Recombinant Mouse IFN-gamma Protein

Recombinant Mouse IFN-gamma (Catalog # 485‑ML) demonstrates anti-viral activity in L‑929 mouse fibroblast cells infected with encephalomyocarditis (EMC) virus. The ED50 for this effect is 0.3-0.9 ng/mL.

1 μg/lane of Recombinant Mouse IFN-gamma was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 11-12 kDa.

• Reactivity: Mu
• Applications: Bioactivity

Recombinant Mouse IFN-gamma Protein Summary

• Details of Functionality: Measured in an anti-viral assay using L‑929 mouse fibroblast cells infected with encephalomyocarditis (EMC) virus. Vogel, S.N. et al. (1982) Infect. Immunol. 38:681. The ED₅₀ for this effect is 0.3-0.9 ng/mL.
• Source: E. coli-derived mouse IFN-gamma protein
  His23-Cys155, with an N-terminal Met
• Accession #: NP_032363
• N-terminal Sequence: Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: Ifng
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 15.6 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 11-12 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in Sodium Succinate, Mannitol,Tween® 80 and TCEP with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IFN-gamma Protein

• IFG
• IFI
• IFNG
• IFNgamma
• IFN-gamma
• Immune interferon
• interferon gamma
• interferon, gamma

Background

Interferon-gamma (IFN-gamma ), also known as type II or immune interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine (1, 2). Mature mouse IFN-gamma exists as a noncovalently linked homodimer of 20-25 kDa variably glycosylated subunits (3). It shares 86% amino acid sequence identity with rat IFN-gamma and 38%-44% with bovine, canine, cotton rat, equine, feline, human, porcine, and rhesus IFN-gamma . IFN-gamma dimers bind to IFN‑ gamma RI (alpha subunits) which then interact with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta subunits. Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction (4, 5). IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells (6). It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up-regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects (6, 7). In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation (8, 9). The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis (7).

1. Billiau, A. and P. Matthys (2009) Cytokine Growth Factor Rev. 20:97.
2. Pestka, S. et al. (2004) Immunol. Rev. 202:8.
3. Gray, P.W. and D.V. Goeddel (1983) Proc. Natl. Acad. Sci. 80:5842.
4. Marsters, S.A. et al. (1995) Proc. Natl. Acad. Sci. 92:5401.
5. Krause, C.D. et al. (2000) J. Biol. Chem. 275:22995.
6. Schroder, K. et al. (2004) J. Leukoc. Biol. 75:163.
7. McLaren, J.E. and D.P. Ramji (2009) Cytokine Growth Factor Rev. 20:125.
8. Muhl, H. and J. Pfeilschifter (2003) Int. Immunopharmacol. 3:1247.
9. Kelchtermans, H. et al. (2008) Trends Immunol. 29:479.

Publications for IFN-gamma (485-MI)(454)

Publications using 485-MI

• Kravets, E;Poschmann, G;Hänsch, S;Raba, V;Weidtkamp?Peters, S;Degrandi, D;Stühler, K;Pfeffer, K; mGBP2 engages Galectin-9 for immunity against Toxoplasma gondii PloS one 2025-01-24 [PMID: 39854420] (Bioassay, Mouse)
• Sato, T;Sugiyama, D;Koseki, J;Kojima, Y;Hattori, S;Sone, K;Nishinakamura, H;Ishikawa, T;Ishikawa, Y;Kato, T;Kiyoi, H;Nishikawa, H; Sustained inhibition of CSF1R signaling augments antitumor immunity through inhibiting tumor-associated macrophages JCI insight 2025-01-09 [PMID: 39782686] (Bioassay, Mouse)
• Zimmerman, B;Dakin, L;Fortier, A;Nanou, E;Blasio, A;Mann, J;Miller, H;Fletcher, M;Wang, T;Nanthakumar, S;McCarthy, G;Matar, C;Matsye, P;Wang, G;Snyder, P;Daniel, K;Swamy, H;Sullivan, K;Bright, F;Powers, A;Gagnon, K;Lü, F;Paula, S;Khare-Pandit, S;Henry, L;Hamel, M;Denis, F;Nicolas, O;Hariparsad, N;Kumar, S;Proctor, J;Senter, T;Furey, B;Bunnage, M; Small molecule APOL1 inhibitors as a precision medicine approach for APOL1-mediated kidney disease Nature communications 2025-01-02 [PMID: 39747090] (In vivo assay, Transgenic Mouse)
• Takashima, S;Sharma, R;Chang, W;Calafiore, M;Fu, Y;Jansen, S;Ito, T;Egorova, A;Kuttiyara, J;Arnhold, V;Sharrock, J;Santosa, E;Chaudhary, O;Geiger, H;Iwasaki, H;Liu, C;Sun, J;Robine, N;Mažutis, L;Lindemans, C;Hanash, A; STAT1 regulates immune-mediated intestinal stem cell proliferation and epithelial regeneration Nature communications 2025-01-02 [PMID: 39746933] (Bioassay, Mouse)
• Takahashi, M;Yamamoto, S;Yamamoto, S;Okubo, A;Nakagawa, Y;Kuwahara, K;Matsusaka, T;Fukuma, S;Yamamoto, M;Matsuda, M;Yanagita, M; ATP dynamics as a predictor of future podocyte structure and function after acute ischemic kidney injury in female mice Nature communications 2024-11-22 [PMID: 39578451] (Bioassay, Mouse)
• Anaya-Sanchez, A;Berry, SB;Espich, S;Zilinskas, A;Tran, PM;Agudelo, C;Samani, H;Darwin, KH;Portnoy, DA;Stanley, SA; Methylglyoxal is an antibacterial effector produced by macrophages during infection bioRxiv : the preprint server for biology 2024-11-03 [PMID: 39554200] (Bioassay, Mouse)
• May, L;Hu, B;Jerajani, P;Jagdeesh, A;Alhawiti, O;Cai, L;Semenova, N;Guo, C;Isbell, M;Deng, X;Faber, A;Pillappa, R;Bandyopadhyay, D;Wang, XY;Neuwelt, A;Koblinski, J;Bos, PD;Li, H;Martin, R;Landry, JW; The Innate Immune System and TRAIL-BCL-XL Axis Mediate a Sex Bias in Lung Cancer and Confer a Therapeutic Vulnerability in Females Cancer research 2024-09-23 [PMID: 39312191] (Cell Culture, Human)
• Cho, HH;Rhee, S;Cho, DI;Jun, JH;Heo, H;Cho, SH;Kim, D;Wang, M;Kang, BG;Yoo, SJ;Cho, M;Lim, SY;Cho, JY;Jeong, IS;Kim, YS;Ahn, Y; IKK?-deficient macrophages impede cardiac repair after myocardial infarction by enhancing the macrophage-myofibroblast transition Experimental & molecular medicine 2024-09-01 [PMID: 39261656] (Bioassay, Mouse)
• Blanco, T;Nakagawa, H;Musayeva, A;Krauthammer, M;Singh, RB;Narimatsu, A;Ge, H;Shoushtari, SI;Dana, R; Acquired Immunostimulatory Phenotype of Migratory CD103+ Dendritic Cells Promotes Alloimmunity Following Corneal Transplantation JCI insight 2024-09-05 [PMID: 39235864] (Bioassay, Mouse)
• Liu, Y;Yin, M;Mao, X;Wu, S;Wei, S;Heng, S;Yang, Y;Huang, J;Guo, Z;Li, C;Ji, C;Hu, L;Liu, W;Zhang, LJ; Defining cell type-specific immune responses in a mouse model of allergic contact dermatitis by single-cell transcriptomics eLife 2024-08-30 [PMID: 39213029] (Bioassay, Mouse)
• Singh, SS;Calvo, R;Kumari, A;Sable, RV;Fang, Y;Tao, D;Hu, X;Castle, SG;Nahar, S;Li, D;Major, E;Sanchez, TW;Kato, R;Xu, X;Zhou, J;Liu, L;LeClair, CA;Simeonov, A;Baljinnyam, B;Henderson, MJ;Marugan, J;Rudloff, U; Fatty acid derivatization and cyclization of the immunomodulatory peptide RP-182 targeting CD206high macrophages improves anti-tumor activity Molecular cancer therapeutics 2024-08-30 [PMID: 39212669] (Bioassay, Mouse)
• Wallings, RL;Gillett, DA;Staley, HA;Mahn, S;Mark, J;Neighbarger, N;Kordasiewicz, H;Hirst, WD;Tansey, MG; ASO-mediated knockdown of GPNMB in mutant- GRN and Grn -deficient peripheral myeloid cells disrupts lysosomal function and immune responses bioRxiv : the preprint server for biology 2024-07-23 [PMID: 39211224] (Bioassay, Mouse)
• Malone, K;Dugas, M;Earl, N;Alain, T;LaCasse, EC;Beug, ST; Astrocytes and the tumor microenvironment inflammatory state dictate the killing of glioblastoma cells by Smac mimetic compounds Cell death & disease 2024-08-15 [PMID: 39147758] (Bioassay, Mouse)
• Barrero, M;Lazarenkov, A;Blanco, E;Palma, LG;López-Rubio, AV;Bauer, M;Bigas, A;Di Croce, L;Sardina, JL;Payer, B; The interferon ? pathway enhances pluripotency and X-chromosome reactivation in iPSC reprogramming Science advances 2024-08-09 [PMID: 39110794] (Bioassay, Mouse)
• Marrufo, AM;Molina, JJ;Gager, C;Andersen, MJ;LaBella, AA;Lucas, ER;Wongso, E;Urmi, T;Arias-Parbul, K;Webster, R;Stuckey, PV;Kohler, KN;Donahue, D;Ploplis, VA;Flick, MJ;Castellino, FJ;Santiago-Tirado, FH;Flores-Mireles, AL; The catheterized bladder environment induces dysregulation of macrophage polarization exacerbating bacterial UTI bioRxiv : the preprint server for biology 2024-07-17 [PMID: 39071295] (Bioassay, Mouse)
• Wofford, W;Kim, J;Kim, D;Janneh, AH;Lee, HG;Atilgan, FC;Oleinik, N;Kassir, MF;Saatci, O;Chakraborty, P;Tokat, UM;Gencer, S;Howley, B;Howe, P;Mehrotra, S;Sahin, O;Ogretmen, B; Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response Cell reports 2024-07-23 [PMID: 39046874] (Bioassay, Human, Mouse)
• Li, C;Wang, B;Tu, J;Liu, C;Wang, Y;Chen, J;Huang, Y;Liu, B;Yuan, X; ATM inhibition enhance immunotherapy by activating STING signaling and augmenting MHC Class I Cell death & disease 2024-07-20 [PMID: 39033176] (Bioassay, Mouse)
• Dutta, B;Mahanty, M;Kesavalu, L;Rahaman, SO; Mechanisms underlying TRPV4-mediated regulation of miR-146a expression bioRxiv : the preprint server for biology 2024-04-03 [PMID: 38617263] (Bioassay, Mouse, Transgenic Mouse)
• Pitter, MR;Kryczek, I;Zhang, H;Nagarsheth, N;Xia, H;Wu, Z;Tian, Y;Okla, K;Liao, P;Wang, W;Zhou, J;Li, G;Lin, H;Vatan, L;Grove, S;Wei, S;Li, Y;Zou, W; PAD4 controls tumor immunity via restraining the MHC class II machinery in macrophages Cell reports 2024-03-13 [PMID: 38489266] (Bioassay, Human)
• Sorenson, CM;Gurel, Z;Song, YS;Peterson, KD;Blodi, BA;Sheibani, N; Thrombospondin-1, BIM and CFH polymorphisms and response to anti-VEGF treatment in neovascular age- related macular degeneration patients PloS one 2024-02-26 [PMID: 38408093] (Bioassay, Mouse, Transgenic Mouse)
• Sun, R;Lei, C;Xu, Z;Gu, X;Huang, L;Chen, L;Tan, Y;Peng, M;Yaddanapudi, K;Siskind, L;Kong, M;Mitchell, R;Yan, J;Deng, Z; Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages Nature communications 2024-02-01 [PMID: 38302493] (Bioassay, Mouse)
• Li, T;Bao, Y;Xia, Y;Meng, H;Zhou, C;Huang, L;Wang, X;Lai, EY;Jiang, P;Mao, J; Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients International journal of biological sciences 2024-01-12 [PMID: 38250156] (Bioassay, Mouse)
• Hou, Y;Wei, D;Zhang, Z;Lei, T;Li, S;Bao, J;Guo, H;Tan, L;Xie, X;Zhuang, Y;Lu, Z;Zhao, Y; Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes Cell reports 2024-01-03 [PMID: 38175755] (Bioassay, Mouse, Transgenic Mouse)
• Lin, YL;Cheng, PY;Chin, CL;Chuang, KT;Lin, JY;Chang, N;Pan, CK;Lin, CS;Pan, SC;Chiang, BL; A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge Journal of biomedical science 2023-12-18 [PMID: 38110940] (Bioassay, Mouse)
• Hilligan, KL;Namasivayam, S;Clancy, CS;Baker, PJ;Old, SI;Peluf, V;Amaral, EP;Oland, SD;O'Mard, D;Laux, J;Cohen, M;Garza, NL;Lafont, BAP;Johnson, RF;Feng, CG;Jankovic, D;Lamiable, O;Mayer-Barber, KD;Sher, A; Bacterial-induced or passively administered interferon gamma conditions the lung for early control of SARS-CoV-2 Nature communications 2023-12-12 [PMID: 38086794] (In vivo assay, Mouse)
• Bao, Y;Qiao, Y;Choi, JE;Zhang, Y;Mannan, R;Cheng, C;He, T;Zheng, Y;Yu, J;Gondal, M;Cruz, G;Grove, S;Cao, X;Su, F;Wang, R;Chang, Y;Kryczek, I;Cieslik, M;Green, MD;Zou, W;Chinnaiyan, AM; Targeting the lipid kinase PIKfyve upregulates surface expression of MHC class I to augment cancer immunotherapy Proceedings of the National Academy of Sciences of the United States of America 2023-12-05 [PMID: 38011559] (ICC, Xenograft)
• Chuang, WH;Pislyagin, E;Lin, LY;Menchinskaya, E;Chernikov, O;Kozhemyako, V;Gorpenchenko, T;Manzhulo, I;Chaikina, E;Agafonova, I;Silchenko, A;Avilov, S;Stonik, V;Tzou, SC;Aminin, D;Wang, YM; Holothurian triterpene glycoside cucumarioside A2-2 induces macrophages activation and polarization in cancer immunotherapy Cancer cell international 2023-11-24 [PMID: 38001420] (Bioassay, Mouse)
• Merchak, AR;Wachamo, S;Brown, LC;Thakur, A;Moreau, B;Brown, RM;Rivet-Noor, C;Raghavan, T;Gaultier, A; Lactobacillus from the Altered Schaedler Flora maintain IFN? homeostasis to promote behavioral stress resilience Brain, behavior, and immunity 2023-11-02 [PMID: 37924959] (In Vivo, Mouse)
• Pan, ML;Ahmad Puzi, NN;Ooi, YY;Ramasamy, R;Vidyadaran, S; Response Profiles of BV2 Microglia to IFN-? and LPS Co-Stimulation and Priming Biomedicines 2023-09-27 [PMID: 37893022] (Bioassay, Mouse)
• Wu, L;Yin, W;Wen, J;Wang, S;Li, H;Wang, X;Zhang, W;Duan, S;Zhu, Q;Gao, E;Wu, S;Zhan, B;Zhou, R;Yang, X; Excretory/secretory products from Trichinella spiralis adult worms ameliorate myocardial infarction by inducing M2 macrophage polarization in a mouse model Parasites & vectors 2023-10-16 [PMID: 37845695] (Bioassay, Mouse)
• Adrian, M;Weber, M;Tsai, MC;Glock, C;Kahn, OI;Phu, L;Cheung, TK;Meilandt, WJ;Rose, CM;Hoogenraad, CC; Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release Nature communications 2023-10-09 [PMID: 37813836] (Bioassay, Mouse)
• Baumgartner, CK;Ebrahimi-Nik, H;Iracheta-Vellve, A;Hamel, KM;Olander, KE;Davis, TGR;McGuire, KA;Halvorsen, GT;Avila, OI;Patel, CH;Kim, SY;Kammula, AV;Muscato, AJ;Halliwill, K;Geda, P;Klinge, KL;Xiong, Z;Duggan, R;Mu, L;Yeary, MD;Patti, JC;Balon, TM;Mathew, R;Backus, C;Kennedy, DE;Chen, A;Longenecker, K;Klahn, JT;Hrusch, CL;Krishnan, N;Hutchins, CW;Dunning, JP;Bulic, M;Tiwari, P;Colvin, KJ;Chuong, CL;Kohnle, IC;Rees, MG;Boghossian, A;Ronan, M;Roth, JA;Wu, MJ;Suermondt, JSMT;Knudsen, NH;Cheruiyot, CK;Sen, DR;Griffin, GK;Golub, TR;El-Bardeesy, N;Decker, JH;Yang, Y;Guffroy, M;Fossey, S;Trusk, P;Sun, IM;Liu, Y;Qiu, W;Sun, Q;Paddock, MN;Farney, EP;Matulenko, MA;Beauregard, C;Frost, JM;Yates, KB;Kym, PR;Manguso, RT; The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity Nature 2023-10-04 [PMID: 37794185] (Bioassay, Mouse)
• Li, H;Wang, Y;Yang, F;Feng, S;Chang, K;Yu, X;Guan, F;Li, X; Clonal MDS/AML cells with enhanced TWIST1 expression reprogram the differentiation of bone marrow MSCs Redox biology 2023-09-21 [PMID: 37748319] (In Vivo, Mouse)
• Aboushousha, R;van der Velden, J;Hamilton, N;Peng, Z;MacPherson, M;Erickson, C;White, S;Wouters, EFM;Reynaert, NL;Seward, DJ;Li, J;Janssen-Heininger, YMW; Glutaredoxin attenuates glutathione levels via deglutathionylation of Otub1 and subsequent destabilization of system xC Science advances 2023-09-15 [PMID: 37703360] (Bioassay, Mouse)
• Arp, NL;Seim, G;Josephson, J;Fan, J; Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenase complex and impact muscle cell metabolism bioRxiv : the preprint server for biology 2023-07-31 [PMID: 37577551] (Bioassay, Mouse)
• Ono, K;Sato, J;Suzuki, H;Sawada, M; Distribution of Signal Peptides in Microvesicles from Activated Macrophage Cells International journal of molecular sciences 2023-07-28 [PMID: 37569508] (Bioassay, Mouse)
• Wang, Y;Wu, T;Tsai, MC;Rezzonico, MG;Abdel-Haleem, AM;Xie, L;Gandham, VD;Ngu, H;Stark, K;Glock, C;Xu, D;Foreman, O;Friedman, BA;Sheng, M;Hanson, JE; TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice eLife 2023-08-09 [PMID: 37555828] (Bioassay, Mouse)
• Castiglioni, A;Yang, Y;Williams, K;Gogineni, A;Lane, RS;Wang, AW;Shyer, JA;Zhang, Z;Mittman, S;Gutierrez, A;Astarita, JL;Thai, M;Hung, J;Yang, YA;Pourmohamad, T;Himmels, P;De Simone, M;Elstrott, J;Capietto, AH;Cubas, R;Modrusan, Z;Sandoval, W;Ziai, J;Gould, SE;Fu, W;Wang, Y;Koerber, JT;Sanjabi, S;Mellman, I;Turley, SJ;Müller, S; Combined PD-L1/TGF? blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors Nature communications 2023-08-05 [PMID: 37543621] (Bioassay, Mouse)
• Rachdi, L;Zhou, Z;Berthault, C;Lourenço, C;Fouque, A;Domet, T;Armanet, M;You, S;Peakman, M;Mallone, R;Scharfmann, R; Tryptophan metabolism promotes immune evasion in human pancreatic beta cells EBioMedicine 2023-08-01 [PMID: 37536063] (Bioassay, Human)
• Olabiyi, BF;Schmoele, AC;Beins, EC;Zimmer, A; Pharmacological blockade of cannabinoid receptor 2 signaling does not affect LPS/IFN-gamma -induced microglial activation Scientific reports 2023-07-10 [PMID: 37429837] (Stimulation, Mouse)
• Bod, L;Kye, YC;Shi, J;Torlai Triglia, E;Schnell, A;Fessler, J;Ostrowski, SM;Von-Franque, MY;Kuchroo, JR;Barilla, RM;Zaghouani, S;Christian, E;Delorey, TM;Mohib, K;Xiao, S;Slingerland, N;Giuliano, CJ;Ashenberg, O;Li, Z;Rothstein, DM;Fisher, DE;Rozenblatt-Rosen, O;Sharpe, AH;Quintana, FJ;Apetoh, L;Regev, A;Kuchroo, VK; B-cell-specific checkpoint molecules that regulate anti-tumour immunity Nature 2023-06-21 [PMID: 37344597] (Cell Culture, Mouse)
• Zhai, R;Lenga Ma Bonda, W;Leclaire, C;Saint-Béat, C;Theilliere, C;Belville, C;Coupet, R;Blondonnet, R;Bouvier, D;Blanchon, L;Sapin, V;Jabaudon, M; Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome Journal of translational medicine 2023-06-18 [PMID: 37331963] (Bioassay, Mouse)
• Baars, I;Jaedtka, M;Dewitz, LA;Fu, Y;Franz, T;Mohr, J;Gintschel, P;Berlin, H;Degen, A;Freier, S;Rygol, SM;Schraven, B;Kahlfuss, S;van Zandbergen, G;Müller, AJ; Leishmania major drives host phagocyte death and cell-to-cell transfer depending on intracellular pathogen proliferation rate JCI insight 2023-06-13 [PMID: 37310793] (Bioassay, Mouse)
• Waugh, KA;Minter, R;Baxter, J;Chi, C;Galbraith, MD;Tuttle, KD;Eduthan, NP;Kinning, KT;Andrysik, Z;Araya, P;Dougherty, H;Dunn, LN;Ludwig, M;Schade, KA;Tracy, D;Smith, KP;Granrath, RE;Busquet, N;Khanal, S;Anderson, RD;Cox, LL;Estrada, BE;Rachubinski, AL;Lyford, HR;Britton, EC;Fantauzzo, KA;Orlicky, DJ;Matsuda, JL;Song, K;Cox, TC;Sullivan, KD;Espinosa, JM; Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model Nature genetics 2023-06-05 [PMID: 37277650] (Bioassay, Transgenic Mouse)
• Nohara, LL;Ellis, SLS;Dreier, C;Dada, S;Saranchova, I;Munro, L;Pfeifer, CG;Coyle, KM;Morrice, JR;Shim, DJS;Ahn, P;De Voogd, N;Williams, DE;Cheng, P;Garrovillas, E;Andersen, RJ;Jefferies, WA; A novel cell-based screen identifies chemical entities that reverse the immune-escape phenotype of metastatic tumours Frontiers in pharmacology 2023-05-15 [PMID: 37256225] (Bioassay, Mouse)
• Wayne, CR;Bremner, L;Faust, TE;Dur�n-Laforet, V;Ampatey, N;Ho, SJ;Feinberg, PA;Arvanitis, P;Ciric, B;Ruan, C;Elyaman, W;Delaney, SL;Vargas, WS;Swedo, S;Menon, V;Schafer, DP;Cutforth, T;Agalliu, D; Distinct Th17 effector cytokines differentially promote microglial and blood-brain barrier inflammatory responses during post-infectious encephalitis bioRxiv : the preprint server for biology 2023-05-09 [PMID: 37215000] (Bioassay, Mouse)
• Naito, Y;Koyama, S;Masuhiro, K;Hirai, T;Uenami, T;Inoue, T;Osa, A;Machiyama, H;Watanabe, G;Sax, N;Villa, J;Kinugasa-Katayama, Y;Nojima, S;Yaga, M;Hosono, Y;Okuzaki, D;Satoh, S;Tsuda, T;Nakanishi, Y;Suga, Y;Morita, T;Fukushima, K;Nishide, M;Shiroyama, T;Miyake, K;Iwahori, K;Hirata, H;Nagatomo, I;Yano, Y;Tamiya, M;Kumagai, T;Takemoto, N;Inohara, H;Yamasaki, S;Yamashita, K;Aoshi, T;Akbay, EA;Hosen, N;Shintani, Y;Takamatsu, H;Mori, M;Takeda, Y;Kumanogoh, A; Tumor-derived semaphorin 4A improves PD-1-blocking antibody efficacy by enhancing CD8+ T cell cytotoxicity and proliferation Science advances 2023-05-19 [PMID: 37205755] (Bioassay, Transgenic Mouse, Mouse)
• Slieker, RC;Donnelly, LA;Akalestou, E;Lopez-Noriega, L;Melhem, R;G�ne?, A;Abou Azar, F;Efanov, A;Georgiadou, E;Muniangi-Muhitu, H;Sheikh, M;Giordano, GN;�kerlund, M;Ahlqvist, E;Ali, A;Banasik, K;Brunak, S;Barovic, M;Bouland, GA;Burdet, F;Canouil, M;Dragan, I;Elders, PJM;Fernandez, C;Festa, A;Fitipaldi, H;Froguel, P;Gudmundsdottir, V;Gudnason, V;Gerl, MJ;van der Heijden, AA;Jennings, LL;Hansen, MK;Kim, M;Leclerc, I;Klose, C;Kuznetsov, D;Mansour Aly, D;Mehl, F;Marek, D;Melander, O;Niknejad, A;Ottosson, F;Pavo, I;Duffin, K;Syed, SK;Shaw, JL;Cabrera, O;Pullen, TJ;Simons, K;Solimena, M;Suvitaival, T;Wretlind, A;Rossing, P;Lyssenko, V;Legido Quigley, C;Groop, L;Thorens, B;Franks, PW;Lim, GE;Estall, J;Ibberson, M;Beulens, JWJ;'t Hart, LM;Pearson, ER;Rutter, GA; Identification of biomarkers for glycaemic deterioration in type 2 diabetes Nature communications 2023-05-03 [PMID: 37137910] (Bioassay, Mouse)
• BD Hobson, AT Stanley, MB De Los San, B Culbertson, EV Mosharov, PA Sims, D Sulzer Conserved and cell type-specific transcriptional responses to IFN-gamma in the ventral midbrain Brain, Behavior, and Immunity, 2023-04-24;0(0):. 2023-04-24 [PMID: 37100211] (Bioassay, Mouse)
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• CY Hsieh, JN Lin, TY Kang, YH Wen, SH Yu, CC Wu, HP Wu Otoprotective Effects of Fucoidan Reduce Cisplatin-Induced Ototoxicity in Mouse Cochlear UB/OC-2 Cells International Journal of Molecular Sciences, 2023-02-10;24(4):. 2023-02-10 [PMID: 36834972] (Bioassay, Mouse)
• EG Foerster, DKL Tsang, S Goyal, SJ Robertson, LM Robert, H Maughan, CJ Streutker, SE Girardin, DJ Philpott ATG16L1 protects from interferon-gamma-induced cell death in the small intestinal crypt Mucosal Immunology, 2023-02-14;0(0):. 2023-02-14 [PMID: 36792009] (Bioassay, Transgenic Mouse)
• WH Lee, GE Kim, KJ Hong, HS Kim, GR Lee Insulin Receptor Substrate 1 Signaling Inhibits Foxp3 Expression and Suppressive Functions in Treg Cells through the mTORC1 Pathway International Journal of Molecular Sciences, 2023-01-29;24(3):. 2023-01-29 [PMID: 36768873] (Bioassay, Mouse)
• WH Lee, GE Kim, KJ Hong, HS Kim, GR Lee Insulin Receptor Substrate 1 Signaling Inhibits Foxp3 Expression and Suppressive Functions in Treg Cells through the mTORC1 Pathway International Journal of Molecular Sciences, 2023;24(3):. 2023 [PMID: 36768873] (Bioassay, Mouse)
• J Yu, Y Shen, J Luo, J Jin, P Li, P Feng, H Guan Upadacitinib inhibits corneal inflammation and neovascularization by suppressing M1 macrophage infiltration in the corneal alkali burn model International immunopharmacology, 2023-02-03;116(0):109680. 2023-02-03 [PMID: 36739832] (Bioassay, Mouse)
• J Li, N Liu, H Zhou, P Xian, Y Song, X Tang, Y Li, M Basler Immunoproteasome inhibition prevents progression of castration-resistant prostate cancer British Journal of Cancer, 2023-01-21;0(0):. 2023-01-21 [PMID: 36681728] (Bioassay, Mouse)
• L Tang, M Zhu, X Che, X Yang, Y Xu, Q Ma, M Zhang, Z Ni, X Shao, S Mou Astragaloside IV Targets Macrophages to Alleviate Renal Ischemia-Reperfusion Injury via the Crosstalk between Hif-1alpha and NF-kappaB (p65)/Smad7 Pathways Journal of personalized medicine, 2022-12-27;13(1):. 2022-12-27 [PMID: 36675720] (Bioassay, Mouse)
• G Spiaggia, P Taladriz-B, S Hengsberge, D Septiadi, C Geers, A Lee, B Rothen-Rut, A Petri-Fink A Near-Infrared Mechanically Switchable Elastomeric Film as a Dynamic Cell Culture Substrate Biomedicines, 2022-12-22;11(1):. 2022-12-22 [PMID: 36672538] (ELISA Control, Mouse)
• YS Song, N Jamali, CM Sorenson, N Sheibani Vitamin D Receptor Expression Limits the Angiogenic and Inflammatory Properties of Retinal Endothelial Cells Cells, 2023-01-16;12(2):. 2023-01-16 [PMID: 36672270] (Bioassay, Mouse)
• M De Burghgr, C Lourenço, C Berthault, V Aiello, A Villalba, A Fouque, M Diedisheim, S You, M Oshima, R Scharfmann Pancreatic Islet Cells Response to IFNgamma Relies on Their Spatial Location within an Islet Cells, 2022-12-28;12(1):. 2022-12-28 [PMID: 36611907] (Bioassay, Mouse)
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• YK Kim, JA Walters, ND Moss, KL Wells, R Sheridan, JG Miranda, RKP Benninger, LL Pyle, RM O'Brien, L Sussel, HW Davidson Zinc Transporter 8 Haploinsufficiency Protects Against Beta Cell Dysfunction in Type 1 Diabetes by Increasing Mitochondrial Respiration Molecular Metabolism, 2022-11-05;66(0):101632. 2022-11-05 [PMID: 36347424] (Bioassay, Mouse)
• P Wang, Z Huang, Y Peng, H Li, T Lin, Y Zhao, Z Hu, Z Zhou, W Zhou, Y Liu, FF Hou Circular RNA circBNC2 inhibits epithelial cell G2-M arrest to prevent fibrotic maladaptive repair Nature Communications, 2022-10-31;13(1):6502. 2022-10-31 [PMID: 36316334] (Bioassay, Mouse)
• KK Myo Min, D Rojas-Cana, D Penko, M DeNichilo, MP Cockshell, CB Ffrench, EJ Thompson, O Asplund, CJ Drogemulle, RB Prasad, L Groop, ST Grey, HE Thomas, T Loudovaris, TW Kay, MG Mahoney, CF Jessup, PT Coates, CS Bonder Desmoglein-2 is important for islet function and beta-cell survival Cell Death & Disease, 2022-10-29;13(10):911. 2022-10-29 [PMID: 36309486] (Bioassay, Mouse)
• F Babaeijand, A Paiero, R Long, LW Tung, SP Smith, R Cheng, J Smandych, N Kajabadi, CK Chang, A Ghassemi, WDM Kennedy, H Soliman, PW Schutz, FMV Rossi TNFalpha and IFNgamma cooperate for efficient pro- to anti-inflammatory transition of macrophages during muscle regeneration Proceedings of the National Academy of Sciences of the United States of America, 2022-10-24;119(44):e2209976119. 2022-10-24 [PMID: 36279473] (Bioassay, Mouse)
• AP Shaik, AS Shaik, M Abudawood, A Al Faraj Detection of Radiolabeled Inflammatory Cell Macrophage Subpopulations in Chronic Respiratory Diseases: Results from Preliminary Analyses BioMed Research International, 2022-10-06;2022(0):9470845. 2022-10-06 [PMID: 36246991] (Bioassay, Mouse)
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• I Mhatre-Win, A Eid, Y Han, K Tieu, JR Richardson Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Microglia from APOE Targeted Replacement Mice International Journal of Molecular Sciences, 2022-08-29;23(17):. 2022-08-29 [PMID: 36077227] (Bioassay, Mouse)
• T Otsuki, N Fukuda, L Chen, A Tsunemi, M Abe Twist-related protein 1 induces epithelial-mesenchymal transition and renal fibrosis through the upregulation of complement 3 PLoS ONE, 2022-08-26;17(8):e0272917. 2022-08-26 [PMID: 36018840] (Bioassay, Mouse)
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• S Ng, S Lim, ACN Sim, R Mangadu, A Lau, C Zhang, SB Martinez, A Chandramoh, UM Lim, SSW Ho, SC Chang, P Gopal, LZ Hong, A Schwaid, AZ Fernandis, A Loboda, C Li, U Phan, B Henry, AW Partridge STUB1 is an intracellular checkpoint for interferon gamma sensing Scientific Reports, 2022-08-18;12(1):14087. 2022-08-18 [PMID: 35982220] (Bioassay, Human)
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• EG Vasquez, N Nasreddin, GN Valbuena, EJ Mulholland, HL Belnoue-Da, HR Eggington, RO Schenck, VM Wouters, P Wirapati, K Gilroy, TRM Lannagan, DJ Flanagan, AK Najumudeen, S Omwenga, AMB McCorry, A Easton, VH Koelzer, JE East, D Morton, L Trusolino, T Maughan, AD Campbell, MB Loughrey, PD Dunne, P Tsantoulis, DJ Huels, S Tejpar, OJ Sansom, SJ Leedham Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia Cell Stem Cell, 2022-08-04;29(8):1213-1228.e8. 2022-08-04 [PMID: 35931031] (Bioassay, Mouse)
• R Guo, X Jia, Z Ding, G Wang, M Jiang, B Li, S Chen, B Xia, Q Zhang, J Liu, R Zheng, Z Gao, X Xie Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation Theranostics, 2022-07-04;12(11):5220-5236. 2022-07-04 [PMID: 35836819] (Bioassay, Mouse)
• MB Bayazit, C Jacovetti, C Cosentino, J Sobel, K Wu, F Brozzi, A Rodriguez-, L Stoll, C Guay, R Regazzi Small RNAs derived from tRNA fragmentation regulate the functional maturation of neonatal beta cells Cell Reports, 2022-07-12;40(2):111069. 2022-07-12 [PMID: 35830789] (Bioassay, Rat)
• MK Ameka, WN Beavers, CM Shaver, LB Ware, VE Kerchberge, KQ Schoenfelt, L Sun, T Koyama, EP Skaar, L Becker, AH Hasty An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload International Journal of Molecular Sciences, 2022-07-03;23(13):. 2022-07-03 [PMID: 35806422] (Bioassay, Mouse)
• H Qu, R Heinbäck, H Salo, E Ewing, A Espinosa, C Aulin, H Erlandsson Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1 Biomolecules, 2022-06-02;12(6):. 2022-06-02 [PMID: 35740904] (Bioassay, Mouse)
• G Coquant, D Aguanno, L Brot, C Belloir, J Delugeard, N Roger, HP Pham, L Briand, M Moreau, L de Sordi, V Carrière, JP Grill, S Thenet, P Seksik 3-oxo-C12:2-HSL, quorum sensing molecule from human intestinal microbiota, inhibits pro-inflammatory pathways in immune cells via bitter taste receptors Oncogene, 2022-06-08;12(1):9440. 2022-06-08 [PMID: 35676403] (Bioassay, Mouse)
• H Kamei, T Ishii, Y Nishii Semaphorin 3A regulates alveolar bone remodeling on orthodontic tooth movement Oncogene, 2022-06-02;12(1):9243. 2022-06-02 [PMID: 35654941] (Bioassay, Mouse)
• Y Jin, Y Liu, L Xu, J Xu, Y Xiong, Y Peng, K Ding, S Zheng, N Yang, Z Zhang, L Li, L Tan, H Song, J Fu Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis Cell Death & Disease, 2022-05-31;13(5):512. 2022-05-31 [PMID: 35641492] (Bioassay, Mouse)
• R Mary, F Chalmin, T Accogli, M Bruchard, C Hibos, J Melin, C Truntzer, E Limagne, V Derangère, M Thibaudin, E Humblin, R Boidot, S Chevrier, L Arnould, C Richard, Q Klopfenste, A Bernard, Y Urade, JA Harker, L Apetoh, F Ghiringhel, F Végran Hematopoietic Prostaglandin D2 Synthase Controls Tfh/Th2 Communication and Limits Tfh Antitumor Effects Cancer Immunology Research, 2022-07-01;0(0):OF1-OF17. 2022-07-01 [PMID: 35612500] (Bioassay, Mouse)
• SO Vasudevan, AJ Russo, P Kumari, SK Vanaja, VA Rathinam A TLR4-independent critical role for CD14 in intracellular LPS sensing Cell Reports, 2022-05-03;39(5):110755. 2022-05-03 [PMID: 35508125] (Bioassay, Mouse)
• A Steiner, K Hrovat-Sch, I Prigione, CH Yu, P Laohamonth, CR Harapas, RRJ Low, D De Nardo, LF Dagley, MJ Mlodzianos, KL Rogers, T Zillinger, G Hartmann, MP Gantier, M Gattorno, M Geyer, S Volpi, S Davidson, SL Masters Deficiency in coatomer complex I causes aberrant activation of STING signalling Nature Communications, 2022-04-28;13(1):2321. 2022-04-28 [PMID: 35484149] (Bioassay, Human)
• W Piao, L Li, V Saxena, J Iyyathurai, R Lakhan, Y Zhang, IT Lape, C Paluskievi, KL Hippen, Y Lee, E Silverman, MW Shirkey, LV Riella, BR Blazar, JS Bromberg PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration Nature Communications, 2022-04-21;13(1):2176. 2022-04-21 [PMID: 35449134] (Bioassay, Mouse)
• ML Yang, S Horstman, R Gee, P Guyer, TT Lam, J Kanyo, AL Perdigoto, C Speake, CJ Greenbaum, A Callebaut, L Overbergh, RG Kibbey, KC Herold, EA James, MJ Mamula Citrullination of glucokinase is linked to autoimmune diabetes Nature Communications, 2022-04-06;13(1):1870. 2022-04-06 [PMID: 35388005] (Bioassay, Rat)
• L Liu, RM Lucas, JD Nanson, Y Li, J Whitfield, JEB Curson, N Tuladhar, K Alexandrov, M Mobli, MJ Sweet, B Kobe, J Stow, L Luo The transmembrane adaptor SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs The Journal of Biological Chemistry, 2022-03-22;0(0):101857. 2022-03-22 [PMID: 35337798] (Bioassay, Mouse)
• A Stancic, T Saksida, M Markelic, M Vucetic, I Grigorov, V Martinovic, D Gajic, A Ivanovic, K Velickovic, N Savic, V Otasevic Ferroptosis as a Novel Determinant of beta-Cell Death in Diabetic Conditions Oxidative Medicine and Cellular Longevity, 2022-03-14;2022(0):3873420. 2022-03-14 [PMID: 35320979] (Cell Culture, Rat)
• A Fedoriw, L Shi, S O'Brien, KN Smitheman, Y Wang, J Hou, C Sherk, S Rajapurkar, J Laraio, LJ Williams, C Xu, G Han, Q Feng, MT Bedford, L Wang, O Barbash, RG Kruger, P Hwu, HP Mohammad, W Peng Inhibiting Type I arginine methyltransferase activity promotes the T cell mediated antitumor immune response Cancer Immunology Research, 2022-04-01;0(0):. 2022-04-01 [PMID: 35181787] (Bioassay, Human)
• SW Tuffs, MI Goncheva, SX Xu, HC Craig, KJ Kasper, J Choi, RS Flannagan, SM Kerfoot, DE Heinrichs, JK McCormick Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma production Proceedings of the National Academy of Sciences of the United States of America, 2022-02-22;119(8):. 2022-02-22 [PMID: 35165181] (Bioassay, Mouse)
• J Jin, I Sivakumar, Y Mironchik, B Krishnamac, F Wildes, JD Barnett, CF Hung, S Nimmagadda, H Kobayashi, ZM Bhujwalla, MF Penet PD-L1 near Infrared Photoimmunotherapy of Ovarian Cancer Model Cancers, 2022-01-26;14(3):. 2022-01-26 [PMID: 35158887] (Bioassay, Mouse)
• EI Arafa, AT Shenoy, KA Barker, NS Etesami, IM Martin, C Lyon De An, E Na, CV Odom, WN Goltry, FT Korkmaz, AK Wooten, AC Belkina, A Guillon, EC Forsberg, MR Jones, LJ Quinton, JP Mizgerd Recruitment and training of alveolar macrophages after pneumococcal pneumonia JCI Insight, 2022-03-08;0(0):. 2022-03-08 [PMID: 35133985] (Bioassay, Mouse)
• Z Wang, K Huang, J Xu, J Liu, Y Zheng Insights from Dysregulated mRNA Expression Profile of beta-Cells in Response to Proinflammatory Cytokines Journal of Immunology Research, 2022-01-22;2022(0):4542487. 2022-01-22 [PMID: 35103245] (Bioassay, Mouse)
• JG Miranda, WE Schleicher, KL Wells, DG Ramirez, SP Landgrave, RK Benninger Dynamic changes in beta-cell [Ca2+] regulates NFAT activation, gene transcription and islet gap junction communication Oncogene, 2021-12-31;0(0):101430. 2021-12-31 [PMID: 34979329] (Bioassay, Mouse)
• H Mo, Q Ren, D Song, B Xu, D Zhou, X Hong, FF Hou, L Zhou, Y Liu CXCR4 induces podocyte injury and proteinuria by activating beta-catenin signaling Theranostics, 2022-01-01;12(2):767-781. 2022-01-01 [PMID: 34976212] (Bioassay, Mouse)
• HR McMurray, A Ambeskovic, LA Newman, J Aldersley, V Balakrishn, B Smith, HA Stern, H Land, MN McCall Gene network modeling via TopNet reveals functional dependencies between diverse tumor-critical mediator genes Cell Reports, 2021-12-21;37(12):110136. 2021-12-21 [PMID: 34936873] (Bioassay, Mouse)
• P Chauhan, WS Sheng, S Hu, S Prasad, JR Lokensgard Differential Cytokine-Induced Responses of Polarized Microglia Brain sciences, 2021-11-10;11(11):. 2021-11-10 [PMID: 34827481] (Bioassay, Mouse)
• Y Zhang, Y Zheng, F Shu, R Zhou, B Bao, S Xiao, K Li, Q Lin, L Zhu, Z Xia In situ-formed adhesive hyaluronic acid hydrogel with prolonged amnion-derived conditioned medium release for diabetic wound repair Carbohydrate polymers, 2021-10-16;276(0):118752. 2021-10-16 [PMID: 34823781] (Bioassay, Mouse)
• A Fu, L van Rooyen, L Evans, N Armstrong, D Avizonis, T Kin, GH Bird, A Reddy, ET Chouchani, M Liesa-Roig, LD Walensky, AMJ Shapiro, NN Danial Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets Cell Reports, 2021-11-23;37(8):110037. 2021-11-23 [PMID: 34818536] (Bioassay, Mouse)
• J Amo-Aparic, J Garcia-Gar, I Francos-Qu, A Urpi, A Esteve-Cod, M Gut, A Quintana, R Lopez-Vale Interleukin-4 and interleukin-13 induce different metabolic profiles in microglia and macrophages that relate with divergent outcomes after spinal cord injury Theranostics, 2021-10-03;11(20):9805-9820. 2021-10-03 [PMID: 34815787] (Bioassay, Mouse)
• KKL Wu, K Long, H Lin, PMF Siu, RLC Hoo, D Ye, A Xu, KKY Cheng The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages Nature Communications, 2021-11-17;12(1):6637. 2021-11-17 [PMID: 34789781] (Bioassay, Mouse)
• P Rozier, M Maumus, ATJ Maria, K Toupet, C Jorgensen, P Guilpain, D Noël Lung Fibrosis Is Improved by Extracellular Vesicles from IFNgamma-Primed Mesenchymal Stromal Cells in Murine Systemic Sclerosis Cells, 2021-10-13;10(10):. 2021-10-13 [PMID: 34685707] (Cell Culture, Mouse)
• JM Motta, VM Rumjanek, A Mantovani, M Locati Tumor-Released Products Promote Bone Marrow-Derived Macrophage Survival and Proliferation Biomedicines, 2021-10-04;9(10):. 2021-10-04 [PMID: 34680504] (Differentiation, Differentiation, Mouse)
• F Progatzky, M Shapiro, SH Chng, B Garcia-Cas, CH Classon, S Sevgi, A Laddach, AC Bon-Frauch, R Lasrado, M Rahim, EM Amaniti, S Boeing, K Shah, LJ Entwistle, A Suárez-Bon, MS Wilson, B Stockinger, V Pachnis Regulation of intestinal immunity and tissue repair by enteric glia Nature, 2021-10-20;599(7883):125-130. 2021-10-20 [PMID: 34671159] (Bioassay, Mouse)
• G Wang, L Xie, B Li, W Sang, J Yan, J Li, H Tian, W Li, Z Zhang, Y Tian, Y Dai A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis Nature Communications, 2021-09-30;12(1):5733. 2021-09-30 [PMID: 34593794] (Bioassay, Mouse)
• Z Qian, H Yang, H Li, C Liu, L Yang, Z Qu, X Li The Cholinergic Anti-Inflammatory Pathway Attenuates the Development of Atherosclerosis in Apoe-/- Mice through Modulating Macrophage Functions Biomedicines, 2021-09-03;9(9):. 2021-09-03 [PMID: 34572339] (Bioassay, Mouse)
• TD Popoola, ST Guetchueng, KJ Ritchie, O Awodele, NM Dempster, O Akinloye, SD Sarker, AA Fatokun Potent Nrf2-inducing, antioxidant, and anti-inflammatory effects and identification of constituents validate the anti-cancer use of Uvaria chamae and Olax subscorpioidea BMC complementary medicine and therapies, 2021-09-18;21(1):234. 2021-09-18 [PMID: 34537049] (Bioassay, Mouse)
• S Lee, G Kalugotla, H Ingle, R Rodgers, C Wu, Y Wang, Y Li, X Yang, J Zhang, NR Borella, H Deng, L Droit, R Hill, ST Peterson, C Desai, D Lawrence, Q Lu, MT Baldridge Intestinal antiviral signaling is controlled by autophagy gene Epg5 independent of the microbiota Autophagy, 2021-09-14;0(0):1-16. 2021-09-14 [PMID: 34520306] (Bioassay, Mouse)
• M Choi, JA Bonanno Mitochondrial Targeting of the Ammonia-Sensitive Uncoupler SLC4A11 by the Chaperone-Mediated Carrier Pathway in Corneal Endothelium Investigative Ophthalmology & Visual Science, 2021-09-02;62(12):4. 2021-09-02 [PMID: 34499705] (Bioassay, Mouse)
• A Gluschko, A Farid, M Herb, D Grumme, M Krönke, M Schramm Macrophages target Listeria monocytogenes by two discrete non-canonical autophagy pathways Autophagy, 2021-09-05;0(0):1-15. 2021-09-05 [PMID: 34482812] (Bioassay, Mouse)
• A Osman, B Yan, Y Li, KD Pavelko, J Quandt, A Saadalla, MP Singh, M Kazemian, F Gounari, K Khazaie TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer Nature Immunology, 2021-08-12;0(0):. 2021-08-12 [PMID: 34385712] (Bioassay, Mouse)
• K Sumi, M Sakuda, K Munakata, K Nakamura, K Ashida alpha-Hydroxyisocaproic Acid Decreases Protein Synthesis but Attenuates TNFalpha/IFNgamma Co-Exposure-Induced Protein Degradation and Myotube Atrophy via Suppression of iNOS and IL-6 in Murine C2C12 Myotube Nutrients, 2021-07-13;13(7):. 2021-07-13 [PMID: 34371902] (Bioassay, Mouse)
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• Butovsky O, Koronyo-Hamaoui M, Kunis G, Ophir E, Landa G, Cohen H, Schwartz M Glatiramer acetate fights against Alzheimer&apos;s disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc. Natl. Acad. Sci. U.S.A., 2006-07-24;103(31):11784-9. 2006-07-24 [PMID: 16864778] (Bioassay, Mouse)
• Butovsky O, Landa G, Kunis G, Ziv Y, Avidan H, Greenberg N, Schwartz A, Smirnov I, Pollack A, Jung S, Schwartz M Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis. J. Clin. Invest., 2006-03-23;116(4):905-15. 2006-03-23 [PMID: 16557302] (Bioassay, Mouse)
• An HJ, Jeong HJ, Um JY, Kim HM, Hong SH Glechoma hederacea inhibits inflammatory mediator release in IFN-gamma and LPS-stimulated mouse peritoneal macrophages. J Ethnopharmacol, 2006-03-10;106(3):418-24. 2006-03-10 [PMID: 16530364] (Bioassay, In Vivo, Mouse)
• Zhang F, Lee J, Wang D, Dong Z Differential Growth of IFN-beta-Engineered Tumor Cells in Nude and IFN Receptor-Null Mice. J. Interferon Cytokine Res., 2006-02-01;26(2):108-18. 2006-02-01 [PMID: 16487031] (Bioassay, Mouse)
• Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar AE, Pluchino S, Martino G, Schwartz M Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol. Cell. Neurosci., 2005-11-16;31(1):149-60. 2005-11-16 [PMID: 16297637] (Bioassay, Mouse)
• Best SM, Morris KL, Shannon JG, Robertson SJ, Mitzel DN, Park GS, Boer E, Wolfinbarger JB, Bloom ME Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist. J. Virol., 2005-10-01;79(20):12828-39. 2005-10-01 [PMID: 16188985] (Bioassay, Mouse)
• Osuchowski MF, Siddiqui J, Copeland S, Remick DG Sequential ELISA to profile multiple cytokines from small volumes. J. Immunol. Methods, 2005-07-01;302(1):172-81. 2005-07-01 [PMID: 16023134] (ELISA (Standard))
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• Zamboni DS, Campos MA, Torrecilhas AC, Kiss K, Samuel JE, Golenbock DT, Lauw FN, Roy CR, Almeida IC, Gazzinelli RT Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection. J. Biol. Chem., 2004-10-13;279(52):54405-15. 2004-10-13 [PMID: 15485838] (Bioassay, Mouse)
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FAQs for IFN-gamma (485-MI). (Showing 1 - 1 of 1 FAQs).

1. Is Recombinant Human IFN-gamma Protein - Clinical grade or preclinical ?
   • We are research use only.

Bioinformatics

• Gene Symbol: Ifng
• Uniprot:
  • NP_032363()