluripotent stem cells into hematopoietic progenitor cells used to make Natural Killer cells (13, 14). VEGF has also been used to transform intermediate mesoderm into kidney glomerular podocytes or stem cell-derived liver spheres (15, 16). VEGF may also be used in assistance of stem cell transplantations by supporting angiogenesis at sites of stem cell transplants or as a honing tool for adipose-derived mesenchymal stem cells or bone marrow stem cells to migrate to (17, 18).

1. Leung, D.W. et al. (1989) Science 246:1306.
2. Keck, P.J. et al. (1989) Science 246:1309.
3. Byrne, A.M. et al. (2005) J. Cell. Mol. Med. 9:777.
4. Robinson, C.J. and S.E. Stringer (2001) J. Cell. Sci. 114:853.
5. Pan, Q. et al. (2007) J. Biol. Chem. 282:24049.
6. Weis, S.M. and D.A. Cheresh (2005) Nature 437:497.
7. Thurston, G. (2002) J. Anat. 200:575.
8. Carvalho, J.F. et al. (2007) J. Clin. Immunol. 27:246.
9. Angelo, L.S. and R. Kurzrock (2007) Clin. Cancer Res. 13:2825.
10. Apte, R.S. et al. (2019) Cell 176(6):1248.
11. Sangro, B. et al. (2021) Nature 18:525-543.
12. Hu, K. & Olsen, B.R. (2016) Bone 91:30-38.
13. Zhou, Y. et al. (2022) Cancers 14:2266.
14. Li, Y. et al. (2018) Cell Stem Cell 23(2):181-192.
15. Musah, S. et al. (2018) Nat. Protoc. 13(7):1662-1685.
16. Meseguer-Ripolles, J. et al. (2021) STAR Protoc. 2(2):100502.
17. Hutchings, G. et al. (2020) Int. J. Mol. Sci. 21(11):3790.
18. Zhang, W. et al. (2014) Euro Cell and Mater. 27:1-12.

Show all background references

Publications for VEGF (293-VE/CF)(428)

Publications using 293-VE/CF

• Maurissen, TL;Spielmann, AJ;Schellenberg, G;Bickle, M;Vieira, JR;Lai, SY;Pavlou, G;Fauser, S;Westenskow, PD;Kamm, RD;Ragelle, H; Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip Nature communications 2024-02-14 [PMID: 38355716] (Bioassay, Human)
• E Lee, EA Lee, E Kong, H Chon, M Llaiqui-Co, CH Park, BY Park, NR Kang, JS Yoo, HS Lee, HS Kim, SH Park, SW Choi, D Vestweber, JH Lee, P Kim, WS Lee, I Kim An agonistic anti-Tie2 antibody suppresses the normal-to-tumor vascular transition in the glioblastoma invasion zone Experimental & Molecular Medicine, 2023-02-24;55(2):470-484. 2023-02-24 [PMID: 36828931] (Bioassay, Human)
• L Feige, T Kozaki, G Dias de Me, V Guillemot, F Larrous, F Ginhoux, H Bourhy Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses Viruses, 2022-12-29;15(1):. 2022-12-29 [PMID: 36680128] (Bioassay, Human)
• T Keratibumr, W Srisuthtay, O Wanachewin, J Klangjorho, T Phitak, P Pothacharo, TH Shwe, P Kongtawele Sesamin Attenuates VEGFA-Induced Angiogenesis via Inhibition of Src and FAK Signaling in Chick Chorioallantoic Membrane Model and Human Endothelial EA.hy926 Cells Biomedicines, 2023-01-11;11(1):. 2023-01-11 [PMID: 36672695] (Cell Culture, Human)
• Y Ichiyama, R Matsumoto, S Obata, O Sawada, Y Saishin, M Kakinoki, T Sawada, M Ohji Assessment of mouse VEGF neutralization by ranibizumab and aflibercept PLoS ONE, 2022-12-21;17(12):e0278951. 2022-12-21 [PMID: 36542626] (Western Blot, N/A)
• T Otsuka, T Masuda, Y Takahashi, A Suzuki, A Uemura, R Arakawa, T Okabe, A Naito Effect of triamcinolone acetonide on retinal inflammation and angiogenesis induced by pericyte depletion in mouse Journal of pharmacological sciences, 2022-10-23;151(1):28-36. 2022-10-23 [PMID: 36522120] (Bioassay, Human)
• H Zhang, B Li, J Ding, R Ye, Z Xu, Q Zhang, S Feng, Q Jiang, W Zhu, B Yan DCZ19931, a novel multi-targeting kinase inhibitor, inhibits ocular neovascularization Scientific Reports, 2022-12-13;12(1):21539. 2022-12-13 [PMID: 36513701] (Cell Culture, Human)
• JE Kaserman, RB Werder, F Wang, T Matte, MI Higgins, M Dodge, J Lindstrom-, P Bawa, A Hinds, E Bullitt, IS Caballero, X Shi, RE Gerszten, N Brunetti-P, M Liesa, C Villacorta, AN Hollenberg, DN Kotton, AA Wilson Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity Cell Reports, 2022-12-06;41(10):111775. 2022-12-06 [PMID: 36476855] (Bioassay, Human)
• JP Borges, RSR Sætra, A Volchuk, M Bugge, P Devant, B Sporsheim, BR Kilburn, CL Evavold, JC Kagan, NM Goldenberg, TH Flo, BE Steinberg Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death Elife, 2022-12-05;11(0):. 2022-12-05 [PMID: 36468682] (Cell Culture, Mouse)
• SM Lee, JW Lee, I Kim, DC Woo, CG Pack, YH Sung, IJ Baek, CH Jung, YH Kim, CH Ha Angiogenic adipokine C1q-TNF-related protein 9 ameliorates myocardial infarction via histone deacetylase 7-mediated MEF2 activation Science Advances, 2022-12-02;8(48):eabq0898. 2022-12-02 [PMID: 36459558] (Bioassay, Human)
• XY Cui, B Stavik, B Thiede, PM Sandset, SM Kanse FSAP Protects against Histone-Mediated Increase in Endothelial Permeability In Vitro International Journal of Molecular Sciences, 2022-11-08;23(22):. 2022-11-08 [PMID: 36430180] (Bioassay, Human)
• JA Oo, K Pálfi, T Warwick, I Wittig, C Prieto-Gar, V Matkovic, I Tomaškovi?, F Boos, J Izquierdo, T Teichmann, K Petriukov, S Haydar, L Maegdefess, Z Wu, MD Pham, J Krishnan, AH Baker, S Günther, HD Ulrich, I Dikic, MS Leisegang, RP Brandes Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2 Cell Reports, 2022-11-15;41(7):111670. 2022-11-15 [PMID: 36384122] (Bioassay, Human)
• SH Choi, MJ Park, H Kim Inhibitor of differentiation 1 in U87MG glioblastoma cells promotes HUVEC sprouting through endothelin-1 Oncology Letters, 2022-09-27;24(5):413. 2022-09-27 [PMID: 36245828] (Bioassay, Human, Mouse)
• H Wang, B Keepers, Y Qian, Y Xie, M Colon, J Liu, L Qian Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes Cell Stem Cell, 2022-10-06;29(10):1491-1504.e9. 2022-10-06 [PMID: 36206732] (Bioassay, Mouse)
• S Wei, Z Li, Q Shi, X Luan, X Yuan, Y Li, C Guo, X Wu, C Shi, G Di Collagen?binding vascular endothelial growth factor (CBD?VEGF) promotes liver regeneration in murine partial hepatectomy Molecular Medicine Reports, 2022-09-07;26(5):. 2022-09-07 [PMID: 36069236] (In Vivo, Mouse)
• D Yang, J Gomez-Garc, S Funakoshi, T Tran, I Fernandes, GD Bader, MA Laflamme, GM Keller Modeling human multi-lineage heart field development with pluripotent stem cells Cell Stem Cell, 2022-09-01;29(9):1382-1401.e8. 2022-09-01 [PMID: 36055193] (Bioassay, Human)
• SY Lee, JH Park, KH Cho, H Kim, HK Shin Isolinderalactone inhibits glioblastoma cell supernatant-induced angiogenesis Oncology Letters, 2022-08-02;24(4):328. 2022-08-02 [PMID: 36039052] (Bioassay, Human)
• R Jing, I Scarfo, MA Najia, E Lummertz d, A Han, M Sanborn, T Bingham, C Kubaczka, DK Jha, M Falchetti, TM Schlaeger, TE North, MV Maus, GQ Daley EZH1 repression generates mature iPSC-derived CAR T�cells with enhanced antitumor activity Cell Stem Cell, 2022-08-04;29(8):1181-1196.e6. 2022-08-04 [PMID: 35931029] (Bioassay, Human)
• B Hwang, Y Gho, H Kim, S Lee, SA Hong, TJ Lee, SC Myung, SJ Yun, YH Choi, WJ Kim, SK Moon Rosa hybrida Petal Extract Exhibits Antitumor Effects by Abrogating Tumor Progression and Angiogenesis in Bladder Cancer Both In Vivo and In Vitro Integrative cancer therapies, 2022-01-01;21(0):1534735422111. 2022-01-01 [PMID: 35912937] (Bioassay, Human)
• SL Lu, H Omori, Y Zhou, YS Lin, CC Liu, JJ Wu, T Noda VEGF-Mediated Augmentation of Autophagic and Lysosomal Activity in Endothelial Cells Defends against Intracellular Streptococcus pyogenes MBio, 2022-07-05;0(0):e0123322. 2022-07-05 [PMID: 35862783] (Bioassay, Human)
• N Gioelli, LJ Neilson, N Wei, G Villari, W Chen, B Kuhle, M Ehling, F Maione, S Willox, S Brundu, D Avanzato, G Koulouras, M Mazzone, E Giraudo, XL Yang, D Valdembri, S Zanivan, G Serini Neuropilin 1 and its inhibitory ligand mini-tryptophanyl-tRNA synthetase inversely regulate VE-cadherin turnover and vascular permeability Nature Communications, 2022-07-20;13(1):4188. 2022-07-20 [PMID: 35858913] (Bioassay, Human)
• Y Tsujisaka, T Hatani, C Okubo, R Ito, A Kimura, M Narita, K Chonabayas, S Funakoshi, A Lucena-Cac, T Toyoda, K Osafune, T Kimura, H Saito, Y Yoshida Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting Stem Cell Reports, 2022-06-09;0(0):. 2022-06-09 [PMID: 35688152] (Bioassay, Human)
• Y Cheng, A Medina, Z Yao, M Basu, JP Natekar, J Lang, E Sanchez, MB Nkembo, C Xu, X Qian, PTT Nguyen, Z Wen, H Song, GL Ming, M Kumar, MA Brinton, MMH Li, H Tang Intrinsic antiviral immunity of barrier cells revealed by an iPSC-derived blood-brain barrier cellular model Cell Reports, 2022-05-31;39(9):110885. 2022-05-31 [PMID: 35649379] (Bioassay, Human)
• HL Deissler, M Rehak, A Wolf Impairment of the Retinal Endothelial Cell Barrier Induced by Long-Term Treatment with VEGF-A165 No Longer Depends on the Growth Factor&#039;s Presence Biomolecules, 2022-05-23;12(5):. 2022-05-23 [PMID: 35625661] (Bovine)
• Q Lian, K Zhang, Z Zhang, F Duan, L Guo, W Luo, BW Mok, A Thakur, X Ke, P Motallebne, V Nicolaescu, J Chen, CY Ma, X Zhou, S Han, T Han, W Zhang, AY Tan, T Zhang, X Wang, D Xu, J Xiang, A Xu, C Liao, FP Huang, YW Chen, J Na, G Randall, HF Tse, Z Chen, Y Chen, HJ Chen Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model Nature Communications, 2022-04-19;13(1):2028. 2022-04-19 [PMID: 35440562] (Bioassay, Human)
• BK Gage, S Merlin, C Olgasi, A Follenzi, GM Keller Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors Cell Reports, 2022-04-05;39(1):110621. 2022-04-05 [PMID: 35385743] (Bioassay, Human)
• Salokas K, Liu X, Ohman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M Physical and functional interactome atlas of human receptor tyrosine kinases. EMBO Rep, 2022-04-05;23(6):e54041. 2022-04-05 [PMID: 35384245] (Bioassay, Human)
• M Willems, P Sebetaenha, I Gies, V Vloeberghs, H Tournaye, D Van Saen, E Goossens Intratesticular xenografting of Klinefelter pre-pubertal testis tissue as potential model to study testicular fibrosis Reproductive biomedicine online, 2022-01-31;0(0):. 2022-01-31 [PMID: 35282995] (Cell Culture, Human)
• Z Wang, HP McWilliams, H Reza, JR Ostberg, W Chen, X Wang, C Huynh, V Vyas, WC Chang, R Starr, JR Wagner, B Aguilar, X Yang, X Wu, J Wang, W Chen, E Koelker-Wo, CS Seet, A Montel-Hag, GM Crooks, SJ Forman, CE Brown 3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T�cells Cell Stem Cell, 2022-03-11;0(0):. 2022-03-11 [PMID: 35278370] (Bioassay, Human)
• DC Kirman, B Renganatha, WK Chui, MW Chen, NA Kaya, R Ge Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis Cell Death & Disease, 2022-02-23;13(2):172. 2022-02-23 [PMID: 35197459] (Bioassay, Human)
• TC Ho, SI Yeh, SL Chen, TW Chu, YP Tsao A short peptide derived from pigment epithelial-derived factor exhibits an angioinhibitory effect BMC ophthalmology, 2022-02-22;22(1):88. 2022-02-22 [PMID: 35193548] (Bioassay, Human)
• S Rosano, S Parab, A Noghero, D Corà, F Bussolino Long Non-Coding RNA LINC02802 Regulates In Vitro Sprouting Angiogenesis by Sponging microRNA-486-5p International Journal of Molecular Sciences, 2022-01-31;23(3):. 2022-01-31 [PMID: 35163581] (Bioassay, Human)
• AM Abu El-Asr, A Ahmad, MI Nawaz, MM Siddiquei, A De Zutter, L Vanbrabant, PW Gikandi, G Opdenakker, S Struyf Tissue Inhibitor of Metalloproteinase-3 Ameliorates Diabetes-Induced Retinal Inflammation Frontiers in Physiology, 2022-01-10;12(0):807747. 2022-01-10 [PMID: 35082694] (Bioassay, Human)
• A Hunziker, I Glas, MO Pohl, S Stertz Phosphoproteomic profiling of influenza virus entry reveals infection-triggered filopodia induction counteracted by dynamic cortactin phosphorylation Cell Reports, 2022-01-25;38(4):110306. 2022-01-25 [PMID: 35081340] (Bioassay, Human)
• A Das, D Ash, AY Fouda, V Sudhahar, YM Kim, Y Hou, FZ Hudson, BK Stansfield, RB Caldwell, M McMenamin, R Littlejohn, H Su, MR Regan, BJ Merrill, LB Poole, JH Kaplan, T Fukai, M Ushio-Fuka Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis Nature Cell Biology, 2022-01-13;24(1):35-50. 2022-01-13 [PMID: 35027734] (Bioassay, Human)
• JH Wang, CL Tseng, FL Lin, J Chen, EH Hsieh, S Lama, YF Chuang, S Kumar, L Zhu, MB McGuinness, J Hernandez, L Tu, PY Wang, GS Liu Topical application of TAK1 inhibitor encapsulated by gelatin particle alleviates corneal neovascularization Theranostics, 2022-01-01;12(2):657-674. 2022-01-01 [PMID: 34976206] (Bioassay, Human)
• M Ling, L Quan, X Lai, L Lang, F Li, X Yang, Y Fu, S Feng, X Yi, C Zhu, P Gao, X Zhu, L Wang, G Shu, Q Jiang, S Wang VEGFB Promotes Myoblasts Proliferation and Differentiation through VEGFR1-PI3K/Akt Signaling Pathway International Journal of Molecular Sciences, 2021-12-12;22(24):. 2021-12-12 [PMID: 34948148] (Bioassay, Mouse)
• R Belvedere, E Morretta, N Novizio, S Morello, O Bruno, C Brullo, A Petrella The Pyrazolyl-Urea Gege3 Inhibits the Activity of ANXA1 in the Angiogenesis Induced by the Pancreatic Cancer Derived EVs Biomolecules, 2021-11-24;11(12):. 2021-11-24 [PMID: 34944403] (Bioassay, Human)
• P Li, Q Li, N Biswas, H Xin, T Diemer, L Liu, L Perez Guti, G Paternostr, C Piermarocc, S Domanskyi, RK Wang, N Ferrara LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy Embo Molecular Medicine, 2021-11-15;0(0):e14511. 2021-11-15 [PMID: 34779136] (Bioassay, In Vivo, Bovine, Mouse)
• RC Jiang, XY Zheng, SL Yang, HJ Shi, JH Xi, YJ Zou, HQ Dou, YJ Wang, Y Qin, XL Zhang, Q Xiao CD146 mediates the anti-apoptotic role of Netrin-1 in endothelial progenitor cells under hypoxic conditions Molecular Medicine Reports, 2021-11-05;25(1):. 2021-11-05 [PMID: 34738629] (Bioassay, Mouse)
• M Moncayo-Do, GA Rico-Llano, DA Garzón-Alv, J Becerra, R Visser, MR Fontanilla The Effect of Pore Directionality of Collagen Scaffolds on Cell Differentiation and In Vivo Osteogenesis Polymers, 2021-09-20;13(18):. 2021-09-20 [PMID: 34578088] (In Vivo, Rats)
• JAF Silva, X Qi, MB Grant, ME Boulton Spatial and temporal VEGF receptor intracellular trafficking in microvascular and macrovascular endothelial cells Scientific Reports, 2021-08-30;11(1):17400. 2021-08-30 [PMID: 34462507] (Bioassay, Human)
• H Yasuda, M Tanaka, A Nishinaka, S Nakamura, M Shimazawa, H Hara Role of Activating Transcription Factor 4 in Murine Choroidal Neovascularization Model International Journal of Molecular Sciences, 2021-08-18;22(16):. 2021-08-18 [PMID: 34445595] (Bioassay, Human)
• Y Wang, Y Zhu, Y Gu, M Ma, Y Wang, S Qi, Y Zeng, R Zhu, X Wang, P Yu, J Xu, Y Shu, FX Yu Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis Cell Reports, 2021-08-24;36(8):109596. 2021-08-24 [PMID: 34433060] (Bioassay, Mouse)
• S Ma, LS Mangala, W Hu, E Bayaktar, A Yokoi, W Hu, S Pradeep, S Lee, PD Piehowski, A Villar-Pra, SY Wu, MH McGuire, OD Lara, C Rodriguez-, CJ LaFargue, NB Jennings, KD Rodland, T Liu, V Kundra, PT Ram, S Ramakrishn, G Lopez-Bere, RL Coleman, AK Sood CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance Cell Reports, 2021-08-17;36(7):109549. 2021-08-17 [PMID: 34407412] (Bioassay, Human)
• P Ebner-Peki, L Krisch, M Wolf, S Hochmann, A Hoog, B Vári, K Muigg, R Poupardin, C Scharler, S Schmidhube, E Russe, H Stachelsch, A Schneeberg, K Schallmose, D Strunk Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration Theranostics, 2021-07-25;11(17):8430-8447. 2021-07-25 [PMID: 34373751] (Bioassay, Human)
• AM Abu El-Asr, MI Nawaz, A Ahmad, MM Siddiquei, E Allegaert, PW Gikandi, G De Hertogh, G Opdenakker CD146/Soluble CD146 Pathway Is a Novel Biomarker of Angiogenesis and Inflammation in Proliferative Diabetic Retinopathy Investigative Ophthalmology & Visual Science, 2021-07-01;62(9):32. 2021-07-01 [PMID: 34293080] (Bioassay, Human)
• M Richards, S Pal, E Sjöberg, P Martinsson, L Venkatrama, L Claesson-W Intra-vessel heterogeneity establishes enhanced sites of macromolecular leakage downstream of laminin &amp;alpha5 Cell Reports, 2021-06-22;35(12):109268. 2021-06-22 [PMID: 34161758] (Bioassay, Human)
• H Iseoka, S Miyagawa, Y Sakai, Y Sawa Cardiac fibrosis models using human induced pluripotent stem cell-derived cardiac tissues allow anti-fibrotic drug screening in vitro Stem Cell Research, 2021-06-11;54(0):102420. 2021-06-11 [PMID: 34126557] (Bioassay, Human)
• L Martin, P Bouvet, N Chounlamou, C Watrin, R Besançon, D Pinatel, D Meyronet, J Honnorat, A Buisson, PA Salin, C Meissirel VEGF counteracts amyloid-&amp;beta-induced synaptic dysfunction Cell Reports, 2021-05-11;35(6):109121. 2021-05-11 [PMID: 33979625] (Bioassay, ELISA Capture, Human)
• MG Dallinga, YI Habani, AWM Schimmel, GM Dallinga-T, CJF van Noorde, I Klaassen, RO Schlingema The Role of Heparan Sulfate and Neuropilin 2 in VEGFA Signaling in Human Endothelial Tip Cells and Non-Tip Cells during Angiogenesis In Vitro Cells, 2021-04-16;10(4):. 2021-04-16 [PMID: 33923753] (Cell Culture, Human)
• CH Dreyer, NR Jørgensen, S Overgaard, L Qin, M Ding Vascular Endothelial Growth Factor and Mesenchymal Stem Cells Revealed Similar Bone Formation to Allograft in a Sheep Model BioMed Research International, 2021-03-03;2021(0):6676609. 2021-03-03 [PMID: 33763484] (Bioassay, Sheep)
• J Wu, M Kong, Y Lou, L Li, C Yang, H Xu, Y Cui, H Hao, Z Liu Simultaneous Activation of Erk1/2 and Akt Signaling is Critical for Formononetin-Induced Promotion of Endothelial Function Frontiers in Pharmacology, 2021-01-11;11(0):608518. 2021-01-11 [PMID: 33505313] (Bioassay, Human, Mouse)
• IO Zabroski, MA Nugent Lipid Raft Association Stabilizes VEGF Receptor 2 in Endothelial Cells International Journal of Molecular Sciences, 2021-01-14;22(2):. 2021-01-14 [PMID: 33466887] (Bioassay, Bovine)
• M Souidi, Y Sleiman, I Acimovic, J Pribyl, A Charrabi, V Baecker, V Scheuerman, M Pesl, S Jelinkova, P Skladal, P Dvorak, A Lacampagne, V Rotrekl, AC Meli Oxygen Is an Ambivalent Factor for the Differentiation of Human Pluripotent Stem Cells in Cardiac 2D Monolayer and 3D Cardiac Spheroids International Journal of Molecular Sciences, 2021-01-11;22(2):. 2021-01-11 [PMID: 33440843] (Bioassay, Human)
• C Zhong, P Li, S Argade, L Liu, A Chilla', W Liang, H Xin, B Eliceiri, B Choudhury, N Ferrara Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways Nature Communications, 2020-12-10;11(1):6330. 2020-12-10 [PMID: 33303737] (Cell Culture, Human)
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• H Zhu, RH Blum, D Bernareggi, EH Ask, Z Wu, HJ Hoel, Z Meng, C Wu, KL Guan, KJ Malmberg, DS Kaufman Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In�Vivo Persistence and Enhances Anti-tumor Activity Cell Stem Cell, 2020-06-11;0(0):. 2020-06-11 [PMID: 32531207] (Bioassay, Human)
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• L Koehler, G Ruiz-Gómez, K Balamuruga, S Rother, J Freyse, S Möller, M Schnabelra, S Köhling, S Djordjevic, D Scharnwebe, J Rademann, MT Pisabarro, V Hintze Dual Action of Sulfated Hyaluronan on Angiogenic Processes in Relation to Vascular Endothelial Growth Factor-A Sci Rep, 2019-12-02;9(1):18143. 2019-12-02 [PMID: 31792253] (Bioassay, Surface Plasmon Resonance (SPR, Human)
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• P Deshors, C Toulas, F Arnauduc, L Malric, A Siegfried, Y Nicaise, A Lemarié, D Larrieu, M Tosolini, E Cohen-Jona, M Courtade-S, SM Evrard Ionizing radiation induces endothelial transdifferentiation of glioblastoma stem-like cells through the Tie2 signaling pathway Cell Death Dis, 2019-10-28;10(11):816. 2019-10-28 [PMID: 31659157] (Bioassay, Human)
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• Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT. Blood, 2012-05-08;119(26):6278-87. 2012-05-08 [PMID: 22569400] (Bioassay, Human)
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• Riccioni R, Diverio D, Mariani G, Buffolino S, Riti V, Saulle E, Petrucci E, Cedrone M, Lo-Coco F, Foa R, Peschle C, Testa U Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts. Stem Cells, 2007-04-19;25(8):1862-71. 2007-04-19 [PMID: 17446561] (Bioassay, Human)
• Srivastava AS, Nedelcu E, Esmaeli-Azad B, Mishra R, Carrier E Thrombopoietin enhances generation of CD34+ cells from human embryonic stem cells. Stem Cells, 2007-03-22;25(6):1456-61. 2007-03-22 [PMID: 17379761] (Bioassay, Human)
• Rajesh</LastName><ForeNam D</Initial, Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells. Stem Cells, 2007-02-01;25(2):490-9. 2007-02-01 [PMID: 17284653] (Bioassay, Mouse)
• Babinska A, Azari BM, Salifu MO, Liu R, Jiang XC, Sobocka MB, Boo D, Al Khoury G, Deitch JS, Marmur JD, Ehrlich YH, Kornecki E The F11 receptor (F11R/JAM-A) in atherothrombosis: overexpression of F11R in atherosclerotic plaques. Thromb. Haemost., 2007-02-01;97(2):272-81. 2007-02-01 [PMID: 17264957] (Bioassay, Human)
• Rusk A, McKeegan E, Haviv F, Majest S, Henkin J, Khanna C Preclinical evaluation of antiangiogenic thrombospondin-1 peptide mimetics, ABT-526 and ABT-510, in companion dogs with naturally occurring cancers. Clin. Cancer Res., 2006-12-15;12(24):7444-55. 2006-12-15 [PMID: 17189418] (Bioassay, Canine, Human)
• Werdich XQ, Penn JS Specific involvement of SRC family kinase activation in the pathogenesis of retinal neovascularization. Invest. Ophthalmol. Vis. Sci., 2006-11-01;47(11):5047-56. 2006-11-01 [PMID: 17065526] (Bioassay, Human)
• Kim KL, Shin IS, Kim JM, Choi JH, Byun J, Jeon ES, Suh W, Kim DK Interaction between Tie receptors modulates angiogenic activity of angiopoietin2 in endothelial progenitor cells. Cardiovasc. Res., 2006-08-07;72(3):394-402. 2006-08-07 [PMID: 17054925] (Bioassay, Human)
• Porat Y, Porozov S, Belkin D, Shimoni D, Fisher Y, Belleli A, Czeiger D, Silverman WF, Belkin M, Battler A, Fulga V, Savion N Isolation of an adult blood-derived progenitor cell population capable of differentiation into angiogenic, myocardial and neural lineages. Br. J. Haematol., 2006-12-01;135(5):703-14. 2006-12-01 [PMID: 17052254] (Bioassay, Human)
• Lake AC, Vassy R, Di Benedetto M, Lavigne D, Le Visage C, Perret GY, Letourneur D Low molecular weight fucoidan increases VEGF165-induced endothelial cell migration by enhancing VEGF165 binding to VEGFR-2 and NRP1. J. Biol. Chem., 2006-10-06;281(49):37844-52. 2006-10-06 [PMID: 17028197] (Bioassay, Human)
• Kim BK, Kim SE, Shim JH, Woo DH, Gil JE, Kim SK, Kim JH Neurogenic effect of vascular endothelial growth factor during germ layer formation of human embryonic stem cells. FEBS Lett., 2006-10-02;580(25):5869-74. 2006-10-02 [PMID: 17027979] (Bioassay, Human)
• Yamagata M, Rook SL, Sassa Y, Ma RC, Geraldes P, Goddard L, Clermont A, Gao B, Salti H, Gundel R, White M, Feener EP, Aiello LP, King GL Bactericidal/permeability-increasing protein&apos;s signaling pathways and its retinal trophic and anti-angiogenic effects. FASEB J., 2006-10-01;20(12):2058-67. 2006-10-01 [PMID: 17012258] (Bioassay, Bovine)
• Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C Multipotent adult progenitor cells from swine bone marrow. Stem Cells, 2006-08-24;24(11):2355-66. 2006-08-24 [PMID: 16931778] (Bioassay, Porcine)
• Lai WK, Sun PJ, Zhang J, Jennings A, Lalor PF, Hubscher S, McKeating JA, Adams DH Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles. Am. J. Pathol., 2006-07-01;169(1):200-8. 2006-07-01 [PMID: 16816373] (Bioassay, Human)
• Ren WP, Markel DC, Zhang R, Peng X, Wu B, Monica H, Wooley PH Association between UHMWPE particle-induced inflammatory osteoclastogenesis and expression of RANKL, VEGF, and Flt-1 in vivo. Biomaterials, 2006-06-30;27(30):5161-9. 2006-06-30 [PMID: 16814378] (In Vivo, Mouse)
• Sreekumar PG, Kannan R, de Silva AT, Burton R, Ryan SJ, Hinton DR Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells. Biochem. Biophys. Res. Commun., 2006-06-12;346(4):1200-6. 2006-06-12 [PMID: 16793007] (Western Blot)
• Kiyono M, Shibuya M Inhibitory Smad transcription factors protect arterial endothelial cells from apoptosis induced by BMP4. Oncogene, 2006-05-29;25(54):7131-7. 2006-05-29 [PMID: 16732319] (Bioassay, Human)
• Kurita R, Sasaki E, Yokoo T, Hiroyama T, Takasugi K, Imoto H, Izawa K, Dong Y, Hashiguchi T, Soda Y, Maeda T, Suehiro Y, Tanioka Y, Nakazaki Y, Tani K Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells. Stem Cells, 2006-05-25;24(9):2014-22. 2006-05-25 [PMID: 16728561] (Bioassay, Primate - Callitrix jacchus (Common Marmoset))
• Hiroyama T, Miharada K, Aoki N, Fujioka T, Sudo K, Danjo I, Nagasawa T, Nakamura Y Long-lasting in vitro hematopoiesis derived from primate embryonic stem cells. Exp. Hematol., 2006-06-01;34(6):760-9. 2006-06-01 [PMID: 16728281] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• Clermont AC, Cahill M, Salti H, Rook SL, Rask-Madsen C, Goddard L, Wong JS, Bursell D, Bursell SE, Aiello LP Hepatocyte growth factor induces retinal vascular permeability via MAP-kinase and PI-3 kinase without altering retinal hemodynamics. Invest. Ophthalmol. Vis. Sci., 2006-06-01;47(6):2701-8. 2006-06-01 [PMID: 16723489] (In Vivo, Rat)
• Getmanova EV, Chen Y, Bloom L, Gokemeijer J, Shamah S, Warikoo V, Wang J, Ling V, Sun L Antagonists to human and mouse vascular endothelial growth factor receptor 2 generated by directed protein evolution in vitro. Chem. Biol., 2006-05-01;13(5):549-56. 2006-05-01 [PMID: 16720276] (Bioassay, Human, Mouse)
• Favier B, Alam A, Barron P, Bonnin J, Laboudie P, Fons P, Mandron M, Herault JP, Neufeld G, Savi P, Herbert JM, Bono F Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration. Blood, 2006-04-18;108(4):1243-50. 2006-04-18 [PMID: 16621967] (Bioassay, Human)
• Moreno MJ, Ball M, Andrade MF, McDermid A, Stanimirovic DB Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells. Glia, 2006-06-01;53(8):845-57. 2006-06-01 [PMID: 16586492] (Bioassay, Human)
• Nozaki M, Sakurai E, Raisler BJ, Baffi JZ, Witta J, Ogura Y, Brekken RA, Sage EH, Ambati BK, Ambati J Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A. J. Clin. Invest., 2006-02-01;116(2):422-9. 2006-02-01 [PMID: 16453023] (In Vivo, Mouse)
• Bates DO, MacMillan PP, Manjaly JG, Qiu Y, Hudson SJ, Bevan HS, Hunter AJ, Soothill PW, Read M, Donaldson LF, Harper SJ The endogenous anti-angiogenic family of splice variants of VEGF, VEGFxxxb, are down-regulated in pre-eclamptic placentae at term. Clin. Sci., 2006-05-01;110(5):575-85. 2006-05-01 [PMID: 16451124] (Western Blot)
• Tsigkos S, Zhou Z, Kotanidou A, Fulton D, Zakynthinos S, Roussos C, Papapetropoulos A Regulation of Ang2 release by PTEN/PI3-kinase/Akt in lung microvascular endothelial cells. J. Cell. Physiol., 2006-05-01;207(2):506-11. 2006-05-01 [PMID: 16447257] (Bioassay, Bovine)
• Anghelina M, Krishnan P, Moldovan L, Moldovan NI Monocytes/macrophages cooperate with progenitor cells during neovascularization and tissue repair: conversion of cell columns into fibrovascular bundles. Am. J. Pathol., 2006-02-01;168(2):529-41. 2006-02-01 [PMID: 16436667] (In Vivo, Mouse)
• Narazaki M, Tosato G Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A. Blood, 2006-01-19;107(10):3892-901. 2006-01-19 [PMID: 16424390] (ELISA (Standard))
• Carr AN, Howard BW, Yang HT, Eby-Wilkens E, Loos P, Varbanov A, Qu A, DeMuth JP, Davis MG, Proia A, Terjung RL, Peters KG Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: support for an endothelium-dependent mechanism. Cardiovasc. Res., 2006-01-10;69(4):925-35. 2006-01-10 [PMID: 16409996] (In Vivo, Rat)
• Jung Y, Wang J, Schneider A, Sun YX, Koh-Paige AJ, Osman NI, McCauley LK, Taichman RS Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing. Bone, 2005-12-05;38(4):497-508. 2005-12-05 [PMID: 16337237] (Bioassay, Human)
• Cross SS, Yang Z, Brown NJ, Balasubramanian SP, Evans CA, Woodward JK, Neville-Webbe HL, Lippitt JM, Reed MW, Coleman RE, Holen I Osteoprotegerin (OPG)--a potential new role in the regulation of endothelial cell phenotype and tumour angiogenesis? Int. J. Cancer, 2006-04-15;118(8):1901-8. 2006-04-15 [PMID: 16287088] (Bioassay, Human)
• Bagley RG, Weber W, Rouleau C, Teicher BA Pericytes and endothelial precursor cells: cellular interactions and contributions to malignancy. Cancer Res., 2005-11-01;65(21):9741-50. 2005-11-01 [PMID: 16266995] (Bioassay, Human)
• Curbishley SM, Eksteen B, Gladue RP, Lalor P, Adams DH CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow. Am. J. Pathol., 2005-09-01;167(3):887-99. 2005-09-01 [PMID: 16127166] (Bioassay, Human)
• Trevino JG, Summy JM, Gray MJ, Nilsson MB, Lesslie DP, Baker CH, Gallick GE Expression and activity of SRC regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis. Cancer Res., 2005-08-15;65(16):7214-22. 2005-08-15 [PMID: 16103072] (In Vivo, Mouse)
• Voisine P, Bianchi C, Khan TA, Ruel M, Xu SH, Feng J, Li J, Malik T, Rosinberg A, Sellke FW Normalization of coronary microvascular reactivity and improvement in myocardial perfusion by surgical vascular endothelial growth factor therapy combined with oral supplementation of l-arginine in a porcine model of endothelial dysfunction. J. Thorac. Cardiovasc. Surg., 2005-06-01;129(6):1414-20. 2005-06-01 [PMID: 15942586] (In Vivo, Porcine)
• Puxeddu I, Alian A, Piliponsky AM, Ribatti D, Panet A, Levi-Schaffer F Human peripheral blood eosinophils induce angiogenesis. Int. J. Biochem. Cell Biol., 2005-03-01;37(3):628-36. 2005-03-01 [PMID: 15618019] (Bioassay, Chicken, Rat)
• Sun JF, Phung T, Shiojima I, Felske T, Upalakalin JN, Feng D, Kornaga T, Dor T, Dvorak AM, Walsh K, Benjamin LE Microvascular patterning is controlled by fine-tuning the Akt signal. Proc. Natl. Acad. Sci. U.S.A., 2004-12-20;102(1):128-33. 2004-12-20 [PMID: 15611473] (Bioassay, Bovine)
• Dikov MM, Ohm JE, Ray N, Tchekneva EE, Burlison J, Moghanaki D, Nadaf S, Carbone DP Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation. J. Immunol., 2005-01-01;174(1):215-22. 2005-01-01 [PMID: 15611243] (Bioassay, Mouse)
• Eubank TD, Roberts R, Galloway M, Wang Y, Cohn DE, Marsh CB GM-CSF induces expression of soluble VEGF receptor-1 from human monocytes and inhibits angiogenesis in mice. Immunity, 2004-12-01;21(6):831-42. 2004-12-01 [PMID: 15589171] (In Vivo, Mouse)
• Martiny-Baron G, Korff T, Schaffner F, Esser N, Eggstein S, Marme D, Augustin HG Inhibition of tumor growth and angiogenesis by soluble EphB4. Neoplasia, 2004-05-01;6(3):248-57. 2004-05-01 [PMID: 15153337] (Bioassay, Human)
• Satchell SC, Anderson KL, Mathieson PW Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties. J. Am. Soc. Nephrol., 2004-03-01;15(3):566-74. 2004-03-01 [PMID: 14978158] (Bioassay, Human)
• Suzuki O, Bishop AT, Sunagawa T, Katsube K, Friedrich PF VEGF-promoted surgical angiogenesis in necrotic bone. Microsurgery, 2004-01-01;24(1):85-91. 2004-01-01 [PMID: 14748033] (In Vivo, Rabbit)
• Usui T, Ishida S, Yamashiro K, Kaji Y, Poulaki V, Moore J, Moore T, Amano S, Horikawa Y, Dartt D, Golding M, Shima DT, Adamis AP VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2. Invest. Ophthalmol. Vis. Sci., 2004-02-01;45(2):368-74. 2004-02-01 [PMID: 14744874] (Bioassay, Human)
• Caine GJ, Blann AD, Stonelake PS, Ryan P, Lip GY Plasma angiopoietin-1, angiopoietin-2 and Tie-2 in breast and prostate cancer: a comparison with VEGF and Flt-1. Eur. J. Clin. Invest., 2003-10-01;33(10):883-90. 2003-10-01 [PMID: 14511360] (ELISA (Standard))
• Danet GH, Pan Y, Luongo JL, Bonnet DA, Simon MC Expansion of human SCID-repopulating cells under hypoxic conditions. J. Clin. Invest., 2003-07-01;112(1):126-35. 2003-07-01 [PMID: 12840067] (Bioassay, Human)
• Fuller T, Korff T, Kilian A, Dandekar G, Augustin HG Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. J. Cell. Sci., 2003-05-06;116(0):2461-70. 2003-05-06 [PMID: 12734395] (Bioassay, Human)
• Mogi K, Goto M, Ohno E, Azumi Y, Takeuchi S, Toyoizumi R Xenopus neurula left-right asymmetry is respeficied by microinjecting TGF-beta5 protein. Int. J. Dev. Biol., 2003-02-01;47(1):15-29. 2003-02-01 [PMID: 12653248] (In Vivo, Xenopus)
• Maynard SE, Min JY, Merchan J, Lim KH, Mondal S, Stillman IE, Epstein FH, Karumanchi SA Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J. Clin. Invest., 2003-03-01;111(5):649-58. 2003-03-01 [PMID: 12618519] (Bioassay, Human)
• Masood R, Kundra A, Zhu S, Xia G, Scalia P, Smith DL, Gill PS Malignant mesothelioma growth inhibition by agents that target the VEGF and VEGF-C autocrine loops. Int. J. Cancer, 2003-05-01;104(5):603-10. 2003-05-01 [PMID: 12594815] (Bioassay, Human)
• Barbour AP, Reeder JA, Walsh MD, Fawcett J, Antalis TM, Gotley DC Expression of the CD44v2-10 isoform confers a metastatic phenotype: importance of the heparan sulfate attachment site CD44v3. Cancer Res., 2003-02-15;63(4):887-92. 2003-02-15 [PMID: 12591743] (Binding Assay, Human)
• Keane MP, Donnelly SC, Belperio JA, Goodman RB, Dy M, Burdick MD, Fishbein MC, Strieter RM Imbalance in the expression of CXC chemokines correlates with bronchoalveolar lavage fluid angiogenic activity and procollagen levels in acute respiratory distress syndrome. J. Immunol., 2002-12-01;169(11):6515-21. 2002-12-01 [PMID: 12444162] (ELISA (Standard))
• Argraves WS, Larue AC, Fleming PA, Drake CJ VEGF signaling is required for the assembly but not the maintenance of embryonic blood vessels. Dev. Dyn., 2002-11-01;225(3):298-304. 2002-11-01 [PMID: 12412012] (Bioassay, In Vivo, Avian - Quail, Mouse)
• Lee S, 107340, Zheng M, Kim B, Rouse BT Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus. Identification of NHLRC1 as a Novel AKT Activator from a Lung Cancer Epigenome-Wide Association Study (EWAS), 2002-10-01;110(8):1105-11. 2002-10-01 [PMID: 12393846] (In Vivo, Mouse)
• Oura H, Bertoncini J, Velasco P, Brown LF, Carmeliet P, Detmar M A critical role of placental growth factor in the induction of inflammation and edema formation. Blood, 2002-09-05;101(2):560-7. 2002-09-05 [PMID: 12393422] (In Vivo, Mouse)
• Gargett CE, Zaitseva M, Bucak K, Chu S, Fuller PJ, Rogers PA 17Beta-estradiol up-regulates vascular endothelial growth factor receptor-2 expression in human myometrial microvascular endothelial cells: role of estrogen receptor-alpha and -beta. J. Clin. Endocrinol. Metab., 2002-09-01;87(9):4341-9. 2002-09-01 [PMID: 12213896] (Bioassay, Human)
• Derevjanik NL, Vinores SA, Xiao WH, Mori K, Turon T, Hudish T, Dong S, Campochiaro PA Quantitative assessment of the integrity of the blood-retinal barrier in mice. Invest. Ophthalmol. Vis. Sci., 2002-07-01;43(7):2462-7. 2002-07-01 [PMID: 12091451] (In Vivo, Mouse)
• Chen CT, 2018, Lin J, Li Q, Phipps SS, Jakubczak JL, Stewart DA, Skripchenko Y, Forry-Schaudies S, Wood J, Schnell C, Hallenbeck PL Antiangiogenic gene therapy for cancer via systemic administration of adenoviral vectors expressing secretable endostatin. 132, 2000-09-20;11(14):1983-96. 2000-09-20 [PMID: 11020798] (Bioassay, In Vivo, Human, Mouse)

FAQs for VEGF (293-VE/CF). (Showing 1 - 1 of 1 FAQs).

1. Why is the molecular weight of VEGF different from the similar antibody, for some companies the the molecular weight is 40KD)?  ..show answer..
   • I can't comment on another company's antibody because I don't have any information about their products. I can tell you that VEGF is expressed in a variety of isoforms and is subject to various post-translational modifications that influence its apparent molecular weight in an SDS-PAGE gel compared to the theoretical molecular weight.

Bioinformatics

• Gene Symbol: VEGFA
• Uniprot:
  • NP_001165097()