Recombinant Mouse GM-CSF Protein, CF

Recombinant Mouse GM-CSF (Catalog # 415-ML/CF) stimulates cell proliferation of the DA3 mouse myeloma cell line. The ED50 for this effect is 5-30 pg/mL.

1 μg/lane of Recombinant Mouse GM-CSF was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa.

• Reactivity: Mu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Mouse GM-CSF Protein, CF Summary

• Details of Functionality: Measured in a cell proliferation assay using DA3 mouse myeloma cells. Ihle, J.N. et al. (1984) Advances in Viral Oncology. In G. Klein (eds): Raven Press, New York, NY. 4:95. The ED₅₀ for this effect is 5‑30 pg/mL.
• Source: E. coli-derived mouse GM-CSF protein
  Ala18-Lys141, with an N-terminal Met
• Accession #: Q14AD9
• N-terminal Sequence: Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: Csf2
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 14.3 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse GM-CSF Protein, CF

• colony stimulating factor 2 (granulocyte-macrophage)
• Colony-stimulating factor
• CSF
• CSF2
• CSF-2
• GMCSF
• GM-CSF
• GMCSFgranulocyte-macrophage colony-stimulating factor
• granulocyte-macrophage colony stimulating factor
• MGC131935
• MGC138897
• Molgramostim
• molgramostin
• Sargramostim

Background

GM-CSF was initially characterized as a factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is also a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. GM-CSF is produced by a number of different cell types (including T cells, B cells, macrophages, mast cells, endothelial cells, fibroblasts, and adipocytes) in response to cytokine or inflammatory stimuli. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages, and eosinophils (1, 2). GM-CSF promotes a Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity (3-5). It shows clinical effectiveness in ameliorating chemotherapy-induced neutropenia, and GM-CSF transfected tumor cells are utilized as cancer vaccines (6, 7). The 22 kDa glycosylated GM-CSF, similar to IL-3 and IL-5, is a cytokine with a core of four bundled alpha ‑helices (8-10). Mature mouse GM-CSF shares 49%-54% amino acid sequence identity with canine, feline, human, and porcine GM-CSF and 69% with rat GM‑CSF. GM‑CSF exerts its biological effects through a heterodimeric receptor complex composed of GM-CSF R alpha /CD116 and the signal transducing common beta chain (CD131) which is also a component of the high-affinity receptors for IL-3 and IL-5 (11, 12). In addition, GM-CSF binds a naturally occurring soluble form of GM-CSF R alpha (13). The activity of GM-CSF is species specific between human and mouse. Mouse GM-CSF is only weakly active on rat cells, although rat GM‑CSF is fully active on mouse cells (14, 15).

1. Martinez-Moczygemba, M. and D.P. Huston (2003) J. Allergy Clin. Immunol. 112:653.
2. Barreda, D.R. et al. (2004) Dev. Comp. Immunol. 28:509.
3. Eksioglu, E.A. et al. (2007) Exp. Hematol. 35:1163.
4. Cao, Y. (2007) J. Clin. Invest. 117:2362.
5. Fleetwood, A.J. et al. (2005) Crit. Rev. Immunol. 25:405.
6. Heuser, M. et al. (2007) Semin. Hematol. 44:148.
7. Hege, K.M. et al. (2006) Int. Rev. Immunol. 25:321.
8. Kaushansky, K. et al. (1992) Biochemistry 31:1881.
9. Diederichs, K. et al. (1991) Science 254:1779.
10. Gough, N.M. et al. (1984) Nature 309:763.
11. Onetto-Pothier, N. et al. (1990) Blood 75:59.
12. Hayashida, K. et al. (1990) Proc. Natl. Acad. Sci. 87:9655.
13. Pelley, J.L. et al. (2007) Exp. Hematol. 35:1483.
14. Oaks, M.K. et al. (1995) J. Interferon Cytokine Res. 15:1095.
15. Vandenabeele, P. et al. (1990) Lymphokine Res. 9:381.

Publications for GM-CSF (415-ML/CF)(330)

Publications using 415-ML/CF

• Rizzo, GP;Sanches, RC;Chavero, C;Bianchi, DS;Apuzzo, E;Herrera, SE;Agazzi, ML;Keitelman, IA;Trevani, AS;Oliveira, SC;Azzaroni, O;Smaldini, PL;Docena, GH; Poly(allylamine)-tripolyphosphate polymeric nanoparticle as an NLRP3-dependent systemic adjuvant for the vaccine development bioRxiv : the preprint server for biology 2024-07-04 [PMID: 39005275] (Bioassay, Mouse)
• J Zeng, S Yang, Y Tuo, X Zha, R Sun, T Lu, H Zhang, L Tan, S Qiao, H Bai IL-27 Signaling Promotes Th1 Response by Downregulating IL-10 Production in DCs during Chlamydial Respiratory Infection Microorganisms, 2023-02-27;11(3):. 2023-02-27 [PMID: 36985179] (Cell Culture, Mouse)
• N Zeren, Z Afzal, S Morgan, G Marshall, M Uppiliappa, J Merritt, SJ Coniglio The Chemokine Receptor CCR1 Mediates Microglia Stimulated Glioma Invasion International Journal of Molecular Sciences, 2023-03-07;24(6):. 2023-03-07 [PMID: 36982211] (Bioassay, Mouse)
• Y Zhang, W Gao, J Yuan, X Zhong, K Yao, R Luo, H Liu CCR7 Mediates Dendritic-Cell-Derived Exosome Migration and Improves Cardiac Function after Myocardial Infarction Pharmaceutics, 2023-01-30;15(2):. 2023-01-30 [PMID: 36839783] (Bioassay, Mouse)
• R Storjohann, B Gericke, J Reifenrath, T Herrmann, P Behrens, H Oltmanns, J Mei beta ner Influence of PEG Chain Length of Functionalized Magnetic Nanoparticles on the Cytocompatibility and Immune Competence of Primary Murine Macrophages and Dendritic Cells International Journal of Molecular Sciences, 2023-01-29;24(3):. 2023-01-29 [PMID: 36768890] (Bioassay, Mouse)
• R Storjohann, B Gericke, J Reifenrath, T Herrmann, P Behrens, H Oltmanns, J Mei beta ner Influence of PEG Chain Length of Functionalized Magnetic Nanoparticles on the Cytocompatibility and Immune Competence of Primary Murine Macrophages and Dendritic Cells International Journal of Molecular Sciences, 2023;24(3):. 2023 [PMID: 36768890] (Bioassay, Mouse)
• NA Pinto, MC Abba, L Laporte, JM Pérez Sáez, AG Blidner, NI Torres, RM Morales, SG Gatto, CA Bach, F Veigas, HJ García Riv, P Song, JH Frederikse, LJ Rasmussen, F Poirier, DO Croci, V Sundblad, GA Rabinovich, JP Cerliani Galectin-7 reprograms skin carcinogenesis by fostering innate immune evasive programs Cell Death and Differentiation, 2023-01-24;0(0):. 2023-01-24 [PMID: 36693903] (Bioassay, Mouse)
• B Ma, SJ Gavzy, V Saxena, Y Song, W Piao, HW Lwin, R Lakhan, J Lyyathurai, L Li, M France, C Paluskievi, MW Shirkey, L Hittle, A Munawwar, EF Mongodin, JS Bromberg Strain-specific alterations in gut microbiome and host immune responses elicited by tolerogenic Bifidobacterium pseudolongum Scientific Reports, 2023-01-19;13(1):1023. 2023-01-19 [PMID: 36658194] (Cell Culture, Mouse)
• J Liu, Y Cheng, X Zhang, Y Chen, H Zhu, K Chen, S Liu, Z Li, X Cao Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity Cell Reports, 2023-01-18;42(1):111991. 2023-01-18 [PMID: 36656709] (Bioassay, Mouse)
• J Wang, K Mao, X Cong, H Tan, C Wu, Z Hu, YG Yang, T Sun Nanoparticle delivery of CD40 siRNA suppresses alloimmune responses by inhibiting activation and differentiation of DCs and macrophages Science Advances, 2022-12-21;8(51):eabq3699. 2022-12-21 [PMID: 36542700] (Cell Culture, Mouse)
• X Liu, N Sato, T Yabushita, J Li, Y Jia, M Tamura, S Asada, T Fujino, T Fukushima, T Yonezawa, Y Tanaka, T Fukuyama, A Tsuchiya, S Shikata, H Iwamura, C Kinouchi, K Komatsu, S Yamasaki, T Shibata, AT Sasaki, J Schibler, M Wunderlich, E O'Brien, B Mizukawa, JC Mulloy, Y Sugiura, H Takizawa, T Shibata, K Miyake, T Kitamura, S Goyama IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia Embo Molecular Medicine, 2022-12-01;0(0):e15631. 2022-12-01 [PMID: 36453131] (Cell Culture, Mouse)
• H Yang, SY Park, H Baek, C Lee, G Chung, X Liu, JH Lee, B Kim, M Kwon, H Choi, HJ Kim, JY Kim, Y Kim, YS Lee, G Lee, SK Kim, JS Kim, YT Chang, WS Jung, KH Kim, H Bae Adoptive therapy with amyloid-beta specific regulatory T cells alleviates Alzheimer&#039;s disease Theranostics, 2022-11-07;12(18):7668-7680. 2022-11-07 [PMID: 36451854] (Bioassay, Mouse)
• CY Chang, R You, D Armstrong, A Bandi, YT Cheng, PM Burkhardt, L Becerra-Do, MC Madison, HY Tung, Z Zeng, Y Wu, L Song, PE Phillips, P Porter, JM Knight, N Putluri, X Yuan, DC Marcano, EA McHugh, JM Tour, A Catic, L Maneix, BM Burt, HS Lee, DB Corry, F Kheradmand Chronic exposure to carbon black ultrafine particles reprograms macrophage metabolism and accelerates lung cancer Science Advances, 2022-11-16;8(46):eabq0615. 2022-11-16 [PMID: 36383649] (Bioassay, Transgenic Mouse)
• KC Huang, CY Lai, WZ Hong, HY Chang, PC Lin, SF Chiang, TW Ke, JA Liang, AC Shiau, PC Yang, WT Chen, KSC Chao A Novel Engineered AAV-based Neoantigen Vaccine in Combination with Radiotherapy Eradicates Tumors Cancer Immunology Research, 2023-01-03;0(0):. 2023-01-03 [PMID: 36315960] (Bioassay, Mouse)
• EY Lee, SM Kim, JH Hwang, SY Jang, S Park, S Choi, GS Lee, J Hwang, JH Moon, PL Fox, S Kim, CH Lee, MH Kim Glutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal anti-inflammatory AKT signaling Nature Communications, 2022-10-29;13(1):6455. 2022-10-29 [PMID: 36309524] (Bioassay, Mouse)
• P Xiong, T Liu, Y Chen, Q Xu, X Hu, F Han, L Shi Interferon-gamma Stimulates Interleukin-27 Derived from Dendritic Cells to Regulate Th9 Differentiation through STAT1/3 Pathway Disease Markers, 2022-10-18;2022(0):1542112. 2022-10-18 [PMID: 36304255] (Bioassay, Mouse)
• S Rotem, E Bar-Haim, U Elia, H Cohen, S Lazar, O Cohen, T Chitlaru, Y Gal A Novel Approach to Vaccine Development: Concomitant Pathogen Inactivation and Host Immune Stimulation by Peroxynitrite Vaccines, 2022-09-22;10(10):. 2022-09-22 [PMID: 36298458] (Bioassay, Mouse)
• T Jiang, H Zhang, Y Li, P Jayakumar, H Liao, H Huang, TR Billiar, M Deng Intraperitoneal injection of class A TLR9 agonist enhances anti-PD-1 immunotherapy in colorectal peritoneal metastases JCI Insight, 2022-10-24;7(20):. 2022-10-24 [PMID: 36278484] (Bioassay, Mouse)
• S Peng, D Stojkov, J Gao, K Oberson, P Latzin, C Casaulta, S Yousefi, HU Simon Nascent RHOH acts as a molecular brake on actomyosin-mediated effector functions of inflammatory neutrophils PloS Biology, 2022-09-15;20(9):e3001794. 2022-09-15 [PMID: 36108062] (Bioassay, Mouse)
• B Zhu, Y Liu, S Hwang, K Archuleta, H Huang, A Campos, R Murad, J Piña-Cresp, H Xu, TY Huang Trem2 deletion enhances tau dispersion and pathology through microglia exosomes Molecular Neurodegeneration, 2022-09-02;17(1):58. 2022-09-02 [PMID: 36056435] (Bioassay, Mouse)
• PS Sung, YC Peng, SP Yang, CH Chiu, SL Hsieh CLEC5A is critical in Pseudomonas aeruginosa-induced acute lung injury JCI Insight, 2022-09-01;0(0):. 2022-09-01 [PMID: 36048544] (Bioassay, Mouse)
• L Li, Y Chen, MN Sluter, R Hou, J Hao, Y Wu, GY Chen, Y Yu, J Jiang Ablation of Siglec-E augments brain inflammation and ischemic injury Journal of Neuroinflammation, 2022-07-20;19(1):191. 2022-07-20 [PMID: 35858866] (Bioassay, Mouse)
• A Manda-Hand, A Mroczek, W Ku?micka, A Cieloch, Z Homoncik, A Muchowicz, U Demkow, M Wachowska Lack of Functional P110delta Affects Expression of Activation Marker CD80 but Does Not Influence Functions of Neutrophils International Journal of Molecular Sciences, 2022-06-07;23(12):. 2022-06-07 [PMID: 35742807] (Bioassay, Mouse)
• C Probst, S Garcia-San, JT Brooks, I Van Der Kl, O Baars, M Ralle, DJ Thiele, JA Alspaugh Interactions between copper homeostasis and the fungal cell wall affect copper stress resistance PloS Pathogens, 2022-06-23;18(6):e1010195. 2022-06-23 [PMID: 35737716] (Bioassay, Mouse)
• AM Jaeger, LE Stopfer, R Ahn, EA Sanders, DA Sandel, WA Freed-Past, WM Rideout, S Naranjo, T Fessenden, KB Nguyen, PS Winter, RE Kohn, PMK Westcott, JM Schenkel, SL Shanahan, AK Shalek, S Spranger, FM White, T Jacks Deciphering the immunopeptidome in vivo reveals new tumour antigens Nature, 2022-06-15;0(0):. 2022-06-15 [PMID: 35705813] (Bioassay, Mouse)
• Q Li, J Peng, Y Luo, J Zhou, T Li, L Cao, S Peng, Z Zuo, Z Wang Far infrared light irradiation enhances Abeta clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer&#039;s disease-like mice Journal of Neuroinflammation, 2022-06-14;19(1):145. 2022-06-14 [PMID: 35701825] (Bioassay, Mouse)
• SY Park, H Yang, M Ye, X Liu, I Shim, YT Chang, H Bae Neuroprotective effects of ex vivo-expanded regulatory T cells on trimethyltin-induced neurodegeneration in mice Journal of Neuroinflammation, 2022-06-11;19(1):143. 2022-06-11 [PMID: 35690816] (Bioassay, Mouse)
• KY Chyu, X Zhao, J Zhou, PC Dimayuga, NW Lio, B Cercek, NT Trac, EJ Chung, PK Shah Immunization using ApoB-100 peptide-linked nanoparticles reduces atherosclerosis JCI Insight, 2022-06-08;0(0):. 2022-06-08 [PMID: 35536648] (Bioassay, Mouse)
• W Piao, L Li, V Saxena, J Iyyathurai, R Lakhan, Y Zhang, IT Lape, C Paluskievi, KL Hippen, Y Lee, E Silverman, MW Shirkey, LV Riella, BR Blazar, JS Bromberg PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration Nature Communications, 2022-04-21;13(1):2176. 2022-04-21 [PMID: 35449134] (Bioassay, Mouse)
• Z Qu, M Li, R An, H Dai, Y Yu, C Li, C Cao, Y Meng, J Wang, M Gao Self-assembled BPIV3 nanoparticles can induce comprehensive immune responses and protection against BPIV3 challenge by inducing dendritic cell maturation in mice Veterinary Microbiology, 2022-03-31;268(0):109415. 2022-03-31 [PMID: 35395543] (Bioassay, Mouse)
• CJ Ortiz-Boni, TP Uccello, SA Gerber, EM Lord, EM Messing, YF Lee Bladder Cancer Extracellular Vesicles Elicit a CD8 T Cell-Mediated Antitumor Immunity International Journal of Molecular Sciences, 2022-03-08;23(6):. 2022-03-08 [PMID: 35328324] (Bioassay, Mouse)
• V Mela, A Sayd Gaban, E O'Neill, S Bechet, A Walsh, MA Lynch The Modulatory Effects of DMF on Microglia in Aged Mice Are Sex-Specific Cells, 2022-02-18;11(4):. 2022-02-18 [PMID: 35203379] (Bioassay, Mouse)
• CY Wu, CW Cheng, CC Kung, KS Liao, JT Jan, C Ma, CH Wong Glycosite-deleted mRNA of SARS-CoV-2 spike protein as a broad-spectrum vaccine Proceedings of the National Academy of Sciences of the United States of America, 2022-03-01;119(9):. 2022-03-01 [PMID: 35149556] (Bioassay, Mouse)
• T Pock, K Schulte, S Schlatt, M Boiani, V Nordhoff GM-CSF perturbs cell identity in mouse pre-implantation embryos PLoS ONE, 2022-02-10;17(2):e0263793. 2022-02-10 [PMID: 35143564] (Bioassay, Mouse)
• H Potter, L Kendall, T Boyd, S Sillau, A Bosco-Laut, N Markham, D Fong, P Clarke, K Tyler GM-CSF Promotes Immune Response and Survival in a Mouse Model of COVID-19 Research square, 2022-01-26;0(0):. 2022-01-26 [PMID: 35118463] (In Vivo, Mouse)
• JD Hathaway-S, JD Aartun, NA Poulides, MB Kuhn, BE McCormick, ME Chew, E Huang, RP Darveau, C Westwater, CM Novince Commensal oral microbiota induces osteoimmunomodulatory effects separate from systemic microbiome in mice JCI Insight, 2022-02-22;0(0):. 2022-02-22 [PMID: 35077397] (Bioassay, Mouse)
• S Chen, Y Bai, Y Wang, C Liang, K Du, S Wang, J Li, YX Chang Immunosuppressive effect of Columbianadin on maturation, migration, allogenic T cell stimulation and phagocytosis capacity of TNF-alpha induced dendritic cells Journal of ethnopharmacology, 2021-12-14;285(0):114918. 2021-12-14 [PMID: 34919989] (Bioassay, Mouse)
• AW Pountain, JR Collette, WM Farrell, MC Lorenz Interactions of Both Pathogenic and Nonpathogenic CUG Clade Candida Species with Macrophages Share a Conserved Transcriptional Landscape MBio, 2021-12-14;12(6):e0331721. 2021-12-14 [PMID: 34903044] (Bioassay, Mouse)
• X Sheng, Y Yao, R Huang, Y Xu, Y Zhu, L Chen, L Zhang, W Wang, R Zhuo, D Can, CF Chang, YW Zhang, H Xu, G Bu, L Zhong, XF Chen Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology Journal of Neuroinflammation, 2021-12-10;18(1):286. 2021-12-10 [PMID: 34893068] (Bioassay, Mouse)
• SJ Coniglio, JE Segall Microglial-stimulation of glioma invasion involves the EGFR ligand amphiregulin PLoS ONE, 2021-11-29;16(11):e0260252. 2021-11-29 [PMID: 34843542] (Bioassay, Mouse)
• K Umeda, Y Goto, K Watanabe, N Ushio, RM Fereig, F Ihara, S Tanaka, Y Suzuki, Y Nishikawa Transcriptomic Analysis of the Effects of Chemokine Receptor CXCR3 Deficiency on Immune Responses in the Mouse Brain during Toxoplasma gondii Infection Microorganisms, 2021-11-12;9(11):. 2021-11-12 [PMID: 34835465] (Bioassay, Mouse)
• J Pei, NR Beri, AJ Zou, P Hubel, HK Dorando, V Bergant, RD Andrews, J Pan, JM Andrews, KCF Sheehan, A Pichlmair, GK Amarasingh, SL Brody, JE Payton, DW Leung Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription Cell Reports, 2021-10-12;37(2):109803. 2021-10-12 [PMID: 34644581] (Bioassay, Human)
• J Hu, C Wang, X Huang, S Yi, S Pan, Y Zhang, G Yuan, Q Cao, X Ye, H Li Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling Cell Reports, 2021-09-21;36(12):109726. 2021-09-21 [PMID: 34551302] (Bioassay, Mouse)
• TT Chu, X Tu, K Yang, J Wu, JJ Repa, N Yan Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C Nature, 2021-07-21;0(0):. 2021-07-21 [PMID: 34290407] (Bioassay, Mouse)
• T Imai Single Amino Acid Deletion at N-Terminus of the Target Antigen in DNA Vaccine Induces Altered CD8+ T Cell Responses against Tumor Antigen Vaccines, 2021-05-21;9(6):. 2021-05-21 [PMID: 34063920] (Bioassay, Mouse)
• NC DeVito, M Sturdivant, B Thievanthi, C Xiao, MP Plebanek, AKS Salama, GM Beasley, A Holtzhause, V Novotny-Di, JH Strickler, BA Hanks Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy Cell Reports, 2021-05-04;35(5):109071. 2021-05-04 [PMID: 33951424] (Bioassay, Mouse)
• D Wan, S Ai, H Ouyang, L Cheng Activation of 4-1BB signaling in bone marrow stromal cells triggers bone loss via the p-38 MAPK-DKK1 axis in aged mice Experimental & Molecular Medicine, 2021-04-15;0(0):. 2021-04-15 [PMID: 33859350] (Bioassay, Mouse)
• LT Wang, MH Lin, KY Liu, SS Chiou, SN Wang, CY Chai, LW Tseng, HC Chiou, HC Wang, KK Yokoyama, SH Hsu, SK Huang WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism Autophagy, 2021-04-14;0(0):1-16. 2021-04-14 [PMID: 33853474] (Bioassay, Mouse)
• Y Wang, M Song, M Liu, G Zhang, X Zhang, MO Li, X Ma, JJ Zhang, XY Huang Fascin inhibitor increases intratumoral dendritic cell activation and anti-cancer immunity Cell Reports, 2021-04-06;35(1):108948. 2021-04-06 [PMID: 33826900] (Bioassay, Mouse)
• M Bednarczyk, C Medina-Mon, FJ Fittler, H Stege, M Roskamp, M Kuske, C Langer, M Vahldieck, E Montermann, I Tubbe, N Röhrig, A Dzionek, S Grabbe, M Bros Complement-Opsonized Nano-Carriers Are Bound by Dendritic Cells (DC) via Complement Receptor (CR)3, and by B Cell Subpopulations via CR-1/2, and Affect the Activation of DC and B-1 Cells International Journal of Molecular Sciences, 2021-03-11;22(6):. 2021-03-11 [PMID: 33799879] (Bioassay, Mouse)
• R Joseph, R Soundarara, S Vasaikar, F Yang, KL Allton, L Tian, P den Hollan, S Isgandarov, M Haemmerle, B Mino, T Zhou, C Shin, M Martinez-P, AA Sahin, J Rodriguez-, J Gelovani, JT Chang, G Acharya, AK Sood, II Wistuba, DL Gibbons, LM Solis, MC Barton, N Varadaraja, JM Rosen, XH Zhang, SA Mani CD8+ T cells inhibit metastasis and CXCL4 regulates its function British Journal of Cancer, 2021-04-01;0(0):. 2021-04-01 [PMID: 33795809] (Bioassay, Mouse)
• H Shi, L Sun, Y Wang, A Liu, X Zhan, X Li, M Tang, P Anderton, S Hildebrand, J Quan, S Ludwig, EMY Moresco, B Beutler N4BP1 negatively regulates NF-&amp;kappaB by binding and inhibiting NEMO oligomerization Nature Communications, 2021-03-02;12(1):1379. 2021-03-02 [PMID: 33654074] (Bioassay, Mouse)
• N Germic, T Fettrelet, D Stojkov, A Hosseini, MP Horn, A Karaulov, D Simon, S Yousefi, HU Simon The Release Kinetics of Eosinophil Peroxidase and Mitochondrial DNA Is Different in Association with Eosinophil Extracellular Trap Formation Cells, 2021-02-03;10(2):. 2021-02-03 [PMID: 33546138] (Bioassay, Human, Mouse)
• SJ Gurczynski, NL Pereira, SM Hrycaj, C Wilke, RL Zemans, BB Moore Stem cell transplantation uncovers TDO-AHR regulation of lung dendritic cells in herpesvirus-induced pathology JCI Insight, 2021-01-25;6(2):. 2021-01-25 [PMID: 33491663] (Bioassay, Mouse)
• RK Arya, R Goswami, SO Rahaman Mechanotransduction via a TRPV4-Rac1 signaling axis plays a role in multinucleated giant cell formation The Journal of Biological Chemistry, 2020-01-01;296(0):100129. 2020-01-01 [PMID: 33460921] (Bioassay, Mouse)
• H Wang, X Teng, G Abboud, W Li, S Ye, L Morel D-mannose ameliorates autoimmune phenotypes in mouse models of lupus BMC immunology, 2021-01-05;22(1):1. 2021-01-05 [PMID: 33402096] (Bioassay, Mouse)
• C Delaney, M Farrell, CP Doherty, K Brennan, E O'Keeffe, C Greene, K Byrne, E Kelly, N Birmingham, P Hickey, S Cronin, SN Savvides, SL Doyle, M Campbell Attenuated CSF-1R signalling drives cerebrovascular pathology Embo Molecular Medicine, 2020-12-22;0(0):e12889. 2020-12-22 [PMID: 33350588] (Cell Culture, Mouse)
• G Gupta, Z Mou, P Jia, R Sharma, R Zayats, SM Viana, L Shan, A Barral, VS Boaventura, TT Murooka, A Soussi-Gou, CI de Oliveir, JE Uzonna The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response Cell Reports, 2020-12-15;33(11):108513. 2020-12-15 [PMID: 33326783] (Bioassay, Transgenic Mouse)
• MJ Park, JA Baek, SY Kim, KA Jung, JW Choi, SH Park, SK Kwok, ML Cho Myeloid-derived suppressor cells therapy enhance immunoregulatory properties in acute graft versus host disease with combination of regulatory T cells Journal of Translational Medicine, 2020-12-14;18(1):483. 2020-12-14 [PMID: 33317573] (Bioassay, Mouse)
• RK Arya, R Goswami, SO Rahaman Mechanotransduction via a TRPV4-Rac1 signaling axis plays a role in multinucleated giant cell formation The Journal of Biological Chemistry, 2020-12-04;0(0):. 2020-12-04 [PMID: 33262217] (Cell Culture, Mouse)
• N Zhao, W Dong, H Kim, R Moallemian, J Lv, H Wang, H Zheng, F Wei, X Ma Capping protein regulator and myosin 1 linker 3 regulates transcription of key cytokines in activated phagocytic cells Cell Signal, 2020-11-24;78(0):109848. 2020-11-24 [PMID: 33246003] (Cell Culture, Mouse)
• YM Hyun, SU Seo, WS Choi, HJ Kwon, DY Kim, S Jeong, GY Kang, E Yi, M Kim, HJ Ryu, MR Looney, EY Choi, HS Kim Endogenous DEL-1 restrains melanoma lung metastasis by limiting myeloid cell-associated lung inflammation Sci Adv, 2020-11-06;6(45):. 2020-11-06 [PMID: 33158867] (Bioassay, In Vivo, Mouse)
• TO Khaliullin, ER Kisin, S Guppi, N Yanamala, V Zhernovkov, AA Shvedova Differential responses of murine alveolar macrophages to elongate mineral particles of asbestiform and non-asbestiform varieties: Cytotoxicity, cytokine secretion and transcriptional changes Toxicology and Applied Pharmacology, 2020-10-24;409(0):115302. 2020-10-24 [PMID: 33148505] (Cell Culture, Mouse)
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• Jung ID, Noh KT, Lee CM, Chun SH, Jeong SK, Park JW, Park WS, Kim HW, Yun CH, Shin YK, Park YM Oncostatin M induces dendritic cell maturation and Th1 polarization. Biochem. Biophys. Res. Commun., 2010-03-04;394(2):272-8. 2010-03-04 [PMID: 20206608] (Cell Culture, Mouse)
• Kallal LE, Schaller MA, Lindell DM, Lira SA, Lukacs NW CCL20/CCR6 blockade enhances immunity to RSV by impairing recruitment of DC. Eur. J. Immunol., 2010-04-01;40(4):1042-52. 2010-04-01 [PMID: 20101616] (Bioassay, Mouse)
• Fukui R, Saitoh S, Matsumoto F, Kozuka-Hata H, Oyama M, Tabeta K, Beutler B, Miyake K Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing. J. Exp. Med., 2009-05-18;206(6):1339-50. 2009-05-18 [PMID: 19451267] (Bioassay, Mouse)
• Claudio E, Sonder SU, Saret S, Carvalho G, Ramalingam TR, Wynn TA, Chariot A, Garcia-Perganeda A, Leonardi A, Paun A, Chen A, Ren NY, Wang H, Siebenlist U The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation. J. Immunol., 2009-02-01;182(3):1617-30. 2009-02-01 [PMID: 19155511] (Bioassay, Mouse)
• Beck JM, Preston AM, Wilcoxen SE, Morris SB, Sturrock A, Paine R Critical roles of inflammation and apoptosis in improved survival in a model of hyperoxia-induced acute lung injury in Pneumocystis murina-infected mice. Infect. Immun., 2009-01-05;77(3):1053-60. 2009-01-05 [PMID: 19124601] (In Vivo, Mouse)
• Liu Q, Cheng LI, Yi L, Zhu N, Wood A, Changpriroa CM, Ward JM, Jackson SH p47phox deficiency induces macrophage dysfunction resulting in progressive crystalline macrophage pneumonia. Am. J. Pathol., 2008-12-18;174(1):153-63. 2008-12-18 [PMID: 19095958] (Bioassay, Mouse)
• Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM Adenosine receptors in regulation of dendritic cell differentiation and function. Blood, 2008-06-17;112(5):1822-31. 2008-06-17 [PMID: 18559975] (Bioassay, Mouse)
• Guo B, Chang EY, Cheng G The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J. Clin. Invest., 2008-05-01;118(5):1680-90. 2008-05-01 [PMID: 18382764] (Bioassay, Mouse)
• Lau AW, Biester S, Cornall RJ, Forrester JV Lipopolysaccharide-activated IL-10-secreting dendritic cells suppress experimental autoimmune uveoretinitis by MHCII-dependent activation of CD62L-expressing regulatory T cells. J. Immunol., 2008-03-15;180(6):3889-99. 2008-03-15 [PMID: 18322197] (Bioassay, Mouse)
• Shojaei F, Wu X, Zhong C, Yu L, Liang XH, Yao J, Blanchard D, Bais C, Peale FV, van Bruggen N, Ho C, Ross J, Tan M, Carano RA, Meng YG, Ferrara N Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature, 2007-12-06;450(7171):825-31. 2007-12-06 [PMID: 18064003] (Bioassay, Mouse)
• Matsumoto K, Fukuyama S, Eguchi-Tsuda M, Nakano T, Matsumoto T, Matsumura M, Moriwaki A, Kan-o K, Wada Y, Yagita H, Shin T, Pardoll DM, Patcharee R, Azuma M, Nakanishi Y, Inoue H B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma. Biochem. Biophys. Res. Commun., 2007-11-05;365(1):170-5. 2007-11-05 [PMID: 17981145] (Bioassay, Mouse)
• Tian F, Grimaldo S, Fujita M, Fugita M, Cutts J, Vujanovic NL, Li LY The endothelial cell-produced antiangiogenic cytokine vascular endothelial growth inhibitor induces dendritic cell maturation. J. Immunol., 2007-09-15;179(6):3742-51. 2007-09-15 [PMID: 17785811] (Bioassay, Mouse)
• Gaudreau S, Guindi C, Menard M, Besin G, Dupuis G, Amrani A Granulocyte-macrophage colony-stimulating factor prevents diabetes development in NOD mice by inducing tolerogenic dendritic cells that sustain the suppressive function of CD4+CD25+ regulatory T cells. J. Immunol., 2007-09-15;179(6):3638-47. 2007-09-15 [PMID: 17785799] (Bioassay, Mouse)
• Perri SR, Annabi B, Galipeau J Angiostatin inhibits monocyte/macrophage migration via disruption of actin cytoskeleton. FASEB J., 2007-07-10;21(14):3928-36. 2007-07-10 [PMID: 17622568] (Bioassay, Mouse)
• Fritz JH, Le Bourhis L, Sellge G, Magalhaes JG, Fsihi H, Kufer TA, Collins C, Viala J, Ferrero RL, Girardin SE, Philpott DJ Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. Immunity, 2007-04-12;26(4):445-59. 2007-04-12 [PMID: 17433730] (Bioassay, Mouse)
• Koya RC, Kimura T, Ribas A, Rozengurt N, Lawson GW, Faure-Kumar E, Wang HJ, Herschman H, Kasahara N, Stripecke R Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines. Mol. Ther., 2007-03-20;15(5):971-80. 2007-03-20 [PMID: 17375074] (Bioassay, Mouse)
• Sugiyama K, Shirai R, Mukae H, Ishimoto H, Nagata T, Sakamoto N, Ishii H, Nakayama S, Yanagihara K, Mizuta Y, Kohno S Differing effects of clarithromycin and azithromycin on cytokine production by murine dendritic cells. Clin. Exp. Immunol., 2007-03-01;147(3):540-6. 2007-03-01 [PMID: 17302905] (Bioassay, Mouse)
• Kurooka M, Kaneda Y Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells. Cancer Res., 2007-01-01;67(1):227-36. 2007-01-01 [PMID: 17210703] (Bioassay, Mouse)
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• Kim SY, Nguyen AD, Gao JL, Murphy PM, Mansfield BC, Chou JY Bone marrow-derived cells require a functional glucose 6-phosphate transporter for normal myeloid functions. J. Biol. Chem., 2006-08-04;281(39):28794-801. 2006-08-04 [PMID: 16891306] (Bioassay, Mouse)
• Liu Q, Chen T, Chen G, Li N, Wang J, Ma P, Cao X Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation. Biochem. Biophys. Res. Commun., 2006-05-12;345(3):1122-30. 2006-05-12 [PMID: 16713992] (Bioassay, Mouse)
• Reed JA, Clegg DJ, Smith KB, Tolod-Richer EG, Matter EK, Picard LS, Seeley RJ GM-CSF action in the CNS decreases food intake and body weight. J. Clin. Invest., 2005-11-01;115(11):3035-44. 2005-11-01 [PMID: 16276414] (In Vivo, Rat)
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• Dikov MM, Ohm JE, Ray N, Tchekneva EE, Burlison J, Moghanaki D, Nadaf S, Carbone DP Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation. J. Immunol., 2005-01-01;174(1):215-22. 2005-01-01 [PMID: 15611243] (Bioassay, Mouse)
• Borg C, Jalil A, Laderach D, Maruyama K, Wakasugi H, Charrier S, Ryffel B, Cambi A, Figdor C, Vainchenker W, Galy A, Caignard A, Zitvogel L NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs. Blood, 2004-07-08;104(10):3267-75. 2004-07-08 [PMID: 15242871] (Bioassay, Mouse)
• Abedi M, Greer DA, Colvin GA, Demers DA, Dooner MS, Harpel JA, Weier HU, Lambert JF, Quesenberry PJ Robust conversion of marrow cells to skeletal muscle with formation of marrow-derived muscle cell colonies: a multifactorial process. Exp. Hematol., 2004-05-01;32(5):426-34. 2004-05-01 [PMID: 15145210] (In Vivo, Mouse)
• Bouis DA, Popova TG, Takashima A, Norgard MV Dendritic cells phagocytose and are activated by Treponema pallidum. Infect. Immun., 2001-01-01;69(1):518-28. 2001-01-01 [PMID: 11119545] (Bioassay, Mouse)
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• Gardner RV, 48657, Oliver P, Astle CM Stem cell factor improves the repopulating ability of primitive hematopoietic stem cells after sublethal irradiation (and, to a lesser extent) after bone marrow transplantation in mice. Involvement of ?-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum, 1998-01-01;16(2):112-9. 1998-01-01 [PMID: 9554035] (In Vivo, Mouse)
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Bioinformatics

• Gene Symbol: Csf2
• Uniprot:
  • Q14AD9()