Recombinant Mouse IL-2 Protein

Recombinant Mouse IL-2 (Catalog # 402‑ML) stimulates cell proliferation of the CTLL‑2 mouse cytotoxic T cell line. The ED50 for this effect is 0.1‑0.4 ng/mL.

1 μg/lane of Recombinant Mouse IL-2 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a band(s) at 19 kDa.

• Reactivity: Mu
• Applications: Bioactivity

Recombinant Mouse IL-2 Protein Summary

• Details of Functionality: Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. Gearing, A.J.H. and C.B. Bird (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 295. The ED₅₀ for this effect is 0.1-0.4 ng/mL.
• Source: E. coli-derived mouse IL-2 protein
  Ala21-Gln169, with and without an N-terminal Met
• Accession #: P04351
• N-terminal Sequence: Ala21 & Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: Il2
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 17.2 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in Sodium Citrate and Tween®-80 with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Reconstitution Instructions: Reconstitute at 100-200 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IL-2 Protein

• Aldesleukin
• IL2
• IL-2
• IL-2lymphokine
• interleukin 2
• interleukin-2
• involved in regulation of T-cell clonal expansion
• Proleukin
• T cell growth factor
• T-cell growth factor
• TCGF

Background

Interleukin‑2 (IL‑2) is a O‑glycosylated four alpha ‑helix bundle cytokine that has potent stimulatory activity for antigen‑activated T cells. It is expressed by CD4⁺ and CD8⁺ T cells, gamma δ T cells, B cells, dendritic cells, and eosinophils (1‑3). Mature mouse IL‑2 shares 56% and 73% aa sequence identity with human and rat IL‑2, respectively. It shows strain‑specific heterogeneity in an N‑terminal region that contains a poly‑glutamine stretch (4). Mouse and human IL‑2 exhibit cross‑species activity (5). The receptor for IL‑2 consists of three subunits that are present on the cell surface in varying preformed complexes (6‑8). The 55 kDa IL‑2 R alpha is specific for IL‑2 and binds with low affinity. The 75 kDa IL‑2 R beta , which is also a component of the IL‑15 receptor, binds IL‑2 with intermediate affinity. The 64 kDa common gamma chain gamma c/IL-2 R gamma , which is shared with the receptors for IL‑4, ‑7, ‑9, ‑15, and ‑21, does not independently interact with IL‑2. Upon ligand binding, signal transduction is performed by both IL‑2 R beta and gamma c. IL‑2 is best known for its autocrine and paracrine activity on T cells. It drives resting T cells to proliferate and induces IL‑2 and IL‑2 R alpha synthesis (1, 2). It contributes to T cell homeostasis by promoting the Fas‑induced death of naïve CD4⁺ T cells but not activated CD4⁺ memory lymphocytes (9). IL‑2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells (10‑12). Thus, IL‑2 may be a key cytokine in the natural suppression of autoimmunity (13, 14).

1. Ma, A. et al. (2006) Annu. Rev. Immunol. 24:657.
2. Gaffen, S.L. and K.D. Liu (2004) Cytokine 28:109.
3. Kashima, N. et al. (1985) Nature 313:402.
4. Matesanz, F. et al. (1993) Immunogenetics 38:300.
5. Mosmann, T.R. et al. (1987) J. Immunol. 138:1813.
6. Liparoto, S.F. et al. (2002) Biochemistry 41:2543.
7. Wang, X. et al. (2005) Science 310:1159.
8. Bodnar, A. et al. (2008) Immunol. Lett. 116:117.
9. Jaleco, S. et al. (2003) J. Immunol. 171:61.
10. Malek, T.R. (2003) J. Leukoc. Biol. 74:961.
11. Laurence, A. et al. (2007) Immunity 26:371.
12. Kryczek, I. et al. (2007) J. Immunol. 178:6730.
13. Afzali, B. et al. (2007) Clin. Exp. Immunol. 148:32.
14. Fehervari, Z. et al. (2006) Trends Immunol. 27:109.

Publications for IL-2 (402-ML)(270)

Publications using 402-ML

• Xie, Y;Liu, Y;Lin, M;Li, Z;Shen, Z;Yin, S;Zheng, Y;Zou, Y;Zhang, Y;Zhan, Y;Fang, Y;Ding, Y; Targeting ATM enhances radiation sensitivity of colorectal cancer by potentiating radiation-induced cell death and antitumor immunity Journal of advanced research 2024-12-19 [PMID: 39708961] (Bioassay, Mouse)
• Westermann, S;Radtke, D;Kramer, L;Wirtz, S;Voehringer, D; Activation of STAT6 in Intestinal Epithelial Cells Predisposes to Gut Inflammation European journal of immunology 2024-12-13 [PMID: 39670708] (Bioassay, Transgenic Mouse)
• Hua, L;Yang, Y;Zhang, H;Jiang, X;Jin, C;Feng, B;Che, L;Xu, S;Lin, Y;Wu, D;Zhuo, Y; Adipocyte FGF21 Signaling Defect Aggravated Adipose Tissue Inflammation in Gestational Diabetes Mellitus Nutrients 2024-11-07 [PMID: 39599611] (Bioassay, Mouse)
• Wang, Z;Elbanna, Y;Godet, I;Peters, L;Lampe, G;Chen, Y;Xavier, J;Huse, M;Massagué, J; TGF-? induces an atypical EMT to evade immune mechanosurveillance in lung adenocarcinoma dormant metastasis bioRxiv : the preprint server for biology 2024-10-15 [PMID: 39463937] (Bioassay, Human)
• Dietz, S;Hebel, J;Rühle, J;Huff, A;Eltzschig, HK;Lajqi, T;Poets, CF;Gille, C;Köstlin-Gille, N; Impact of the adenosine receptor A2BR expressed on myeloid cells on immune regulation during pregnancy European journal of immunology 2024-10-25 [PMID: 39460389] (Bioassay, Mouse)
• Thylur Puttalingaiah, R;Dean, MJ;Zheng, L;Philbrook, P;Wyczechowska, D;Kayes, T;Del Valle, L;Danos, D;Sanchez-Pino, MD; Excess Potassium Promotes Autophagy to Maintain the Immunosuppressive Capacity of Myeloid-Derived Suppressor Cells Independent of Arginase 1 Cells 2024-10-19 [PMID: 39451254] (Bioassay, Mouse)
• Zhao, X;Li, F;Cheng, C;Bi, M;Li, J;Cong, J;Wang, X; Social isolation promotes tumor immune evasion via ?2-adrenergic receptor Brain, behavior, and immunity 2024-10-12 [PMID: 39401555] (Bioassay, Mouse)
• May, L;Hu, B;Jerajani, P;Jagdeesh, A;Alhawiti, O;Cai, L;Semenova, N;Guo, C;Isbell, M;Deng, X;Faber, A;Pillappa, R;Bandyopadhyay, D;Wang, XY;Neuwelt, A;Koblinski, J;Bos, PD;Li, H;Martin, R;Landry, JW; The Innate Immune System and TRAIL-BCL-XL Axis Mediate a Sex Bias in Lung Cancer and Confer a Therapeutic Vulnerability in Females Cancer research 2024-09-23 [PMID: 39312191] (Cell Culture, Human)
• Chang, YH;Yamamoto, K;Fujino, T;Wang, TW;Sugimoto, E;Zhang, W;Yabushita, T;Suzaki, K;Pietsch, EC;Weir, BA;Crescenzo, R;Cowley, GS;Attar, R;Philippar, U;Wunderlich, M;Mizukawa, B;Zheng, Y;Enomoto, Y;Imai, Y;Kitamura, T;Goyama, S; SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation Cell reports 2024-07-30 [PMID: 39096901] (Bioassay, Mouse)
• Port, JR;Riopelle, JC;Smith, SG;Myers, L;Kaiser, FK;Lewis, MC;Gallogly, S;Okumura, A;Bushmaker, T;Schulz, JE;Rosenke, R;Prado-Smith, J;Carmody, A;Bane, S;Smith, BJ;Saturday, G;Feldmann, H;Rosenke, K;Munster, VJ; Infection with mpox virus via the genital mucosae increases shedding and transmission in the multimammate rat (Mastomys natalensis) Nature microbiology 2024-04-22 [PMID: 38649413] (Bioassay, Mouse)
• Choi, SC;Park, YP;Roach, T;Jimenez, D;Fisher, A;Zadeh, M;Ma, L;Sobel, ES;Ge, Y;Mohamadzadeh, M;Morel, L; Lupus susceptibility gene Pbx1 controls the development, stability, and function of regulatory T cells via Rtkn2 expression Science advances 2024-03-29 [PMID: 38536923] (Bioassay, Mouse)
• Durand, A;Bonilla, N;Level, T;Ginestet, Z;Lombès, A;Guichard, V;Germain, M;Jacques, S;Letourneur, F;Do Cruzeiro, M;Marchiol, C;Renault, G;Le Gall, M;Charvet, C;Le Bon, A;Martin, B;Auffray, C;Lucas, B; Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice Nature communications 2024-02-26 [PMID: 38409097] (Bioassay, Mouse)
• Jiang, B;Zhou, H;Xie, X;Xia, T;Ke, C; Down-regulation of zinc finger protein 335 undermines natural killer cell function in mouse colitis-associated colorectal carcinoma Heliyon 2024-02-29 [PMID: 38375265] (Bioassay, Mouse)
• Hirai, T;Naito, Y;Koyama, S;Nakanishi, Y;Masuhiro, K;Izumi, M;Kuge, T;Naito, M;Mizuno, Y;Yamaguchi, Y;Kang, S;Yaga, M;Futami, Y;Nojima, S;Nishide, M;Morita, T;Kato, Y;Tsuda, T;Takemoto, N;Kinugasa-Katayama, Y;Aoshi, T;Villa, JK;Yamashita, K;Enokida, T;Hoshi, Y;Matsuura, K;Tahara, M;Takamatsu, H;Takeda, Y;Inohara, H;Kumanogoh, A; Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer JCI insight 2024-02-08 [PMID: 38329122] (Stimulation, Mouse)
• Landoni, E;Woodcock, MG;Barragan, G;Casirati, G;Cinella, V;Stucchi, S;Flick, LM;Withers, TA;Hudson, H;Casorati, G;Dellabona, P;Genovese, P;Savoldo, B;Metelitsa, LS;Dotti, G; IL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activity Nature communications 2024-01-02 [PMID: 38167707] (Bioassay, Human)
• Su, HH;Cheng, CM;Yang, YN;Chang, YW;Li, CY;Wu, ST;Lin, CC;Wu, HE;Suen, JL; Acrylamide, an Air Pollutant, Enhances Allergen-Induced Eosinophilic Lung Inflammation via Group 2 Innate Lymphoid Cells Mucosal immunology 2023-10-05 [PMID: 37805143] (Bioassay, Mouse)
• Baumgartner, CK;Ebrahimi-Nik, H;Iracheta-Vellve, A;Hamel, KM;Olander, KE;Davis, TGR;McGuire, KA;Halvorsen, GT;Avila, OI;Patel, CH;Kim, SY;Kammula, AV;Muscato, AJ;Halliwill, K;Geda, P;Klinge, KL;Xiong, Z;Duggan, R;Mu, L;Yeary, MD;Patti, JC;Balon, TM;Mathew, R;Backus, C;Kennedy, DE;Chen, A;Longenecker, K;Klahn, JT;Hrusch, CL;Krishnan, N;Hutchins, CW;Dunning, JP;Bulic, M;Tiwari, P;Colvin, KJ;Chuong, CL;Kohnle, IC;Rees, MG;Boghossian, A;Ronan, M;Roth, JA;Wu, MJ;Suermondt, JSMT;Knudsen, NH;Cheruiyot, CK;Sen, DR;Griffin, GK;Golub, TR;El-Bardeesy, N;Decker, JH;Yang, Y;Guffroy, M;Fossey, S;Trusk, P;Sun, IM;Liu, Y;Qiu, W;Sun, Q;Paddock, MN;Farney, EP;Matulenko, MA;Beauregard, C;Frost, JM;Yates, KB;Kym, PR;Manguso, RT; The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity Nature 2023-10-04 [PMID: 37794185] (Bioassay, Mouse)
• Jiao, D;Sun, R;Ren, X;Wang, Y;Tian, P;Wang, Y;Yuan, D;Yue, X;Wu, Z;Li, C;Gao, L;Ma, C;Liang, X; Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity Cell reports 2023-10-03 [PMID: 37792534] (Bioassay, Human)
• van Os, BW;Vos, WG;Bosmans, LA;van Tiel, CM;Toom, MD;Beckers, L;Admiraal, M;Hoeksema, MA;de Winther, MP;Lutgens, E; CD40L modulates CD4+ T cell activation through receptor for activated C kinase 1 European journal of immunology 2023-09-08 [PMID: 37683186] (Bioassay, Mouse)
• Zhao, H;Wu, L;Dai, J;Sun, K;Zi, Z;Guan, J;Zhang, L; Ligand-based adoptive T cell targeting CA125 in ovarian cancer Journal of translational medicine 2023-09-05 [PMID: 37670338] (Cell Culture, Mouse)
• van der Ploeg, EK;Krabbendam, L;Vroman, H;van Nimwegen, M;de Bruijn, MJW;de Boer, GM;Bergen, IM;Kool, M;Tramper-Standers, GA;Braunstahl, GJ;Huylebroeck, D;Hendriks, RW;Stadhouders, R; Type-2 CD8+ T-cell formation relies on interleukin-33 and is linked to asthma exacerbations Nature communications 2023-08-23 [PMID: 37612281] (In vivo assay, Mouse)
• Tamura, S;Ishiguro, H;Suwabe, T;Katagiri, T;Cho, K;Fuse, K;Shibasaki, Y;Mikami, T;Shindo, T;Kitagawa, H;Igarashi, M;Sone, H;Masuko, M;Ushiki, T; Genetic manipulation resulting in decreased donor chondroitin sulfate synthesis mitigates hepatic GVHD via suppression of T cell activity Scientific reports 2023-08-11 [PMID: 37567982] (Bioassay, Mouse)
• Rashu, R;Ninkov, M;Wardell, CM;Benoit, JM;Wang, NI;Meilleur, CE;D'Agostino, MR;Zhang, A;Feng, E;Saeedian, N;Bell, GI;Vahedi, F;Hess, DA;Barr, SD;Troyer, RM;Kang, CY;Ashkar, AA;Miller, MS;Haeryfar, SMM; Targeting the MR1-MAIT cell axis improves vaccine efficacy and affords protection against viral pathogens PLoS pathogens 2023-06-29 [PMID: 37384813] (Bioassay, Mouse)
• Suzuki, K;Kunisada, Y;Miyamura, N;Eikawa, S;Hurtado de Mendoza, T;Mose, ES;Lu, C;Kuroda, Y;Ruoslahti, E;Lowy, AM;Sugahara, KN; Tumor-resident regulatory T cells in pancreatic cancer express the ?v?5 integrin as a targetable activation marker bioRxiv : the preprint server for biology 2023-05-24 [PMID: 37292693] (Bioassay, Mouse)
• Naito, Y;Koyama, S;Masuhiro, K;Hirai, T;Uenami, T;Inoue, T;Osa, A;Machiyama, H;Watanabe, G;Sax, N;Villa, J;Kinugasa-Katayama, Y;Nojima, S;Yaga, M;Hosono, Y;Okuzaki, D;Satoh, S;Tsuda, T;Nakanishi, Y;Suga, Y;Morita, T;Fukushima, K;Nishide, M;Shiroyama, T;Miyake, K;Iwahori, K;Hirata, H;Nagatomo, I;Yano, Y;Tamiya, M;Kumagai, T;Takemoto, N;Inohara, H;Yamasaki, S;Yamashita, K;Aoshi, T;Akbay, EA;Hosen, N;Shintani, Y;Takamatsu, H;Mori, M;Takeda, Y;Kumanogoh, A; Tumor-derived semaphorin 4A improves PD-1-blocking antibody efficacy by enhancing CD8+ T cell cytotoxicity and proliferation Science advances 2023-05-19 [PMID: 37205755] (Bioassay, Mouse, Transgenic Mouse)
• Laragione, T;Harris, C;Azizgolshani, N;Beeton, C;Bongers, G;Gulko, PS; Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome EBioMedicine 2023-05-16 [PMID: 37201335] (Bioassay, Mouse)
• Cheu, JW;Chiu, DK;Kwan, KK;Yang, C;Yuen, VW;Goh, CC;Chui, NN;Shen, W;Law, CT;Li, Q;Zhang, MS;Bao, MH;Wong, BP;Chan, CY;Liu, CX;Sit, GF;Ooi, ZY;Deng, H;Tse, AP;Ng, IO;Wong, CC; Hypoxia-inducible factor orchestrates adenosine metabolism to promote liver cancer development Science advances 2023-05-05 [PMID: 37146141] (Bioassay, Mouse)
• CP Camargo, AK Muhuri, Y Alapan, LF Sestito, M Khosla, MP Manspeaker, AS Smith, CM Paulos, SN Thomas A dhesion analysis via a tumor vasculature-like microfluidic device identifies CD8+ T�cells with enhanced tumor homing to improve cell therapy Cell Reports, 2023-02-26;42(3):112175. 2023-02-26 [PMID: 36848287] (Bioassay, Human, Mouse)
• Y Liao, L Sun, M Nie, J Li, X Huang, S Heng, W Zhang, T Xia, Z Guo, Q Zhao, LJ Zhang Modulation of Skin Inflammatory Responses by Aluminum Adjuvant Pharmaceutics, 2023-02-08;15(2):. 2023-02-08 [PMID: 36839900] (Bioassay, Mouse)
• JA O'Sullivan, FJ Kohlhapp, A Zloza, L Plaza-Roja, B Burke, NO Dulin, JA Guevara-Pa Memory Precursors and Short-Lived Effector T cell Subsets Have Different Sensitivities to TGFbeta International Journal of Molecular Sciences, 2023-02-15;24(4):. 2023-02-15 [PMID: 36835342] (Bioassay, Mouse, Transgenic Mouse)
• WH Lee, GE Kim, KJ Hong, HS Kim, GR Lee Insulin Receptor Substrate 1 Signaling Inhibits Foxp3 Expression and Suppressive Functions in Treg Cells through the mTORC1 Pathway International Journal of Molecular Sciences, 2023-01-29;24(3):. 2023-01-29 [PMID: 36768873] (Bioassay, Mouse)
• WH Lee, GE Kim, KJ Hong, HS Kim, GR Lee Insulin Receptor Substrate 1 Signaling Inhibits Foxp3 Expression and Suppressive Functions in Treg Cells through the mTORC1 Pathway International Journal of Molecular Sciences, 2023;24(3):. 2023 [PMID: 36768873] (Bioassay, Mouse)
• RK Gurram, D Wei, Q Yu, MJ Butcher, X Chen, K Cui, G Hu, M Zheng, X Zhu, J Oh, B Sun, JF Urban, K Zhao, WJ Leonard, J Zhu Crosstalk between ILC2s and Th2 cells varies among mouse models Cell Reports, 2023-02-02;42(2):112073. 2023-02-02 [PMID: 36735533] (Bioassay, Mouse)
• W Lin, L Chen, H Zhang, X Qiu, Q Huang, F Wan, Z Le, S Geng, A Zhang, S Qiu, L Chen, L Kong, JJ Lu Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation Nature Communications, 2023-01-17;14(1):265. 2023-01-17 [PMID: 36650153] (Bioassay, Mouse)
• T Blanco, R Bir Singh, H Nakagawa, Y Taketani, TH Dohlman, Y Chen, SK Chauhan, J Yin, R Danan Conventional Type I Migratory CD103+ Dendritic Cells are Required for Corneal Allograft Survival Mucosal Immunology, 2023-01-13;0(0):. 2023-01-13 [PMID: 36642378] (Bioassay, Mouse)
• D Shore, N Griggs, V Graffeo, ARMR Amin, XM Zha, Y Xu, JP McAleer GPR68 limits the severity of chemical-induced oral epithelial dysplasia Scientific Reports, 2023-01-07;13(1):353. 2023-01-07 [PMID: 36611126] (Differentiation, Differentiation, Mouse)
• M Scherlinge, W Pan, R Hisada, A Boulougour, N Yoshida, M Vukelic, M Umeda, S Krishfield, MG Tsokos, GC Tsokos Phosphofructokinase P fine-tunes T regulatory cell metabolism, function, and stability in systemic autoimmunity Science Advances, 2022-11-30;8(48):eadc9657. 2022-11-30 [PMID: 36449620] (Bioassay, Transgenic Mouse)
• S Ganesan, H Acosta, C Brigolin, K Orange, K Trabbic, C Chen, CE Lien, YJ Lin, MY Lin, YS Chuang, A Fattom, V Bitko Intranasal nanoemulsion adjuvanted S-2P vaccine demonstrates protection in hamsters and induces systemic, cell-mediated and mucosal immunity in mice PLoS ONE, 2022-11-02;17(11):e0272594. 2022-11-02 [PMID: 36322572] (Bioassay, Mouse)
• SA Park, YJ Lim, WL Ku, D Zhang, K Cui, LY Tang, C Chia, P Zanvit, Z Chen, W Jin, D Wang, J Xu, O Liu, F Wang, A Cain, N Guo, H Nakatsukas, C Wu, YE Zhang, K Zhao, W Chen Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation Nature Communications, 2022-10-14;13(1):6069. 2022-10-14 [PMID: 36241625] (Bioassay, Mouse)
• S Peng, D Xing, L Ferrall, YC Tsai, CF Hung, TC Wu Identification of human MHC-I HPV18 E6/E7-specific CD8?+?T cell epitopes and generation of an HPV18 E6/E7-expressing adenosquamous carcinoma in HLA-A2 transgenic mice Journal of Biomedical Science, 2022-10-12;29(1):80. 2022-10-12 [PMID: 36224625] (Bioassay, Mouse)
• L Rani, A Kumar, J Karhade, G Pandey, A Guha, GC Mishra, MR Wani IL-3 regulates the differentiation of pathogenic Th17 cells European Journal of Immunology, 2022-09-26;0(0):. 2022-09-26 [PMID: 36074916] (Bioassay, Mouse)
• JN Chi, JY Yang, CH Hsueh, CY Tsai, HC Chuang, TH Tan MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKbeta and inducing IKKbeta-mediated FoxO1 nuclear export and Foxp3 downregulation Theranostics, 2022-07-18;12(13):5744-5760. 2022-07-18 [PMID: 35966593] (Cell Culture, Human)
• JH Badrani, AN Strohm, L Lacasa, B Civello, K Cavagnero, YA Haung, M Amadeo, LH Naji, SJ Lund, A Leng, H Kim, RE Baum, N Khorram, M Mondal, G Seumois, J Pilotte, PW Vanderklis, HM McGee, TA Doherty RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R Nature Communications, 2022-07-30;13(1):4435. 2022-07-30 [PMID: 35908044] (Bioassay, Mouse)
• HS Lee, HW Park IL-23 plays a significant role in the augmentation of particulate matter-mediated allergic airway inflammation Journal of Cellular and Molecular Medicine, 2022-07-08;0(0):. 2022-07-08 [PMID: 35801505] (Bioassay, Mouse)
• E Shelkey, D Oommen, ER Stirling, DR Soto-Panto, KL Cook, Y Lu, KI Votanopoul, S Soker Immuno-reactive cancer organoid model to assess effects of the microbiome on cancer immunotherapy Scientific Reports, 2022-06-15;12(1):9983. 2022-06-15 [PMID: 35705580] (Bioassay, Mouse)
• LEA Damasceno, GCM Cebinelli, MF Fernandes, DC Nascimento, GA Públio, MAR Vinolo, SC Oliveira, T Sparwasser, TM Cunha, FQ Cunha, JC Alves-Filh STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program Cell Reports, 2022-05-24;39(8):110838. 2022-05-24 [PMID: 35613599] (Bioassay, Mouse)
• PL Vu, J Vadakekola, S Idri, H Nicholls, M Cavaignac, S Reeder, MA Khan, D Christense, AG Pockley, SE McArdle A Mutated Prostatic Acid Phosphatase (PAP) Peptide-Based Vaccine Induces PAP-Specific CD8+ T Cells with Ex Vivo Cytotoxic Capacities in HHDII/DR1 Transgenic Mice Cancers, 2022-04-13;14(8):. 2022-04-13 [PMID: 35454873] (Bioassay, Mouse)
• B Wu, X Zhang, HC Chiang, H Pan, B Yuan, P Mitra, L Qi, H Simonyan, CN Young, E Yvon, Y Hu, N Zhang, R Li RNA polymerase II pausing factor NELF in CD8+ T cells promotes antitumor immunity Nature Communications, 2022-04-20;13(1):2155. 2022-04-20 [PMID: 35444206] (Bioassay, Mouse)
• S Peng, D Xing, L Ferrall, YC Tsai, RBS Roden, CF Hung, TC Wu Development of a Spontaneous HPV16 E6/E7-Expressing Head and Neck Squamous Cell Carcinoma in HLA-A2 Transgenic Mice MBio, 2022-01-04;0(0):e0325221. 2022-01-04 [PMID: 35089069] (Bioassay, Mouse)
• A Jorapur, LA Marshall, S Jacobson, M Xu, S Marubayash, M Zibinsky, DX Hu, O Robles, JJ Jackson, V Baloche, P Busson, D Wustrow, DG Brockstedt, O Talay, PD Kassner, G Cutler EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22 PloS Pathogens, 2022-01-13;18(1):e1010200. 2022-01-13 [PMID: 35025968] (Bioassay, Mouse)
• M Fleury, C Vazquez-Ma, J Hernandez-, H Dooms Partial STAT5 signaling is sufficient for CD4+ T cell priming but not memory formation Cytokine, 2021-11-26;150(0):155770. 2021-11-26 [PMID: 34839177] (Bioassay, Mouse)
• HZ Guo, ZH Guo, SH Yu, LT Niu, WT Qiang, MM Huang, YY Tian, J Chen, H Yang, XQ Weng, Y Zhang, W Zhang, SY Hu, J Shi, J Zhu Leukemic progenitor cells enable immunosuppression and post-chemotherapy relapse via IL-36-inflammatory monocyte axis Science Advances, 2021-10-08;7(41):eabg4167. 2021-10-08 [PMID: 34623912] (Bioassay, Mouse)
• I Safina, ZAN Al Sudani, A Hashoosh, E Darrigues, F Watanabe, AS Biris, RPM Dings, K Bao Vang Gold nanorods enhance different immune cells and allow for efficient targeting of CD4+ Foxp3+ Tregulatory cells PLoS ONE, 2021-08-30;16(8):e0241882. 2021-08-30 [PMID: 34460818] (Bioassay, Mouse)
• JL Sun, NP Zhang, RC Xu, GC Zhang, ZY Liu, W Abuduwaili, F Wang, XN Yu, X Shi, GQ Song, H Wu, TT Liu, XZ Shen, B Deng, SQ Weng, L Dong, JM Zhu Tumor cell-imposed iron restriction drives immunosuppressive polarization of tumor-associated macrophages Journal of Translational Medicine, 2021-08-13;19(1):347. 2021-08-13 [PMID: 34389031] (Bioassay, Mouse)
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• Rothchild A, Jayaraman P, Nunes-Alves C, Behar S iNKT cell production of GM-CSF controls Mycobacterium tuberculosis. PLoS Pathog, 2014-01-02;10(1):e1003805. 2014-01-02 [PMID: 24391492] (Bioassay, Mouse)
• Zhong W, Su W, Zhang Y, Liu Q, Wu J, Di C, Zhang Z, Xia Z Basophils as a primary inducer of the T helper type 2 immunity in ovalbumin-induced allergic airway inflammation. Immunology, 2014-06-01;142(2):202-15. 2014-06-01 [PMID: 24383680] (Bioassay, Mouse)
• Ashino S, Takeda K, Li H, Taylor V, Joetham A, Pine P, Gelfand E Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses. J Allergy Clin Immunol, 2013-12-22;133(4):1162-74. 2013-12-22 [PMID: 24365136] (Bioassay, Mouse)
• Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone J, Takayanagi H Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. Nat Med, 2013-12-22;20(1):62-8. 2013-12-22 [PMID: 24362934] (Bioassay, Mouse)
• Nomachi , Akira, Yoshinaga , Masanori, Liu , Jaron, Kanchanawong , Pakorn, Tohyama , Kiyoshi, Thumkeo , Dean, Watanabe , Takeshi, Narumiya , Shuh, Hirata , Takako Moesin controls clathrin-mediated S1PR1 internalization in T cells. PLoS ONE, 2013-12-16;8(12):e82590. 2013-12-16 [PMID: 24358210] (Bioassay, Mouse)
• Dong B, Zhang S, Gao W, Su H, Chen J, Jin F, Bhargava A, Chen X, Jorgensen L, Alberts A, Zhang J, Siminovitch K Mammalian diaphanous-related formin 1 regulates GSK3beta-dependent microtubule dynamics required for T cell migratory polarization. PLoS ONE, 2013-11-18;8(11):e80500. 2013-11-18 [PMID: 24260404] (Bioassay, Mouse)
• Liu , Jia, Jiang , Min, Ma , Zhiyong, Dietze , Kirsten, Zelinskyy , Gennadiy, Yang , Donglian, Dittmer , Ulf, Schlaak , Joerg F, Roggendorf , Michael, Lu , Mengji TLR1/2 ligand-stimulated mouse liver endothelial cells secrete IL-12 and trigger CD8+ T cell immunity in vitro. J Immunol, 2013-11-13;191(12):6178-90. 2013-11-13 [PMID: 24227786] (Stimulation, Mouse)
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• Jiang E, Perrard X, Yang D, Khan I, Perrard J, Smith C, Ballantyne C, Wu H Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue. Arterioscler Thromb Vasc Biol, 2013-10-24;34(1):34-43. 2013-10-24 [PMID: 24158516] (Bioassay, Mouse)
• Jachetti , Elena, Mazzoleni , Stefania, Grioni , Matteo, Ricupito , Alessia, Brambillasca , Chiara, Generoso , Luca, Calcinotto , Arianna, Freschi , Massimo, Mondino , Anna, Galli , Rossella, Bellone , Matteo Prostate cancer stem cells are targets of both innate and adaptive immunity and elicit tumor-specific immune responses. Oncoimmunology, 2013-04-16;2(5):e24520. 2013-04-16 [PMID: 23762811] (Bioassay, Mouse)
• Hoffmann U, Pink M, Lauer U, Heimesaat M, Winsauer C, Kruglov A, Schlawe K, Leichsenring C, Liesenfeld O, Hamann A, Syrbe U Regulation and migratory role of P-selectin ligands during intestinal inflammation. PLoS ONE, 2013-04-22;8(4):e62055. 2013-04-22 [PMID: 23630623] (Bioassay, Mouse)
• Dudda J, Salaun B, Ji Y, Palmer D, Monnot G, Merck E, Boudousquie C, Utzschneider D, Escobar T, Perret R, Muljo S, Hebeisen M, Rufer N, Zehn D, Donda A, Restifo N, Held W, Gattinoni L, Romero P MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer. Immunity, 2013-04-18;38(4):742-53. 2013-04-18 [PMID: 23601686] (Bioassay, Mouse)
• Zarling S, Berenzon D, Dalai S, Liepinsh D, Steers N, Krzych U The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria. J Immunol, 2013-04-15;190(10):5128-41. 2013-04-15 [PMID: 23589611] (Bioassay, Mouse)
• Kidani , Yoko, Elsaesser , Heidi, Hock , M Benjam, Vergnes , Laurent, Williams , Kevin J, Argus , Joseph P, Marbois , Beth N, Komisopoulou , Evangeli, Wilson , Elizabet, Osborne , Timothy, Graeber , Thomas G, Reue , Karen, Brooks , David G, Bensinger , Steven J Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity. Nat Immunol, 2013-04-07;14(5):489-99. 2013-04-07 [PMID: 23563690] (Bioassay, Mouse)
• Carey , Kirstyn, Tan , Kheng H, Ng , Judy, Liddicoat , Douglas, Godfrey , Dale I, Cole , Timothy Nfil3 is a glucocorticoid-regulated gene required for glucocorticoid-induced apoptosis in male murine T cells. Endocrinology, 2013-02-20;154(4):1540-52. 2013-02-20 [PMID: 23425966] (Bioassay, Mouse)
• Golden-Mason L, McMahan R, Strong M, Reisdorph R, Mahaffey S, Palmer B, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen H Galectin-9 functionally impairs natural killer cells in humans and mice. J Virol, 2013-02-13;87(9):4835-45. 2013-02-13 [PMID: 23408620] (Bioassay, Mouse)
• Purushothaman D, Marcel N, Garg M, Venkataraman R, Sarin A Apoptotic programs are determined during lineage commitment of CD4+ T effectors: selective regulation of T effector-memory apoptosis by inducible nitric oxide synthase. J Immunol, 2012-12-05;190(1):97-105. 2012-12-05 [PMID: 23225886] (Cell Culture, Mouse)
• Arias , Mauricio, Van Roey , Griet A, Tregoning , John S, Moutaftsi , Magdalin, Coler , Rhea N, Windish , Hillarie, Reed , Steven G, Carter , Darrick, Shattock , Robin J Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 agonist, promotes potent systemic and mucosal responses to intranasal immunization with HIVgp140. PLoS ONE, 2012-07-19;7(7):e41144. 2012-07-19 [PMID: 22829921] (Bioassay, Mouse)
• Zhao E, Wang L, Dai J, Kryczek I, Wei S, Vatan L, Altuwaijri S, Sparwasser T, Wang G, Keller E, Zou W Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer. Oncoimmunology, 2012-03-01;1(2):152-161. 2012-03-01 [PMID: 22720236] (Bioassay, Mouse)
• Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)
• Yoshida S, Mohamed RH, Kajikawa M, Koizumi J, Tanaka M, Fugo K, Otsuka N, Maenaka K, Yagita H, Chiba H, Kasahara M Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair. J. Immunol., 2012-03-07;188(8):3972-9. 2012-03-07 [PMID: 22403443] (Bioassay, Mouse)
• Radulovic K, Manta C, Rossini V, Holzmann K, Kestler HA, Wegenka UM, Nakayama T, Niess JH CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential. J. Immunol., 2012-01-16;188(4):2001-13. 2012-01-16 [PMID: 22250092] (Bioassay, Mouse)
• Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs. J. Immunol., 2011-12-23;188(3):1503-13. 2011-12-23 [PMID: 22198948] (Bioassay, Mouse)
• Reddy PB, Sehrawat S, Suryawanshi A Influence of galectin-9/Tim-3 interaction on herpes simplex virus-1 latency. J. Immunol., 2011-10-21;187(11):5745-55. 2011-10-21 [PMID: 22021615] (Bioassay, Mouse)
• Monticelli LA, Sonnenberg GF, Abt MC Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat. Immunol., 2011-11-01;12(11):1045-54. 2011-11-01 [PMID: 21946417] (Bioassay, Mouse)
• Cao W, Yang Y, Wang Z, Liu A, Fang L, Wu F, Hong J, Shi Y, Leung S, Dong C, Zhang JZ Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease. Immunity, 2011-08-11;35(2):273-84. 2011-08-11 [PMID: 21835648] (Bioassay, Mouse)
• El-Behi M, Ciric B, Dai H The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat. Immunol., 2011-04-24;12(6):568-75. 2011-04-24 [PMID: 21516111] (Bioassay, Mouse)
• Kashiwada M, Cassel SL, Colgan JD NFIL3/E4BP4 controls type 2 T helper cell cytokine expression. EMBO J., 2011-04-15;30(10):2071-82. 2011-04-15 [PMID: 21499227] (Bioassay, Mouse)
• Smith C, Martinez M, Peet J, Khanna R Differential outcome of IL-2/anti-IL-2 complex therapy on effector and memory CD8+ T cells following vaccination with an adenoviral vector encoding EBV epitopes. J. Immunol., 2011-04-11;186(10):5784-90. 2011-04-11 [PMID: 21482735] (In Vivo, Mouse)
• Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J. Virol., 2010-09-29;84(24):12703-12. 2010-09-29 [PMID: 20881038] (In Vivo, Mouse)
• Filardy AA, Pires DR, Nunes MP, Takiya CM, Freire-de-Lima CG, Ribeiro-Gomes FL, DosReis GA Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages. J. Immunol., 2010-07-21;185(4):2044-50. 2010-07-21 [PMID: 20660352] (Bioassay, Mouse)
• Wildbaum G, Zohar Y, Karin N Antigen-specific CD25- Foxp3- IFN-gamma(high) CD4+ T cells restrain the development of experimental allergic encephalomyelitis by suppressing Th17. Am. J. Pathol., 2010-04-09;176(6):2764-75. 2010-04-09 [PMID: 20382706] (Bioassay, Mouse)
• Emoto M, Shimizu T, Koike H, Yoshizawa I, Hurwitz R, Kaufmann SH, Emoto Y Dissociated expression of natural killer 1.1 and T-cell receptor by invariant natural killer T cells after interleukin-12 receptor and T-cell receptor signalling. Immunology, 2010-01-01;129(1):62-74. 2010-01-01 [PMID: 20028429] (Bioassay, Mouse)
• Humrich JY, Morbach H, Undeutsch R, Enghard P, Rosenberger S, Weigert O, Kloke L, Heimann J, Gaber T, Brandenburg S, Scheffold A, Huehn J, Radbruch A, Burmester GR, Riemekasten G Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus. Proc. Natl. Acad. Sci. U.S.A., 2009-12-14;107(1):204-9. 2009-12-14 [PMID: 20018660] (In Vivo, Mouse)
• Yu J, Wei M, Mao H, Zhang J, Hughes T, Mitsui T, Park IK, Hwang C, Liu S, Marcucci G, Trotta R, Benson DM, Caligiuri MA CD94 defines phenotypically and functionally distinct mouse NK cell subsets. J. Immunol., 2009-10-15;183(8):4968-74. 2009-10-15 [PMID: 19801519] (In Vivo, Mouse)
• Purushothaman D, Sarin A Cytokine-dependent regulation of NADPH oxidase activity and the consequences for activated T cell homeostasis. J. Exp. Med., 2009-06-22;206(7):1515-23. 2009-06-22 [PMID: 19546249] (Bioassay, Mouse)
• Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, Briso EM, Charland C, Leonard WJ, Ciliberto G, Teuscher C, Haynes L, Rincon M The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J. Exp. Med., 2009-01-12;206(1):69-78. 2009-01-12 [PMID: 19139170] (Bioassay, Mouse)
• Kaya Z, Goser S, Buss SJ, Leuschner F, Ottl R, Li J, Volkers M, Zittrich S, Pfitzer G, Rose NR, Katus HA Identification of cardiac troponin I sequence motifs leading to heart failure by induction of myocardial inflammation and fibrosis. Circulation, 2008-10-27;118(20):2063-72. 2008-10-27 [PMID: 18955666] (Bioassay, Mouse)
• McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, Henry A, Irvin CG, Piganelli JD, Ray A, Kolls JK TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J. Immunol., 2008-09-15;181(6):4089-97. 2008-09-15 [PMID: 18768865] (Bioassay, Mouse)
• Jacobsen EA, Ochkur SI, Pero RS, Taranova AG, Protheroe CA, Colbert DC, Lee NA, Lee JJ Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells. J. Exp. Med., 2008-03-03;205(3):699-710. 2008-03-03 [PMID: 18316417] (Bioassay, Mouse)
• Takada A, Yoshida S, Kajikawa M, Miyatake Y, Tomaru U, Sakai M, Chiba H, Maenaka K, Kohda D, Fugo K, Kasahara M Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D. J. Immunol., 2008-02-01;180(3):1678-85. 2008-02-01 [PMID: 18209064] (Bioassay, Mouse)
• Seshasayee D, Lee WP, Zhou M, Shu J, Suto E, Zhang J, Diehl L, Austin CD, Meng YG, Tan M, Bullens SL, Seeber S, Fuentes ME, Labrijn AF, Graus YM, Miller LA, Schelegle ES, Hyde DM, Wu LC, Hymowitz SG, Martin F In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation. J. Clin. Invest., 2007-12-01;117(12):3868-3878. 2007-12-01 [PMID: 18060034] (Bioassay, Mouse)
• Ruzek MC, Waire JS, Hopkins D, Lacorcia G, Sullivan J, Roberts BL, Richards SM, Nahill SR, Williams JM, Scaria A, Dzuris J, Shankara S, Garman RD Characterization of in vitro antimurine thymocyte globulin-induced regulatory T cells that inhibit graft-versus-host disease in vivo. Blood, 2007-11-19;111(3):1726-34. 2007-11-19 [PMID: 18025149] (Bioassay, Mouse)
• Li W, Kashiwamura S, Ueda H, Sekiyama A, Okamura H Protection of CD8+ T cells from activation-induced cell death by IL-18. J. Leukoc. Biol., 2007-03-30;82(1):142-51. 2007-03-30 [PMID: 17400610] (Bioassay, Mouse)
• Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways. J. Allergy Clin. Immunol., 2007-03-01;119(3):662-70. 2007-03-01 [PMID: 17336616] (Bioassay, Mouse)
• Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat. Genet., 2007-02-04;39(3):329-37. 2007-02-04 [PMID: 17277778] (Bioassay, Mouse)
• Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J. Immunol., 2007-02-15;178(4):2018-27. 2007-02-15 [PMID: 17277105] (Bioassay, Mouse)
• Chiang YM, Chang CL, Chang SL, Yang WC, Shyur LF Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator. J Ethnopharmacol, 2006-10-19;110(3):532-8. 2006-10-19 [PMID: 17101254] (Bioassay, Mouse)
• Ogawa K, Funaba M, Chen Y, Tsujimoto M Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages. J. Immunol., 2006-11-15;177(10):6787-94. 2006-11-15 [PMID: 17082592] (Bioassay, Mouse)
• Bheeshmachar G, Purushotaman D, Sade H, Gunasekharan V, Rangarajan A, Sarin A Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells. J. Immunol., 2006-10-15;177(8):5041-50. 2006-10-15 [PMID: 17015687] (Bioassay, Mouse)
• de la Fuente MA, Kumar L, Lu B, Geha RS 3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation. Mol. Cell. Biol., 2006-07-01;26(14):5214-25. 2006-07-01 [PMID: 16809760] (Bioassay, Mouse)
• Christensen JE, de Lemos C, Moos T, Christensen JP, Thomsen AR CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system. J. Immunol., 2006-04-01;176(7):4235-43. 2006-04-01 [PMID: 16547260] (Bioassay, Mouse)
• Vugmeyster Y, Seshasayee D, Chang W, Storn A, Howell K, Sa S, Nelson T, Martin F, Grewal I, Gilkerson E, Wu B, Thompson J, Ehrenfels BN, Ren S, Song A, Gelzleichter TR, Danilenko DM A soluble BAFF antagonist, BR3-Fc, decreases peripheral blood B cells and lymphoid tissue marginal zone and follicular B cells in cynomolgus monkeys. Am. J. Pathol., 2006-02-01;168(2):476-89. 2006-02-01 [PMID: 16436662] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• Harrington , Laurie E, Hatton , Robin D, Mangan , Paul R, Turner , Henriett, Murphy , Theresa, Murphy , Kenneth, Weaver , Casey T Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol, 2005-10-02;6(11):1123-32. 2005-10-02 [PMID: 16200070] (Bioassay, Mouse)
• La Cava A, Ebling FM, Hahn BH Ig-reactive CD4+CD25+ T cells from tolerized (New Zealand Black x New Zealand White)F1 mice suppress in vitro production of antibodies to DNA. J. Immunol., 2004-09-01;173(5):3542-8. 2004-09-01 [PMID: 15322219] (Bioassay, Mouse)
• Kipnis J, Cardon M, Avidan H, Lewitus GM, Mordechay S, Rolls A, Shani Y, Schwartz M Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration. J. Neurosci., 2004-07-07;24(27):6133-43. 2004-07-07 [PMID: 15240805] (Bioassay, Mouse)
• Upadhya S, Mooteri S, Peckham N, Pai RG Atherogenic effect of interleukin-2 and antiatherogenic effect of interleukin-2 antibody in apo-E-deficient mice. Angiology, 2004-05-01;55(3):289-94. 2004-05-01 [PMID: 15156262] (In Vivo, Mouse)
• Schleicher U, Mattner J, Blos M, Schindler H, Rollinghoff M, Karaghiosoff M, Muller M, Werner-Felmayer G, Bogdan C Control of Leishmania major in the absence of Tyk2 kinase. Eur. J. Immunol., 2004-02-01;34(2):519-29. 2004-02-01 [PMID: 14768057] (Bioassay, Mouse)
• Brady J, Hayakawa Y, Smyth MJ, Nutt SL IL-21 induces the functional maturation of murine NK cells. J. Immunol., 2004-02-15;172(4):2048-58. 2004-02-15 [PMID: 14764669] (Bioassay, Mouse)
• Nguyen P, Moisini I, Geiger TL Identification of a murine CD28 dileucine motif that suppresses single-chain chimeric T-cell receptor expression and function. Blood, 2003-08-28;102(13):4320-5. 2003-08-28 [PMID: 12946999] (Bioassay, Mouse)
• Kulms D, Schwarz T Ultraviolet radiation inhibits interleukin-2-induced tyrosine phosphorylation and the activation of STAT5 in T lymphocytes. J. Biol. Chem., 2001-01-23;276(16):12849-55. 2001-01-23 [PMID: 11278301] (Bioassay, Mouse)

Bioinformatics

• Gene Symbol: Il2
• Uniprot:
  • P04351()