Recombinant Human Wnt-3a Protein, CF

Recombinant Human Wnt-3a (Catalog # 5036-WN/CF) induces alkaline phosphatase production by the MC3T3-E1 mouse preosteoblast cell line. The ED50 is 1.7-fold better with more than twice the maximum response compared to the top competitor's Wnt-3a.

The lot-to-lot consistency of Recombinant Human Wnt-3a (Catalog # 5036-WN/CF) was assessed by testing the ability of three independent lots of the protein to induce alkaline phosphatase production in the MC3T3-E1 mouse preosteoblast cell line. Each trace on the graph represents data obtained from Recombinant Human Wnt-3a from a different manufacturing run. The ED50 for this effect is 5.00-25.0 ng/mL.

iPSC-derived human intestinal organoids were cultured using Cultrex™ UltiMatrix RGF Basement Membrane Extract (BME001-05) and intestinal organoid culture medium, which includes Recombinant Human Wnt-3a (Catalog # 5036-WN/CF), Recombinant Human EGF (236-EG), Recombinant Human Noggin (6057-NG), Recombinant Human R-Spondin 1 (4645-RS), along with the other reagents listed in the intestinal organoid culture medium recipe in the human intestinal organoid culture protocol. (A) Human intestinal organoids were stained using a Rat Anti-Human/Mouse/Rat Vimentin Monoclonal Antibody (MAB2105; green) and a Goat Anti-Human/Mouse Desmin Antigen Affinity-purified Polyclonal Antibody (AF3844; red) to visualize myofibroblast cells and counterstained with DAPI (5748; blue). (B) Human intestinal organoids were stained using a Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (AF748; green) and a Mouse Anti-Human MUC2 Monoclonal Antibody (Novus Biologicals, Catalog # NBP2-44431; red) and counterstained with DAPI (5748; blue).

Adult stem cells isolated from human descending colon were embedded in Cultrex UltiMatrix RGF Basement Membrane Extract (BME001-05) and cultured for 30 days in intestinal organoid culture medium, which includes Recombinant Human Wnt-3a (Catalog # 5036-WN/CF), Recombinant Human EGF (236-EG), Recombinant Human Noggin (6057-NG), Recombinant Human R-Spondin 1 (4645-RS), along with the other reagents listed in the intestinal organoid culture medium recipe in the human intestinal organoid culture protocol. (A) Organoids were fixed and stained with a Mouse Anti-Human MUC2 Monoclonal Antibody (Novus Biologicals; Catalog # NBP2-44431; green) to visualize intestinal goblet cells and counterstained with a Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (AF748; red) and DAPI (5748; blue). The image shown was taken at 10x magnification. (B) Organoids were fixed and stained with a Mouse Anti-Human Chromogranin A Monoclonal Antibody (MAB90981; green) to visualize enteroendocrine cells and counterstained with a Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (AF748; red) and DAPI (5748; blue). The image shown was taken at 20x magnification.

• Reactivity: Hu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Human Wnt-3a Protein, CF Summary

• Details of Functionality: Measured by its ability to induce alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells. The ED₅₀ for this effect is 5.00-25.0 ng/mL. Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. The ED₅₀ for this effect is <500 ng/mL. Protein concentrations should be titrated based on cell type and if appropriate, passage number of the cell line.
  Optimal concentrations should be determined by each laboratory for each application.
• Source: Chinese Hamster Ovary cell line, CHO-derived human Wnt-3a protein
  Ser19-Lys352
• Accession #: NP_149122
• N-terminal Sequence: Ser19
• Protein/Peptide Type: Recombinant Proteins
• Gene: WNT3A
• Purity: >75%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
  • Bioactivity2
• Theoretical MW: 37.4 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 40 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and CHAPS.
• Purity: >75%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 200 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human Wnt-3a Protein, CF

• MGC119418
• MGC119419
• MGC119420
• protein Wnt-3a
• wingless-type MMTV integration site family, member 3A
• Wnt3a
• Wnt-3a

Background

Wnt-3a is one of 19 vertebrate members of the Wingless-type MMTV integration site (Wnt) family of highly conserved cysteine-rich secreted glycoproteins important for normal developmental processes (1). Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta -catenin levels (2). As intracellular beta -catenin levels rise, beta -catenin binds to TCF/LEF transcription factors leading to expression of Wnt target genes (3). Endo-IWR 1 (Catalog # 3532, # PSM1324) is a cell-permeant small molecule inhibitor of Axin turnover that suppresses Wnt signal transduction by stabilizing the beta -catenin destruction complex (4). Wnt-3a is a 44 kDa secreted hydrophobic glycoprotein containing a conserved pattern of 24 cysteine residues (5). Wnt-3a has two N-linked glycosylation sites (Asn 87, Asn 298), and Ser 209 is modified with palmitoleic acid (6). Glycosylation and acylation are essential for efficient Wnt secretion and biological activity, respectively (6, 7). Human Wnt-3a shares 96% amino acid (aa) identity with mouse mouse, bovine and canine Wnt-3a, and 89%, 86% and 84% aa identity with chicken, Xenopus and zebrafish Wnt-3a, respectively. It also shares 87% aa identity with Wnt3. During embryonic development, Wnt-3a is necessary for proper development of the hippocampus, anterior-posterior patterning, somite development, and tailbud formation (9-12). Wnt-3a also promotes self-renewal of hematopoietic stem cells, neural stem cells, and embryonic stem cells (13, 14).

1. Willert, K. and Nusse, R. (2012) Cold Spring Harb. Perspect. Biol. 4:a007864.
2. MacDonald, B.T. and X. He (2012) Cold Spring Harb. Perspect. Biol. 4:a007880.
3. Korinek, V. et al. (1997) Science 275:1784.
4. Chen, B. et al. (2009) Nat. Chem. Biol. 5:100.
5. Smolich, B.D. et al. (1993) Mol. Biol. Cell 4:1267.
6. Takada, R. et al. (2006) Dev. Cell 11:791.
7. Komekado, H. (2007) Genes Cells 12:521.
8. Dunty Jr. W. C. et al. (2008) Development 135:85.
9. Ikeya, M. and S. Takada (2001) Mech. Dev. 103:27.
10. Lee, S. M. et al. (2000) Development 127:457.
11. Takada, S. et al. (1994) Genes Dev. 8:174.
12. Willert, K. et al. (2003) Nature 423:6938.
13. Kalani, M.Y. et al. (2008) Proc. Natl. Acad. Sci. USA 105:16970.
14. Ten Berge, D. et al. (2011) Nat. Cell Biol. 13:1070.

Publications for Wnt-3a (5036-WN/CF)(330)

Publications using 5036-WN/CF

• Ma, HY;Li, Q;Wong, WR;N'Diaye, EN;Caplazi, P;Bender, H;Huang, Z;Arlantico, A;Jeet, S;Wong, A;Emson, C;Brightbill, H;Tam, L;Newman, R;Roose-Girma, M;Sandoval, W;Ding, N; LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lung Science advances 2023-05-26 [PMID: 37235663] (Bioassay, Human)
• G Cencelli, L Pacini, A De Luca, I Messia, A Gentile, Y Kang, V Nobile, E Tabolacci, P Jin, MG Farace, C Bagni Age-Dependent Dysregulation of APP in Neuronal and Skin Cells from Fragile X Individuals Cells, 2023-02-27;12(5):. 2023-02-27 [PMID: 36899894] (Bioassay, Human)
• YC Hsueh, RE Pratt, VJ Dzau, CP Hodgkinson Novel method of differentiating human induced pluripotent stem cells to mature cardiomyocytes via Sfrp2 Scientific Reports, 2023-03-09;13(1):3920. 2023-03-09 [PMID: 36894665] (Bioassay, Human)
• C Seidl, F Da Silva, K Zhang, K Wohlgemuth, H Omran, C Niehrs Mucociliary Wnt signaling promotes cilia biogenesis and beating Nature Communications, 2023-03-06;14(1):1259. 2023-03-06 [PMID: 36878953] (Bioassay, Frog)
• C Seidl, F Da Silva, K Zhang, K Wohlgemuth, H Omran, C Niehrs Mucociliary Wnt signaling promotes cilia biogenesis and beating Nature Communications, 2023;14(1):1259. 2023 [PMID: 36878953] (Bioassay, Frog)
• Y Shen, Y Chen, Y Lin, Y Li, P Liu, B Zhang, Y Wang, KC Chan, NK Mak, M Kahn, RZ Qi, H Yang CDK5RAP2 is a Wnt target gene and promotes stemness and progression of oral squamous cell carcinoma Cell Death & Disease, 2023-02-11;14(2):107. 2023-02-11 [PMID: 36774351] (Bioassay, Human)
• LH Cheng, CC Hsu, HW Tsai, WY Liao, PM Yang, TY Liao, HY Hsieh, TS Chan, KK Tsai ASPM activates Hedgehog and Wnt signaling to promote small cell lung cancer stemness and progression Cancer Research, 2023-03-15;0(0):. 2023-03-15 [PMID: 36638332] (Bioassay, Human)
• K Wang, F Ma, S Arai, Y Wang, A Varkaris, L Poluben, O Voznesensk, F Xie, X Zhang, X Yuan, SP Balk WNT5a Signaling through ROR2 Activates the Hippo Pathway to Suppress YAP1 Activity and Tumor Growth Cancer Research, 2023-04-04;0(0):. 2023-04-04 [PMID: 36622276] (Bioassay, Human)
• K Stoletov, S Sanchez, I Gorroño, M Rabano, M Vivanco, R Kypta, JD Lewis Intravital imaging of Wnt/beta-catenin and ATF2-dependent signalling pathways during tumour cell invasion and metastasis Journal of Cell Science, 2023-02-10;0(0):. 2023-02-10 [PMID: 36621522] (Bioassay, Human)
• MG Lee, H Oh, JW Park, JS You, JW Han Nuclear S6K1 Enhances Oncogenic Wnt Signaling by Inducing Wnt/beta-Catenin Transcriptional Complex Formation International Journal of Molecular Sciences, 2022-12-18;23(24):. 2022-12-18 [PMID: 36555784] (Cell Culture, Human)
• D Song, J Shang, Y Long, M Zhong, L Li, J Chen, Y Xiang, H Tan, H Zhu, X Hong, FF Hou, H Fu, Y Liu Insulin-like growth factor 2 mRNA-binding protein 3 promotes kidney injury by regulating beta-catenin signaling JCI Insight, 2023-01-24;0(0):. 2023-01-24 [PMID: 36520532] (Cell Culture, Human)
• H Ngai, GA Barragán, G Tian, JC Balzeau, C Zhang, AN Courtney, L Guo, X Xu, MS Wood, JM Drabek, T Demberg, CM Sands, CN Chauvin-Fl, EJ Di Pierro, JM Rosen, LS Metelitsa LEF1 drives a central memory program and supports antitumor activity of natural killer T cells Cancer Immunology Research, 2023-02-03;0(0):. 2023-02-03 [PMID: 36484736] (Stimulation, Human)
• Y Shi, J Deng, X Sang, Y Wang, F He, X Chen, A Xu, F Wu Generation of Hepatocytes and Nonparenchymal Cell Codifferentiation System from Human-Induced Pluripotent Stem Cells Stem Cells International, 2022-11-22;2022(0):3222427. 2022-11-22 [PMID: 36467281] (Bioassay, Human)
• L Jiang, YJ Sun, XH Song, YY Sun, WY Yang, J Li, YJ Wu Ivermectin inhibits tumor metastasis by regulating the Wnt/beta-catenin/integrin beta1/FAK signaling pathway American journal of cancer research, 2022-10-15;12(10):4502-4519. 2022-10-15 [PMID: 36381328] (Bioassay, Human)
• K Nagano, K Yamana, H Saito, R Kiviranta, AC Pedroni, D Raval, C Niehrs, F Gori, R Baron R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton Elife, 2022-11-02;11(0):. 2022-11-02 [PMID: 36321691] (Bioassay, Mouse)
• WC Hwang, D Song, H Lee, C Oh, SH Lim, HJ Bae, ND Kim, G Han, DS Min Inhibition of phospholipase D1 induces immunogenic cell death and potentiates cancer immunotherapy in colorectal cancer Experimental & Molecular Medicine, 2022-09-21;0(0):. 2022-09-21 [PMID: 36131027] (Bioassay, Human)
• Y Tian, W Wang, S Lautrup, H Zhao, X Li, PWN Law, ND Dinh, EF Fang, HH Cheung, WY Chan WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome Nature Communications, 2022-09-16;13(1):5456. 2022-09-16 [PMID: 36114168] (Bioassay, Human)
• A Fregnani, L Saggin, K Gianesin, L Quotti Tub, M Carraro, G Barilà, G Scapinello, G Bonetto, M Pesavento, T Berno, A Branca, C Gurrieri, R Zambello, G Semenzato, L Trentin, S Manni, F Piazza CK1alpha/RUNX2 Axis in the Bone Marrow Microenvironment: A Novel Therapeutic Target in Multiple Myeloma Cancers, 2022-08-29;14(17):. 2022-08-29 [PMID: 36077711] (Bioassay, Human)
• M Naumann, T Czempiel, AJ Lö beta ner, K Pape, E Beyreuther, S Löck, S Drukewitz, A Hennig, C von Neubec, B Klink, M Krause, D William, DE Stange, R Bütof, A Dietrich Combined Systemic Drug Treatment with Proton Therapy: Investigations on Patient-Derived Organoids Cancers, 2022-08-03;14(15):. 2022-08-03 [PMID: 35954444] (Cell Culture, Human)
• S Gupta, R Kawaguchi, E Heinrichs, S Gallardo, S Castellano, I Mandric, BG Novitch, SJ Butler In�vitro atlas of dorsal spinal interneurons reveals Wnt signaling as a critical regulator of progenitor expansion Oncogene, 2022-07-19;40(3):111119. 2022-07-19 [PMID: 35858555] (Bioassay, Human)
• R Moser, J Annis, O Nikolova, CJ Whatcott, KE Gurley, E Mendez, K Moran-Jone, C Dorrell, RC Sears, CJ Kuo, H Han, AV Biankin, C Grandori, DD Von Hoff, CJ Kemp Pharmacological targeting of TFIIH suppresses KRAS mutant pancreatic ductal adenocarcinoma and synergizes with TRAIL Cancer Research, 2022-09-16;0(0):. 2022-09-16 [PMID: 35819261] (Bioassay, Human)
• S Condello, M Prasad, R Atwani, D Matei Tissue transglutaminase activates integrin-linked kinase and beta-catenin in ovarian cancer The Journal of Biological Chemistry, 2022-07-08;0(0):102242. 2022-07-08 [PMID: 35810788] (Bioassay, Human)
• C Shen, A Nayak, LR Neitzel, F Yang, B Li, CH Williams, CC Hong, Y Ahmed, E Lee, DJ Robbins The Casein kinase 1alpha agonist pyrvinium attenuates Wnt-mediated CK1alpha degradation via interaction with the E3 ubiquitin ligase component Cereblon The Journal of Biological Chemistry, 2022-07-01;0(0):102227. 2022-07-01 [PMID: 35780831] (Bioassay, Human)
• V Lungova, K Wendt, SL Thibeault Exposure to e-cigarette vapor extract induces vocal fold epithelial injury and triggers intense mucosal remodeling Oncogene, 2022-08-23;0(0):. 2022-08-23 [PMID: 35770504] (Bioassay, Human)
• J Fu, L Jiang, B Yu, Y Liu, R Wei, Y Hu, WI Ho, B Yang, M Chu, HF Tse, J Yang Generation of a human iPSC line CIBi010-A with a reporter for ASGR1 using CRISPR/Cas9 Stem Cell Research, 2022-05-05;62(0):102800. 2022-05-05 [PMID: 35561459] (Bioassay, Human)
• J Jeong, TH Kim, M Kim, YK Jung, KS Kim, S Shim, H Jang, WI Jang, SB Lee, D Choi Elimination of Reprogramming Transgenes Facilitates the Differentiation of Induced Pluripotent Stem Cells into Hepatocyte-like Cells and Hepatic Organoids Biology, 2022-03-23;11(4):. 2022-03-23 [PMID: 35453693] (Bioassay, Human)
• CJ Brereton, L Yao, ER Davies, Y Zhou, M Vukmirovic, JA Bell, S Wang, RA Ridley, LSN Dean, OG Andriotis, F Conforti, L Brewitz, S Mohammed, T Wallis, A Tavassoli, RM Ewing, A Alzetani, BG Marshall, SV Fletcher, PJ Thurner, A Fabre, N Kaminski, L Richeldi, A Bhaskar, CJ Schofield, M Loxham, DE Davies, Y Wang, MG Jones Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis Elife, 2022-02-21;11(0):. 2022-02-21 [PMID: 35188460] (Bioassay, Human)
• MM Capeling, S Huang, CJ Childs, JH Wu, YH Tsai, A Wu, N Garg, EM Holloway, N Sundaram, C Bouffi, M Helmrath, JR Spence Suspension culture promotes serosal mesothelial development in human intestinal organoids Cell Reports, 2022-02-15;38(7):110379. 2022-02-15 [PMID: 35172130] (Bioassay, Human)
• CW Wasson, B Caballero-, J Gillespie, E Derrett-Sm, J Mankouri, CP Denton, G Canettieri, NA Riobo-Del, F Del Galdo Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-beta/Wnt3a Is Mediated by GLI2 Upregulation Cells, 2022-02-03;11(3):. 2022-02-03 [PMID: 35159339] (Bioassay, Human)
• Z Li, Y Wu, ME Yates, N Tasdemir, A Bahreini, J Chen, KM Levine, NM Priedigkei, A Nasrazadan, S Ali, L Buluwela, S Arnesen, J Gertz, JK Richer, B Troness, D El-Ashry, Q Zhang, L Gerratana, Y Zhang, M Cristofani, MA Montanez, P Sundd, CT Wallace, SC Watkins, C Fumagalli, E Guerini-Ro, L Zhu, GC Tseng, N Wagle, JS Carroll, P Jank, C Denkert, MM Karsten, JU Blohmer, BH Park, PC Lucas, JM Atkinson, AV Lee, S Oesterreic Hotspot ESR1 mutations are multimodal and contextual modulators of breast cancer metastasis Cancer Research, 2022-04-01;0(0):. 2022-04-01 [PMID: 35078818] (Bioassay, Human)
• B Geleta, FS Tout, SC Lim, S Sahni, PJ Jansson, MV Apte, DR Richardson, Ž Kova?evi? Targeting Wnt/Tenascin C-Mediated Cross Talk between Pancreatic Cancer Cells and Stellate Cells via activation of the Metastasis Suppressor NDRG1 The Journal of Biological Chemistry, 2022-01-20;0(0):101608. 2022-01-20 [PMID: 35065073] (Bioassay, Human)
• Y Han, A Villarreal, G Gutierrez, Q Nguyen, P Sun, T Wu, B Sui, G Berx, T Brabletz, K Kessenbroc, YA Zeng, K Watanabe, X Dai Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1 Cell Reports, 2022-01-11;38(2):110240. 2022-01-11 [PMID: 35021086] (Bioassay, Mouse)
• M Romano, R Elgueta, D McCluskey, AM Ortega-Pri, E Stolarczyk, F Dazzi, B Lucendo-Vi, J Meseguer-R, J Williams, G Fanelli, DC Hay, FM Watt, G Lombardi Pluripotent Stem Cell-Derived Hepatocytes Inhibit T Cell Proliferation In Vitro through Tryptophan Starvation Cells, 2021-12-22;11(1):. 2021-12-22 [PMID: 35011586] (Bioassay, Human)
• V Chesnokova, S Zonis, A Apostolou, HQ Estrada, S Knott, K Wawrowsky, K Michelsen, A Ben-Shlomo, R Barrett, V Gorbunova, K Karalis, S Melmed Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage Cell Reports, 2021-12-14;37(11):110068. 2021-12-14 [PMID: 34910915] (Bioassay, Human)
• AK Eicher, DO Kechele, N Sundaram, HM Berns, HM Poling, LE Haines, JG Sanchez, K Kishimoto, M Krishnamur, L Han, AM Zorn, MA Helmrath, JM Wells Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells Cell Stem Cell, 2021-12-01;0(0):. 2021-12-01 [PMID: 34856121] (Bioassay, Human)
• C Völkner, M Liedtke, R Untucht, A Hermann, MJ Frech Patient-Specific iPSC-Derived Neural Differentiated and Hepatocyte-like Cells, Carrying the Compound Heterozygous Mutation p.V1023Sfs*15/p.G992R, Present the &quot;Variant&quot; Biochemical Phenotype of Niemann-Pick Type C1 Disease International Journal of Molecular Sciences, 2021-11-10;22(22):. 2021-11-10 [PMID: 34830064] (Bioassay, Human)
• C Gil-Recio, S Montori, S Al Demour, MA Ababneh, E Ferrés-Pad, C Marti, E Ferrés-Ama, M Barajas, A Al Madhoun, M Atari Chemically Defined Conditions Mediate an Efficient Induction of Dental Pulp Pluripotent-Like Stem Cells into Hepatocyte-Like Cells Stem Cells International, 2021-11-08;2021(0):5212852. 2021-11-08 [PMID: 34795766] (Bioassay, Human)
• M Kowalski-J, H Schihada, A Turku, T Huber, TP Sakmar, G Schulte Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain Science Advances, 2021-11-10;7(46):eabj7917. 2021-11-10 [PMID: 34757789] (Bioassay, Human)
• SA Saenz, A Local, T Carr, A Shakya, S Koul, H Hu, L Chourb, J Stedman, J Malley, LA D'Agostino, V Shanmugasu, J Malona, CE Schwartz, L Beebe, M Clements, G Rajaraman, J Cho, L Jiang, A Dubrovskiy, M Kreilein, R Shimanovic, LG Hamann, L Escoubet, JM Ellis Small molecule allosteric inhibitors of RORgammat block Th17-dependent inflammation and associated gene expression in vivo PLoS ONE, 2021-11-09;16(11):e0248034. 2021-11-09 [PMID: 34752458] (Bioassay, Human)
• S Hu, S Ren, Y Cai, J Liu, Y Han, Y Zhao, J Yang, X Zhou, X Wang Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt-beta-catenin-STAT3 signaling Cell Death and Differentiation, 2021-11-06;0(0):. 2021-11-06 [PMID: 34743203] (Bioassay, Human)
• T Radaszkiew, M Nosková, K Gömöryová, O Vondálová, KA Radaszkiew, M Picková, R Víchová, T Gybe?, K Kaiser, L Demková, L Ku?erová, T Bárta, D Pot?šil, Z Zdráhal, K Sou?ek, V Bryja RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy Elife, 2021-10-27;10(0):. 2021-10-27 [PMID: 34702444] (Bioassay, Human)
• L Johnson Ch, H Lahlou, C Steinacher, S Assou, Y Messat, J Dudás, A Edge, B Crespo, M Crosier, C Sergi, A Schrott-Fi, A Zine Transcriptome-Wide Analysis Reveals a Role for Extracellular Matrix and Integrin Receptor Genes in Otic Neurosensory Differentiation from Human iPSCs International Journal of Molecular Sciences, 2021-10-07;22(19):. 2021-10-07 [PMID: 34639189] (Bioassay, Human)
• L Chen, Z Xu, Q Li, Q Feng, C Zheng, Y Du, R Yuan, X Peng USP28 facilitates pancreatic cancer progression through activation of Wnt/beta-catenin pathway via stabilising FOXM1 Cell Death & Disease, 2021-09-28;12(10):887. 2021-09-28 [PMID: 34584067] (Bioassay, Human)
• C Shen, A Nayak, LR Neitzel, AA Adams, M Silver-Ise, LM Sawyer, H Benchabane, H Wang, N Bunnag, B Li, DT Wynn, F Yang, M Garcia-Con, CH Williams, S Dakshanamu, CC Hong, NG Ayad, AJ Capobianco, Y Ahmed, E Lee, DJ Robbins The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling Nature Communications, 2021-09-06;12(1):5263. 2021-09-06 [PMID: 34489457] (Bioassay, Human)
• A Sagara, K Nakata, S Matsumoto, W Guan, T Shinkawa, C Iwamoto, N Ikenaga, K Ohuchida, M Nakamura Repositioning of duloxetine to target pancreatic stellate cells Oncology Letters, 2021-08-20;22(4):744. 2021-08-20 [PMID: 34466156] (Bioassay, Human)
• M Yang, YM Han, Q Han, XZ Rong, XF Liu, XY Ln KCTD11 inhibits progression of lung cancer by binding to beta-catenin to regulate the activity of the Wnt and Hippo pathways Journal of Cellular and Molecular Medicine, 2021-08-28;0(0):. 2021-08-28 [PMID: 34453479] (Bioassay, Human)
• Y Kang, Y Zhou, Y Li, Y Han, J Xu, W Niu, Z Li, S Liu, H Feng, W Huang, R Duan, T Xu, N Raj, F Zhang, J Dou, C Xu, H Wu, GJ Bassell, ST Warren, EG Allen, P Jin, Z Wen A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies Nature Neuroscience, 2021-08-19;0(0):. 2021-08-19 [PMID: 34413513] (Bioassay, Human)
• AV Parent, G Faleo, J Chavez, M Saxton, DI Berrios, NR Kerper, Q Tang, M Hebrok Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection Cell Reports, 2021-08-17;36(7):109538. 2021-08-17 [PMID: 34407395] (Bioassay, Human)
• KM Mackinlay, BA Weatherbee, V Souza Rosa, CE Handford, G Hudson, T Coorens, LV Pereira, S Behjati, L Vallier, MN Shahbazi, M Zernicka-G An in vitro stem cell model of human epiblast and yolk sac interaction Elife, 2021-08-17;10(0):. 2021-08-17 [PMID: 34403333] (Bioassay, Human)
• S Hellman Generation of equine enteroids and enteroid-derived 2D monolayers that are responsive to microbial mimics Veterinary research, 2021-08-14;52(1):108. 2021-08-14 [PMID: 34391473] (Bioassay, Equine)
• I Fischer, J Küchler, C Schaar, T Fisch, J Cernoch, K Fischer, V Fernández, P Kühnen, H Stachelsch Generation of human induced pluripotent stem cell lines from 2 patients with MIRAGE syndrome Stem Cell Research, 2021-06-10;54(0):102417. 2021-06-10 [PMID: 34119956] (Cell Culture, Human)
• P Paclíková, TW Radaszkiew, D Pot?šil, J Harnoš, Z Zdráhal, V Bryja Roles of individual human Dishevelled paralogs in the Wnt signalling pathways Cellular Signalling, 2021-05-31;85(0):110058. 2021-05-31 [PMID: 34082011] (Cell Culture, Human)
• O Kwon, KB Jung, KR Lee, YS Son, H Lee, JJ Kim, K Kim, S Lee, YK Song, J Jung, K Park, DS Kim, MJ Son, MO Lee, TS Han, HS Cho, SJ Oh, H Chung, SH Kim, KS Chung, J Kim, CR Jung, MY Son The development of a functional human small intestinal epithelium model for drug absorption Science Advances, 2021-06-02;7(23):. 2021-06-02 [PMID: 34078609] (Bioassay, Human)
• TW Fowler, TL Mitchell, CY Janda, L Xie, S Tu, H Chen, H Zhang, J Ye, B Ouyang, TZ Yuan, SJ Lee, M Newman, N Tripuranen, ES Rego, D Mutha, A Dilip, M Vuppalapat, H Baribault, WC Yeh, Y Li Development of selective bispecific Wnt mimetics for bone loss and repair Nature Communications, 2021-05-31;12(1):3247. 2021-05-31 [PMID: 34059688] (Bioassay, Human)
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• Kang , Minyong, Han , Yong-Mah Differentiation of human pluripotent stem cells into nephron progenitor cells in a serum and feeder free system. PLoS ONE, 2014-04-11;9(4):e94888. 2014-04-11 [PMID: 24728509] (Bioassay, Human)
• Nakamura I, Zakharia K, Banini B, Mikhail D, Kim T, Yang J, Moser C, Shaleh H, Thornburgh S, Walters I, Roberts L Brivanib attenuates hepatic fibrosis in vivo and stellate cell activation in vitro by inhibition of FGF, VEGF and PDGF signaling. PLoS ONE, 2014-04-07;9(4):e92273. 2014-04-07 [PMID: 24710173] (Bioassay, Human)
• Chen E, DeRan M, Ignatius M, Grandinetti K, Clagg R, McCarthy K, Lobbardi R, Brockmann J, Keller C, Wu X, Langenau D Glycogen synthase kinase 3 inhibitors induce the canonical WNT/beta-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma. Proc Natl Acad Sci U S A, 2014-03-24;111(14):5349-54. 2014-03-24 [PMID: 24706870] (Bioassay, Human)
• Cnossen W, te Morsche R, Hoischen A, Gilissen C, Chrispijn M, Venselaar H, Mehdi S, Bergmann C, Veltman J, Drenth J Whole-exome sequencing reveals LRP5 mutations and canonical Wnt signaling associated with hepatic cystogenesis. Proc Natl Acad Sci U S A, 2014-03-24;111(14):5343-8. 2014-03-24 [PMID: 24706814] (Bioassay, Human)
• Carmon K, Gong X, Yi J, Thomas A, Liu Q RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. Proc Natl Acad Sci U S A, 2014-03-17;111(13):E1221-9. 2014-03-17 [PMID: 24639526] (Bioassay, Human)
• Todaro M, Gaggianesi M, Catalano V, Benfante A, Iovino F, Biffoni M, Apuzzo T, Sperduti I, Volpe S, Cocorullo G, Gulotta G, Dieli F, De Maria R, Stassi G CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis. Cell Stem Cell, 2014-03-06;14(3):342-56. 2014-03-06 [PMID: 24607406] (Bioassay, Human)
• Meinhardt G, Haider S, Haslinger P, Proestling K, Fiala C, Pollheimer J, Knofler M Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility. Endocrinology, 2014-02-26;155(5):1908-20. 2014-02-26 [PMID: 24605829] (Bioassay, Human)
• Guezguez A, Pare F, Benoit Y, Basora N, Beaulieu J Modulation of stemness in a human normal intestinal epithelial crypt cell line by activation of the WNT signaling pathway. Exp Cell Res, 2014-02-15;322(2):355-64. 2014-02-15 [PMID: 24534551] (Bioassay, Human)
• Lin , I-Ying, Chiu , Feng-Lan, Yeang , Chen-Hsi, Chen , Hsin-Fu, Chuang , Ching-Yu, Yang , Shii-Yi, Hou , Pei-Shan, Sintupisut , Nardnisa, Ho , Hong-Ner, Kuo , Hung-Chi, Lin , Kuo-I Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cells. Stem Cell Reports, 2014-01-23;2(2):189-204. 2014-01-23 [PMID: 24527393] (Bioassay, Human)
• Wu C, Qiu S, Lu L, Zou J, Li W, Wang O, Zhao H, Wang H, Tang J, Chen L, Xu T, Sun Z, Liao W, Luo G, Lu X RSPO2-LGR5 signaling has tumour-suppressive activity in colorectal cancer. Nat Commun, 2014-01-01;5(0):3149. 2014-01-01 [PMID: 24476626] (Bioassay, Human)
• van den Bosch M, Blom A, van Lent P, van Beuningen H, Blaney Davidson E, van der Kraan P, van den Berg W Canonical Wnt signaling skews TGF-beta signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8. Cell Signal, 2014-01-23;26(5):951-8. 2014-01-23 [PMID: 24463008] (Bioassay, Human)
• Aloia L, Di Stefano B, Sessa A, Morey L, Santanach A, Gutierrez A, Cozzuto L, Benitah S, Graf T, Broccoli V, Di Croce L Zrf1 is required to establish and maintain neural progenitor identity. Genes Dev, 2014-01-15;28(2):182-97. 2014-01-15 [PMID: 24449271] (Bioassay, Human)
• Massumi M, Hoveizi E, Baktash P, Hooti A, Ghazizadeh L, Nadri S, Pourasgari F, Hajarizadeh A, Soleimani M, Nabiuni M, Khorramizadeh M Efficient programming of human eye conjunctiva-derived induced pluripotent stem (ECiPS) cells into definitive endoderm-like cells. Exp Cell Res, 2014-01-13;322(1):51-61. 2014-01-13 [PMID: 24434355] (Bioassay, Human)
• Dhamdhere , Girija R, Fang , Mark Y, Jiang , Jie, Lee , Katherin, Cheng , Du, Olveda , Rebecca, Liu , Bo, Mulligan , Kimberle, Carlson , Jeffery, Ransom , Ryan C, Weis , William, Helms , Jill A Drugging a stem cell compartment using Wnt3a protein as a therapeutic. PLoS ONE, 2014-01-06;9(1):e83650. 2014-01-06 [PMID: 24400074] (Bioassay, Human)
• Cechin S, Alvarez-Cubela S, Giraldo J, Molano R, Villate S, Ricordi C, Pileggi A, Inverardi L, Fraker C, Dominguez-Bendala J Influence of in vitro and in vivo oxygen modulation on beta cell differentiation from human embryonic stem cells. Stem Cells Transl Med, 2013-12-27;3(3):277-89. 2013-12-27 [PMID: 24375542] (Bioassay, Human)
• Lam A, Freedman B, Morizane R, Lerou P, Valerius M, Bonventre J Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. J Am Soc Nephrol, 2013-12-19;25(6):1211-25. 2013-12-19 [PMID: 24357672] (Bioassay, Human)
• Hannan , Nicholas, Fordham , Robert P, Syed , Yasir A, Moignard , Victoria, Berry , Andrew, Bautista , Ruben, Hanley , Neil A, Jensen , Kim B, Vallier , Ludovic Generation of multipotent foregut stem cells from human pluripotent stem cells. Stem Cell Reports, 2013-10-10;1(4):293-306. 2013-10-10 [PMID: 24319665] (Bioassay, Human)
• Listerman I, Gazzaniga F, Blackburn E An investigation of the effects of the core protein telomerase reverse transcriptase on Wnt signaling in breast cancer cells. Mol Cell Biol, 2013-11-11;34(2):280-9. 2013-11-11 [PMID: 24216762] (Bioassay, Human)
• Goto T, Sato A, Adachi S, Iemura S, Natsume T, Shibuya H IQGAP1 protein regulates nuclear localization of beta-catenin via importin-beta5 protein in Wnt signaling. J Biol Chem, 2013-11-06;288(51):36351-60. 2013-11-06 [PMID: 24196961] (Cell Culture, Human)
• Thrasivoulou C, Millar M, Ahmed A Activation of intracellular calcium by multiple Wnt ligands and translocation of beta-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/beta-catenin pathways. J Biol Chem, 2013-10-24;288(50):35651-9. 2013-10-24 [PMID: 24158438] (Bioassay, Human)
• Jiang Y, Dai J, Zhang H, Sottnik J, Keller J, Escott K, Sanganee H, Yao Z, McCauley L, Keller E Activation of the Wnt pathway through AR79, a GSK3beta inhibitor, promotes prostate cancer growth in soft tissue and bone. Mol Cancer Res, 2013-10-02;11(12):1597-610. 2013-10-02 [PMID: 24088787] (Bioassay, Human)
• Lin P, Hung S, Yang Y, Liao L, Hsieh Y, Yen H, Lu H, Lee M, Chu I, Hwang S A synthetic peptide-acrylate surface for production of insulin-producing cells from human embryonic stem cells. Stem Cells Dev, 2013-11-16;23(4):372-9. 2013-11-16 [PMID: 24083371] (Bioassay, Human)
• Rezania A, Bruin J, Xu J, Narayan K, Fox J, O'Neil J, Kieffer T Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo. Stem Cells, 2013-11-01;31(11):2432-42. 2013-11-01 [PMID: 23897760] (Bioassay, Human)
• Rasmussen N, Wright T, Brooks S, Hacker K, Debebe Z, Sendor A, Walker M, Major M, Green J, Wahl G, Rathmell W Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer. J Biol Chem, 2013-07-26;288(36):26301-10. 2013-07-26 [PMID: 23893409] (Bioassay, Human)
• Loh Y, Hedditch E, Baker L, Jary E, Ward R, Ford C The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer. BMC Cancer, 2013-04-02;13(0):174. 2013-04-02 [PMID: 23547709] (Bioassay, Human)
• Hernandez-Maqueda J, Luna-Ulloa L, Santoyo-Ramos P, Castaneda-Patlan M, Robles-Flores M Protein kinase C delta negatively modulates canonical Wnt pathway and cell proliferation in colon tumor cell lines. PLoS ONE, 2013-03-08;8(3):e58540. 2013-03-08 [PMID: 23520519] (Bioassay, Human)
• Greer Y, Fields A, Brown A, Rubin J Atypical protein kinase Ciota is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated dishevelled 2. J Biol Chem, 2013-02-08;288(13):9438-46. 2013-02-08 [PMID: 23396968] (Bioassay, Human)
• Tahir S, Yang G, Goltsov A, Song K, Ren C, Wang J, Chang W, Thompson T Caveolin-1-LRP6 signaling module stimulates aerobic glycolysis in prostate cancer. Cancer Res, 2013-01-09;73(6):1900-11. 2013-01-09 [PMID: 23302227] (Bioassay, Human)
• Thatava T, Kudva Y, Edukulla R, Squillace K, De Lamo J, Khan Y, Sakuma T, Ohmine S, Terzic A, Ikeda Y Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells. Mol Ther, 2012-11-27;21(1):228-39. 2012-11-27 [PMID: 23183535] (Bioassay, Human)
• Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors. Cell Signal, 2012-09-27;25(1):178-89. 2012-09-27 [PMID: 23022962] (Bioassay, Human, Mouse)
• Sui L, Mfopou J, Geens M, Sermon K, Bouwens L FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells. Biochem Biophys Res Commun, 2012-08-29;426(3):380-5. 2012-08-29 [PMID: 22960178] (Bioassay, Human)
• Aad , Pauline, Echternkamp , Sherrill, Sypherd , David D, Schreiber , Nicole B, Spicer , Leon J The hedgehog system in ovarian follicles of cattle selected for twin ovulations and births: evidence of a link between the IGF and hedgehog systems. Biol Reprod, 2012-10-04;87(4):79. 2012-10-04 [PMID: 22811575] (Bioassay, Bovine)
• Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)
• Cohen E, Miller M, Wang Z, Moon R, Morrisey E Wnt5a and Wnt11 are essential for second heart field progenitor development. Development, 2012-06-01;139(11):1931-40. 2012-06-01 [PMID: 22569553] (Bioassay, Mouse)
• Erceg S, Lukovic D, Moreno-Manzano V, Stojkovic M, Bhattacharya S Derivation of cerebellar neurons from human pluripotent stem cells. Curr Protoc Stem Cell Biol, 2012-03-01;20(0):1H.51. 2012-03-01 [PMID: 22415839] (Bioassay, Human)
• Prabakar K, Dominguez-Bendala J, Molano R, Pileggi A, Villate S, Ricordi C, Inverardi L Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells. Cell Transplant, 2011-12-21;21(6):1321-39. 2011-12-21 [PMID: 22195604] (Cell Culture, Human)
• Ichii , Michiko, Frank , Mark Bar, Iozzo , Renato V, Kincade , Paul W The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells. Blood, 2011-11-23;119(7):1683-92. 2011-11-23 [PMID: 22117039] (Bioassay, Human)
• Liu N, Shi S, Deng M, Tang L, Zhang G, Liu N, Ding B, Liu W, Liu Y, Shi H, Liu L, Jin Y High levels of beta-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway. J. Bone Miner. Res., 2011-09-01;26(9):2082-95. 2011-09-01 [PMID: 21638320] (Bioassay, Human)
• Spence JR, Mayhew CN, Rankin SA Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature, 2010-12-12;470(7332):105-9. 2010-12-12 [PMID: 21151107] (Bioassay, Human)
• Kohler EE, Cowan CE, Chatterjee I NANOG induction of fetal liver kinase-1 (FLK1) transcription regulates endothelial cell proliferation and angiogenesis. Blood, 2010-11-30;117(5):1761-9. 2010-11-30 [PMID: 21119109] (Bioassay, Human)
• Gudjonsson JE, Johnston A, Stoll SW Evidence for altered Wnt signaling in psoriatic skin. J. Invest. Dermatol., 2010-04-08;130(7):1849-59. 2010-04-08 [PMID: 20376066] (Bioassay, Human)
• Liu G, Vijayakumar S, Grumolato L, Arroyave R, Qiao H, Akiri G, Aaronson SA Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells. J. Cell Biol., 2009-04-06;185(1):67-75. 2009-04-06 [PMID: 19349579] (Bioassay, Human)

Bioinformatics

• Gene Symbol: WNT3A
• Uniprot:
  • NP_149122(Human)