Recombinant Mouse GM-CSF Protein

Recombinant Mouse GM-CSF Protein (Catalog # 415-ML) has a molecular weight (MW) of 14.3 kDa as analyzed by SEC-MALS, suggesting that this protein is a monomer.

Recombinant Mouse GM-CSF (Catalog # 415-ML) stimulates cell proliferation of the DA3 mouse myeloma cell line. The ED50 for this effect is 5-30 pg/mL.

1 μg/lane of Recombinant Mouse GM-CSF was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa.

• Reactivity: Mu
• Applications: Bioactivity

Recombinant Mouse GM-CSF Protein Summary

• Additional Information: Analyzed by SEC-MALS
• Details of Functionality: Measured in a cell proliferation assay using DA3 mouse myeloma cells. Ihle, J.N. et al. (1984) Advances in Viral Oncology. In G. Klein (eds): Raven Press, New York, NY. 4:95. The ED₅₀ for this effect is 5‑30 pg/mL.
• Source: E. coli-derived mouse GM-CSF protein
  Ala18-Lys141, with an N-terminal Met
• Accession #: Q14AD9
• N-terminal Sequence: Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: Csf2
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 14.3 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse GM-CSF Protein

• colony stimulating factor 2 (granulocyte-macrophage)
• Colony-stimulating factor
• CSF
• CSF2
• CSF-2
• GMCSF
• GM-CSF
• GMCSFgranulocyte-macrophage colony-stimulating factor
• granulocyte-macrophage colony stimulating factor
• MGC131935
• MGC138897
• Molgramostim
• molgramostin
• Sargramostim

Background

GM-CSF was initially characterized as a factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is also a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. GM-CSF is produced by a number of different cell types (including T cells, B cells, macrophages, mast cells, endothelial cells, fibroblasts, and adipocytes) in response to cytokine or inflammatory stimuli. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages, and eosinophils (1, 2). GM-CSF promotes a Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity (3-5). It shows clinical effectiveness in ameliorating chemotherapy-induced neutropenia, and GM-CSF transfected tumor cells are utilized as cancer vaccines (6, 7). The 22 kDa glycosylated GM-CSF, similar to IL-3 and IL-5, is a cytokine with a core of four bundled alpha ‑helices (8-10). Mature mouse GM-CSF shares 49%-54% amino acid sequence identity with canine, feline, human, and porcine GM-CSF and 69% with rat GM‑CSF. GM‑CSF exerts its biological effects through a heterodimeric receptor complex composed of GM-CSF R alpha /CD116 and the signal transducing common beta chain (CD131) which is also a component of the high-affinity receptors for IL-3 and IL-5 (11, 12). In addition, GM-CSF binds a naturally occurring soluble form of GM-CSF R alpha (13). The activity of GM-CSF is species specific between human and mouse. Mouse GM-CSF is only weakly active on rat cells, although rat GM‑CSF is fully active on mouse cells (14, 15).

1. Martinez-Moczygemba, M. and D.P. Huston (2003) J. Allergy Clin. Immunol. 112:653.
2. Barreda, D.R. et al. (2004) Dev. Comp. Immunol. 28:509.
3. Eksioglu, E.A. et al. (2007) Exp. Hematol. 35:1163.
4. Cao, Y. (2007) J. Clin. Invest. 117:2362.
5. Fleetwood, A.J. et al. (2005) Crit. Rev. Immunol. 25:405.
6. Heuser, M. et al. (2007) Semin. Hematol. 44:148.
7. Hege, K.M. et al. (2006) Int. Rev. Immunol. 25:321.
8. Kaushansky, K. et al. (1992) Biochemistry 31:1881.
9. Diederichs, K. et al. (1991) Science 254:1779.
10. Gough, N.M. et al. (1984) Nature 309:763.
11. Onetto-Pothier, N. et al. (1990) Blood 75:59.
12. Hayashida, K. et al. (1990) Proc. Natl. Acad. Sci. 87:9655.
13. Pelley, J.L. et al. (2007) Exp. Hematol. 35:1483.
14. Oaks, M.K. et al. (1995) J. Interferon Cytokine Res. 15:1095.
15. Vandenabeele, P. et al. (1990) Lymphokine Res. 9:381.

Publications for GM-CSF (415-ML)(373)

Publications using 415-ML

• Zhao, Q;Wang, Q;Yao, Q;Yang, Z;Li, W;Cheng, X;Wen, Y;Chen, R;Xu, J;Wang, X;Qin, D;Zhu, S;He, L;Li, N;Wu, Y;Yu, Y;Cao, X;Wang, P; Nonenzymatic lysine D-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses Cell research 2025-01-06 [PMID: 39757301] (Bioassay, Mouse)
• Patel, AR;Garg, A;Rosberger, HT;Kowdle, S;Reis, RA;Frere, JJ;Januska, MN;Dawodu, G;Valencia, E;Yang, MC;Stevens, CS;Rao, VN;Haas, GD;Chen, YW;Lee, B;Lim, JK; Alveolar macrophages are early targets of mumps virus Proceedings of the National Academy of Sciences of the United States of America 2024-12-24 [PMID: 39700136] (Bioassay, Mouse)
• Karakousi, T;Cristaldi, V;Lopes de Oliveira, ML;Medeiros Geraldo, LH;González-Robles, TJ;da Silva, G;Breazeale, AP;Encarnacion-Rosado, J;Pozniak, J;Kimmelman, AC;Ruggles, KV;Chris Marine, J;Chandel, NS;Lund, AW; IFN?-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma bioRxiv : the preprint server for biology 2024-12-05 [PMID: 39677662] (Bioassay, Mouse)
• Lin, C;Herlihy, SE;Li, M;Deng, H;Kim, R;Bernabei, L;Rosenwasser, M;Gabrilovich, DI;Vogl, DT;Nefedova, Y; Neutrophil extracellular traps promote tumor chemoresistance to anthracyclines bioRxiv : the preprint server for biology 2024-11-11 [PMID: 39605505] (Bioassay, Mouse)
• Carling, GK;Fan, L;Foxe, NR;Norman, K;Ye, P;Wong, MY;Zhu, D;Corona, C;Razzoli, A;Yu, F;Yarahmady, A;Ye, P;Chen, H;Huang, Y;Amin, S;Sereda, R;Lopez-Lee, C;Zacharioudakis, E;Chen, X;Xu, J;Cheng, F;Gavathiotis, E;Cuervo, AM;Holtzman, DM;Mok, SA;Sinha, SC;Sidoli, S;Ratan, RR;Luo, W;Gong, S;Gan, L; Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model Neuron 2024-12-04 [PMID: 39353433] (Bioassay, Transgenic Mouse)
• Takacs, GP;Garcia, JS;Hodges, CA;Kreiger, CJ;Sherman, A;Harrison, JK; CSF1R Ligands Expressed by Murine Gliomas Promote M-MDSCs to Suppress CD8+ T Cells in a NOS-Dependent Manner Cancers 2024-09-01 [PMID: 39272914] (Bioassay, Mouse)
• Bernard, A;Eggstein, C;Tang, L;Keller, M;Körner, A;Mirakaj, V;Rosenberger, P; Plexin C1 influences immune response to intracellular LPS and survival in murine sepsis Journal of biomedical science 2024-08-21 [PMID: 39169397] (Bioassay, Transgenic Mouse)
• Vijaya, AK;Kuras, S;Šimoli?nas, E;Mingaila, J;Makovskyt?, K;Buišas, R;Daliri, EB;Meškys, R;Baltriukien?, D;Burokas, A; Prebiotics mitigate the detrimental effects of High-Fat diet on Memory, anxiety and microglia functionality in ageing mice Brain, behavior, and immunity 2024-08-12 [PMID: 39142421] (Bioassay, Mouse)
• Smith, HL;Goodlett, BL;Navaneethabalakrishnan, S;Mitchell, BM; Elevated Salt or Angiotensin II Levels Induce CD38+ Innate Immune Cells in the Presence of Granulocyte-Macrophage Colony Stimulating Factor Cells 2024-08-04 [PMID: 39120331] (Bioassay, Mouse)
• Pianalto, KM;Telzrow, CL;Harding, HB;Brooks, JT;Granek, JA;Gushiken-Ibañez, E;LeibundGut-Landmann, S;Heitman, J;Ianiri, G;Alspaugh, JA; Malassezia responds to environmental pH signals through the conserved Rim/Pal pathway bioRxiv : the preprint server for biology 2024-07-11 [PMID: 39026808] (Bioassay, Mouse)
• Jiang, X;Luo, T;Yang, K;Lee, MJ;Liu, J;Tillman, L;Zhen, W;Weichselbaum, RR;Lin, W; STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition Science advances 2024-07-19 [PMID: 39018400] (Bioassay, Mouse)
• Zewdie, EY;Edwards, GM;Hunter, DM;Earp, HS;Holtzhausen, A; MerTK Induces Dysfunctional Dendritic Cells by Metabolic Reprogramming Cancer immunology research 2024-07-08 [PMID: 38976507] (Bioassay, Mouse)
• Takacs, GP;Garcia, JS;Hodges, CA;Kreiger, CJ;Sherman, A;Harrison, JK; Glioma-derived M-CSF and IL-34 license M-MDSCs to suppress CD8+ T cells in a NOS-dependent manner bioRxiv : the preprint server for biology 2024-06-06 [PMID: 38895268] (Bioassay, Mouse)
• Zhou, JR;Kinno, S;Kaihara, K;Sawai, M;Ishida, T;Takechi, S;Fang, J;Nohara, T;Yokomizo, K; Saponin Esculeoside A and Aglycon Esculeogenin A from Ripe Tomatoes Inhibit Dendritic Cell Function by Attenuation of Toll-like Receptor 4 Signaling Nutrients 2024-05-30 [PMID: 38892635] (Bioassay, Mouse)
• Nieto-Caballero, VE;Reijneveld, JF;Ruvalcaba, A;Innocenzi, G;Abeydeera, N;Asgari, S;Lopez, K;Iwany, SK;Luo, Y;Nathan, A;Fernandez-Salinas, D;Chiñas, M;Huang, CC;Zhang, Z;León, SR;Calderon, RI;Lecca, L;Budzik, JM;Murray, M;Van Rhijn, I;Raychaudhuri, S;Moody, DB;Suliman, S;Gutierrez-Arcelus, M; History of tuberculosis disease is associated with genetic regulatory variation in Peruvians PLoS genetics 2024-06-13 [PMID: 38870230] (Bioassay, Mouse)
• Elfiky, AMI;López Canñizares, J;Li, J;Li Yim, AYF;Verhoeven, AJ;Ghiboub, M;de Jonge, WJ; Carboxylesterase 1 mediates a distinctive metabolic profile of dendritic cells to attain an inflammatory phenotype Journal of leukocyte biology 2024-06-13 [PMID: 38869086] (Bioassay, Mouse, Transgenic Mouse)
• Gigon, L;Müller, P;Haenni, B;Iacovache, I;Barbo, M;Gosheva, G;Yousefi, S;Soragni, A;von Ballmoos, C;Zuber, B;Simon, HU; Membrane damage by MBP-1 is mediated by pore formation and amplified by mtDNA Cell reports 2024-04-06 [PMID: 38583154] (Bioassay, Mouse)
• Hardaker, EL;Sanseviero, E;Karmokar, A;Taylor, D;Milo, M;Michaloglou, C;Hughes, A;Mai, M;King, M;Solanki, A;Magiera, L;Miragaia, R;Kar, G;Standifer, N;Surace, M;Gill, S;Peter, A;Talbot, S;Tohumeken, S;Fryer, H;Mostafa, A;Mulgrew, K;Lam, C;Hoffmann, S;Sutton, D;Carnevalli, L;Calero-Nieto, FJ;Jones, GN;Pierce, AJ;Wilson, Z;Campbell, D;Nyoni, L;Martins, CP;Baker, T;Serrano de Almeida, G;Ramlaoui, Z;Bidar, A;Phillips, B;Boland, J;Iyer, S;Barrett, JC;Loembé, AB;Fuchs, SY;Duvvuri, U;Lou, PJ;Nance, MA;Gomez Roca, CA;Cadogan, E;Critichlow, SE;Fawell, S;Cobbold, M;Dean, E;Valge-Archer, V;Lau, A;Gabrilovich, DI;Barry, ST; The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment Nature communications 2024-02-24 [PMID: 38402224] (Bioassay, Mouse)
• Hirai, T;Naito, Y;Koyama, S;Nakanishi, Y;Masuhiro, K;Izumi, M;Kuge, T;Naito, M;Mizuno, Y;Yamaguchi, Y;Kang, S;Yaga, M;Futami, Y;Nojima, S;Nishide, M;Morita, T;Kato, Y;Tsuda, T;Takemoto, N;Kinugasa-Katayama, Y;Aoshi, T;Villa, JK;Yamashita, K;Enokida, T;Hoshi, Y;Matsuura, K;Tahara, M;Takamatsu, H;Takeda, Y;Inohara, H;Kumanogoh, A; Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer JCI insight 2024-02-08 [PMID: 38329122] (Cell Culture)
• Carling, GK;Fan, L;Foxe, NR;Norman, K;Ye, P;Wong, MY;Zhu, D;Yu, F;Xu, J;Yarahmady, A;Chen, H;Huang, Y;Amin, S;Zacharioudakis, E;Chen, X;Holtzman, DM;Mok, SA;Gavathiotis, E;Sinha, SC;Cheng, F;Luo, W;Gong, S;Gan, L; Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model bioRxiv : the preprint server for biology 2024-01-25 [PMID: 38328219] (Bioassay, Mouse)
• Anindita, J;Tanaka, H;Oyama, R;Hagiwara, S;Shirane, D;Taneichi, S;Nakai, Y;Tange, K;Hatakeyama, H;Sakurai, Y;Akita, H; Development of a Ready-to-Use-Type RNA Vaccine Carrier Based on an Intracellular Environment-Responsive Lipid-like Material with Immune-Activating Vitamin E Scaffolds Pharmaceutics 2023-11-29 [PMID: 38140043] (Bioassay, Mouse)
• Steinberg, N;Galleguillos, D;Zaidi, A;Horkey, M;Sipione, S; Naïve Huntington's disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1 Journal of neuroinflammation 2023-11-23 [PMID: 37996924] (Bioassay, Transgenic Mouse, Mouse)
• Stickdorn, J;Czysch, C;Medina-Montano, C;Stein, L;Xu, L;Scherger, M;Schild, H;Grabbe, S;Nuhn, L; Peptide-Decorated Degradable Polycarbonate Nanogels for Eliciting Antigen-Specific Immune Responses International journal of molecular sciences 2023-10-21 [PMID: 37895096] (Bioassay, Mouse)
• Park, SY;Yang, H;Kim, S;Yang, J;Go, H;Bae, H; Alpha-Synuclein-Specific Regulatory T Cells Ameliorate Parkinson's Disease Progression in Mice International journal of molecular sciences 2023-10-16 [PMID: 37894917] (Bioassay, Mouse)
• Petersen-Cherubini, CL;Murphy, SP;Xin, M;Liu, Y;Deffenbaugh, JL;Jahan, I;Rau, CN;Yang, Y;Lovett-Racke, AE; Autotaxin in encephalitogenic CD4 T cells as a therapeutic target for multiple sclerosis European journal of immunology 2023-10-18 [PMID: 37850588] (Bioassay, Mouse)
• Miramón, P;Pountain, AW;Lorenz, MC; Candida auris-macrophage cellular interactions and transcriptional response Infection and immunity 2023-10-10 [PMID: 37815367] (Bioassay, Mouse)
• Anang, V;Singh, A;Kumar Rana, A;Saraswati, SSK;Bandyopadhyay, U;Verma, C;Chadha, A;Natarajan, K; Mycobacteria modulate SUMOylation to suppresses protective responses in dendritic cells PloS one 2023-09-29 [PMID: 37773921] (Cell Culture, Human)
• Minns, MS;Liboro, K;Lima, TS;Abbondante, S;Miller, BA;Marshall, ME;Tran Chau, J;Roistacher, A;Rietsch, A;Dubyak, GR;Pearlman, E; NLRP3 selectively drives IL-1? secretion by Pseudomonas aeruginosa infected neutrophils and regulates corneal disease severity Nature communications 2023-09-20 [PMID: 37730693] (Bioassay, Mouse)
• Chen, S;Wang, J;Zhang, K;Ma, B;Li, X;Wei, R;Nian, H; LncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation Cell death & disease 2023-09-16 [PMID: 37716986] (Bioassay, Mouse)
• Ueda, K;Sato, Y;Shimizu, S;Suzuki, T;Onoda, A;Miura, R;Go, S;Mimatsu, H;Kitase, Y;Yamashita, Y;Irie, K;Tsuji, M;Mishima, K;Mizuno, M;Takahashi, Y;Dezawa, M;Hayakawa, M; Systemic administration of clinical-grade multilineage-differentiating stress-enduring cells ameliorates hypoxic-ischemic brain injury in neonatal rats Scientific reports 2023-09-11 [PMID: 37696826] (Bioassay, Rat)
• Wu, J;Hu, Y;Song, J;Xu, J;Zhang, Q;Chai, Y;Wang, X;Wang, B;Zhao, Y;Cao, X;Xu, X; Lysine methyltransferase SMYD2 inhibits antiviral innate immunity by promoting IRF3 dephosphorylation Cell death & disease 2023-09-06 [PMID: 37673879] (Bioassay, Mouse)
• Naser, W;Maymand, S;Dlugolenski, D;Basheer, F;Ward, AC; The Role of Cytokine-Inducible SH2 Domain-Containing Protein (CISH) in the Regulation of Basal and Cytokine-Mediated Myelopoiesis International journal of molecular sciences 2023-08-14 [PMID: 37628937] (In Vivo, Mouse)
• Wu, M;Luo, Z;Cai, Z;Mao, Q;Li, Z;Li, H;Zhang, C;Zhang, Y;Zhong, A;Wu, L;Liu, X; Spleen-targeted neoantigen DNA vaccine for personalized immunotherapy of hepatocellular carcinoma EMBO molecular medicine 2023-08-08 [PMID: 37552209] (Cell Culture, Mouse)
• Malinczak, CA;Fonseca, W;Mire, MM;Parolia, A;Chinnaiyan, A;Rasky, AJ;Morris, S;Yagi, K;Bermick, JR;Lukacs, NW; Sex-associated Early-life viral Innate Immune Response is Transcriptionally Associated with chromatin remodeling of Type-I IFN-inducible Genes Mucosal immunology 2023-06-09 [PMID: 37302711] (Bioassay, Mouse)
• Li, TT;Lin, CL;Chiang, M;He, JT;Hung, CH;Hsieh, CC; Cytokine-Induced Myeloid-Derived Suppressor Cells Demonstrate Their Immunoregulatory Functions to Prolong the Survival of Diabetic Mice Cells 2023-05-29 [PMID: 37296628] (Bioassay, Mouse)
• Sawa, T;Endo, K;Nakashima, A;Tanaka, Y;Makabe, H;Tanaka, S; Procyanidin B2 3,3''-di-O-gallate ameliorates imiquimod-induced skin inflammation by suppressing TLR7 signaling through the inhibition of endosomal acidification in dendritic cells International immunopharmacology 2023-06-07 [PMID: 37295030] (Bioassay, Mouse)
• Colombo, E;De Angelis, A;Bassani, C;Ruffini, F;Ottoboni, L;Garzetti, L;Finardi, A;Martino, G;Furlan, R;Farina, C; iAstrocytes do not restrain T cell proliferation in vitro BMC neuroscience 2023-06-07 [PMID: 37286983] (Bioassay, Mouse)
• Williams, O;Hu, L;Huang, W;Patel, P;Bartom, ET;Bei, L;Hjort, E;Hijiya, C;Eklund, EA; Nore1 inhibits age-associated myeloid lineage skewing and clonal hematopoiesis, but facilitates termination of emergency (stress) granulopoiesis The Journal of biological chemistry 2023-05-27 [PMID: 37247756] (Bioassay, Mouse)
• Wayne, CR;Bremner, L;Faust, TE;Dur�n-Laforet, V;Ampatey, N;Ho, SJ;Feinberg, PA;Arvanitis, P;Ciric, B;Ruan, C;Elyaman, W;Delaney, SL;Vargas, WS;Swedo, S;Menon, V;Schafer, DP;Cutforth, T;Agalliu, D; Distinct Th17 effector cytokines differentially promote microglial and blood-brain barrier inflammatory responses during post-infectious encephalitis bioRxiv : the preprint server for biology 2023-05-09 [PMID: 37215000] (Bioassay, Mouse)
• Naito, Y;Koyama, S;Masuhiro, K;Hirai, T;Uenami, T;Inoue, T;Osa, A;Machiyama, H;Watanabe, G;Sax, N;Villa, J;Kinugasa-Katayama, Y;Nojima, S;Yaga, M;Hosono, Y;Okuzaki, D;Satoh, S;Tsuda, T;Nakanishi, Y;Suga, Y;Morita, T;Fukushima, K;Nishide, M;Shiroyama, T;Miyake, K;Iwahori, K;Hirata, H;Nagatomo, I;Yano, Y;Tamiya, M;Kumagai, T;Takemoto, N;Inohara, H;Yamasaki, S;Yamashita, K;Aoshi, T;Akbay, EA;Hosen, N;Shintani, Y;Takamatsu, H;Mori, M;Takeda, Y;Kumanogoh, A; Tumor-derived semaphorin 4A improves PD-1-blocking antibody efficacy by enhancing CD8+ T cell cytotoxicity and proliferation Science advances 2023-05-19 [PMID: 37205755] (Bioassay, Transgenic Mouse, Mouse)
• Cheu, JW;Chiu, DK;Kwan, KK;Yang, C;Yuen, VW;Goh, CC;Chui, NN;Shen, W;Law, CT;Li, Q;Zhang, MS;Bao, MH;Wong, BP;Chan, CY;Liu, CX;Sit, GF;Ooi, ZY;Deng, H;Tse, AP;Ng, IO;Wong, CC; Hypoxia-inducible factor orchestrates adenosine metabolism to promote liver cancer development Science advances 2023-05-05 [PMID: 37146141] (Bioassay, Mouse)
• J Zeng, S Yang, Y Tuo, X Zha, R Sun, T Lu, H Zhang, L Tan, S Qiao, H Bai IL-27 Signaling Promotes Th1 Response by Downregulating IL-10 Production in DCs during Chlamydial Respiratory Infection Microorganisms, 2023-02-27;11(3):. 2023-02-27 [PMID: 36985179] (Cell Culture, Mouse)
• N Zeren, Z Afzal, S Morgan, G Marshall, M Uppiliappa, J Merritt, SJ Coniglio The Chemokine Receptor CCR1 Mediates Microglia Stimulated Glioma Invasion International Journal of Molecular Sciences, 2023-03-07;24(6):. 2023-03-07 [PMID: 36982211] (Bioassay, Mouse)
• Y Zhang, W Gao, J Yuan, X Zhong, K Yao, R Luo, H Liu CCR7 Mediates Dendritic-Cell-Derived Exosome Migration and Improves Cardiac Function after Myocardial Infarction Pharmaceutics, 2023-01-30;15(2):. 2023-01-30 [PMID: 36839783] (Bioassay, Mouse)
• R Storjohann, B Gericke, J Reifenrath, T Herrmann, P Behrens, H Oltmanns, J Mei beta ner Influence of PEG Chain Length of Functionalized Magnetic Nanoparticles on the Cytocompatibility and Immune Competence of Primary Murine Macrophages and Dendritic Cells International Journal of Molecular Sciences, 2023-01-29;24(3):. 2023-01-29 [PMID: 36768890] (Bioassay, Mouse)
• R Storjohann, B Gericke, J Reifenrath, T Herrmann, P Behrens, H Oltmanns, J Mei beta ner Influence of PEG Chain Length of Functionalized Magnetic Nanoparticles on the Cytocompatibility and Immune Competence of Primary Murine Macrophages and Dendritic Cells International Journal of Molecular Sciences, 2023;24(3):. 2023 [PMID: 36768890] (Bioassay, Mouse)
• NA Pinto, MC Abba, L Laporte, JM Pérez Sáez, AG Blidner, NI Torres, RM Morales, SG Gatto, CA Bach, F Veigas, HJ García Riv, P Song, JH Frederikse, LJ Rasmussen, F Poirier, DO Croci, V Sundblad, GA Rabinovich, JP Cerliani Galectin-7 reprograms skin carcinogenesis by fostering innate immune evasive programs Cell Death and Differentiation, 2023-01-24;0(0):. 2023-01-24 [PMID: 36693903] (Bioassay, Mouse)
• B Ma, SJ Gavzy, V Saxena, Y Song, W Piao, HW Lwin, R Lakhan, J Lyyathurai, L Li, M France, C Paluskievi, MW Shirkey, L Hittle, A Munawwar, EF Mongodin, JS Bromberg Strain-specific alterations in gut microbiome and host immune responses elicited by tolerogenic Bifidobacterium pseudolongum Scientific Reports, 2023-01-19;13(1):1023. 2023-01-19 [PMID: 36658194] (Cell Culture, Mouse)
• J Liu, Y Cheng, X Zhang, Y Chen, H Zhu, K Chen, S Liu, Z Li, X Cao Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity Cell Reports, 2023-01-18;42(1):111991. 2023-01-18 [PMID: 36656709] (Bioassay, Mouse)
• J Wang, K Mao, X Cong, H Tan, C Wu, Z Hu, YG Yang, T Sun Nanoparticle delivery of CD40 siRNA suppresses alloimmune responses by inhibiting activation and differentiation of DCs and macrophages Science Advances, 2022-12-21;8(51):eabq3699. 2022-12-21 [PMID: 36542700] (Cell Culture, Mouse)
• X Liu, N Sato, T Yabushita, J Li, Y Jia, M Tamura, S Asada, T Fujino, T Fukushima, T Yonezawa, Y Tanaka, T Fukuyama, A Tsuchiya, S Shikata, H Iwamura, C Kinouchi, K Komatsu, S Yamasaki, T Shibata, AT Sasaki, J Schibler, M Wunderlich, E O'Brien, B Mizukawa, JC Mulloy, Y Sugiura, H Takizawa, T Shibata, K Miyake, T Kitamura, S Goyama IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia Embo Molecular Medicine, 2022-12-01;0(0):e15631. 2022-12-01 [PMID: 36453131] (Cell Culture, Mouse)
• H Yang, SY Park, H Baek, C Lee, G Chung, X Liu, JH Lee, B Kim, M Kwon, H Choi, HJ Kim, JY Kim, Y Kim, YS Lee, G Lee, SK Kim, JS Kim, YT Chang, WS Jung, KH Kim, H Bae Adoptive therapy with amyloid-beta specific regulatory T cells alleviates Alzheimer&#039;s disease Theranostics, 2022-11-07;12(18):7668-7680. 2022-11-07 [PMID: 36451854] (Bioassay, Mouse)
• CY Chang, R You, D Armstrong, A Bandi, YT Cheng, PM Burkhardt, L Becerra-Do, MC Madison, HY Tung, Z Zeng, Y Wu, L Song, PE Phillips, P Porter, JM Knight, N Putluri, X Yuan, DC Marcano, EA McHugh, JM Tour, A Catic, L Maneix, BM Burt, HS Lee, DB Corry, F Kheradmand Chronic exposure to carbon black ultrafine particles reprograms macrophage metabolism and accelerates lung cancer Science Advances, 2022-11-16;8(46):eabq0615. 2022-11-16 [PMID: 36383649] (Bioassay, Transgenic Mouse)
• KC Huang, CY Lai, WZ Hong, HY Chang, PC Lin, SF Chiang, TW Ke, JA Liang, AC Shiau, PC Yang, WT Chen, KSC Chao A Novel Engineered AAV-based Neoantigen Vaccine in Combination with Radiotherapy Eradicates Tumors Cancer Immunology Research, 2023-01-03;0(0):. 2023-01-03 [PMID: 36315960] (Bioassay, Mouse)
• EY Lee, SM Kim, JH Hwang, SY Jang, S Park, S Choi, GS Lee, J Hwang, JH Moon, PL Fox, S Kim, CH Lee, MH Kim Glutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal anti-inflammatory AKT signaling Nature Communications, 2022-10-29;13(1):6455. 2022-10-29 [PMID: 36309524] (Bioassay, Mouse)
• P Xiong, T Liu, Y Chen, Q Xu, X Hu, F Han, L Shi Interferon-gamma Stimulates Interleukin-27 Derived from Dendritic Cells to Regulate Th9 Differentiation through STAT1/3 Pathway Disease Markers, 2022-10-18;2022(0):1542112. 2022-10-18 [PMID: 36304255] (Bioassay, Mouse)
• S Rotem, E Bar-Haim, U Elia, H Cohen, S Lazar, O Cohen, T Chitlaru, Y Gal A Novel Approach to Vaccine Development: Concomitant Pathogen Inactivation and Host Immune Stimulation by Peroxynitrite Vaccines, 2022-09-22;10(10):. 2022-09-22 [PMID: 36298458] (Bioassay, Mouse)
• T Jiang, H Zhang, Y Li, P Jayakumar, H Liao, H Huang, TR Billiar, M Deng Intraperitoneal injection of class A TLR9 agonist enhances anti-PD-1 immunotherapy in colorectal peritoneal metastases JCI Insight, 2022-10-24;7(20):. 2022-10-24 [PMID: 36278484] (Bioassay, Mouse)
• S Peng, D Stojkov, J Gao, K Oberson, P Latzin, C Casaulta, S Yousefi, HU Simon Nascent RHOH acts as a molecular brake on actomyosin-mediated effector functions of inflammatory neutrophils PloS Biology, 2022-09-15;20(9):e3001794. 2022-09-15 [PMID: 36108062] (Bioassay, Mouse)
• B Zhu, Y Liu, S Hwang, K Archuleta, H Huang, A Campos, R Murad, J Piña-Cresp, H Xu, TY Huang Trem2 deletion enhances tau dispersion and pathology through microglia exosomes Molecular Neurodegeneration, 2022-09-02;17(1):58. 2022-09-02 [PMID: 36056435] (Bioassay, Mouse)
• PS Sung, YC Peng, SP Yang, CH Chiu, SL Hsieh CLEC5A is critical in Pseudomonas aeruginosa-induced acute lung injury JCI Insight, 2022-09-01;0(0):. 2022-09-01 [PMID: 36048544] (Bioassay, Mouse)
• Maša Filipović, Darja Flegar, Alan Šućur, Dino Šisl, Inga Kavazović, Mariastefania Antica et al. Inhibition of Notch Signaling Stimulates Osteoclastogenesis From the Common Trilineage Progenitor Under Inflammatory Conditions Frontiers in Immunology 2022-07-05 [PMID: 35865541] (Bioassay, Mouse)
• L Li, Y Chen, MN Sluter, R Hou, J Hao, Y Wu, GY Chen, Y Yu, J Jiang Ablation of Siglec-E augments brain inflammation and ischemic injury Journal of Neuroinflammation, 2022-07-20;19(1):191. 2022-07-20 [PMID: 35858866] (Bioassay, Mouse)
• A Manda-Hand, A Mroczek, W Ku?micka, A Cieloch, Z Homoncik, A Muchowicz, U Demkow, M Wachowska Lack of Functional P110delta Affects Expression of Activation Marker CD80 but Does Not Influence Functions of Neutrophils International Journal of Molecular Sciences, 2022-06-07;23(12):. 2022-06-07 [PMID: 35742807] (Bioassay, Mouse)
• C Probst, S Garcia-San, JT Brooks, I Van Der Kl, O Baars, M Ralle, DJ Thiele, JA Alspaugh Interactions between copper homeostasis and the fungal cell wall affect copper stress resistance PloS Pathogens, 2022-06-23;18(6):e1010195. 2022-06-23 [PMID: 35737716] (Bioassay, Mouse)
• AM Jaeger, LE Stopfer, R Ahn, EA Sanders, DA Sandel, WA Freed-Past, WM Rideout, S Naranjo, T Fessenden, KB Nguyen, PS Winter, RE Kohn, PMK Westcott, JM Schenkel, SL Shanahan, AK Shalek, S Spranger, FM White, T Jacks Deciphering the immunopeptidome in vivo reveals new tumour antigens Nature, 2022-06-15;0(0):. 2022-06-15 [PMID: 35705813] (Bioassay, Mouse)
• Q Li, J Peng, Y Luo, J Zhou, T Li, L Cao, S Peng, Z Zuo, Z Wang Far infrared light irradiation enhances Abeta clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer&#039;s disease-like mice Journal of Neuroinflammation, 2022-06-14;19(1):145. 2022-06-14 [PMID: 35701825] (Bioassay, Mouse)
• SY Park, H Yang, M Ye, X Liu, I Shim, YT Chang, H Bae Neuroprotective effects of ex vivo-expanded regulatory T cells on trimethyltin-induced neurodegeneration in mice Journal of Neuroinflammation, 2022-06-11;19(1):143. 2022-06-11 [PMID: 35690816] (Bioassay, Mouse)
• KY Chyu, X Zhao, J Zhou, PC Dimayuga, NW Lio, B Cercek, NT Trac, EJ Chung, PK Shah Immunization using ApoB-100 peptide-linked nanoparticles reduces atherosclerosis JCI Insight, 2022-06-08;0(0):. 2022-06-08 [PMID: 35536648] (Bioassay, Mouse)
• W Piao, L Li, V Saxena, J Iyyathurai, R Lakhan, Y Zhang, IT Lape, C Paluskievi, KL Hippen, Y Lee, E Silverman, MW Shirkey, LV Riella, BR Blazar, JS Bromberg PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration Nature Communications, 2022-04-21;13(1):2176. 2022-04-21 [PMID: 35449134] (Bioassay, Mouse)
• K Ming-Chin, AA Achuthan, DP De Souza, TJ Lupancu, KJ Binger, MKS Lee, Y Xu, MJ McConville, NA de Weerd, D Dragoljevi, PJ Hertzog, AJ Murphy, JA Hamilton, AJ Fleetwood Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization Cell Reports, 2022-04-19;39(3):110719. 2022-04-19 [PMID: 35443173] (Bioassay, In Vivo, Mouse)
• Z Qu, M Li, R An, H Dai, Y Yu, C Li, C Cao, Y Meng, J Wang, M Gao Self-assembled BPIV3 nanoparticles can induce comprehensive immune responses and protection against BPIV3 challenge by inducing dendritic cell maturation in mice Veterinary Microbiology, 2022-03-31;268(0):109415. 2022-03-31 [PMID: 35395543] (Bioassay, Mouse)
• CJ Ortiz-Boni, TP Uccello, SA Gerber, EM Lord, EM Messing, YF Lee Bladder Cancer Extracellular Vesicles Elicit a CD8 T Cell-Mediated Antitumor Immunity International Journal of Molecular Sciences, 2022-03-08;23(6):. 2022-03-08 [PMID: 35328324] (Bioassay, Mouse)
• V Mela, A Sayd Gaban, E O'Neill, S Bechet, A Walsh, MA Lynch The Modulatory Effects of DMF on Microglia in Aged Mice Are Sex-Specific Cells, 2022-02-18;11(4):. 2022-02-18 [PMID: 35203379] (Bioassay, Mouse)
• CY Wu, CW Cheng, CC Kung, KS Liao, JT Jan, C Ma, CH Wong Glycosite-deleted mRNA of SARS-CoV-2 spike protein as a broad-spectrum vaccine Proceedings of the National Academy of Sciences of the United States of America, 2022-03-01;119(9):. 2022-03-01 [PMID: 35149556] (Bioassay, Mouse)
• T Pock, K Schulte, S Schlatt, M Boiani, V Nordhoff GM-CSF perturbs cell identity in mouse pre-implantation embryos PLoS ONE, 2022-02-10;17(2):e0263793. 2022-02-10 [PMID: 35143564] (Bioassay, Mouse)
• H Potter, L Kendall, T Boyd, S Sillau, A Bosco-Laut, N Markham, D Fong, P Clarke, K Tyler GM-CSF Promotes Immune Response and Survival in a Mouse Model of COVID-19 Research square, 2022-01-26;0(0):. 2022-01-26 [PMID: 35118463] (In Vivo, Mouse)
• JD Hathaway-S, JD Aartun, NA Poulides, MB Kuhn, BE McCormick, ME Chew, E Huang, RP Darveau, C Westwater, CM Novince Commensal oral microbiota induces osteoimmunomodulatory effects separate from systemic microbiome in mice JCI Insight, 2022-02-22;0(0):. 2022-02-22 [PMID: 35077397] (Bioassay, Mouse)
• S Chen, Y Bai, Y Wang, C Liang, K Du, S Wang, J Li, YX Chang Immunosuppressive effect of Columbianadin on maturation, migration, allogenic T cell stimulation and phagocytosis capacity of TNF-alpha induced dendritic cells Journal of ethnopharmacology, 2021-12-14;285(0):114918. 2021-12-14 [PMID: 34919989] (Bioassay, Mouse)
• AW Pountain, JR Collette, WM Farrell, MC Lorenz Interactions of Both Pathogenic and Nonpathogenic CUG Clade Candida Species with Macrophages Share a Conserved Transcriptional Landscape MBio, 2021-12-14;12(6):e0331721. 2021-12-14 [PMID: 34903044] (Bioassay, Mouse)
• X Sheng, Y Yao, R Huang, Y Xu, Y Zhu, L Chen, L Zhang, W Wang, R Zhuo, D Can, CF Chang, YW Zhang, H Xu, G Bu, L Zhong, XF Chen Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology Journal of Neuroinflammation, 2021-12-10;18(1):286. 2021-12-10 [PMID: 34893068] (Bioassay, Mouse)
• SJ Coniglio, JE Segall Microglial-stimulation of glioma invasion involves the EGFR ligand amphiregulin PLoS ONE, 2021-11-29;16(11):e0260252. 2021-11-29 [PMID: 34843542] (Bioassay, Mouse)
• K Umeda, Y Goto, K Watanabe, N Ushio, RM Fereig, F Ihara, S Tanaka, Y Suzuki, Y Nishikawa Transcriptomic Analysis of the Effects of Chemokine Receptor CXCR3 Deficiency on Immune Responses in the Mouse Brain during Toxoplasma gondii Infection Microorganisms, 2021-11-12;9(11):. 2021-11-12 [PMID: 34835465] (Bioassay, Mouse)
• J Pei, NR Beri, AJ Zou, P Hubel, HK Dorando, V Bergant, RD Andrews, J Pan, JM Andrews, KCF Sheehan, A Pichlmair, GK Amarasingh, SL Brody, JE Payton, DW Leung Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription Cell Reports, 2021-10-12;37(2):109803. 2021-10-12 [PMID: 34644581] (Bioassay, Human)
• J Hu, C Wang, X Huang, S Yi, S Pan, Y Zhang, G Yuan, Q Cao, X Ye, H Li Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling Cell Reports, 2021-09-21;36(12):109726. 2021-09-21 [PMID: 34551302] (Bioassay, Mouse)
• TT Chu, X Tu, K Yang, J Wu, JJ Repa, N Yan Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C Nature, 2021-07-21;0(0):. 2021-07-21 [PMID: 34290407] (Bioassay, Mouse)
• T Imai Single Amino Acid Deletion at N-Terminus of the Target Antigen in DNA Vaccine Induces Altered CD8+ T Cell Responses against Tumor Antigen Vaccines, 2021-05-21;9(6):. 2021-05-21 [PMID: 34063920] (Bioassay, Mouse)
• NC DeVito, M Sturdivant, B Thievanthi, C Xiao, MP Plebanek, AKS Salama, GM Beasley, A Holtzhause, V Novotny-Di, JH Strickler, BA Hanks Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy Cell Reports, 2021-05-04;35(5):109071. 2021-05-04 [PMID: 33951424] (Bioassay, Mouse)
• D Wan, S Ai, H Ouyang, L Cheng Activation of 4-1BB signaling in bone marrow stromal cells triggers bone loss via the p-38 MAPK-DKK1 axis in aged mice Experimental & Molecular Medicine, 2021-04-15;0(0):. 2021-04-15 [PMID: 33859350] (Bioassay, Mouse)
• LT Wang, MH Lin, KY Liu, SS Chiou, SN Wang, CY Chai, LW Tseng, HC Chiou, HC Wang, KK Yokoyama, SH Hsu, SK Huang WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism Autophagy, 2021-04-14;0(0):1-16. 2021-04-14 [PMID: 33853474] (Bioassay, Mouse)
• Y Wang, M Song, M Liu, G Zhang, X Zhang, MO Li, X Ma, JJ Zhang, XY Huang Fascin inhibitor increases intratumoral dendritic cell activation and anti-cancer immunity Cell Reports, 2021-04-06;35(1):108948. 2021-04-06 [PMID: 33826900] (Bioassay, Mouse)
• M Bednarczyk, C Medina-Mon, FJ Fittler, H Stege, M Roskamp, M Kuske, C Langer, M Vahldieck, E Montermann, I Tubbe, N Röhrig, A Dzionek, S Grabbe, M Bros Complement-Opsonized Nano-Carriers Are Bound by Dendritic Cells (DC) via Complement Receptor (CR)3, and by B Cell Subpopulations via CR-1/2, and Affect the Activation of DC and B-1 Cells International Journal of Molecular Sciences, 2021-03-11;22(6):. 2021-03-11 [PMID: 33799879] (Bioassay, Mouse)
• R Joseph, R Soundarara, S Vasaikar, F Yang, KL Allton, L Tian, P den Hollan, S Isgandarov, M Haemmerle, B Mino, T Zhou, C Shin, M Martinez-P, AA Sahin, J Rodriguez-, J Gelovani, JT Chang, G Acharya, AK Sood, II Wistuba, DL Gibbons, LM Solis, MC Barton, N Varadaraja, JM Rosen, XH Zhang, SA Mani CD8+ T cells inhibit metastasis and CXCL4 regulates its function British Journal of Cancer, 2021-04-01;0(0):. 2021-04-01 [PMID: 33795809] (Bioassay, Mouse)
• H Shi, L Sun, Y Wang, A Liu, X Zhan, X Li, M Tang, P Anderton, S Hildebrand, J Quan, S Ludwig, EMY Moresco, B Beutler N4BP1 negatively regulates NF-&amp;kappaB by binding and inhibiting NEMO oligomerization Nature Communications, 2021-03-02;12(1):1379. 2021-03-02 [PMID: 33654074] (Bioassay, Mouse)
• N Germic, T Fettrelet, D Stojkov, A Hosseini, MP Horn, A Karaulov, D Simon, S Yousefi, HU Simon The Release Kinetics of Eosinophil Peroxidase and Mitochondrial DNA Is Different in Association with Eosinophil Extracellular Trap Formation Cells, 2021-02-03;10(2):. 2021-02-03 [PMID: 33546138] (Bioassay, Human, Mouse)
• SJ Gurczynski, NL Pereira, SM Hrycaj, C Wilke, RL Zemans, BB Moore Stem cell transplantation uncovers TDO-AHR regulation of lung dendritic cells in herpesvirus-induced pathology JCI Insight, 2021-01-25;6(2):. 2021-01-25 [PMID: 33491663] (Bioassay, Mouse)
• RK Arya, R Goswami, SO Rahaman Mechanotransduction via a TRPV4-Rac1 signaling axis plays a role in multinucleated giant cell formation The Journal of Biological Chemistry, 2020-01-01;296(0):100129. 2020-01-01 [PMID: 33460921] (Bioassay, Mouse)
• H Wang, X Teng, G Abboud, W Li, S Ye, L Morel D-mannose ameliorates autoimmune phenotypes in mouse models of lupus BMC immunology, 2021-01-05;22(1):1. 2021-01-05 [PMID: 33402096] (Bioassay, Mouse)
• C Delaney, M Farrell, CP Doherty, K Brennan, E O'Keeffe, C Greene, K Byrne, E Kelly, N Birmingham, P Hickey, S Cronin, SN Savvides, SL Doyle, M Campbell Attenuated CSF-1R signalling drives cerebrovascular pathology Embo Molecular Medicine, 2020-12-22;0(0):e12889. 2020-12-22 [PMID: 33350588] (Cell Culture, Mouse)
• G Gupta, Z Mou, P Jia, R Sharma, R Zayats, SM Viana, L Shan, A Barral, VS Boaventura, TT Murooka, A Soussi-Gou, CI de Oliveir, JE Uzonna The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response Cell Reports, 2020-12-15;33(11):108513. 2020-12-15 [PMID: 33326783] (Bioassay, Transgenic Mouse)
• MJ Park, JA Baek, SY Kim, KA Jung, JW Choi, SH Park, SK Kwok, ML Cho Myeloid-derived suppressor cells therapy enhance immunoregulatory properties in acute graft versus host disease with combination of regulatory T cells Journal of Translational Medicine, 2020-12-14;18(1):483. 2020-12-14 [PMID: 33317573] (Bioassay, Mouse)
• RK Arya, R Goswami, SO Rahaman Mechanotransduction via a TRPV4-Rac1 signaling axis plays a role in multinucleated giant cell formation The Journal of Biological Chemistry, 2020-12-04;0(0):. 2020-12-04 [PMID: 33262217] (Cell Culture, Mouse)
• N Zhao, W Dong, H Kim, R Moallemian, J Lv, H Wang, H Zheng, F Wei, X Ma Capping protein regulator and myosin 1 linker 3 regulates transcription of key cytokines in activated phagocytic cells Cell Signal, 2020-11-24;78(0):109848. 2020-11-24 [PMID: 33246003] (Cell Culture, Mouse)
• YM Hyun, SU Seo, WS Choi, HJ Kwon, DY Kim, S Jeong, GY Kang, E Yi, M Kim, HJ Ryu, MR Looney, EY Choi, HS Kim Endogenous DEL-1 restrains melanoma lung metastasis by limiting myeloid cell-associated lung inflammation Sci Adv, 2020-11-06;6(45):. 2020-11-06 [PMID: 33158867] (Bioassay, In Vivo, Mouse)
• TO Khaliullin, ER Kisin, S Guppi, N Yanamala, V Zhernovkov, AA Shvedova Differential responses of murine alveolar macrophages to elongate mineral particles of asbestiform and non-asbestiform varieties: Cytotoxicity, cytokine secretion and transcriptional changes Toxicology and Applied Pharmacology, 2020-10-24;409(0):115302. 2020-10-24 [PMID: 33148505] (Cell Culture, Mouse)
• Z Liu, J Ning, X Zheng, J Meng, L Han, H Zheng, L Zhong, XF Chen, X Zhang, H Luo, D Can, H Xu, YW Zhang TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities Cell Death Dis, 2020-08-13;11(8):678. 2020-08-13 [PMID: 32826884] (Bioassay, Mouse)
• ME McCauley, JG O'Rourke, A Yáñez, JL Markman, R Ho, X Wang, S Chen, D Lall, M Jin, AKMG Muhammad, S Bell, J Landeros, V Valencia, M Harms, M Arditi, C Jefferies, RH Baloh C9orf72 in myeloid cells suppresses STING-induced inflammation Nature, 2020-08-19;585(7823):96-101. 2020-08-19 [PMID: 32814898] (Bioassay, Mouse, Transgenic Mouse)
• M Koide, T Yamashita, K Murakami, S Uehara, K Nakamura, M Nakamura, M Matsushita, T Ara, H Yasuda, JM Penninger, N Takahashi, N Udagawa, Y Kobayashi Sclerostin expression in trabecular bone is downregulated by osteoclasts Sci Rep, 2020-08-13;10(1):13751. 2020-08-13 [PMID: 32792620] (Bioassay, Cell Culture, Mouse)
• K Maruyama, H Kidoya, N Takemura, E Sugisawa, O Takeuchi, T Kondo, MMA Eid, H Tanaka, MM Martino, N Takakura, Y Takayama, S Akira, A Vandenbon, Y Kumagai Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages Cell Rep, 2020-07-14;32(2):107906. 2020-07-14 [PMID: 32668247] (Bioassay, Mouse)
• X Hong, X Zhong, G Du, Y Hou, Y Zhang, Z Zhang, T Gong, L Zhang, X Sun The pore size of mesoporous silica nanoparticles regulates their antigen delivery efficiency Sci Adv, 2020-06-19;6(25):eaaz4462. 2020-06-19 [PMID: 32596445] (Bioassay, Mouse)
• J Lee, S Boyce, J Powers, C Baer, CM Sassetti, SM Behar CD11cHi�monocyte-derived macrophages are a major cellular compartment infected by Mycobacterium tuberculosis PLoS Pathog., 2020-06-16;16(6):e1008621. 2020-06-16 [PMID: 32544188] (Bioassay, Mouse)
• M Kubota, E Iizasa, Y Chuuma, H Kiyohara, H Hara, H Yoshida Adjuvant activity of Mycobacteria-derived mycolic acids Heliyon, 2020-05-27;6(5):e04064. 2020-05-27 [PMID: 32490252] (Bioassay, Mouse)
• KM Lee, Z Zhang, A Achuthan, AJ Fleetwood, JE Smith, JA Hamilton, AD Cook IL-23 in arthritic and inflammatory pain development in mice Arthritis Res. Ther., 2020-05-29;22(1):123. 2020-05-29 [PMID: 32471485] (In Vivo, Mouse)
• EJ Thak, SB Lee, S Xu-Vanpala, DJ Lee, SY Chung, YS Bahn, DB Oh, ML Shinohara, HA Kang Core N-Glycan Structures Are Critical for the Pathogenicity of Cryptococcus neoformans by Modulating Host Cell Death MBio, 2020-05-12;11(3):. 2020-05-12 [PMID: 32398313] (Cell Culture, Mouse)
• X Guo, Y Pan, M Xiong, S Sanapala, C Anastasaki, O Cobb, S Dahiya, DH Gutmann Midkine activation of CD8+ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth Nat Commun, 2020-05-01;11(1):2177. 2020-05-01 [PMID: 32358581] (Cell Culture, Mouse)
• W Lin, Y Xu, X Chen, J Liu, Y Weng, Q Zhuang, F Lin, Z Huang, S Wu, J Ding, L Chen, X Qiu, L Zhang, J Wu, D Lin, S Qiu Radiation-induced small extracellular vesicles as &quot;carriages&quot; promote tumor antigen release and trigger antitumor immunity Theranostics, 2020-03-26;10(11):4871-4884. 2020-03-26 [PMID: 32308755] (Cell Culture, Mouse)
• H Fan, D Li, X Guan, Y Yang, J Yan, J Shi, R Ma, Q Shu MsrA Suppresses Inflammatory Activation of Microglia and Oxidative Stress to Prevent Demyelination via Inhibition of the NOX2-MAPKs/NF-&amp;kappaB Signaling Pathway Drug Des Devel Ther, 2020-04-05;14(0):1377-1389. 2020-04-05 [PMID: 32308370] (Bioassay, Mouse)
• A Rossi, V Lucarini, I Macchia, P Sestili, C Buccione, S Donati, M Ciccolella, A Sistigu, MT D'Urso, AM Pacca, E Cardarelli, F Mattei, E Proietti, G Schiavoni, L Bracci Tumor-Intrinsic or Drug-Induced Immunogenicity Dictates the Therapeutic Success of the PD1/PDL Axis Blockade Cells, 2020-04-10;9(4):. 2020-04-10 [PMID: 32290265] (Bioassay, Mouse)
• C Goda, D Balli, M Black, D Milewski, T Le, V Ustiyan, X Ren, VV Kalinichen, TV Kalin Loss of FOXM1 in macrophages promotes pulmonary fibrosis by activating p38 MAPK signaling pathway PLoS Genet., 2020-04-09;16(4):e1008692. 2020-04-09 [PMID: 32271749] (Bioassay, Mouse)
• Y Zhao, J Wang, Z Min, L Peng, S Qi, W Lin I-alowCD11bhigh DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis Mediators Inflamm., 2020-03-10;2020(0):6947482. 2020-03-10 [PMID: 32256194] (Bioassay, Mouse)
• CA von Roemel, Y Wang, Y Qie, H Yuan, H Zhao, X Liu, Z Yang, M Yang, W Deng, KA Bruno, CK Chan, AS Lee, SS Rosenfeld, K Yun, AJ Johnson, DA Mitchell, W Jiang, BYS Kim Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity Nat Commun, 2020-03-20;11(1):1508. 2020-03-20 [PMID: 32198351] (Cell Culture, Mouse)
• M Viaud, O Abdel-Waha, J Gall, S Ivanov, R Guinamard, S Sore, J Merlin, M Ayrault, E Guilbaud, A Jacquel, P Auberger, N Wang, RL Levine, AR Tall, L Yvan-Charv ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative Neoplasms Cell Rep, 2020-03-10;30(10):3397-3410.e5. 2020-03-10 [PMID: 32160545] (Bioassay, Mouse)
• S Elesela, SB Morris, S Narayanan, S Kumar, DB Lombard, NW Lukacs Sirtuin 1 regulates mitochondrial function and immune homeostasis in respiratory syncytial virus infected dendritic cells PLoS Pathog., 2020-02-27;16(2):e1008319. 2020-02-27 [PMID: 32106265] (Bioassay, Mouse)
• S Somanathan, R Calcedo, JM Wilson Adenovirus-Antibody Complexes Contributed to Lethal Systemic Inflammation in a Gene Therapy Trial Mol. Ther., 2020-02-07;0(0):. 2020-02-07 [PMID: 32035027] (Cell Culture, Mouse)
• D Tewari, AD Cook, MC Lee, AD Christense, A Croxford, B Becher, D Poole, P Rajasekhar, N Bunnett, JE Smith, JA Hamilton, SB McMahon Granulocyte-macrophage colony stimulating factor as an indirect mediator of nociceptor activation and pain J. Neurosci., 2020-02-04;0(0):. 2020-02-04 [PMID: 32019828] (In Vivo, Mouse)
• MH Chen, MT Huang, WK Yu, SS Lee, JH Wang, TR Cheng, MR Bowman, SL Hsieh Antibody blockade of Dectin-2 suppresses house dust mite-induced Th2 cytokine production in dendritic cell- and monocyte-depleted peripheral blood mononuclear cell co-cultures from asthma patients J. Biomed. Sci., 2019-12-20;26(1):97. 2019-12-20 [PMID: 31861989] (Cell Culture, Mouse)
• MM de Rezende, JP Ng-Blichfe, GZ Justo, EJ Paredes-Ga, R Gosens Divergent effects of Wnt5b on IL-3- and GM-CSF-induced myeloid differentiation Cell. Signal., 2019-12-17;67(0):109507. 2019-12-17 [PMID: 31857239] (Bioassay, Mouse)
• L Wu, Z Luo, Y Liu, L Jia, Y Jiang, J Du, L Guo, Y Bai, Y Liu Aspirin inhibits RANKL-induced osteoclast differentiation in dendritic cells by suppressing NF-kappaB and NFATc1 activation Stem Cell Res Ther, 2019-12-05;10(1):375. 2019-12-05 [PMID: 31805984] (Bioassay, Mouse)
• AI Birmpilis, CE Karachalio, P Samara, K Ioannou, P Selemenaki, IV Kostopoulo, N Kavrochori, H Kalbacher, E Livaniou, S Haralambou, A Kotsinas, F Farzaneh, IP Trougakos, W Voelter, MA Dimopoulos, A Bamias, O Tsitsiloni Antitumor Reactive T-Cell Responses Are Enhanced In Vivo by DAMP Prothymosin Alpha and Its C-Terminal Decapeptide Cancers (Basel), 2019-11-09;11(11):. 2019-11-09 [PMID: 31717548] (In Vivo, Mouse)
• J Nagai, B Balestrier, LB Fanning, T Kyin, H Cirka, J Lin, M Idzko, A Zech, EY Kim, PJ Brennan, JA Boyce P2Y6 signaling in alveolar macrophages prevents leukotriene-dependent type 2 allergic lung inflammation J. Clin. Invest., 2019-12-02;0(0):. 2019-12-02 [PMID: 31638598] (Bioassay, Mouse)
• CC Hsieh, CH Hung, M Chiang, YC Tsai, JT He Hepatic Stellate Cells Enhance Liver Cancer Progression by Inducing Myeloid-Derived Suppressor Cells through Interleukin-6 Signaling Int J Mol Sci, 2019-10-13;20(20):. 2019-10-13 [PMID: 31614930] (Bioassay, Mouse)
• LP Garo, AK Ajay, M Fujiwara, V Beynon, C Kuhn, G Gabriely, S Sadhukan, R Raheja, S Rubino, HL Weiner, G Murugaiyan Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity Cell Rep, 2019-09-24;28(13):3353-3366.e5. 2019-09-24 [PMID: 31553906] (Cell Culture, Mouse)
• LP Araujo, JT Maricato, MG Guereschi, MC Takenaka, VM Nascimento, FM de Melo, FJ Quintana, PC Brum, AS Basso The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells Cell Rep, 2019-09-17;28(12):3120-3130.e5. 2019-09-17 [PMID: 31533035] (Cell Culture, Mouse)
• T Ondee, J Gillen, P Visitchana, P Somparn, J Issara-Amp, C Dang Phi, W Chancharoe, D Gurusamy, A Nita-Lazar, A Leelahavan Lipocalin-2 (Lcn-2) Attenuates Polymicrobial Sepsis with LPS Preconditioning (LPS Tolerance) in FcGRIIb Deficient Lupus Mice Cells, 2019-09-11;8(9):. 2019-09-11 [PMID: 31514375] (Bioassay, Mouse)
• KS Cho, SA Kang, SD Kim, SJ Mun, HS Yu, HJ Roh Dendritic cells and M2 macrophage play an important role in suppression of Th2-mediated inflammation by adipose stem cells-derived extracellular vesicles Stem Cell Res, 2019-07-12;39(0):101500. 2019-07-12 [PMID: 31344653] (Bioassay, Mouse)
• T Martinov, LA Swanson, ER Breed, CG Tucker, AJ Dwyer, JK Johnson, JS Mitchell, NL Sahli, JC Wilson, LM Singh, KA Hogquist, JA Spanier, BT Fife Programmed Death-1 Restrains the Germinal Center in Type 1 Diabetes J. Immunol., 2019-07-19;0(0):. 2019-07-19 [PMID: 31324724] (Bioassay, Mouse)
• H Prill, A Luu, B Yip, J Holtzinger, MJ Lo, TM Christians, G Yogalingam, M Aoyagi-Sch, JH LeBowitz, BE Crawford, R Lawrence Differential Uptake of NAGLU-IGF2 and Unmodified NAGLU in Cellular Models of Sanfilippo Syndrome Type B Mol Ther Methods Clin Dev, 2019-05-24;14(0):56-63. 2019-05-24 [PMID: 31309128] (Bioassay, Mouse)
• S Sharif, N Ueda, Y Nakatani, LM Wise, S Clifton, Z Lateef, AA Mercer, SB Fleming Chemokine-Binding Proteins Encoded by Parapoxvirus of Red Deer of New Zealand Display Evidence of Gene Duplication and Divergence of Ligand Specificity Front Microbiol, 2019-06-25;10(0):1421. 2019-06-25 [PMID: 31293551] (Cell Culture, Mouse)
• R Zhao, X Shao, G Jia, Y Huang, Z Liu, B Song, J Hou Anti-cervical carcinoma effect of Portulaca oleracea L. polysaccharides by oral administration on intestinal dendritic cells BMC Complement Altern Med, 2019-07-05;19(1):161. 2019-07-05 [PMID: 31277622] (Bioassay, Mouse)
• VV Kurilin, JN Khantakova, VP Tereschenk, JA Lopatnikov, IA Obleukhova, SV Sennikov The Effects of Immunosuppressive Factors on Primary Dendritic Cells from C57BL/6 and CBA Mice J Immunol Res, 2019-04-18;2019(0):7029726. 2019-04-18 [PMID: 31143783] (Bioassay, Mouse)
• ML Capitano, N Mor-Vaknin, AK Saha, S Cooper, M Legendre, H Guo, R Contreras-, F Kappes, MA Sartor, CT Lee, X Huang, DM Markovitz, HE Broxmeyer Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling J. Clin. Invest., 2019-05-20;130(0):2555-2570. 2019-05-20 [PMID: 31107242] (Bioassay, Mouse)
• M Bossowska-, MB Mielcarska, M Romaniewic, MM Kaczmarek, KP Gregorczyk, J Struzik, M Grodzik, MM Giery?ska, FN Toka, L Szulc-D?br Ectromelia virus suppresses expression of cathepsins and cystatins in conventional dendritic cells to efficiently execute the replication process BMC Microbiol., 2019-05-10;19(1):92. 2019-05-10 [PMID: 31077130] (Bioassay, Mouse)
• C Li, L Dong, R Su, Y Bi, Y Qing, X Deng, Y Zhou, C Hu, M Yu, H Huang, X Jiang, X Li, X He, D Zou, C Shen, L Han, M Sun, J Skibbe, K Ferchen, X Qin, H Weng, H Huang, C Song, J Chen, J Jin Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC Haematologica, 2019-04-11;0(0):. 2019-04-11 [PMID: 30975912] (Bioassay, Mouse)
• B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, JJ Kwan, KR Brown, E Titus, M Atkins, KSK Chan, L Munsie, A Habsid, H Han, M Kennedy, B Cohen, G Keller, J Moffat Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies Cell Rep, 2019-04-09;27(2):599-615.e12. 2019-04-09 [PMID: 30970261] (Differentiation, Differentiation, Human)
• T Matsumura, T Ikebe, K Arikawa, M Hosokawa, M Aiko, A Iguchi, I Togashi, S Kai, S Ohara, N Ohara, M Ohnishi, H Watanabe, K Kobayashi, H Takeyama, S Yamasaki, Y Takahashi, M Ato Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice Cell Rep, 2019-04-09;27(2):561-571.e6. 2019-04-09 [PMID: 30970258] (Bioassay, Mouse)
• J Wang, J Sun, LN Liu, DB Flies, X Nie, M Toki, J Zhang, C Song, M Zarr, X Zhou, X Han, KA Archer, T O'Neill, RS Herbst, AN Boto, MF Sanmamed, S Langermann, DL Rimm, L Chen Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy Nat. Med., 2019-03-04;0(0):. 2019-03-04 [PMID: 30833750] (Bioassay, Mouse)
• M Ahn, DE Anderson, Q Zhang, CW Tan, BL Lim, K Luko, M Wen, WN Chia, S Mani, LC Wang, JHJ Ng, RM Sobota, CA Dutertre, F Ginhoux, ZL Shi, AT Irving, LF Wang Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host Nat Microbiol, 2019-02-25;0(0):. 2019-02-25 [PMID: 30804542] (Bioassay, Mouse)
• K Kramer, F Al-Barwani, MA Baird, VL Young, DS Larsen, VK Ward, SL Young Functionalisation of Virus-Like Particles Enhances Antitumour Immune Responses J Immunol Res, 2019-01-08;2019(0):5364632. 2019-01-08 [PMID: 30729137] (Bioassay, Mouse)
• K Yasuda, Y Kitagawa, R Kawakami, Y Isaka, H Watanabe, G Kondoh, T Kohwi-Shig, S Sakaguchi, K Hirota Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation Nat Commun, 2019-02-01;10(1):549. 2019-02-01 [PMID: 30710091] (Bioassay, Mouse)
• F Ribezzo, IAM Snoeren, S Ziegler, J Stoelben, PA Olofsen, A Henic, MV Ferreira, S Chen, USA Stalmann, G Buesche, RM Hoogenboez, R Kramann, U Platzbecke, MHGP Raaijmaker, BL Ebert, RK Schneider Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome Leukemia, 2019-01-16;0(0):. 2019-01-16 [PMID: 30651631] (Bioassay, Mouse)
• L Zebertavag, S Bambina, J Shugart, A Alice, KD Zens, P Lauer, B Hanson, MJ Gough, MR Crittenden, KS Bahjat A microbial-based cancer vaccine for induction of EGFRvIII-specific CD8+ T cells and anti-tumor immunity PLoS ONE, 2019-01-02;14(1):e0209153. 2019-01-02 [PMID: 30601871] (Neutralization, Mouse)
• Q Tong, Y Zhu, D Zhang, Q Cai, W Qu, CDO Cooper, J Wang, PC McHugh MicroRNA Quantitation During Dendritic Cell Endocytosis Using Imaging Flow Cytometry: Key Factors and Requirements Cell. Physiol. Biochem., 2018-11-21;51(2):793-811. 2018-11-21 [PMID: 30463060] (Bioassay, Mouse)
• A Sturrock, D Woller, A Freeman, K Sanders, R Paine Consequences of Hypoxia for the Pulmonary Alveolar Epithelial Cell Innate Immune Response J. Immunol., 2018-10-31;0(0):. 2018-10-31 [PMID: 30381478] (Cell Culture, Mouse)
• CJ Zhang, M Jiang, H Zhou, W Liu, C Wang, Z Kang, B Han, Q Zhang, X Chen, J Xiao, A Fisher, WJ Kaiser, MA Murayama, Y Iwakura, J Gao, J Carman, A Dongre, G Dubyak, DW Abbott, FD Shi, RM Ransohoff, X Li TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation J. Clin. Invest., 2018-10-29;0(0):. 2018-10-29 [PMID: 30372424] (Bioassay, Mouse)
• A Rubio-Arai, OM Finucane, S Keogh, MA Lynch Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of ?-amyloid J Neuroinflammation, 2018-08-31;15(1):247. 2018-08-31 [PMID: 30170611] (Mouse)
• Y Wang, L Su, MD Morin, BT Jones, Y Mifune, H Shi, KW Wang, X Zhan, A Liu, J Wang, X Li, M Tang, S Ludwig, S Hildebrand, K Zhou, DJ Siegwart, EMY Moresco, H Zhang, DL Boger, B Beutler Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice Proc. Natl. Acad. Sci. U.S.A., 2018-08-27;0(0):. 2018-08-27 [PMID: 30150374] (Bioassay, Mouse)
• W Piao, Y Xiong, K Famulski, CC Brinkman, L Li, N Toney, C Wagner, V Saxena, T Simon, JS Bromberg Regulation of T cell afferent lymphatic migration by targeting LT?R-mediated non-classical NF?B signaling Nat Commun, 2018-08-01;9(1):3020. 2018-08-01 [PMID: 30069025] (Bioassay, Mouse)
• S Srivastava, E Katorcha, N Makarava, JP Barrett, DJ Loane, IV Baskakov Inflammatory response of microglia to prions is controlled by sialylation of PrPSc Sci Rep, 2018-07-27;8(1):11326. 2018-07-27 [PMID: 30054538]
• CC Hsieh, CL Lin, JT He, M Chiang, Y Wang, YC Tsai, CH Hung, PJ Chang Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice Stem Cell Res Ther, 2018-07-04;9(1):183. 2018-07-04 [PMID: 29973247] (Bioassay, Mouse)
• SK Tasian, JA Casas, D Posocco, S Gandre-Bab, AL Gagne, G Liang, ML Loh, MJ Weiss, DL French, ST Chou Mutation-specific signaling profiles and kinase inhibitor sensitivities of juvenile myelomonocytic leukemia revealed by induced pluripotent stem cells Leukemia, 2018-06-08;0(0):. 2018-06-08 [PMID: 29884903] (Bioassay, Mouse)
• SK Esher, KS Ost, MA Kohlbrenne, KM Pianalto, CL Telzrow, A Campuzano, CB Nichols, C Munro, FL Wormley, JA Alspaugh Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition PLoS Pathog., 2018-06-04;14(6):e1007126. 2018-06-04 [PMID: 29864141] (Bioassay, Mouse)
• A Rasheed, R Tsai, CL Cummins Loss of the Liver X Receptors Disrupts the Balance of Hematopoietic Populations, With Detrimental Effects on Endothelial Progenitor Cells J Am Heart Assoc, 2018-05-08;7(10):. 2018-05-08 [PMID: 29739800] (Bioassay, Mouse)
• S Kinsella, M Fichtner, O Watters, HG König, JHM Prehn Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation J Neuroinflammation, 2018-05-02;15(1):130. 2018-05-02 [PMID: 29720226] (Bioassay, Mouse)
• R Nagase, D Inoue, A Pastore, T Fujino, HA Hou, N Yamasaki, S Goyama, M Saika, A Kanai, Y Sera, S Horikawa, Y Ota, S Asada, Y Hayashi, KC Kawabata, R Takeda, HF Tien, H Honda, O Abdel-Waha, T Kitamura Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation J. Exp. Med., 2018-04-11;0(0):. 2018-04-11 [PMID: 29643185] (Bioassay, Mouse)
• LH Chu, M Indramohan, RA Ratsimandr, A Gangopadhy, EP Morris, DM Monack, A Dorfleutne, C Stehlik The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages Nat Commun, 2018-03-08;9(1):996. 2018-03-08 [PMID: 29520027] (Bioassay, Mouse)
• Y Zhao, X Wu, X Li, LL Jiang, X Gui, Y Liu, Y Sun, B Zhu, JC Piña-Cresp, M Zhang, N Zhang, X Chen, G Bu, Z An, TY Huang, H Xu TREM2 Is a Receptor for ?-Amyloid that Mediates Microglial Function Neuron, 2018-03-07;97(5):1023-1031.e7. 2018-03-07 [PMID: 29518356] (Bioassay, Mouse)
• B Sun, L Zhu, Y Tao, HX Sun, Y Li, P Wang, Y Hou, Y Zhao, X Zhang, L Zhang, N Na, Y Zhao Characterization and allergic role of IL-33-induced neutrophil polarization Cell. Mol. Immunol., 2018-03-05;0(0):. 2018-03-05 [PMID: 29503441] (Bioassay, Mouse)
• H Wang, L Bei, CA Shah, W Huang, LC Platanias, EA Eklund The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia Oncogene, 2018-02-20;0(0):. 2018-02-20 [PMID: 29459712] (Bioassay, Mouse)
• D Szpak, L Izem, D Verbovetsk, DA Soloviev, VP Yakubenko, E Pluskota ?M?2Is Antiatherogenic in Female but Not Male Mice J. Immunol., 2018-02-19;0(0):. 2018-02-19 [PMID: 29459405] (Bioassay, Mouse)
• AM Nixon, E Neely, IA Simpson, JR Connor The role of HFE genotype in macrophage phenotype J Neuroinflammation, 2018-02-01;15(1):30. 2018-02-01 [PMID: 29391061] (Bioassay, Mouse)
• SA O'Sullivan, C O'Sullivan, LM Healy, KK Dev, GK Sheridan Sphingosine 1-phosphate receptors regulate TLR4-induced CXCL5 release from astrocytes and microglia J. Neurochem., 2018-02-21;0(0):. 2018-02-21 [PMID: 29377126] (Bioassay, Mouse)
• YS Kim, MN Kim, KE Lee, JY Hong, MS Oh, SY Kim, KW Kim, MH Sohn Activated leukocyte cell adhesion molecule (ALCAM/CD166) regulates T cell responses in a murine model of food allergy Clin. Exp. Immunol., 2018-02-20;0(0):. 2018-02-20 [PMID: 29363753] (Bioassay, Mouse)
• F Borriello, C Pietrasant, JCY Lai, LM Walsh, P Sharma, DN O'Driscoll, J Ramirez, S Brightman, L Pugni, F Mosca, DJ Burkhart, DJ Dowling, O Levy Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization Front Immunol, 2017-12-12;8(0):1772. 2017-12-12 [PMID: 29312305] (Bioassay, Mouse)
• M Zhang, L Chun, V Sandoval, H Graor, J Myers, J Nthale, P Rauhe, Z Senders, K Choong, AY Huang, J Kim Systemic administration of ?-glucan of 200�kDa modulates melanoma microenvironment and suppresses metastatic cancer Oncoimmunology, 2017-10-30;7(2):e1387347. 2017-10-30 [PMID: 29308312] (Cell Culture, Mouse)
• J Ahn, S Son, SC Oliveira, GN Barber STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis Cell Rep, 2017-12-26;21(13):3873-3884. 2017-12-26 [PMID: 29281834] (Bioassay, Mouse)
• BF Westendorp, NVJA Büller, ON Karpus, WA van Dop, J Koster, R Versteeg, PJ Koelink, CY Snel, S Meisner, JJTH Roelofs, A Uhmann, E Ver Loren, J Heijmans, H Hahn, V Muncan, ME Wildenberg, GR van den Br Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response Cell Mol Gastroenterol Hepatol, 2017-09-05;5(1):67-82.e1. 2017-09-05 [PMID: 29276753] (Bioassay, Mouse)
• J Laiño, A Wangorsch, F Blanco, S Wolfheimer, M Krause, A Flaczyk, TM Möller, M Tsai, S Galli, S Vieths, M Toda, S Scheurer, S Schülke Targeting of Immune Cells by Dual TLR2/7 Ligands Suppresses Features of Allergic Th2 Immune Responses in Mice J Immunol Res, 2017-10-24;2017(0):7983217. 2017-10-24 [PMID: 29204451] (Bioassay, Mouse)
• A Floudas, CD Cluxton, J Fahel, AR Khan, SP Saunders, S Amu, A Alcami, PG Fallon Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A PLoS Negl Trop Dis, 2017-10-26;11(10):e0006012. 2017-10-26 [PMID: 29073139] (Bioassay, Mouse)
• C Song, H Phuengkham, SY Kim, MS Lee, JH Jeong, SJ Shin, YT Lim Aminated nanomicelles as a designer vaccine adjuvant to trigger inflammasomes and multiple arms of the innate immune response in lymph nodes Int J Nanomedicine, 2017-10-12;12(0):7501-7517. 2017-10-12 [PMID: 29066896] (Bioassay, Mouse)
• L Parviainen, S Dihanich, GW Anderson, AM Wong, HR Brooks, R Abeti, P Rezaie, G Lalli, S Pope, SJ Heales, HM Mitchison, BP Williams, JD Cooper Glial cells are functionally impaired in juvenile neuronal ceroid lipofuscinosis and detrimental to neurons Acta Neuropathol Commun, 2017-10-17;5(1):74. 2017-10-17 [PMID: 29041969] (Bioassay, Mouse)
• CL Shrestha, KD Assani, H Rinehardt, F Albastroiu, S Zhang, R Shell, AO Amer, LS Schlesinge, BT Kopp Cysteamine-mediated clearance of antibiotic-resistant pathogens in human cystic fibrosis macrophages PLoS ONE, 2017-10-05;12(10):e0186169. 2017-10-05 [PMID: 28982193] (Bioassay, Human)
• S Stefan, K Kirsten, W Sonja, D Nadine, W Andrea, R Andreas, B Peter, P Isabel, G Gabriele, F Fatima, V Stefan, T Masako, S Stephan Conjugation of wildtype and hypoallergenic mugwort allergen Art v 1 to flagellin induces IL-10-DC and suppresses allergen-specific TH2-responses in vivo Sci Rep, 2017-09-18;7(1):11782. 2017-09-18 [PMID: 28924222] (Bioassay, Mouse)
• SM Kim, BR Mun, SJ Lee, Y Joh, HY Lee, KY Ji, HR Choi, EH Lee, EM Kim, JH Jang, HW Song, I Mook-Jung, WS Choi, HS Kang TREM2 promotes A? phagocytosis by upregulating C/EBP?-dependent CD36 expression in microglia Sci Rep, 2017-09-11;7(1):11118. 2017-09-11 [PMID: 28894284] (Bioassay, Mouse)
• DK Chiu, AP Tse, IM Xu, J Di Cui, RK Lai, LL Li, HY Koh, FH Tsang, LL Wei, CM Wong, IO Ng, CC Wong Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma Nat Commun, 2017-09-11;8(1):517. 2017-09-11 [PMID: 28894087] (Bioassay, Mouse)
• CA Sorgi, S Zarini, SA Martin, RL Sanchez, RF Scandiuzzi, MA Gijón, C Guijas, N Flamand, RC Murphy, LH Faccioli Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonic acid Sci Rep, 2017-09-08;7(1):10981. 2017-09-08 [PMID: 28887514] (Bioassay, Mouse)
• JP Antonios, H Soto, RG Everson, DL Moughon, AC Wang, J Orpilla, C Radu, BM Ellingson, JT Lee, T Cloughesy, ME Phelps, J Czernin, LM Liau, RM Prins Detection of immune responses after immunotherapy in glioblastoma using PET and MRI Proc. Natl. Acad. Sci. U.S.A., 2017-09-05;0(0):. 2017-09-05 [PMID: 28874539] (Bioassay, Mouse)
• P Thornton, J Sevalle, MJ Deery, G Fraser, Y Zhou, S Ståhl, EH Franssen, RB Dodd, S Qamar, B Gomez Pere, LS Nicol, S Eketjäll, J Revell, C Jones, A Billinton, PH St George-, I Chessell, DC Crowther TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer&#039;s disease-associated H157Y variant EMBO Mol Med, 2017-10-01;0(0):. 2017-10-01 [PMID: 28855301] (Bioassay, Mouse)
• Andreas Warnecke, Sonja Abele, Sravani Musunuri, Jonas Bergquist, Robert A. Harris Scavenger Receptor A Mediates the Clearance and Immunological Screening of MDA-Modified Antigen by M2-Type Macrophages NeuroMolecular Medicine 2017-12-01 [PMID: 28828577] (Bioassay, Mouse)
• KM Schneider, NB Watson, SB Minchenber, PT Massa The influence of macrophage growth factors on Theiler&#039;s Murine Encephalomyelitis Virus (TMEV) infection and activation of macrophages Cytokine, 2017-08-09;0(0):. 2017-08-09 [PMID: 28800924] (Bioassay, Mouse)
• SJ Kim, YW Jang, KE Hyung, DK Lee, KH Hyun, SY Park, ES Park, KW Hwang Therapeutic Effects of Methanol Extract from Euphorbia kansui Radix on Imiquimod-Induced Psoriasis J Immunol Res, 2017-07-02;2017(0):7052560. 2017-07-02 [PMID: 28761880] (Bioassay, Mouse)
• N Okamoto, K Mizote, H Honda, A Saeki, Y Watanabe, T Yamaguchi-, R Fukui, N Tanimura, Y Motoi, S Akashi-Tak, T Kato, S Fujishita, T Kimura, U Ohto, T Shimizu, T Hirokawa, K Miyake, K Fukase, Y Fujimoto, Y Nagai, K Takatsu Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex J. Biol. Chem., 2017-07-28;0(0):. 2017-07-28 [PMID: 28754693] (Bioassay, Mouse)
• A McDonough, RV Lee, S Noor, C Lee, T Le, M Iorga, JLH Phillips, S Murphy, T Möller, JR Weinstein Ischemia/Reperfusion Induces Interferon Stimulated Gene Expression in Microglia J. Neurosci., 2017-07-26;0(0):. 2017-07-26 [PMID: 28747383] (Bioassay, Mouse)
• AK Savage, HE Liang, RM Locksley The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine J. Immunol., 2017-07-26;0(0):. 2017-07-26 [PMID: 28747343] (Bioassay, Mouse)
• R Uchiyama, S Yonehara, S Taniguchi, S Ishido, KJ Ishii, H Tsutsui Inflammasome and Fas-Mediated IL-1? Contributes to Th17/Th1 Cell Induction in Pathogenic Bacterial Infection In Vivo J. Immunol., 2017-07-03;0(0):. 2017-07-03 [PMID: 28674179] (Bioassay, Mouse)
• L Szulc-D?br, J Struzik, A Ostrowska, M Guzera, FN Toka, M Bossowska-, MM Giery?ska, A Winnicka, Z Nowak, MG Niemia?tow Functional paralysis of GM-CSF-derived bone marrow cells productively infected with ectromelia virus PLoS ONE, 2017-06-12;12(6):e0179166. 2017-06-12 [PMID: 28604814] (Bioassay, Mouse)
• J Zhu, K Yao, J Guo, H Shi, L Ma, Q Wang, H Liu, W Gao, A Sun, Y Zou, J Ge miR-181a and miR-150 regulate dendritic cell immune inflammatory responses and cardiomyocyte apoptosis via targeting JAK1-STAT1/c-Fos pathway J. Cell. Mol. Med., 2017-06-09;0(0):. 2017-06-09 [PMID: 28597963] (Bioassay, Mouse)
• JY Ao, XD Zhu, ZT Chai, H Cai, YY Zhang, KZ Zhang, LQ Kong, N Zhang, BG Ye, DN Ma, HC Sun Colony-stimulating factor 1 receptor blockade inhibits tumor growth by altering the polarization of tumor-associated macrophages in hepatocellular carcinoma Mol. Cancer Ther., 2017-06-01;0(0):. 2017-06-01 [PMID: 28572167] (Bioassay, Mouse)
• J Wang, H Ye, D Zhang, K Cheng, Y Hu, X Yu, L Lu, J Hu, C Zuo, B Qian, Y Yu, S Liu, G Liu, C Mao, S Liu Cancer-derived Circulating MicroRNAs Promote Tumor Angiogenesis by Entering Dendritic Cells to Degrade Highly Complementary MicroRNAs Theranostics, 2017-03-24;7(6):1407-1421. 2017-03-24 [PMID: 28529626] (Bioassay, Mouse)
• CH Son, J Bae, HR Lee, K Yang, YS Park Enhancement of antitumor immunity by combination of anti-CTLA-4 antibody and radioimmunotherapy through the suppression of Tregs Oncol Lett, 2017-03-28;13(5):3781-3786. 2017-03-28 [PMID: 28521478] (Bioassay, Mouse)
• S Ma, X Wan, Z Deng, L Shi, C Hao, Z Zhou, C Zhou, Y Fang, J Liu, J Yang, X Chen, T Li, A Zang, S Yin, B Li, J Plumas, L Chaperot, X Zhang, G Xu, L Jiang, N Shen, S Xiong, X Gao, Y Zhang, H Xiao Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs J. Exp. Med., 2017-04-17;0(0):. 2017-04-17 [PMID: 28416650] (Bioassay, Mouse)
• K Fujiu, M Shibata, Y Nakayama, F Ogata, S Matsumoto, K Noshita, S Iwami, S Nakae, I Komuro, R Nagai, I Manabe A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation Nat. Med., 2017-04-10;23(5):611-622. 2017-04-10 [PMID: 28394333] (In Vivo, Mouse)
• OC Olson, H Kim, DF Quail, EA Foley, JA Joyce Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents Cell Rep, 2017-04-04;19(1):101-113. 2017-04-04 [PMID: 28380350] (Bioassay, Mouse)
• C Zhang, S Wang, J Li, W Zhang, L Zheng, C Yang, T Zhu, R Rong The mTOR signal regulates myeloid-derived suppressor cells differentiation and immunosuppressive function in acute kidney injury Cell Death Dis, 2017-03-23;8(3):e2695. 2017-03-23 [PMID: 28333137] (Bioassay, Mouse)
• Z Solhjou, M Uehara, B Bahmani, OH Maarouf, T Ichimura, CR Brooks, W Xu, M Yilmaz, A Elkhal, SG Tullius, I Guleria, M McGrath, R Abdi Novel application of localized nanodelivery of anti-IL6 protects organ transplant from ischemia reperfusion injuries Am. J. Transplant, 2017-04-18;0(0):. 2017-04-18 [PMID: 28296000] (Bioassay, Mouse)
• AV Kostarnoy, PG Gancheva, B Lepenies, AI Tukhvatuli, AS Dzharullae, NB Polyakov, DA Grumov, DA Egorova, AY Kulibin, MA Bobrov, EA Malolina, PA Zykin, AI Soloviev, E Riabenko, DV Maltseva, DA Sakharov, AG Tonevitsky, LV Verkhovska, DY Logunov, BS Naroditsky, AL Gintsburg Receptor Mincle promotes skin allergies and is capable of recognizing cholesterol sulfate Proc. Natl. Acad. Sci. U.S.A, 2017-03-14;0(0):. 2017-03-14 [PMID: 28292894] (Bioassay, Mouse)
• AE Samarasing, RC Melo, S Duan, KS LeMessurie, S Liedmann, SL Surman, JJ Lee, JL Hurwitz, PG Thomas, JA McCullers Eosinophils Promote Antiviral Immunity in Mice Infected with Influenza A Virus J. Immunol, 2017-03-10;0(0):. 2017-03-10 [PMID: 28283567] (Bioassay, Mouse)
• A Itoh-Nakad, M Matsumoto, H Kato, J Sasaki, Y Uehara, Y Sato, R Ebina-Shib, M Morooka, R Funayama, K Nakayama, K Ochiai, A Muto, K Igarashi A Bach2-Cebp Gene Regulatory Network for the Commitment of Multipotent Hematopoietic Progenitors Cell Rep, 2017-03-07;18(10):2401-2414. 2017-03-07 [PMID: 28273455] (Bioassay, Mouse)
• Q Pu, C Gan, R Li, Y Li, S Tan, X Li, Y Wei, L Lan, X Deng, H Liang, F Ma, M Wu Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis J. Immunol, 2017-03-03;0(0):. 2017-03-03 [PMID: 28258192] (Bioassay, Mouse)
• Q Zheng, X Li, X Cheng, T Cui, Y Zhuo, W Ma, X Zhao, P Zhao, X Liu, W Feng Granulocyte-macrophage colony-stimulating factor increases tumor growth and angiogenesis directly by promoting endothelial cell function and indirectly by enhancing the mobilization and recruitment of proangiogenic granulocytes Tumour Biol, 2017-02-01;39(2):1010428317692. 2017-02-01 [PMID: 28240048] (In Vivo, Mouse)
• HC Watkins, CG Rappazzo, JS Higgins, X Sun, N Brock, A Chau, A Misra, JP Cannizzo, MR King, TR Maines, CA Leifer, GR Whittaker, MP DeLisa, D Putnam Safe Recombinant Outer Membrane Vesicles that Display M2e Elicit Heterologous Influenza Protection Mol. Ther, 2017-02-16;0(0):. 2017-02-16 [PMID: 28215994] (Bioassay, Mouse)
• Y Fang, B Wang, Y Zhao, Z Xiao, J Li, Y Cui, S Han, J Wei, B Chen, J Han, Q Meng, X Hou, J Luo, J Dai, Z Jing Collagen scaffold microenvironments modulate cell lineage commitment for differentiation of bone marrow cells into regulatory dendritic cells Sci Rep, 2017-02-07;7(0):42049. 2017-02-07 [PMID: 28169322] (Bioassay, Mouse)
• Anna Daria Young microglia restore amyloid plaque clearance of aged microglia EMBO J, 2016-12-21;0(0):. 2016-12-21 [PMID: 28007893] (Bioassay, Mouse)
• Sabrina Ceeraz VISTA deficiency accelerates the development of fatal murine lupus nephritis Arthritis & rheumatology (Hoboken, N.J.), 2017-04-01;0(0):. 2017-04-01 [PMID: 27992697] (Bioassay, Mouse)
• Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia Oncogene, 2016-12-19;0(0):. 2016-12-19 [PMID: 27991934] (Bioassay, Mouse)
• LRP1 modulates the microglial immune response via regulation of JNK and NF-?B signaling pathways J Neuroinflammation, 2016-12-08;13(1):304. 2016-12-08 [PMID: 27931217] (Bioassay, Mouse)
• L Ge, NL Vujanovic Soluble TNF Regulates TACE via AP-2? Transcription Factor in Mouse Dendritic Cells J. Immunol., 2016-11-16;198(1):417-427. 2016-11-16 [PMID: 27852742] (Bioassay, Mouse)
• Roles of endoplasmic reticulum stress-mediated apoptosis in M1-polarized macrophages during mycobacterial infections Sci Rep, 2016-11-15;6(0):37211. 2016-11-15 [PMID: 27845414] (Bioassay, Mouse)
• Kazumi Taguchi, Atsushi Okada, Shuzo Hamamoto, Rei Unno, Yoshinobu Moritoki, Ryosuke Ando, Kentaro Mizuno, Keiichi Tozawa, Kenjiro Kohri, Takahiro Yasui M1/M2-macrophage phenotypes regulate renal calcium oxalate crystal development. Scientific Reports, 2016-10-12;0(0):2045-2322. 2016-10-12 [PMID: 27731368] (Bioassay, Mouse)
• Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart Eur J Immunol, 2016-10-25;0(0):. 2016-10-25 [PMID: 27621211] (Bioassay, Mouse)
• Aripiprazole inhibits polyI:C-induced microglial activation possibly via TRPM7 Schizophr Res, 2016-09-07;0(0):. 2016-09-07 [PMID: 27614570] (Bioassay, Mouse)
• Interferon regulatory factor 4 (IRF4) controls myeloid-derived suppressor cell (MDSC) differentiation and function J Leukoc Biol, 2016-09-06;0(0):. 2016-09-06 [PMID: 27601624] (Bioassay, Mouse)
• Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation J Clin Invest, 2016-08-15;0(0):. 2016-08-15 [PMID: 27525438] (In Vivo, Mouse)
• CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells J Leukoc Biol, 2016-08-11;0(0):. 2016-08-11 [PMID: 27515950] (Bioassay, Mouse)
• Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages Sci Rep, 2016-07-13;6(0):29673. 2016-07-13 [PMID: 27406916] (Bioassay, Mouse)
• Hepatitis C Virus Stimulates Murine CD8?-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner PLoS Pathog, 2016-07-06;12(7):e1005736. 2016-07-06 [PMID: 27385030] (Bioassay, Mouse)
• Stefan Schülke A Fusion Protein Consisting of the Vaccine Adjuvant Monophosphoryl Lipid A and the Allergen Ovalbumin Boosts Allergen-Specific Th1, Th2, and Th17 Responses In Vitro J Immunol Res, 2016-06-01;2016(0):4156456. 2016-06-01 [PMID: 27340679] (Bioassay, Mouse)
• Jonatan Ersching A Human Trypanosome Suppresses CD8+ T Cell Priming by Dendritic Cells through the Induction of Immune Regulatory CD4+ Foxp3+ T Cells PLoS Pathog, 2016-06-22;12(6):e1005698. 2016-06-22 [PMID: 27332899] (Bioassay, Mouse)
• Kei Suzuki Structure of the Plexin Ectodomain Bound by Semaphorin-Mimicking Antibodies PLoS ONE, 2016-06-03;11(6):e0156719. 2016-06-03 [PMID: 27258772] (Bioassay, Mouse)
• Mithun Maji A Lipid Based Antigen Delivery System Efficiently Facilitates MHC Class-I Antigen Presentation in Dendritic Cells to Stimulate CD8(+) T Cells Sci Rep, 2016-06-02;6(0):27206. 2016-06-02 [PMID: 27251373] (Bioassay, Mouse)
• Ahmed S Elshikha Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus PLoS ONE, 2016-05-27;11(5):e0156583. 2016-05-27 [PMID: 27232337] (Bioassay, Mouse)
• Bone Marrow CD11c+ Cell-Derived Amphiregulin Promotes Pulmonary Fibrosis J Immunol, 2016-05-20;0(0):. 2016-05-20 [PMID: 27206766] (Bioassay, Mouse)
• Dendritic Cell-Like Cells Accumulate in Regenerating Murine Skeletal Muscle after Injury and Boost Adaptive Immune Responses Only upon a Microbial Challenge PLoS ONE, 2016-05-19;11(5):e0155870. 2016-05-19 [PMID: 27196728] (Bioassay, Mouse)
• Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU) PLoS ONE, 2016-05-19;11(5):e0155953. 2016-05-19 [PMID: 27196432] (Bioassay, Mouse)
• Powerful Complex Immunoadjuvant Based on Synergistic Effect of Combined TLR4 and NOD2 Activation Significantly Enhances Magnitude of Humoral and Cellular Adaptive Immune Responses PLoS ONE, 2016-05-17;11(5):e0155650. 2016-05-17 [PMID: 27187797] (Bioassay, Mouse)
• Tania L Slatter Antitumor cytotoxicity induced by bone-marrow-derived antigen-presenting cells is facilitated by the tumor suppressor protein p53 via regulation of IL-12 Oncoimmunology, 2015-12-17;5(3):e1112941. 2015-12-17 [PMID: 27141366] (Bioassay, Mouse)
• Alternatively activated macrophages determine repair of the infarcted adult murine heart J Clin Invest, 2016-05-03;0(0):. 2016-05-03 [PMID: 27140396] (Bioassay, Mouse)
• The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8+ T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi PLoS Pathog, 2016-04-29;12(4):e1005593. 2016-04-29 [PMID: 27128676] (Bioassay, Mouse)
• D Torres, A Köhler, S Delbauve, I Caminschi, MH Lahoud, K Shortman, V Flamand IL-12p40/IL-10 Producing preCD8?/Clec9A+ Dendritic Cells Are Induced in Neonates upon Listeria monocytogenes Infection PLoS Pathog, 2016-04-13;12(4):e1005561. 2016-04-13 [PMID: 27074026] (Bioassay, Mouse)
• BW Wortham, BL Eppert, JL Flury, SM Garcia, WR Donica, A Osterburg, B Joyce-Shai, DJ Cua, MT Borchers Cutting Edge: CLEC5A Mediates Macrophage Function and Chronic Obstructive Pulmonary Disease Pathologies J. Immunol., 2016-02-29;196(8):3227-31. 2016-02-29 [PMID: 26927798] (Bioassay, Mouse)
• Wang Y, Su L, Morin M, Jones B, Whitby L, Surakattula M, Huang H, Shi H, Choi J, Wang K, Moresco E, Berger M, Zhan X, Zhang H, Boger D, Beutler B TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS. Proc Natl Acad Sci U S A, 2016-02-01;113(7):E884-93. 2016-02-01 [PMID: 26831104] (Bioassay, Mouse)
• Wertz I, Newton K, Seshasayee D, Kusam S, Lam C, Zhang J, Popovych N, Helgason E, Schoeffler A, Jeet S, Ramamoorthi N, Kategaya L, Newman R, Horikawa K, Dugger D, Sandoval W, Mukund S, Zindal A, Martin F, Quan C, Tom J, Fairbrother W, Townsend M, Warming S, DeVoss J, Liu J, Dueber E, Caplazi P, Lee W, Goodnow C, Balazs M, Yu K, Kolumam G, Dixit V Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature, 2015-12-09;528(7582):370-5. 2015-12-09 [PMID: 26649818] (Bioassay, Mouse)
• Chessa F, Mathow D, Wang S, Hielscher T, Atzberger A, Porubsky S, Gretz N, Burgdorf S, Grone H, Popovic Z The renal microenvironment modifies dendritic cell phenotype. Kidney Int, 2016-01-04;0(0):. 2016-01-04 [PMID: 26466317] (Bioassay, Mouse)
• Talaei N, Yu T, Manion K, Bremner R, Wither J Identification of the SLAM Adapter Molecule EAT-2 as a Lupus-Susceptibility Gene That Acts through Impaired Negative Regulation of Dendritic Cell Signaling. J Immunol, 2015-10-02;195(10):4623-31. 2015-10-02 [PMID: 26432891] (Bioassay, Mouse)
• Agrawal K, Kale S, Arora N Protease activity of Per a 10 potentiates Th2 polarization by increasing IL-23 and OX40L. Eur J Immunol, 2015-10-16;45(12):3375-85. 2015-10-16 [PMID: 26417883] (Bioassay, Mouse)
• Sahin E, Brunner J, Kral J, Kuttke M, Hanzl L, Datler H, Paar H, Neuwinger N, Saferding V, Zinser E, Halfmann A, Soukup K, Hainzl E, Lohmeyer T, Niederreiter B, Haider T, Dohnal A, Kronke G, Bluml S, Schabbauer G Loss of Phosphatase and Tensin Homolog in APCs Impedes Th17-Mediated Autoimmune Encephalomyelitis. J Immunol, 2015-08-05;195(6):2560-70. 2015-08-05 [PMID: 26246144] (Bioassay, Mouse)
• Vashishta M, Khan N, Mehto S, Sehgal D, Natarajan K Pneumococal Surface Protein A (PspA) Regulates Programmed Death Ligand 1 Expression on Dendritic Cells in a Toll-Like Receptor 2 and Calcium Dependent Manner. PLoS ONE, 2015-07-27;10(7):e0133601. 2015-07-27 [PMID: 26214513] (Bioassay, Mouse)
• Noman M, Janji B, Hu S, Wu J, Martelli F, Bronte V, Chouaib S Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210. Cancer Res, 2015-07-23;75(18):3771-87. 2015-07-23 [PMID: 26206559] (Bioassay, Mouse)
• Chen M, Liang D, Zuo A, Shao H, Kaplan H, Sun D An A2B Adenosine Receptor Agonist Promotes Th17 Autoimmune Responses in Experimental Autoimmune Uveitis (EAU) via Dendritic Cell Activation. PLoS ONE, 2015-07-06;10(7):e0132348. 2015-07-06 [PMID: 26147733] (Bioassay, Mouse)
• Ptaschinski C, Mukherjee S, Moore M, Albert M, Helin K, Kunkel S, Lukacs N RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo. PLoS Pathog, 2015-06-17;11(6):e1004978. 2015-06-17 [PMID: 26083387] (Bioassay, Mouse)
• Schumacher A, Denecke B, Braunschweig T, Stahlschmidt J, Ziegler S, Brandenburg L, Stope M, Martincuks A, Vogt M, Gortz D, Camporeale A, Poli V, Muller-Newen G, Brummendorf T, Ziegler P Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy. J Hematol Oncol, 2015-06-09;8(0):64. 2015-06-09 [PMID: 26054961] (Bioassay, Mouse)
• Pamir N, Liu N, Irwin A, Becker L, Peng Y, Ronsein G, Bornfeldt K, Duffield J, Heinecke J Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion. J Biol Chem, 2015-04-30;290(23):14656-67. 2015-04-30 [PMID: 25931125] (Bioassay, Mouse)
• Gao F, Liu C, Guo J, Sun W, Xian L, Bai D, Liu H, Cheng Y, Li B, Cui J, Zhang C, Cai J Radiation-driven lipid accumulation and dendritic cell dysfunction in cancer. Sci Rep, 2015-04-29;5(0):9613. 2015-04-29 [PMID: 25923834] (Bioassay, Mouse)
• Wang H, Bei L, Shah C, Hu L, Eklund E HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1. J Immunol, 2015-04-20;194(11):5375-87. 2015-04-20 [PMID: 25895533] (Bioassay, Mouse)
• Lee J, Martinez N, West K, Kornfeld H Differential adjuvant activities of TLR7 and TLR9 agonists inversely correlate with nitric oxide and PGE2 production. PLoS ONE, 2015-04-13;10(4):e0123165. 2015-04-13 [PMID: 25875128] (Bioassay, Mouse)
• Chen , Yan, Zhang , Jin, Lu , Yong, Wang , Libo Immunosuppression in early postnatal days induces persistent and allergen-specific immune tolerance to asthma in adult mice. PLoS ONE, 2015-04-10;10(4):e0122990. 2015-04-10 [PMID: 25860995] (Bioassay, Mouse)
• Raich-Regue D, Rosborough B, Watson A, McGeachy M, Turnquist H, Thomson A mTORC2 Deficiency in Myeloid Dendritic Cells Enhances Their Allogeneic Th1 and Th17 Stimulatory Ability after TLR4 Ligation In Vitro and In Vivo. J Immunol, 2015-04-03;194(10):4767-76. 2015-04-03 [PMID: 25840913] (Bioassay, Mouse)
• Liang X, Liu Y, Mei S, Zhang M, Xin J, Zhang Y, Yang R MicroRNA-22 impairs anti-tumor ability of dendritic cells by targeting p38. PLoS ONE, 2015-03-31;10(3):e0121510. 2015-03-31 [PMID: 25826372] (Bioassay, Mouse)
• Liu X, Ren S, Ge C, Cheng K, Zenke M, Keating A, Zhao R Sca-1+Lin-CD117- mesenchymal stem/stromal cells induce the generation of novel IRF8-controlled regulatory dendritic cells through Notch-RBP-J signaling. J Immunol, 2015-03-30;194(9):4298-308. 2015-03-30 [PMID: 25825436] (Bioassay, Mouse)
• Noh K, Son K, Jung I, Kang T, Choi C, Park Y Glycogen Synthase Kinase-3beta (GSK-3beta) Inhibition Enhances Dendritic Cell-based Cancer Vaccine Potency via Suppression of Interferon-gamma-induced Indoleamine 2,3-Dioxygenase Expression. J Biol Chem, 2015-03-26;290(19):12394-402. 2015-03-26 [PMID: 25814664] (Bioassay, Mouse)
• Shan , Chan-Cha, Shi , Liang-Ro, Ding , Mei-Qian, Zhu , Yi-Bei, Li , Xiao-Don, Xu , Bin, Jiang , Jing-Tin, Wu , Chang-Pi Cytokine-induced killer cells co-cultured with dendritic cells loaded with the protein lysate produced by radiofrequency ablation induce a specific antitumor response. Oncol Lett, 2015-02-17;9(4):1549-1556. 2015-02-17 [PMID: 25788999] (Bioassay, Mouse)
• Park , Minhwa, Kim , Yu-Hee, Ryu , Jung-Hwa, Woo , So-Youn, Ryu , Kyung-Ha Immune suppressive effects of tonsil-derived mesenchymal stem cells on mouse bone-marrow-derived dendritic cells. Stem Cells Int, 2015-02-16;2015(0):106540. 2015-02-16 [PMID: 25784940] (Bioassay, Mouse)
• Nakano H, Moran T, Nakano K, Gerrish K, Bortner C, Cook D Complement receptor C5aR1/CD88 and dipeptidyl peptidase-4/CD26 define distinct hematopoietic lineages of dendritic cells. J Immunol, 2015-03-13;194(8):3808-19. 2015-03-13 [PMID: 25769922] (Bioassay, Mouse)
• Anthony S, Howard M, Hailemichael Y, Overwijk W, Schluns K Soluble interleukin-15 complexes are generated in vivo by type I interferon dependent and independent pathways. PLoS ONE, 2015-03-10;10(3):e0120274. 2015-03-10 [PMID: 25756182] (Bioassay, Mouse)
• Arieta Kuksin C, Gonzalez-Perez G, Minter L CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia. Blood, 2015-02-03;125(13):2087-94. 2015-02-03 [PMID: 25647836] (Bioassay, Mouse)
• Kim J, Kang M, Kim W, Han S, Kim H, Kim H, Kwon K, Kim S, Cha S, Eum S, Koh W, Cho S, Park J, Shin S Essential engagement of Toll-like receptor 2 in initiation of early protective Th1 response against rough variants of Mycobacterium abscessus. Infect Immun, 2015-02-02;83(4):1556-67. 2015-02-02 [PMID: 25644006] (Bioassay, Mouse)
• Scheuplein V, Seifried J, Malczyk A, Miller L, Hocker L, Vergara-Alert J, Dolnik O, Zielecki F, Becker B, Spreitzer I, Konig R, Becker S, Waibler Z, Muhlebach M High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus. J Virol, 2015-01-21;89(7):3859-69. 2015-01-21 [PMID: 25609809] (Bioassay, Mouse)
• Mierzejewska K, Borkowska S, Suszynska E, Suszynska M, Poniewierska-Baran A, Maj M, Pedziwiatr D, Adamiak M, Abdel-Latif A, Kakar S, Ratajczak J, Kucia M, Ratajczak M Hematopoietic stem/progenitor cells express several functional sex hormone receptors-novel evidence for a potential developmental link between hematopoiesis and primordial germ cells. Stem Cells Dev, 2015-03-03;24(8):927-37. 2015-03-03 [PMID: 25607657] (Bioassay, Mouse)
• Sun C, Schattgen S, Pisitkun P, Jorgensen J, Hilterbrand A, Wang L, West J, Hansen K, Horan K, Jakobsen M, O'Hare P, Adler H, Sun R, Ploegh H, Damania B, Upton J, Fitzgerald K, Paludan S Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection. J Immunol, 2015-01-16;194(4):1819-31. 2015-01-16 [PMID: 25595793] (Bioassay, Mouse)
• Yao Y, Matsushima H, Ohtola J, Geng S, Lu R, Takashima A Neutrophil priming occurs in a sequential manner and can be visualized in living animals by monitoring IL-1beta promoter activation. J Immunol, 2014-12-19;194(3):1211-24. 2014-12-19 [PMID: 25527787] (Bioassay, Mouse)
• Miyawaki K, Arinobu Y, Iwasaki H, Kohno K, Tsuzuki H, Iino T, Shima T, Kikushige Y, Takenaka K, Miyamoto T, Akashi K CD41 marks the initial myelo-erythroid lineage specification in adult mouse hematopoiesis: redefinition of murine common myeloid progenitor. Stem Cells, 2015-03-01;33(3):976-87. 2015-03-01 [PMID: 25446279] (Bioassay, Mouse)
• Jacob W, Rosenzweig D, Vazquez-Martin C, Duce S, Cohen P Decreased adipogenesis and adipose tissue in mice with inactivated protein phosphatase 5. Biochem J, 2015-02-15;466(0):163-76. 2015-02-15 [PMID: 25437352] (Bioassay, Mouse)
• Rozman S, Yousefi S, Oberson K, Kaufmann T, Benarafa C, Simon H The generation of neutrophils in the bone marrow is controlled by autophagy. Cell Death Differ, 2014-10-17;22(3):445-56. 2014-10-17 [PMID: 25323583] (Bioassay, Mouse)
• Ye C, Choi J, Abraham S, Shankar P, Manjunath N Targeting DNA vaccines to myeloid cells using a small peptide. Eur J Immunol, 2014-11-02;45(1):82-8. 2014-11-02 [PMID: 25270431] (Bioassay, Mouse)
• Salama A, Fichou N, Allard M, Dubreil L, De Beaurepaire L, Viel A, Jegou D, Bosch S, Bach J MicroRNA-29b modulates innate and antigen-specific immune responses in mouse models of autoimmunity. PLoS ONE, 2014-09-09;9(9):e106153. 2014-09-09 [PMID: 25203514] (Bioassay, Cell Culture, Mouse)
• Kuwahara G, Nishinakamura H, Kojima D, Tashiro T, Kodama S GM-CSF treated F4/80+ BMCs improve murine hind limb ischemia similar to M-CSF differentiated macrophages. PLoS ONE, 2014-09-09;9(9):e106987. 2014-09-09 [PMID: 25202910] (Bioassay, Mouse)
• Pennati A, Deng J, Galipeau J Maltose-binding protein fusion allows for high level bacterial expression and purification of bioactive mammalian cytokine derivatives. PLoS ONE, 2014-09-08;9(9):e106724. 2014-09-08 [PMID: 25198691] (Western Blot)
• Ryzhov S, Pickup M, Chytil A, Gorska A, Zhang Q, Owens P, Feoktistov I, Moses H, Novitskiy S Role of TGF-beta signaling in generation of CD39+CD73+ myeloid cells in tumors. J Immunol, 2014-08-15;193(6):3155-64. 2014-08-15 [PMID: 25127858] (Bioassay, Mouse)
• Ohm I, Alfsnes K, Belland Olsen M, Ranheim T, Sandanger O, Dahl T, Aukrust P, Finsen A, Yndestad A, Vinge L Toll-like receptor 9 mediated responses in cardiac fibroblasts. PLoS ONE, 2014-08-15;9(8):e104398. 2014-08-15 [PMID: 25126740] (Bioassay, Mouse)
• Lee S, Shin S, Lee M, Lee M, Kang T, Park W, Soh B, Park J, Shin Y, Kim H, Yun C, Jung I, Park Y A potential protein adjuvant derived from Mycobacterium tuberculosis Rv0652 enhances dendritic cells-based tumor immunotherapy. PLoS ONE, 2014-08-07;9(8):e104351. 2014-08-07 [PMID: 25102137] (Differentiation, Differentiation, Mouse)
• Sahin E, Haubenwallner S, Kuttke M, Kollmann I, Halfmann A, Dohnal A, Chen L, Cheng P, Hoesel B, Einwallner E, Brunner J, Kral J, Schrottmaier W, Thell K, Saferding V, Bluml S, Schabbauer G Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses. J Immunol, 2014-07-11;193(4):1717-27. 2014-07-11 [PMID: 25015834] (Bioassay, Mouse)
• Boettcher S, Gerosa R, Radpour R, Bauer J, Ampenberger F, Heikenwalder M, Kopf M, Manz M Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis. Blood, 2014-07-02;124(9):1393-403. 2014-07-02 [PMID: 24990886] (Bioassay, Mouse)
• Jung I, Shin S, Lee M, Kang T, Han H, Lee S, Kim W, Kim H, Park W, Kim H, Yun C, Lee E, Wu T, Park Y Enhancement of tumor-specific T cell-mediated immunity in dendritic cell-based vaccines by Mycobacterium tuberculosis heat shock protein X. J Immunol, 2014-07-02;193(3):1233-45. 2014-07-02 [PMID: 24990079] (Bioassay, Mouse)
• Lu H, Lu N, Weng L, Yuan B, Liu Y, Zhang Z DHX15 senses double-stranded RNA in myeloid dendritic cells. J Immunol, 2014-07-02;193(3):1364-72. 2014-07-02 [PMID: 24990078] (Bioassay, Mouse)
• Ilett E, Kottke T, Donnelly O, Thompson J, Willmon C, Diaz R, Zaidi S, Coffey M, Selby P, Harrington K, Pandha H, Melcher A, Vile R Cytokine conditioning enhances systemic delivery and therapy of an oncolytic virus. Mol Ther, 2014-06-24;22(10):1851-63. 2014-06-24 [PMID: 24957982] (In Vivo, Mouse)
• Satchidanandam V, Kumar N, Jumani R, Challu V, Elangovan S, Khan N The glycosylated Rv1860 protein of mycobacterium tuberculosis inhibits dendritic cell mediated TH1 and TH17 polarization of T cells and abrogates protective immunity conferred by BCG. PLoS Pathog, 2014-06-12;10(6):e1004176. 2014-06-12 [PMID: 24945624] (Bioassay, Mouse)
• Wu L, Ong S, Talor M, Barin J, Baldeviano G, Kass D, Bedja D, Zhang H, Sheikh A, Margolick J, Iwakura Y, Rose N, Cihakova D Cardiac fibroblasts mediate IL-17A-driven inflammatory dilated cardiomyopathy. J Exp Med, 2014-06-16;211(7):1449-64. 2014-06-16 [PMID: 24935258] (In Vivo, Mouse)
• Miller , Ian S, Didier , Sebastie, Murray , David W, Turner , Tia H, Issaivanan , Magimair, Ruggieri , Rosamari, Al-Abed , Yousef, Symons , Marc Semapimod sensitizes glioblastoma tumors to ionizing radiation by targeting microglia. PLoS ONE, 2014-05-09;9(5):e95885. 2014-05-09 [PMID: 24816734] (Bioassay, Mouse)
• Nagareddy P, Kraakman M, Masters S, Stirzaker R, Gorman D, Grant R, Dragoljevic D, Hong E, Abdel-Latif A, Smyth S, Choi S, Korner J, Bornfeldt K, Fisher E, Dixit V, Tall A, Goldberg I, Murphy A Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. Cell Metab, 2014-05-06;19(5):821-35. 2014-05-06 [PMID: 24807222] (Bioassay, Mouse)
• Noman M, Desantis G, Janji B, Hasmim M, Karray S, Dessen P, Bronte V, Chouaib S PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J Exp Med, 2014-04-28;211(5):781-90. 2014-04-28 [PMID: 24778419] (Bioassay, Mouse)
• Spoerl S, Mathew N, Bscheider M, Schmitt-Graeff A, Chen S, Mueller T, Verbeek M, Fischer J, Otten V, Schmickl M, Maas-Bauer K, Finke J, Peschel C, Duyster J, Poeck H, Zeiser R, von Bubnoff N Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease. Blood, 2014-04-07;123(24):3832-42. 2014-04-07 [PMID: 24711661] (Bioassay, Mouse)
• Tseng J, Yang C, Liang S, Liu R, Yang S, Lin J, Chen Y, Wu Y, Jiang J, Lin C Interleukin-17A modulates circulating tumor cells in tumor draining vein of colorectal cancers and affects metastases. Clin Cancer Res, 2014-03-27;20(11):2885-97. 2014-03-27 [PMID: 24677375] (In Vivo, Mouse)
• Shibata T, Habiel D, Coelho A, Kunkel S, Lukacs N, Hogaboam C Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma. J Immunol, 2014-03-21;192(8):3569-81. 2014-03-21 [PMID: 24659691] (Bioassay, Mouse)
• Park , Mi Kyung, Cho , Min Kyou, Kang , Shin Ae, Park , Hye-Kyun, Kim , Dong-Hee, Yu , Hak Sun Acanthamoeba protease activity promotes allergic airway inflammation via protease-activated receptor 2. PLoS ONE, 2014-03-21;9(3):e92726. 2014-03-21 [PMID: 24658532] (Bioassay, Mouse)
• Moraes-Vieira P, Yore M, Dwyer P, Syed I, Aryal P, Kahn B RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance. Cell Metab, 2014-03-04;19(3):512-26. 2014-03-04 [PMID: 24606904] (Bioassay, Mouse)
• MacMillan C, Doucette C, Warford J, Furlong S, Hoskin D, Easton A Murine experimental autoimmune encephalomyelitis is diminished by treatment with the angiogenesis inhibitors B20-4.1.1 and angiostatin (K1-3). PLoS ONE, 2014-02-26;9(2):e89770. 2014-02-26 [PMID: 24587024] (Bioassay, Mouse)
• Taguchi K, Okada A, Kitamura H, Yasui T, Naiki T, Hamamoto S, Ando R, Mizuno K, Kawai N, Tozawa K, Asano K, Tanaka M, Miyoshi I, Kohri K Colony-stimulating factor-1 signaling suppresses renal crystal formation. J Am Soc Nephrol, 2014-02-27;25(8):1680-97. 2014-02-27 [PMID: 24578130] (Bioassay, Mouse)
• VanGundy , Zachary, Guerau-de-Arellano , Mireia, Baker , Julie D, Strange , Heather, Olivo-Marston , Susan, Muth , Dillon C, Papenfuss , Tracey L Continuous retinoic acid induces the differentiation of mature regulatory monocytes but fails to induce regulatory dendritic cells. BMC Immunol, 2014-02-18;15(0):8. 2014-02-18 [PMID: 24548459] (Bioassay, Mouse)
• Robertson S, Lubick K, Freedman B, Carmody A, Best S Tick-borne flaviviruses antagonize both IRF-1 and type I IFN signaling to inhibit dendritic cell function. J Immunol, 2014-02-14;192(6):2744-55. 2014-02-14 [PMID: 24532583] (Bioassay, Mouse)
• Kim E, Miyake B, Aggarwal M, Voetlause R, Griffith M, Zavazava N Embryonic stem cell-derived haematopoietic progenitor cells down-regulate the CD3 xi chain on T cells, abrogating alloreactive T cells. Immunology, 2014-07-01;142(3):421-30. 2014-07-01 [PMID: 24527810] (Bioassay, Mouse)
• Winkelmann E, Widman D, Xia J, Johnson A, Van Rooijen N, Mason P, Bourne N, Milligan G Subcapsular sinus macrophages limit dissemination of West Nile virus particles after inoculation but are not essential for the development of West Nile virus-specific T cell responses. Virology, 2014-01-10;450(0):278-89. 2014-01-10 [PMID: 24503091] (Bioassay, Mouse)
• Ko H, Brady J, Ryg-Cornejo V, Hansen D, Vremec D, Shortman K, Zhan Y, Lew A GM-CSF-responsive monocyte-derived dendritic cells are pivotal in Th17 pathogenesis. J Immunol, 2014-01-31;192(5):2202-9. 2014-01-31 [PMID: 24489100] (Bioassay, Mouse)
• Han , Ji Eun, Wui , Seo Ri, Kim , Kwang Su, Cho , Yang Je, Cho , Wan Je, Lee , Na Gyong Characterization of the structure and immunostimulatory activity of a vaccine adjuvant, de-O-acylated lipooligosaccharide. PLoS ONE, 2014-01-22;9(1):e85838. 2014-01-22 [PMID: 24465739] (Bioassay, Mouse)
• Li X, Jiang L, Chen L, Ding M, Guo H, Zhang W, Zhang H, Ma X, Liu X, Xi X, Chen S, Chen Z, Zhu J RIG-I modulates Src-mediated AKT activation to restrain leukemic stemness. Mol Cell, 2014-01-09;53(3):407-19. 2014-01-09 [PMID: 24412064] (Bioassay, Mouse)
• Chang Y, Olson J, Beasley F, Tung C, Zhang J, Crocker P, Varki A, Nizet V Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo. PLoS Pathog, 2014-01-02;10(1):e1003846. 2014-01-02 [PMID: 24391502] (Bioassay, Mouse)
• Mikyskova R, Indrova M, Vlkova V, Bieblova J, Simova J, Parackova Z, Pajtasz-Piasecka E, Rossowska J, Reinis M DNA demethylating agent 5-azacytidine inhibits myeloid-derived suppressor cells induced by tumor growth and cyclophosphamide treatment. J Leukoc Biol, 2014-01-03;0(0):. 2014-01-03 [PMID: 24389335] (Bioassay, Mouse)
• Sturrock , Anne, Mir-Kasimov , Mustafa, Baker , Jessica, Rowley , Jesse, Paine , Robert 3 Key role of microRNA in the regulation of granulocyte macrophage colony-stimulating factor expression in murine alveolar epithelial cells during oxidative stress. J Biol Chem, 2013-12-26;289(7):4095-105. 2013-12-26 [PMID: 24371146] (Bioassay, Mouse)
• Chung Y, Zhang N, Wooten R Borrelia burgdorferi elicited-IL-10 suppresses the production of inflammatory mediators, phagocytosis, and expression of co-stimulatory receptors by murine macrophages and/or dendritic cells. PLoS ONE, 2013-12-19;8(12):e84980. 2013-12-19 [PMID: 24367705] (Bioassay, Mouse)
• Nacionales D, Gentile L, Vanzant E, Lopez M, Cuenca A, Cuenca A, Ungaro R, Li Y, Baslanti T, Bihorac A, Moore F, Baker H, Leeuwenburgh C, Moldawer L, Efron P Aged mice are unable to mount an effective myeloid response to sepsis. J Immunol, 2013-12-13;192(2):612-22. 2013-12-13 [PMID: 24337739] (Bioassay, Mouse)
• Garg S, Delaney C, Toubai T, Ghosh A, Reddy P, Banerjee R, Yung R Aging is associated with increased regulatory T-cell function. Aging Cell, 2014-02-25;13(3):441-8. 2014-02-25 [PMID: 24325345] (Bioassay, Mouse)
• Liu Y, Holdbrooks A, De Sarno P, Rowse A, Yanagisawa L, McFarland B, Harrington L, Raman C, Sabbaj S, Benveniste E, Qin H Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis. J Immunol, 2013-12-09;192(1):59-72. 2013-12-09 [PMID: 24323580] (Bioassay, Mouse)
• Buchta C, Bishop G TRAF5 negatively regulates TLR signaling in B lymphocytes. J Immunol, 2013-11-20;192(1):145-50. 2013-11-20 [PMID: 24259503] (Bioassay, Mouse)
• Dowty , Martin E, Jesson , Michael, Ghosh , Sarbani, Lee , Jamie, Meyer , Debra M, Krishnaswami , Sriram, Kishore , Nandini Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis. J Pharmacol Exp Ther, 2013-11-11;348(1):165-73. 2013-11-11 [PMID: 24218541] (Bioassay, Mouse)
• Shah , Chirag A, Bei , Ling, Wang , Hao, Platanias , Leonidas, Eklund , Elizabet The leukemia-associated Mll-Ell oncoprotein induces fibroblast growth factor 2 (Fgf2)-dependent cytokine hypersensitivity in myeloid progenitor cells. J Biol Chem, 2013-10-02;288(45):32490-505. 2013-10-02 [PMID: 24089521] (Bioassay, Mouse)
• Benasciutti E, Mariani E, Oliva L, Scolari M, Perilli E, Barras E, Milan E, Orfanelli U, Fazzalari N, Campana L, Capobianco A, Otten L, Particelli F, Acha-Orbea H, Baruffaldi F, Faccio R, Sitia R, Reith W, Cenci S MHC class II transactivator is an in vivo regulator of osteoclast differentiation and bone homeostasis co-opted from adaptive immunity. J Bone Miner Res, 2014-02-01;29(2):290-303. 2014-02-01 [PMID: 24038328] (Bioassay, Mouse)
• Kim J, Kim W, Choi H, Jang B, Lee K, Park J, Kim H, Cho S, Shin S Mycobacterium tuberculosis RpfB drives Th1-type T cell immunity via a TLR4-dependent activation of dendritic cells. J Leukoc Biol, 2013-07-03;94(4):733-49. 2013-07-03 [PMID: 23825389] (Bioassay, Mouse)
• Jachetti , Elena, Mazzoleni , Stefania, Grioni , Matteo, Ricupito , Alessia, Brambillasca , Chiara, Generoso , Luca, Calcinotto , Arianna, Freschi , Massimo, Mondino , Anna, Galli , Rossella, Bellone , Matteo Prostate cancer stem cells are targets of both innate and adaptive immunity and elicit tumor-specific immune responses. Oncoimmunology, 2013-04-16;2(5):e24520. 2013-04-16 [PMID: 23762811] (Bioassay, Mouse)
• Casella C, Mitchell T Inefficient TLR4/MD-2 heterotetramerization by monophosphoryl lipid A. PLoS ONE, 2013-04-26;8(4):e62622. 2013-04-26 [PMID: 23638128] (Bioassay, Mouse)
• Toki S, Goleniewska K, Huckabee M, Zhou W, Newcomb D, FitzGerald G, Lawson W, Peebles R PGI(2) signaling inhibits antigen uptake and increases migration of immature dendritic cells. J Leukoc Biol, 2013-04-26;94(1):77-88. 2013-04-26 [PMID: 23625201] (Bioassay, Mouse)
• Elcombe S, Naqvi S, van den Bosch M, Mackenzie K, Cianfanelli F, Brown G, Arthur J Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers. PLoS ONE, 2013-03-22;8(3):e60086. 2013-03-22 [PMID: 23533666] (Bioassay, Mouse)
• Ichihashi , Toru, Satoh , Toshifum, Sugimoto , Chihiro, Kajino , Kiichi Emulsified phosphatidylserine, simple and effective peptide carrier for induction of potent epitope-specific T cell responses. PLoS ONE, 2013-03-22;8(3):e60068. 2013-03-22 [PMID: 23533665] (Bioassay, Mouse)
• Han W, Li H, Cai J, Gleaves L, Polosukhin V, Segal B, Yull F, Blackwell T NADPH oxidase limits lipopolysaccharide-induced lung inflammation and injury in mice through reduction-oxidation regulation of NF-kappaB activity. J Immunol, 2013-03-25;190(9):4786-94. 2013-03-25 [PMID: 23530143] (Bioassay, Mouse)
• Huang W, Bei L, Eklund E Fas-associated phosphatase 1 (Fap1) influences betacatenin activity in myeloid progenitor cells expressing the Bcr-abl oncogene. J Biol Chem, 2013-03-21;288(18):12766-76. 2013-03-21 [PMID: 23519466] (Bioassay, Mouse)
• Lapid K, Itkin T, D'Uva G, Ovadya Y, Ludin A, Caglio G, Kalinkovich A, Golan K, Porat Z, Zollo M, Lapidot T GSK3beta regulates physiological migration of stem/progenitor cells via cytoskeletal rearrangement. J Clin Invest, 2013-03-08;123(4):1705-17. 2013-03-08 [PMID: 23478410] (Bioassay, Mouse)
• Huang Q, Koessler R, Birkett R, Perlman H, Xing L, Pope R TLR2 deletion promotes arthritis through reduction of IL-10. J Leukoc Biol, 2013-02-27;93(5):751-9. 2013-02-27 [PMID: 23446149] (Bioassay, Mouse)
• Napolitano , Anna, Pittoni , Paola, Beaudoin , Lucie, Lehuen , Agnes, Voehringer , David, MacDonald , H Robson, Dellabona , Paolo, Casorati , Giulia Functional education of invariant NKT cells by dendritic cell tuning of SHP-1. J Immunol, 2013-02-20;190(7):3299-308. 2013-02-20 [PMID: 23427253] (Bioassay, Mouse)
• Gartlan K, Wee J, Demaria M, Nastovska R, Chang T, Jones E, Apostolopoulos V, Pietersz G, Hickey M, van Spriel A, Wright M Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration. Eur J Immunol, 2013-03-25;43(5):1208-19. 2013-03-25 [PMID: 23420539] (Bioassay, Mouse)
• Kumar M, Roe K, Orillo B, Muruve D, Nerurkar V, Gale M, Verma S Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis. J Virol, 2013-01-09;87(7):3655-67. 2013-01-09 [PMID: 23302887] (Bioassay, Mouse)
• Jang , Sihyug, Smit , Joost, Kallal , Lara E, Lukacs , Nicholas Respiratory syncytial virus infection modifies and accelerates pulmonary disease via DC activation and migration. J Leukoc Biol, 2013-01-04;94(1):5-15. 2013-01-04 [PMID: 23293372] (Bioassay, Mouse)
• Vermeer D, Spanos W, Vermeer P, Bruns A, Lee K, Lee J Radiation-induced loss of cell surface CD47 enhances immune-mediated clearance of human papillomavirus-positive cancer. Int J Cancer, 2013-02-12;133(1):120-9. 2013-02-12 [PMID: 23292955] (Bioassay, Mouse)
• Xu Q, Chai S, Qian Y, Zhang M, Wang K Breast regression protein-39 (BRP-39) promotes dendritic cell maturation in vitro and enhances Th2 inflammation in murine model of asthma. Acta Pharmacol Sin, 2012-11-26;33(12):1525-32. 2012-11-26 [PMID: 23178461] (Cell Culture, Mouse)
• Munich S, Sobo-Vujanovic A, Buchser W, Beer-Stolz D, Vujanovic N Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands. Oncoimmunology, 2012-10-01;1(7):1074-1083. 2012-10-01 [PMID: 23170255] (Bioassay, Mouse)
• Jacome-Galarza C, Lee S, Lorenzo J, Aguila H Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery. J Bone Miner Res, 2013-05-01;28(5):1203-13. 2013-05-01 [PMID: 23165930] (Bioassay, Mouse)
• Charles , Julia F, Hsu , Lih-Yun, Niemi , Erene C, Weiss , Arthur, Aliprantis , Antonios, Nakamura , Mary C Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. J Clin Invest, 2012-11-01;122(12):4592-605. 2012-11-01 [PMID: 23114597] (Bioassay, Mouse)
• Umeshappa C, Nanjundappa R, Xie Y, Freywald A, Xu Q, Xiang J Differential requirements of CD4(+) T-cell signals for effector cytotoxic T-lymphocyte (CTL) priming and functional memory CTL development at higher CD8(+) T-cell precursor frequency. Immunology, 2013-04-01;138(4):298-306. 2013-04-01 [PMID: 23113741] (Bioassay, Mouse)
• Hou J, Liu Y, Liu Y, Shao Y The MSHA Strain of Pseudomonas Aeruginosa Activated TLR Pathway and Enhanced HIV-1 DNA Vaccine Immunoreactivity. PLoS ONE, 2012-10-15;7(10):e47724. 2012-10-15 [PMID: 23077664] (Bioassay, Mouse)
• Mun S, Won H, Hernandez P, Aguila H, Lee S Deletion of CD74, a putative MIF receptor, in mice enhances osteoclastogenesis and decreases bone mass. J Bone Miner Res, 2013-04-01;28(4):948-59. 2013-04-01 [PMID: 23044992] (Bioassay, Mouse)
• Domingos-Pereira S, Decrausaz L, Derre L, Bobst M, Romero P, Schiller J, Jichlinski P, Nardelli-Haefliger D Intravaginal TLR agonists increase local vaccine-specific CD8 T cells and human papillomavirus-associated genital-tumor regression in mice. Mucosal Immunol, 2012-09-12;6(2):393-404. 2012-09-12 [PMID: 22968420] (Bioassay, Mouse)
• Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)
• Noh KT, Son KH, Jung ID, Kang HK, Hwang SA, Lee WS, You JC, Park YM Protein kinase C delta (PKCdelta)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia. J. Biol. Chem., 2012-03-05;287(17):14226-33. 2012-03-05 [PMID: 22393041] (Bioassay, Mouse)
• Barin JG, Baldeviano GC, Talor MV, Wu L, Ong S, Quader F, Chen P, Zheng D, Caturegli P, Rose NR, Cihakova D Macrophages participate in IL-17-mediated inflammation. Eur. J. Immunol., 2012-01-23;42(3):726-36. 2012-01-23 [PMID: 22161142] (Bioassay, Mouse)
• Chen M, Forrester JV, Xu H Dysregulation in Retinal Para-Inflammation and Age-Related Retinal Degeneration in CCL2 or CCR2 Deficient Mice. PLoS ONE, 2011-08-05;6(8):e22818. 2011-08-05 [PMID: 21850237] (Bioassay, Mouse)
• Kinzfogl J, Hangoc G, Broxmeyer HE Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells. Blood, 2011-05-31;118(3):565-75. 2011-05-31 [PMID: 21628410] (Bioassay, Mouse)
• Cook BD, Liu S, Evans T Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment. Blood, 2011-04-22;117(24):6489-97. 2011-04-22 [PMID: 21515822] (Bioassay, Mouse)
• Jung ID, Noh KT, Lee CM, Chun SH, Jeong SK, Park JW, Park WS, Kim HW, Yun CH, Shin YK, Park YM Oncostatin M induces dendritic cell maturation and Th1 polarization. Biochem. Biophys. Res. Commun., 2010-03-04;394(2):272-8. 2010-03-04 [PMID: 20206608] (Cell Culture, Mouse)
• Kallal LE, Schaller MA, Lindell DM, Lira SA, Lukacs NW CCL20/CCR6 blockade enhances immunity to RSV by impairing recruitment of DC. Eur. J. Immunol., 2010-04-01;40(4):1042-52. 2010-04-01 [PMID: 20101616] (Bioassay, Mouse)
• Fukui R, Saitoh S, Matsumoto F, Kozuka-Hata H, Oyama M, Tabeta K, Beutler B, Miyake K Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing. J. Exp. Med., 2009-05-18;206(6):1339-50. 2009-05-18 [PMID: 19451267] (Bioassay, Mouse)
• Claudio E, Sonder SU, Saret S, Carvalho G, Ramalingam TR, Wynn TA, Chariot A, Garcia-Perganeda A, Leonardi A, Paun A, Chen A, Ren NY, Wang H, Siebenlist U The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation. J. Immunol., 2009-02-01;182(3):1617-30. 2009-02-01 [PMID: 19155511] (Bioassay, Mouse)
• Beck JM, Preston AM, Wilcoxen SE, Morris SB, Sturrock A, Paine R Critical roles of inflammation and apoptosis in improved survival in a model of hyperoxia-induced acute lung injury in Pneumocystis murina-infected mice. Infect. Immun., 2009-01-05;77(3):1053-60. 2009-01-05 [PMID: 19124601] (In Vivo, Mouse)
• Liu Q, Cheng LI, Yi L, Zhu N, Wood A, Changpriroa CM, Ward JM, Jackson SH p47phox deficiency induces macrophage dysfunction resulting in progressive crystalline macrophage pneumonia. Am. J. Pathol., 2008-12-18;174(1):153-63. 2008-12-18 [PMID: 19095958] (Bioassay, Mouse)
• Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM Adenosine receptors in regulation of dendritic cell differentiation and function. Blood, 2008-06-17;112(5):1822-31. 2008-06-17 [PMID: 18559975] (Bioassay, Mouse)
• Guo B, Chang EY, Cheng G The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J. Clin. Invest., 2008-05-01;118(5):1680-90. 2008-05-01 [PMID: 18382764] (Bioassay, Mouse)
• Lau AW, Biester S, Cornall RJ, Forrester JV Lipopolysaccharide-activated IL-10-secreting dendritic cells suppress experimental autoimmune uveoretinitis by MHCII-dependent activation of CD62L-expressing regulatory T cells. J. Immunol., 2008-03-15;180(6):3889-99. 2008-03-15 [PMID: 18322197] (Bioassay, Mouse)
• Shojaei F, Wu X, Zhong C, Yu L, Liang XH, Yao J, Blanchard D, Bais C, Peale FV, van Bruggen N, Ho C, Ross J, Tan M, Carano RA, Meng YG, Ferrara N Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature, 2007-12-06;450(7171):825-31. 2007-12-06 [PMID: 18064003] (Bioassay, Mouse)
• Matsumoto K, Fukuyama S, Eguchi-Tsuda M, Nakano T, Matsumoto T, Matsumura M, Moriwaki A, Kan-o K, Wada Y, Yagita H, Shin T, Pardoll DM, Patcharee R, Azuma M, Nakanishi Y, Inoue H B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma. Biochem. Biophys. Res. Commun., 2007-11-05;365(1):170-5. 2007-11-05 [PMID: 17981145] (Bioassay, Mouse)
• Tian F, Grimaldo S, Fujita M, Fugita M, Cutts J, Vujanovic NL, Li LY The endothelial cell-produced antiangiogenic cytokine vascular endothelial growth inhibitor induces dendritic cell maturation. J. Immunol., 2007-09-15;179(6):3742-51. 2007-09-15 [PMID: 17785811] (Bioassay, Mouse)
• Gaudreau S, Guindi C, Menard M, Besin G, Dupuis G, Amrani A Granulocyte-macrophage colony-stimulating factor prevents diabetes development in NOD mice by inducing tolerogenic dendritic cells that sustain the suppressive function of CD4+CD25+ regulatory T cells. J. Immunol., 2007-09-15;179(6):3638-47. 2007-09-15 [PMID: 17785799] (Bioassay, Mouse)
• Perri SR, Annabi B, Galipeau J Angiostatin inhibits monocyte/macrophage migration via disruption of actin cytoskeleton. FASEB J., 2007-07-10;21(14):3928-36. 2007-07-10 [PMID: 17622568] (Bioassay, Mouse)
• Fritz JH, Le Bourhis L, Sellge G, Magalhaes JG, Fsihi H, Kufer TA, Collins C, Viala J, Ferrero RL, Girardin SE, Philpott DJ Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. Immunity, 2007-04-12;26(4):445-59. 2007-04-12 [PMID: 17433730] (Bioassay, Mouse)
• Koya RC, Kimura T, Ribas A, Rozengurt N, Lawson GW, Faure-Kumar E, Wang HJ, Herschman H, Kasahara N, Stripecke R Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines. Mol. Ther., 2007-03-20;15(5):971-80. 2007-03-20 [PMID: 17375074] (Bioassay, Mouse)
• Sugiyama K, Shirai R, Mukae H, Ishimoto H, Nagata T, Sakamoto N, Ishii H, Nakayama S, Yanagihara K, Mizuta Y, Kohno S Differing effects of clarithromycin and azithromycin on cytokine production by murine dendritic cells. Clin. Exp. Immunol., 2007-03-01;147(3):540-6. 2007-03-01 [PMID: 17302905] (Bioassay, Mouse)
• Kurooka M, Kaneda Y Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells. Cancer Res., 2007-01-01;67(1):227-36. 2007-01-01 [PMID: 17210703] (Bioassay, Mouse)
• Rafei M, Wu JH, Annabi B, Lejeune L, Francois M, Galipeau J A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex. Blood, 2006-11-02;109(5):2234-42. 2006-11-02 [PMID: 17082320] (Bioassay, Mouse)
• Kim SY, Nguyen AD, Gao JL, Murphy PM, Mansfield BC, Chou JY Bone marrow-derived cells require a functional glucose 6-phosphate transporter for normal myeloid functions. J. Biol. Chem., 2006-08-04;281(39):28794-801. 2006-08-04 [PMID: 16891306] (Bioassay, Mouse)
• Liu Q, Chen T, Chen G, Li N, Wang J, Ma P, Cao X Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation. Biochem. Biophys. Res. Commun., 2006-05-12;345(3):1122-30. 2006-05-12 [PMID: 16713992] (Bioassay, Mouse)
• Reed JA, Clegg DJ, Smith KB, Tolod-Richer EG, Matter EK, Picard LS, Seeley RJ GM-CSF action in the CNS decreases food intake and body weight. J. Clin. Invest., 2005-11-01;115(11):3035-44. 2005-11-01 [PMID: 16276414] (In Vivo, Rat)
• Wada A, Tada Y, Shimozato O, Takiguchi Y, Tatsumi K, Kuriyama T, Tagawa M Vaccination of apoptotic Fas ligand-expressing tumors decreased antitumor responses by enhanced production of immunosuppressive cytokines. Anticancer Res., 2005-01-01;25(1):299-303. 2005-01-01 [PMID: 15816551] (Bioassay, Mouse)
• Dikov MM, Ohm JE, Ray N, Tchekneva EE, Burlison J, Moghanaki D, Nadaf S, Carbone DP Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation. J. Immunol., 2005-01-01;174(1):215-22. 2005-01-01 [PMID: 15611243] (Bioassay, Mouse)
• Borg C, Jalil A, Laderach D, Maruyama K, Wakasugi H, Charrier S, Ryffel B, Cambi A, Figdor C, Vainchenker W, Galy A, Caignard A, Zitvogel L NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs. Blood, 2004-07-08;104(10):3267-75. 2004-07-08 [PMID: 15242871] (Bioassay, Mouse)
• Abedi M, Greer DA, Colvin GA, Demers DA, Dooner MS, Harpel JA, Weier HU, Lambert JF, Quesenberry PJ Robust conversion of marrow cells to skeletal muscle with formation of marrow-derived muscle cell colonies: a multifactorial process. Exp. Hematol., 2004-05-01;32(5):426-34. 2004-05-01 [PMID: 15145210] (In Vivo, Mouse)
• Bouis DA, Popova TG, Takashima A, Norgard MV Dendritic cells phagocytose and are activated by Treponema pallidum. Infect. Immun., 2001-01-01;69(1):518-28. 2001-01-01 [PMID: 11119545] (Bioassay, Mouse)
• Gabrilovich DI, 2018, Ishida T, Nadaf S, Ohm JE, Carbone DP Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. 1537, 1999-10-01;5(10):2963-70. 1999-10-01 [PMID: 10537366] (Bioassay, Mouse)
• Gardner RV, 48657, Oliver P, Astle CM Stem cell factor improves the repopulating ability of primitive hematopoietic stem cells after sublethal irradiation (and, to a lesser extent) after bone marrow transplantation in mice. Involvement of ?-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum, 1998-01-01;16(2):112-9. 1998-01-01 [PMID: 9554035] (In Vivo, Mouse)
• Liu F, Poursine-Laurent J, Wu HY, Link DC Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation. Blood, 1997-10-01;90(7):2583-90. 1997-10-01 [PMID: 9326224] (Bioassay, Mouse)

Bioinformatics

• Gene Symbol: Csf2
• Uniprot:
  • Q14AD9()