Recombinant Mouse FGF basic/FGF2/bFGF Protein

Recombinant Mouse FGF basic/FGF2/bFGF (Catalog # 3139-FB) stimulates cell proliferation of the NR6R‑3T3 mouse fibroblast cell line. The ED50 for this effect is 0.3-1.8 ng/mL.

Recombinant Mouse FGF basic/FGF2/bFGF (Catalog # 3139-FB) stimulates cell proliferation of the NR6R‑3T3 mouse fibroblast cell line. The ED50 for this effect is 0.3-1.8 ng/mL.

1 μg/lane of Recombinant Mouse FGF basic/FGF2/bFGF was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 18 kDa.

• Reactivity: Mu
• Applications: Bioactivity

Recombinant Mouse FGF basic/FGF2/bFGF Protein Summary

• Details of Functionality: Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. Raines, E.W. et al. (1985) Methods Enzymol. 109:749. The ED₅₀ for this effect is 0.3-1.8 ng/mL.
• Source: E. coli-derived mouse FGF basic/FGF2/bFGF protein
  Ala11-Ser154
• Accession #: P15655
• N-terminal Sequence: Ala11
• Protein/Peptide Type: Recombinant Proteins
• Gene: Fgf2
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 16.2 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in MOPS, Na₂SO₄, EDTA and DTT with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse FGF basic/FGF2/bFGF Protein

• basic fibroblast growth factor bFGF
• Basic fibroblast growth factor
• bFGF
• FGF basic
• FGF2
• FGF-2
• FGFBprostatropin
• fibroblast growth factor 2 (basic)
• HBGF-2
• heparin-binding growth factor 2
• Prostatropin

Background

FGF basic (FGF-2, HBGF-2) is one of at least 22 mitogenic proteins of the FGF family, which show 35-60% amino acid conservation (1-3). Unlike other FGFs, FGF acidic and basic lack signal peptides and are secreted by an alternate pathway. Storage pools within the cell or on cell surface heparan sulfate proteoglycans (HSPG) are likely. The predicted 17 kDa FGF basic isoform can be located in both the cytoplasm and the nucleus and is presumed to be the form secreted (4). Transcription from alternate start sites produces 21-24 kDa forms found only in the nucleus. High and low molecular weight human FGF basic targets the expression of different genes when expressed in NIH-3T3 cells (5). The 17 kDa mouse sequence has 98% aa identity with rat, and 95% identity with human, bovine and sheep FGF basic (6, 7). Autocrine, intracrine and paracrine actions of FGF basic have been identified. Binding of FGF to heparin or cell surface HSPG is necessary for binding, dimerization and activation of tyrosine kinase FGF receptors. FGF basic binds other proteins, polysaccharides and lipids with lower affinity (3). Expression of FGF basic is nearly ubiquitous but disruption of the mouse FGF basic gene gives a relatively mild phenotype, suggesting compensation by other FGF family members. FGF basic modulates such normal processes as angiogenesis, wound healing and tissue repair, embryonic development and differentiation, neuronal function and neural degeneration. Transgenic overexpression of FGF basic results in excessive proliferation and angiogenesis reminiscent of a variety of pathological conditions (1-3).

1. Coulier, F. et al. (1997) J. Mol. Evol. 44:43.
2. Fernig, D. et al. (1994) Prog. Growth Factor Res. 5:353.
3. Presta, M. et al. (2005) Cytokine. Growth Factor Rev. 16:159.
4. Claus, P. et al. (2003) J. Biol. Chem. 278:479.
5. Quarto, N. et al. (2005) Gene 356:49.
6. Tsuneto, M. et al. (2005) Biochem. Biophys. Res. Comm. 335:1239.
7. Hebert, J. M. et al. (1990) Dev. Biol. 138:454.

Show all background references

Publications for FGF basic/FGF2/bFGF (3139-FB)(200)

Publications using 3139-FB

• Perrin, S;Ethel, M;Bretegnier, V;Goachet, C;Wotawa, CA;Luka, M;Coulpier, F;Masson, C;Ménager, M;Colnot, C; Single-nucleus transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration eLife 2024-12-06 [PMID: 39642053] (Bioassay, Transgenic Mouse)
• Kokkali, M;Karali, K;Thanou, E;Papadopoulou, MA;Zota, I;Tsimpolis, A;Efstathopoulos, P;Calogeropoulou, T;Li, KW;Sidiropoulou, K;Gravanis, A;Charalampopoulos, I; Multimodal beneficial effects of BNN27, a nerve growth factor synthetic mimetic, in the 5xFAD mouse model of Alzheimer's disease Molecular psychiatry 2024-11-25 [PMID: 39587294] (Bioassay, Mouse)
• Wang, Q;Li, H;Mao, Y;Garg, A;Park, ES;Wu, Y;Chow, A;Peregrin, J;Zhang, X; Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development bioRxiv : the preprint server for biology 2025-01-06 [PMID: 39484547] (Bioassay, Mouse)
• Perrin, S;Ethel, M;Bretegnier, V;Goachet, C;Wotawa, CA;Luka, M;Coulpier, F;Masson, C;Ménager, M;Colnot, C; Single nuclei transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration bioRxiv : the preprint server for biology 2024-07-26 [PMID: 39211065] (Bioassay, Transgenic Mouse)
• Boucherie, C;Alkailani, M;Jossin, Y;Ruiz-Reig, N;Mahdi, A;Aldaalis, A;Aittaleb, M;Tissir, F; Auts2 enhances neurogenesis and promotes expansion of the cerebral cortex Journal of advanced research 2024-07-14 [PMID: 39013538] (Bioassay, Mouse)
• Verdikt, R;Armstrong, AA;Cheng, J;Hwang, YS;Clark, AT;Yang, X;Allard, P; Metabolic memory of ?9-tetrahydrocannabinol exposure in pluripotent stem cells and primordial germ cells-like cells eLife 2023-12-27 [PMID: 38150302] (Cell Culture, Mouse)
• Chaube, B;Citrin, KM;Sahraei, M;Singh, AK;de Urturi, DS;Ding, W;Pierce, RW;Raaisa, R;Cardone, R;Kibbey, R;Fernández-Hernando, C;Suárez, Y; Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis Nature communications 2023-12-12 [PMID: 38086791] (Bioassay, Mouse)
• Shao, A;Kissil, JL;Fan, CM; The L27 Domain of MPP7 enhances TAZ-YY1 Cooperation to Renew Muscle Stem Cells bioRxiv : the preprint server for biology 2023-11-04 [PMID: 37961392] (Cell Culture, Mouse)
• da Silva, VA;Bobotis, BC;Correia, FF;Lima-Vasconcellos, TH;Chiarantin, GMD;De La Vega, L;Lombello, CB;Willerth, SM;Malmonge, SM;Paschon, V;Kihara, AH; The Impact of Biomaterial Surface Properties on Engineering Neural Tissue for Spinal Cord Regeneration International journal of molecular sciences 2023-09-04 [PMID: 37686446] (Bioassay, Transgenic Mouse)
• Zeng, C;Chen, J;Cooke, EW;Subuddhi, A;Roodman, ET;Chen, FX;Cao, K; Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition Nature communications 2023-08-22 [PMID: 37607921] (Bioassay, Mouse)
• Zeng, C;Chen, J;Cooke, EW;Subuddhi, A;Roodman, ET;Chen, FX;Cao, K; Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition Nature communications 2023-08-22 [PMID: 37607921] (Bioassay, Mouse)
• Scacchetti, A;Shields, EJ;Trigg, NA;Wilusz, JE;Conine, CC;Bonasio, R; A ligation-independent sequencing method reveals tRNA-derived RNAs with blocked 3' termini bioRxiv : the preprint server for biology 2023-06-08 [PMID: 37333231] (Bioassay, Mouse)
• DuCote, TJ;Song, X;Naughton, KJ;Chen, F;Plaugher, DR;Childress, AR;Edgin, AR;Qu, X;Liu, J;Liu, J;Li, F;Wong, KK;Brainson, CF; EZH2 inhibition promotes tumor immunogenicity in lung squamous cell carcinomas bioRxiv : the preprint server for biology 2023-06-08 [PMID: 37333199] (Bioassay, Mouse)
• Basu, R;Ganesan, S;Winkler, CW;Anzick, SL;Martens, C;Peterson, KE;Fraser, IDC; Identification of age-specific gene regulators of La Crosse virus neuroinvasion and pathogenesis Nature communications 2023-05-18 [PMID: 37202395] (Bioassay, Mouse)
• Pascual, F;Icyuz, M;Karmaus, P;Brooks, A;Van Gorder, E;Fessler, MB;Shaw, ND; Cholesterol biosynthesis modulates differentiation in murine cranial neural crest cells Scientific reports 2023-05-01 [PMID: 37127649] (Bioassay, Mouse)
• X Wang, W Fan, N Li, Y Ma, M Yao, G Wang, S He, W Li, J Tan, Q Lu, S Hou YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2 Genome Biology, 2023-04-21;24(1):87. 2023-04-21 [PMID: 37085894] (Bioassay, Mouse)
• V Davalos, CD Lovell, R Von Itter, I Dolgalev, P Agrawal, G Baptiste, DJ Kahler, E Sokolova, S Moran, L Piqué, E Vega-Saenz, B Fontanals-, A Karz, A Tsirigos, C Yun, F Darvishian, HC Etchevers, I Osman, M Esteller, M Schober, E Hernando An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma Nature Communications, 2023-04-04;14(1):1867. 2023-04-04 [PMID: 37015919] (Bioassay, Mouse)
• E Ugur, A de la Port, W Qin, S Bultmann, A Ivanova, M Drukker, M Mann, M Wierer, H Leonhardt Comprehensive chromatin proteomics resolves functional phases of pluripotency and identifies changes in regulatory components Nucleic Acids Research, 2023-04-11;0(0):. 2023-04-11 [PMID: 36806742] (Bioassay, Mouse)
• EB Choi, M Vodnala, P Saini, S Anugula, M Zerbato, JJ Ho, J Wang, SJ Ho Sui, J Yoon, M Roels, C Inouye, YW Fong Transcription factor SOX15 regulates stem cell pluripotency and promotes neural fate during differentiation by activating the neurogenic gene Hes5 The Journal of Biological Chemistry, 2023-02-09;0(0):102996. 2023-02-09 [PMID: 36764520] (Bioassay, Mouse)
• X Tang, C Zhang, T Tian, X Dai, Y Xing, Y Wang, D Yang, H Li, Y Wang, X Lv, H Wang Posttreatment with dexmedetomidine aggravates LPS-induced myocardial dysfunction partly via activating cardiac endothelial alpha2A-AR in mice International immunopharmacology, 2023-01-23;116(0):109724. 2023-01-23 [PMID: 36696856] (Cell Culture, Mouse)
• S Wu, NC Hernandez, DW Sirkis, I Thomas-Wri, R Wade-Marti, R Schekman Unconventional secretion of alpha-synuclein mediated by palmitoylated DNAJC5 oligomers Elife, 2023-01-10;12(0):. 2023-01-10 [PMID: 36626307] (Bioassay, Mouse)
• A Gravina, G Tediashvil, R Rajalingam, Z Quandt, C Deisenroth, S Schrepfer, T Deuse Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression Nature Biotechnology, 2023-01-02;0(0):. 2023-01-02 [PMID: 36593395] (Bioassay, Mouse)
• X Hong, Y Jian, S Ding, J Zhou, X Zheng, H Zhang, B Zhou, C Zhuang, J Wan, X Tong Kir4.1 channel activation in NG2 glia contributes to remyelination in ischemic stroke EBioMedicine, 2022-12-15;87(0):104406. 2022-12-15 [PMID: 36527899] (Bioassay, Mouse)
• Y Geng, L Li, J Yan, K Liu, A Yang, L Zhang, Y Shen, H Gao, X Wu, I Noth, Y Huang, J Liu, X Fan PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis Nature Communications, 2022-11-19;13(1):7114. 2022-11-19 [PMID: 36402779] (Bioassay, Mouse)
• LP Fernandes, R Enriquez-G, PA Gould, JH Holt, L Conde, G Ecco, J Herrero, R Gifford, D Trono, G Kassiotis, HM Rowe A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819 Science Advances, 2022-10-28;8(43):eabp8085. 2022-10-28 [PMID: 36306355] (Bioassay, Mouse)
• MRF Gosselin, V Mournetas, M Borczyk, S Verma, A Occhipinti, J Róg, L Bozycki, M Korostynsk, SC Robson, C Angione, C Pinset, DC Gorecki Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts Elife, 2022-09-27;11(0):. 2022-09-27 [PMID: 36164827] (Bioassay, Mouse)
• M Tiana, E Lopez-Jime, JS de Aja, A Barral, J Victorino, C Badia-Care, I Rollan, R Rouco, E Santos, H Sanchez-Ir, RD Acemel, C Torroja, J Adan, E Andres-Leo, JL Gomez-Skar, G Giovinazzo, F Sanchez-Ca, M Manzanares Pluripotency factors regulate the onset of Hox cluster activation in the early embryo Oncogene, 2022-07-15;8(28):eabo3583. 2022-07-15 [PMID: 35857513] (Bioassay, Mouse)
• E Gara, E Zucchelli, A Nemes, Z Jakus, K Ajtay, É Kemecsei, G Kiszler, N Heged?s, K Szigeti, I Földes, K Árvai, J Kósa, K Kolev, E Komorowicz, P Padmanabha, P Maurovich-, E Dósa, G Várady, M Pólos, I Hartyánszk, SE Harding, B Merkely, D Máthé, G Szabó, T Radovits, G Földes 3D culturing of human pluripotent stem cells-derived endothelial cells for vascular regeneration Theranostics, 2022-06-06;12(10):4684-4702. 2022-06-06 [PMID: 35832092] (In Vivo, Mouse)
• Y Han, M King, E Tikhomirov, P Barasa, CDS Souza, J Lindh, D Baltriukie, L Ferraiuolo, M Azzouz, MR Gullo, EN Kozlova Towards 3D Bioprinted Spinal Cord Organoids International Journal of Molecular Sciences, 2022-05-21;23(10):. 2022-05-21 [PMID: 35628601] (Bioassay, Mouse)
• M Jumabay, L Zhang, J Yao, KI Boström Progenitor cells from brown adipose tissue undergo neurogenic differentiation Scientific Reports, 2022-04-04;12(1):5614. 2022-04-04 [PMID: 35379860] (Bioassay, Mouse)
• H Kim, BW Song, SJ Park, SW Choi, H Moon, KC Hwang, SW Kang, SH Moon, Y Yang, IC Kwon, SH Kim Ultraefficient extracellular vesicle-guided direct reprogramming of fibroblasts into functional cardiomyocytes Science Advances, 2022-02-25;8(8):eabj6621. 2022-02-25 [PMID: 35213232] (Bioassay, Mouse)
• H Ni, C Liu, Y Chen, Y Lu, Y Ji, M Xiang, Y Xie MGP Regulates Perivascular Adipose-Derived Stem Cells Differentiation Toward Smooth Muscle Cells Via BMP2/SMAD Pathway Enhancing Neointimal Formation Cell Transplantation, 2022-01-01;31(0):9636897221075. 2022-01-01 [PMID: 35168405] (Bioassay, Mouse)
• C Dong, X Wang, L Sun, L Zhu, D Yang, S Gao, W Zhang, B Ling, A Liang, Z Gao, J Xu ATM modulates subventricular zone neural stem cell maintenance and senescence through Notch signaling pathway Stem Cell Research, 2021-12-07;58(0):102618. 2021-12-07 [PMID: 34915311] (Bioassay, Mouse)
• M Vega-Sendi, T Olbrich, D Tillo, AD Tran, CN Domingo, M Franco, PC FitzGerald, MJ Kruhlak, S Ruiz The ETS transcription factor ERF controls the exit from the na�ve pluripotent state in a MAPK-dependent manner Science Advances, 2021-10-01;7(40):eabg8306. 2021-10-01 [PMID: 34597136] (Bioassay, Transgenic Mouse)
• SKT Ooi, H Jiang, Y Kang, P Allard Examining the Developmental Trajectory of an in Vitro Model of Mouse Primordial Germ Cells following Exposure to Environmentally Relevant Bisphenol A Levels Environmental health perspectives, 2021-09-29;129(9):97013. 2021-09-29 [PMID: 34585602] (Bioassay, Mouse)
• M Wei, J Zhang, J Liu, C Zhao, S Cao, X Yan, B Wu, S Bao Derivation of Mouse Parthenogenetic Advanced Stem Cells International Journal of Molecular Sciences, 2021-08-20;22(16):. 2021-08-20 [PMID: 34445681] (Bioassay, Mouse)
• Y Wang, Y Zhu, Y Gu, M Ma, Y Wang, S Qi, Y Zeng, R Zhu, X Wang, P Yu, J Xu, Y Shu, FX Yu Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis Cell Reports, 2021-08-24;36(8):109596. 2021-08-24 [PMID: 34433060] (Bioassay, Mouse)
• R Basu, V Nair, CW Winkler, TA Woods, IDC Fraser, KE Peterson Age influences susceptibility of brain capillary endothelial cells to La Crosse virus infection and cell death Journal of Neuroinflammation, 2021-06-03;18(1):125. 2021-06-03 [PMID: 34082753] (Bioassay, Mouse)
• A Shintani, M Higuchi Isolation of PRRX1-positive adult pituitary stem/progenitor cells from the marginal cell layer of the mouse anterior lobe Stem Cell Research, 2021-02-02;52(0):102223. 2021-02-02 [PMID: 33561660] (Bioassay, Mouse)
• N Joffin, VA Paschoal, CM Gliniak, C Crewe, A Elnwasany, LI Szweda, Q Zhang, C Hepler, CM Kusminski, R Gordillo, DY Oh, RK Gupta, PE Scherer Mitochondrial metabolism is a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue Cell Stem Cell, 2021-02-03;0(0):. 2021-02-03 [PMID: 33539722] (Bioassay, Mouse)
• MG Reccia, F Volpicelli, E Benedikz, ÅF Svenningse, L Colucci-D' Generation of High-Yield, Functional Oligodendrocytes from a c-myc Immortalized Neural Cell Line, Endowed with Staminal Properties International Journal of Molecular Sciences, 2021-01-23;22(3):. 2021-01-23 [PMID: 33498778] (Bioassay, Mouse)
• M Kubota, M Scheibinge, TA Jan, S Heller Greater epithelial ridge cells are the principal organoid-forming progenitors of the mouse cochlea Cell Reports, 2021-01-19;34(3):108646. 2021-01-19 [PMID: 33472062] (Bioassay, Mouse)
• Z Yang, Y Huang, L Zhu, K Yang, K Liang, J Tan, B Yu SIRT6 promotes angiogenesis and hemorrhage of carotid plaque via regulating HIF-1&amp;alpha and reactive oxygen species Cell Death & Disease, 2021-01-12;12(1):77. 2021-01-12 [PMID: 33436551] (In Vivo, Mouse)
• S Tanigawa, M Fujita, C Moyama, S Ando, H Ii, Y Kojima, T Fujishita, M Aoki, H Takeuchi, T Yamanaka, Y Takahashi, N Hashimoto, S Nakata Inhibition of Gli2 suppresses tumorigenicity in glioblastoma stem cells derived from a de novo murine brain cancer model Cancer Gene Therapy, 2021-01-07;0(0):. 2021-01-07 [PMID: 33414520] (Bioassay, Mouse)
• MF Leyton-Jai, P Ivert, J Hoeber, Y Han, A Feiler, C Zhou, S Pankratova, V Shoshan-Ba, A Israelson, EN Kozlova Empty mesoporous silica particles significantly delay disease progression and extend survival in a mouse model of ALS Sci Rep, 2020-11-26;10(1):20675. 2020-11-26 [PMID: 33244084] (Cell Culture, Mouse)
• P Ruis, D Van Ly, V Borel, GR Kafer, A McCarthy, S Howell, R Blassberg, AP Snijders, J Briscoe, KK Niakan, P Marzec, AJ Cesare, SJ Boulton TRF2-independent chromosome end protection during pluripotency Nature, 2020-11-25;0(0):. 2020-11-25 [PMID: 33239783] (Bioassay, Mouse)
• CB Mulholland, A Nishiyama, J Ryan, R Nakamura, M Yi?it, IM Glück, C Trummer, W Qin, MD Bartoschek, FR Traube, E Parsa, E Ugur, M Modic, A Acharya, P Stolz, C Ziegenhain, M Wierer, W Enard, T Carell, DC Lamb, H Takeda, M Nakanishi, S Bultmann, H Leonhardt Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals Nature Communications, 2020-11-24;11(1):5972. 2020-11-24 [PMID: 33235224] (Cell Culture, Mouse)
• KC Allan, LR Hu, MA Scavuzzo, AR Morton, AS Gevorgyan, EF Cohn, BLL Clayton, IR Bederman, S Hung, CF Bartels, M Madhavan, PJ Tesar Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function Cell Stem Cell, 2020-10-21;0(0):. 2020-10-21 [PMID: 33091368] (Bioassay, Mouse)
• BM Schmitt, AS Boewe, V Becker, L Nalbach, Y Gu, C Götz, MD Menger, MW Laschke, E Ampofo Protein Kinase CK2 Regulates Nerve/Glial Antigen (NG)2-Mediated Angiogenic Activity of Human Pericytes Cells, 2020-06-25;9(6):. 2020-06-25 [PMID: 32630438] (In Vivo, Mouse)
• C Zhou, H Chen, JF Zheng, ZD Guo, ZJ Huang, Y Wu, JJ Zhong, XC Sun, CJ Cheng Pentraxin 3 contributes to neurogenesis after traumatic brain injury in mice Neural Regen Res, 2020-12-01;15(12):2318-2326. 2020-12-01 [PMID: 32594056] (Bioassay, Mouse)
• R Shukla, HK Mjoseng, JP Thomson, S Kling, D Sproul, DS Dunican, B Ramsahoye, T Wongtawan, F Treindl, MF Templin, IR Adams, S Pennings, RR Meehan Activation of transcription factor circuity in 2i-induced ground state pluripotency is independent of repressive global epigenetic landscapes Nucleic Acids Res., 2020-08-20;0(0):. 2020-08-20 [PMID: 32585002] (Bioassay, Mouse)
• D Xiao, Q Deng, Y Guo, X Huang, M Zou, J Zhong, P Rao, Z Xu, Y Liu, Y Hu, Y Shen, K Jin, M Xiang Generation of self-organized sensory ganglion organoids and retinal ganglion cells from fibroblasts Sci Adv, 2020-05-29;6(22):eaaz5858. 2020-05-29 [PMID: 32523990] (Bioassay, Mouse)
• JM Kim, YS Yang, KH Park, X Ge, R Xu, N Li, M Song, H Chun, S Bok, JF Charles, O Filhol-Coc, B Boldyreff, T Dinter, PB Yu, N Kon, W Gu, T Takarada, MB Greenblatt, JH Shim A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation Nat Commun, 2020-05-08;11(1):2289. 2020-05-08 [PMID: 32385263] (Bioassay, Mouse)
• Y Atlasi, SM Jafarnejad, CG Gkogkas, M Vermeulen, N Sonenberg, HG Stunnenber The translational landscape of ground state pluripotency Nat Commun, 2020-04-01;11(1):1617. 2020-04-01 [PMID: 32238817] (Bioassay, Mouse)
• K Ichikawa, S Watanabe M, Y Minoshima, J Matsui, Y Funahashi Activated FGF2 signaling pathway in tumor vasculature is essential for acquired resistance to anti-VEGF therapy Sci Rep, 2020-02-19;10(1):2939. 2020-02-19 [PMID: 32076044] (IP, Mouse)
• HJ Kim, SH Choi, NE Lee, HJ Cho, H Rhim, HC Kim, SH Hwang, SY Nah Effects of Gintonin-Enriched Fraction on Methylmercury-Induced Neurotoxicity and Organ Methylmercury Elimination Int J Environ Res Public Health, 2020-01-29;17(3):. 2020-01-29 [PMID: 32013120] (Cell Culture, Mouse)
• M Chen, P Lu, Q Ma, Y Cao, N Chen, W Li, S Zhao, B Chen, J Shi, Y Sun, H Shen, L Sun, J Shen, Q Liao, Y Zhang, J Hong, W Gu, R Liu, G Ning, W Wang, J Wang CTNNB1/&amp;beta-catenin dysfunction contributes to adiposity by regulating the cross-talk of mature adipocytes and preadipocytes Sci Adv, 2020-01-08;6(2):eaax9605. 2020-01-08 [PMID: 31934629] (Cell Culture, Mouse)
• H Li, J Li, R Han, X Deng, J Shi, H Huang, N Hamad, A McCaughley, J Liu, C Wang, K Chen, D Wei, J Qiang, S Thatcher, Y Wu, C Liu, O Thibault, X Wei, S Chen, H Qian, BP Zhou, P Xu, XH Yang Deletion of tetraspanin CD151 alters the Wnt oncogene-induced mammary tumorigenesis: A cell type-linked function and signaling Neoplasia, 2019-11-26;21(12):1151-1163. 2019-11-26 [PMID: 31783316] (Bioassay, Mouse)
• M Matjusaiti, LJ Wagstaff, A Martella, B Baranowski, C Blin, S Gogolok, A Williams, SM Pollard Reprogramming of Fibroblasts to Oligodendrocyte Progenitor-like Cells Using CRISPR/Cas9-Based Synthetic Transcription Factors Stem Cell Reports, 2019-11-07;13(6):1053-1067. 2019-11-07 [PMID: 31708478] (Cell Culture, Mouse)
• OA Bahri, N Naldaiz-Ga, DC Kennedy, AM Wheatley, A Izeta, KJA McCullagh The panniculus carnosus muscle: A novel model of striated muscle regeneration that exhibits sex differences in the mdx mouse Sci Rep, 2019-11-04;9(1):15964. 2019-11-04 [PMID: 31685850] (Bioassay, Mouse)
• X Yuan, M Liu, X Cao, S Yang Ciliary IFT80 regulates dental pulp stem cells differentiation by FGF/FGFR1 and Hh/BMP2 signaling Int. J. Biol. Sci., 2019-08-06;15(10):2087-2099. 2019-08-06 [PMID: 31592124] (Bioassay, Mouse)
• Y Rong, W Liu, C Lv, J Wang, Y Luo, D Jiang, L Li, Z Zhou, W Zhou, Q Li, G Yin, L Yu, J Fan, W Cai Neural stem cell small extracellular vesicle-based delivery of 14-3-3t reduces apoptosis and neuroinflammation following traumatic spinal cord injury by enhancing autophagy by targeting Beclin-1 Aging (Albany NY), 2019-09-28;11(18):7723-7745. 2019-09-28 [PMID: 31563124] (Bioassay, Mouse)
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• Kharitonenkov , Alexei, Beals , John M, Micanovic , Radmila, Strifler , Beth A, Rathnachalam , Radhakri, Wroblewski , Victor J, Li , Shun, Koester , Anja, Ford , Amy M, Coskun , Tamer, Dunbar , James D, Cheng , Christin, Frye , Christop, Bumol , Thomas F, Moller , David E Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319. PLoS ONE, 2013-03-11;8(3):e58575. 2013-03-11 [PMID: 23536797] (Stimulation, Mouse)
• Liu , Xian Shu, Chopp , Michael, Wang , Xin Li, Zhang , Li, Hozeska-Solgot , Ann, Tang , Tao, Kassis , Haifa, Zhang , Rui Lan, Chen , Charles, Xu , Jennifer, Zhang , Zheng Ga MicroRNA-17-92 cluster mediates the proliferation and survival of neural progenitor cells after stroke. J Biol Chem, 2013-03-19;288(18):12478-88. 2013-03-19 [PMID: 23511639] (Bioassay, Mouse)
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FAQs for FGF basic/FGF2/bFGF (3139-FB). (Showing 1 - 1 of 1 FAQs).

1. I am looking for an ovine antibody for bFGF and PDGF-AB and ELISA Kits for both. It is for a research work on meniscus healing in sheep. Do you have anything suitable? How is the homology with sheep? Is it ever tested and/or published in papers?  ..show answer..
   • Unfortunately, most of the products you are interested in have not yet been tested in sheep, but this should not be a problem, due to sequence homology, and our Innovators Reward Program. In terms of an antibody for bFGF, also called FGF-2, we have several antibodies that are validated to detect the bovine protein, which is almost identical to that from sheep (99% homology). We only have FGF2 ELISA kits that have been tested with human or mouse. Mouse FGF-2 has 94% homology with sheep; human has 98% homology for most of its sequence, but also has an additional stretch of amino acids that is not present in the sheep protein. I therefore think that the mouse kit would be most suitable, just in case the human kit targets the region of the human protein not present in mouse. We sell antibodies to PDGF-A or PDGF-B rather than PDGF-AB. We don't have any PDGF-A antibodies that have been tested in sheep but there are several options you may find of interest. There isn't a sheep PDGFA sequence in UniProt, so I can't comment on how similar it is to the PDGFA from other species. Nevertheless, our NBP1-52533 PDGFB antibody has been shown to work in sheep. We sell two PDGF-AB ELISA kits , but these are for human and rat. I'm not sure how well these would work with sheep. Note that if you test a product with a species (or application) that it has not yet been validated in, you are eligible for our Innovator's Reward: Novus would provide you a 50% refund on the purchased product as well as a 50% discount on a future product of equal or lesser value. You would email innovators@novusbio.com to apply for your award, and we

Bioinformatics

• Gene Symbol: Fgf2
• Uniprot:
  • P15655()