Recombinant Mouse IL-3 Protein

Recombinant Mouse IL-3 Protein (Catalog # 403-ML) has a molecular weight (MW) of 14.9 kDa as analyzed by SEC-MALS, suggesting that this protein is a monomer.

Recombinant Mouse IL-3 Protein (Catalog # 403-ML) has a molecular weight (MW) of 14.9 kDa as analyzed by SEC-MALS, suggesting that this protein is a monomer.

Recombinant Mouse IL-3 (Catalog # 403-ML) stimulates cell proliferation of the NFS-60 mouse myelogenous leukemia lymphoblast cell line. The ED50 for this effect is 20-100 pg/mL.

1 μg/lane of Recombinant Mouse IL-3 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 15 kDa.

• Reactivity: Mu
• Applications: Bioactivity

Recombinant Mouse IL-3 Protein Summary

• Additional Information: Analyzed by SEC-MALS
• Details of Functionality: Measured in a cell proliferation assay using NFS‑60 mouse myelogenous leukemia lymphoblast cells. Holmes, K.L. et al. (1985) Proc. Natl. Acad. Sci. USA 82:6687. The ED₅₀ for this effect is 20-100 pg/mL.
• Source: E. coli-derived mouse IL-3 protein
  Asp33-Cys166, with an N-terminal Met
• Accession #: NP_034686
• N-terminal Sequence: Asp33
• Protein/Peptide Type: Recombinant Proteins
• Gene: Il3
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 15 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IL-3 Protein

• Hematopoietic growth factor
• IL3
• IL-3
• IL-3MGC79398
• interleukin 3 (colony-stimulating factor, multiple)
• interleukin-3
• Mast cell growth factor
• mast-cell growth factor
• MCGF
• MCGFMGC79399
• MULTI-CSF
• multilineage-colony-stimulating factor
• Multipotential colony-stimulating factor
• P-cell stimulating factor
• P-cell-stimulating factor

Background

Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. In addition, IL-3 also affects the functional activity of mature mast cells, basophils, eosinophils and macrophages. Because of its multiple functions and targets, it was originally studied under different names, including mast cell growth factor P-cell stimulating factor, burst promoting activity, multi-colony stimulating factor, thy-1 inducing factor and WEHI-3 growth factor. In addition to activated T cells, other cell types such as human thymic epithelial cells, activated mouse mast cells, mouse keratinocytes and neurons/astrocytes can also produce IL-3. At the amino acid sequence level, mature human and mouse IL-3 share only 29% sequence identity. Consistent with this lack of homology, IL-3 activity is highly species-specific and human IL-3 does not show activity on mouse cells.

IL-3 exerts its biological activities through binding to specific cell surface receptors. The high affinity receptor responsible for IL-3 signaling is composed of alpha and beta subunits. The IL-3R alpha is a member of the cytokine receptor super family and binds IL-3 with low affinity. Two distinct beta subunits, AIC2A ( beta _IL-3) and AIC2B ( beta _c) are present in mouse cells. beta _IL-3 also binds IL-3 with low affinity and forms a high affinity receptor with the alpha subunit. The beta _c subunits does not bind any cytokine but forms functional high affinity receptors with the alpha subunit of the IL-3, IL-5 and GM-CSF receptors. Receptors for IL-3 are present on bone marrow progenitors, macrophages, mast cells, eosinophils, megakaryocytes, basophils and various myeloid leukemic cells.

1. Yokota, T. et al., 1984, Proc. Natl. Acad. Sci. USA 81:1070.
2. Fung, M.C. et al., 1984, Nature 307:233.
3. Miyatake, S. et al., 1985, Proc. Natl. Acad. Sci. USA 82:316.

Publications for IL-3 (403-ML)(181)

Publications using 403-ML

• Liu, K;Katayama, T;Sato, H;Hamaoka-Tamura, Y;Saito, M;Furuta, K;Tanaka, S; &lt;i&gt;Staphylococcus aureus&lt;/i&gt; ?-Toxin Induces Ca&lt;sup&gt;2+&lt;/sup&gt; Influx-Independent Degranulation of Murine Cultured Mast Cells Biological and Pharmaceutical Bulletin 2024-12-15 [PMID: 39675960] (Bioassay, Mouse)
• Bang, I;Hattori, T;Leloup, N;Corrado, A;Nyamaa, A;Koide, A;Geles, K;Buck, E;Koide, S; Selective targeting of oncogenic hotspot mutations of the HER2 extracellular domain Nature chemical biology 2024-10-22 [PMID: 39438724] (Bioassay, Mouse)
• Chang, YH;Yamamoto, K;Fujino, T;Wang, TW;Sugimoto, E;Zhang, W;Yabushita, T;Suzaki, K;Pietsch, EC;Weir, BA;Crescenzo, R;Cowley, GS;Attar, R;Philippar, U;Wunderlich, M;Mizukawa, B;Zheng, Y;Enomoto, Y;Imai, Y;Kitamura, T;Goyama, S; SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation Cell reports 2024-07-30 [PMID: 39096901] (Bioassay, Mouse)
• Wu, W;Lam, AR;Suarez, K;Smith, GN;Duquette, SM;Yu, J;Mankus, D;Bisher, M;Lytton-Jean, A;Manalis, SR;Miettinen, TP; Constant surface area-to-volume ratio during cell growth as a design principle in mammalian cells bioRxiv : the preprint server for biology 2024-07-18 [PMID: 39005340] (Bioassay, Mouse)
• Joshi, JN;Lerner, AD;Scallo, F;Grumet, AN;Matteson, P;Millonig, JH;Valvezan, AJ; mTORC1 activity oscillates throughout the cell cycle promoting mitotic entry and differentially influencing autophagy induction bioRxiv : the preprint server for biology 2024-02-07 [PMID: 38370755] (Bioassay, Mouse)
• Pv, A;Mehatre, SH;Verfaillie, CM;Alam, MT;Khurana, S; Glycolytic state of aortic endothelium favors hematopoietic transition during the emergence of definitive hematopoiesis Science advances 2024-02-16 [PMID: 38363844] (Bioassay, Mouse)
• Brady, A;Sheneman, KR;Pulsifer, AR;Price, SL;Garrison, TM;Maddipati, KR;Bodduluri, SR;Pan, J;Boyd, NL;Zheng, JJ;Rai, SN;Hellmann, J;Haribabu, B;Uriarte, SM;Lawrenz, MB; Type 3 secretion system induced leukotriene B4 synthesis by leukocytes is actively inhibited by Yersinia pestis to evade early immune recognition PLoS pathogens 2024-01-25 [PMID: 38271464] (Bioassay, Mouse)
• Wang, P;Zhang, Y;Xiang, R;Yang, J;Xu, Y;Deng, T;Zhou, W;Wang, C;Xiao, X;Wang, S; Foretinib is effective in acute myeloid leukemia by inhibiting FLT3 and overcoming secondary mutations that drive resistance to quizartinib and gilteritinib Cancer research 2024-01-17 [PMID: 38231480] (Cell Culture, Mouse)
• Okura, Y;Ikawa-Teranishi, Y;Mizoroki, A;Takahashi, N;Tsushima, T;Irie, M;Harfuddin, Z;Miura-Okuda, M;Ito, S;Nakamura, G;Takesue, H;Ozono, Y;Nishihara, M;Yamada, K;Gan, SW;Hayasaka, A;Ishii, S;Wakabayashi, T;Muraoka, M;Nagaya, N;Hino, H;Nemoto, T;Kuramochi, T;Torizawa, T;Shimada, H;Kitazawa, T;Okazaki, M;Nezu, J;Sollid, LM;Igawa, T; Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease Nature communications 2023-12-22 [PMID: 38135691] (Bioassay, Mouse)
• Luis, TC;Barkas, N;Carrelha, J;Giustacchini, A;Mazzi, S;Norfo, R;Wu, B;Aliouat, A;Guerrero, JA;Rodriguez-Meira, A;Bouriez-Jones, T;Macaulay, IC;Jasztal, M;Zhu, G;Ni, H;Robson, MJ;Blakely, RD;Mead, AJ;Nerlov, C;Ghevaert, C;Jacobsen, SEW; Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner Nature communications 2023-09-28 [PMID: 37770432] (Bioassay, Mouse)
• Hoffmann, T;Hörmann, A;Corcokovic, M;Zmajkovic, J;Hinterndorfer, M;Salkanovic, J;Spreitzer, F;Köferle, A;Gitschtaler, K;Popa, A;Oberndorfer, S;Andersch, F;Schaefer, M;Fellner, M;Budano, N;Ruppert, JG;Chetta, P;Wurm, M;Zuber, J;Neumüller, RA; Precision RNAi using synthetic shRNAmir target sites eLife 2023-08-08 [PMID: 37552050] (Bioassay, Mouse)
• Bénard, A;Mittelstädt, A;Klösch, B;Glanz, K;Müller, J;Schoen, J;Nüse, B;Brunner, M;Naschberger, E;Stürzl, M;Mattner, J;Muñoz, LE;Sohn, K;Grützmann, R;Weber, GF; IL-3 orchestrates ulcerative colitis pathogenesis by controlling the development and the recruitment of splenic reservoir neutrophils Cell reports 2023-06-08 [PMID: 37300834] (Tissue Culture, Mouse)
• Williams, O;Hu, L;Huang, W;Patel, P;Bartom, ET;Bei, L;Hjort, E;Hijiya, C;Eklund, EA; Nore1 inhibits age-associated myeloid lineage skewing and clonal hematopoiesis, but facilitates termination of emergency (stress) granulopoiesis The Journal of biological chemistry 2023-05-27 [PMID: 37247756] (Bioassay, Mouse)
• L Schubert, AT Le, TK Hinz, A Navarro, SK Nelson-Tay, RA Nemenoff, LE Heasley, RC Doebele A Rapid, Functional sgRNA Screening Method for Generating Murine RET and NTRK1 Fusion Oncogenes bioRxiv : the preprint server for biology, 2023-04-06;0(0):. 2023-04-06 [PMID: 37066347] (Bioassay, Mouse)
• H Huang, Y Li, G Zhang, GX Ruan, Z Zhu, W Chen, J Zou, R Zhang, J Wang, Y Ouyang, S Xu, X Ou The RNA-binding protein hnRNP F is required for the germinal center B cell response Nature Communications, 2023-03-30;14(1):1731. 2023-03-30 [PMID: 36997512] (Bioassay, Mouse)
• X Cui, C Zhang, F Wang, X Zhao, S Wang, J Liu, D He, C Wang, FC Yang, S Tong, Y Liang Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1 Cell Reports, 2023-03-16;42(3):112274. 2023-03-16 [PMID: 36933218] (Bioassay, Mouse)
• K Ames, I Kaur, Y Shi, MM Tong, T Sinclair, S Hemmati, SG Glushakow-, E Tein, L Gurska, U Steidl, R Dubin, J Shan, C Montagna, K Pradhan, A Verma, K Gritsman PI3-kinase deletion promotes myelodysplasia by dysregulating autophagy in hematopoietic stem cells Science Advances, 2023-02-22;9(8):eade8222. 2023-02-22 [PMID: 36812307] (Bioassay, Mouse)
• X Liu, N Sato, T Yabushita, J Li, Y Jia, M Tamura, S Asada, T Fujino, T Fukushima, T Yonezawa, Y Tanaka, T Fukuyama, A Tsuchiya, S Shikata, H Iwamura, C Kinouchi, K Komatsu, S Yamasaki, T Shibata, AT Sasaki, J Schibler, M Wunderlich, E O'Brien, B Mizukawa, JC Mulloy, Y Sugiura, H Takizawa, T Shibata, K Miyake, T Kitamura, S Goyama IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia Embo Molecular Medicine, 2022-12-01;0(0):e15631. 2022-12-01 [PMID: 36453131] (Cell Culture, Mouse)
• S Xiang, J Wang, H Huang, Z Wang, X Song, Y Zhou, F Jin, X He, ZM Zhang, Z Tu, K Ding, Z Zhang, X Lu Switch type I to type II TRK inhibitors for combating clinical resistance induced by xDFG mutation for cancer therapy European Journal of Medicinal Chemistry, 2022-11-12;245(0):114899. 2022-11-12 [PMID: 36410169] (Bioassay, Mouse)
• JA Iskarpatyo, J Shi, MA Abraham, APS Rathore, Y Miao, SN Abraham Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter Cell Reports, 2022-09-27;40(13):111346. 2022-09-27 [PMID: 36170813] (Bioassay, Mouse)
• S Chakrabort, G Andrieux, P Kastl, L Adlung, S Altamura, ME Boehm, LE Schwarzmül, Y Abdullah, MC Wagner, B Helm, HJ Gröne, WD Lehmann, M Boerries, H Busch, MU Muckenthal, M Schilling, U Klingmülle Erythropoietin-driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo Cell Reports, 2022-09-20;40(12):111360. 2022-09-20 [PMID: 36130519] (Bioassay, Mouse)
• L Rani, A Kumar, J Karhade, G Pandey, A Guha, GC Mishra, MR Wani IL-3 regulates the differentiation of pathogenic Th17 cells European Journal of Immunology, 2022-09-26;0(0):. 2022-09-26 [PMID: 36074916] (Bioassay, Mouse)
• HJ Shin, SU Bak, HN La, JS Kang, HH Lee, HJ Eom, BK Lee, HA Kang Efficient transdermal delivery of functional protein cargoes by a hydrophobic peptide MTD�1067 Oncogene, 2022-06-27;12(1):10853. 2022-06-27 [PMID: 35760980] (Bioassay, Mouse)
• H Fujita, T Fujita, H Fujii IL-3-Induced Immediate Expression of c-fos and c-jun Is Modulated by the IKK2-JNK Axis Cells, 2022-04-25;11(9):. 2022-04-25 [PMID: 35563758] (Bioassay, Mouse)
• T Doke, A Abedini, DL Aldridge, YW Yang, J Park, CM Hernandez, MS Balzer, R Shrestra, G Coppock, JMI Rico, SY Han, J Kim, S Xin, AM Piliponsky, M Angelozzi, V Lefebvre, MC Siracusa, CA Hunter, K Susztak Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis Nature Immunology, 2022-05-12;0(0):. 2022-05-12 [PMID: 35552540] (In Vivo, Mouse)
• Y Hayashi, KC Kawabata, Y Tanaka, Y Uehara, Y Mabuchi, K Murakami, A Nishiyama, S Kiryu, Y Yoshioka, Y Ota, T Sugiyama, K Mikami, M Tamura, T Fukushima, S Asada, R Takeda, Y Kunisaki, T Fukuyama, K Yokoyama, T Uchida, M Hagihara, N Ohno, K Usuki, A Tojo, Y Katayama, S Goyama, F Arai, T Tamura, T Nagasawa, T Ochiya, D Inoue, T Kitamura MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis Cell Reports, 2022-05-10;39(6):110805. 2022-05-10 [PMID: 35545056] (Bioassay, Mouse)
• KMZ Savill, BB Lee, J Oeh, J Lin, E Lin, WJ Chung, A Young, W Chen, M Mi?, K Mesh, J Eastham, F Gnad, Z Jiang, EW Stawiski, B Haley, A Daemen, X Wang, H Koeppen, Z Modrusan, SE Martin, D Sampath, K Lin Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors Nature Communications, 2022-04-19;13(1):2057. 2022-04-19 [PMID: 35440108] (Bioassay, Mouse)
• J Li, H Lu, PK Ng, A Pantazi, CKM Ip, KJ Jeong, B Amador, R Tran, YH Tsang, L Yang, X Song, T Dogruluk, X Ren, A Hadjipanay, CA Bristow, S Lee, M Kucherlapa, M Parfenov, J Tang, S Seth, HS Mahadeshwa, K Mojumdar, D Zeng, J Zhang, A Protopopov, JG Seidman, CJ Creighton, Y Lu, N Sahni, KR Shaw, F Meric-Bern, A Futreal, L Chin, KL Scott, R Kucherlapa, GB Mills, H Liang A functional genomic approach to actionable gene fusions for precision oncology Science Advances, 2022-02-09;8(6):eabm2382. 2022-02-09 [PMID: 35138907] (Bioassay, Human)
• Q Zhang, L Zhao, Y Yang, S Li, Y Liu, C Chen Mosaic loss of chromosome Y promotes leukemogenesis and clonal hematopoiesis JCI Insight, 2022-02-08;7(3):. 2022-02-08 [PMID: 35132955] (Bioassay, Mouse)
• BE Thacker, KJ Thorne, C Cartwright, J Park, K Glass, A Chea, BP Kellman, NE Lewis, Z Wang, A Di Nardo, ST Sharfstein, W Jeske, J Walenga, J Hogwood, E Gray, B Mulloy, JD Esko, CA Glass Multiplex genome editing of mammalian cells for producing recombinant heparin Metabolic engineering, 2022-01-14;0(0):. 2022-01-14 [PMID: 35038554] (Bioassay, Mouse)
• HZ Guo, ZH Guo, SH Yu, LT Niu, WT Qiang, MM Huang, YY Tian, J Chen, H Yang, XQ Weng, Y Zhang, W Zhang, SY Hu, J Shi, J Zhu Leukemic progenitor cells enable immunosuppression and post-chemotherapy relapse via IL-36-inflammatory monocyte axis Science Advances, 2021-10-08;7(41):eabg4167. 2021-10-08 [PMID: 34623912] (Bioassay, Mouse)
• T Kongkrongt, R Zhang, M Kawahara Rational design of heterodimeric receptors capable of activating target signaling molecules Scientific Reports, 2021-08-19;11(1):16809. 2021-08-19 [PMID: 34413422] (Bioassay, Mouse)
• KR Thomas, EJ Allenspach, ND Camp, MN Wray-Dutra, S Khim, A Zielinska-, AE Timms, JP Loftus, HD Liggitt, K Georgopoul, SK Tasian, RG James, DJ Rawlings Activated interleukin-7 receptor signaling drives B-cell acute lymphoblastic leukemia in mice Leukemia, 2021-06-30;0(0):. 2021-06-30 [PMID: 34193976] (Bioassay, Mouse)
• N Ohashi, T Terashima, M Katagi, Y Nakae, J Okano, Y Suzuki, H Kojima GLT1 gene delivery based on bone marrow-derived cells ameliorates motor function and survival in a mouse model of ALS Scientific Reports, 2021-06-17;11(1):12803. 2021-06-17 [PMID: 34140581] (Cell Culture, Mouse)
• D Kashima, M Kawahara Evolution of KIPPIS as a versatile platform for evaluating intracellularly functional peptide aptamers Scientific Reports, 2021-06-03;11(1):11758. 2021-06-03 [PMID: 34083659] (Cell Culture, Mouse)
• JF Fu, LY Shih, TH Yen HOXA11 plays critical roles in disease progression and response to cytarabine in AML Oncology reports, 2021-06-03;46(1):. 2021-06-03 [PMID: 34080665] (Cell Culture, Mouse)
• X Wang, U Ros, D Agrawal, EC Keller, J Slotta-Hus, V Dill, B Shen, R Shi, T Herold, C Belka, R Misra, F Bassermann, AJ Garcia-Sae, PJ Jost MLKL promotes cellular differentiation in myeloid leukemia by facilitating the release of G-CSF Cell Death and Differentiation, 2021-06-02;0(0):. 2021-06-02 [PMID: 34079078] (Bioassay, Mouse)
• F Herbst, TJL Lang, ESP Eckert, P Wünsche, AA Wurm, T Kindinger, K Laaber, S Hemmati, A Hotz-Wagen, O Zavidij, A Paruzynski, J Lu, C von Kalle, T Zenz, C Klein, M Schmidt, CR Ball, H Glimm The balance between the intronic miR-342 and its host gene Evl determines hematopoietic cell fate decision Leukemia, 2021-05-21;0(0):. 2021-05-21 [PMID: 34021250] (Bioassay, Mouse)
• T Song, Y Guo, Z Xue, Z Guo, Z Wang, D Lin, H Zhang, H Pan, X Zhang, F Yin, H Wang, LB Uwituze, Z Zhang Small-molecule inhibitor targeting the Hsp70-Bim protein-protein interaction in CML cells overcomes BCR-ABL-independent TKI resistance Leukemia, 2021-05-18;0(0):. 2021-05-18 [PMID: 34007045] (Bioassay, Mouse)
• Z Wang, T Song, Z Guo, LB Uwituze, Y Guo, H Zhang, H Wang, X Zhang, H Pan, T Ji, F Yin, S Zhou, J Dai, Z Zhang A novel Hsp70 inhibitor specifically targeting the cancer-related Hsp70-Bim protein-protein interaction European Journal of Medicinal Chemistry, 2021-04-14;220(0):113452. 2021-04-14 [PMID: 33906046] (Bioassay, Mouse)
• RA Cardenas, R Gonzalez, E Sanchez, MA Ramos, EI Cardenas, AI Rodarte, RJ Alcazar-Fe, A Isaza, AR Burns, R Heidelberg, R Adachi SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis The Journal of Biological Chemistry, 2021-01-08;296(0):100268. 2021-01-08 [PMID: 33837726] (Cell Culture, Mouse)
• S Takashima, S Usui, O Inoue, C Goten, K Yamaguchi, Y Takeda, S Cui, Y Sakai, K Hayashi, K Sakata, MA Kawashiri, M Takamura Myocyte-specific enhancer factor 2c triggers transdifferentiation of adipose tissue-derived stromal cells into spontaneously beating cardiomyocyte-like cells Scientific Reports, 2021-01-15;11(1):1520. 2021-01-15 [PMID: 33452355] (Bioassay, Mouse)
• AE Engler, AB Ysasi, RMF Pihl, C Villacorta, HM Heston, HMK Richardson, BR Thapa, NR Moniz, AC Belkina, SA Mazzilli, JR Rock Airway-Associated Macrophages in Homeostasis and Repair Cell Reports, 2020-12-29;33(13):108553. 2020-12-29 [PMID: 33378665] (Bioassay, Transgenic Mouse)
• D Gonçalves, G Rignol, P Dellugat, G Hartmann, S Sarrazy Ga, J Stavenhage, L Santarelli, E Gouze, C Czech In vitro and in vivo characterization of Recifercept, a soluble fibroblast growth factor receptor 3, as treatment for achondroplasia PLoS ONE, 2020-12-28;15(12):e0244368. 2020-12-28 [PMID: 33370388] (Bioassay, Mouse)
• Y Hong, N Singh, S Bamopoulos, E Gjerga, LK Schmalbroc, K Balabanian, M Schick, U Keller, M Wirth Authentication of Primary Murine Cell Lines by a Microfluidics-Based Lab-On-Chip System Biomedicines, 2020-12-09;8(12):. 2020-12-09 [PMID: 33317212] (Bioassay, Mouse)
• M Girotra, V Trachsel, A Roch, MP Lutolf In Vivo Pre-Instructed HSCs Robustly Execute Asymmetric Cell Divisions In Vitro Int J Mol Sci, 2020-11-03;21(21):. 2020-11-03 [PMID: 33153113] (Bioassay, Mouse)
• JH Kang, G Katsikis, Z Li, KM Sapp, MA Stockslage, D Lim, MG Vander Hei, MB Yaffe, SR Manalis, TP Miettinen Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division Nat Commun, 2020-10-05;11(1):4983. 2020-10-05 [PMID: 33020492] (Bioassay, Mouse)
• H Huang, CA Howard, S Zari, HJ Cho, S Shukla, H Li, J Ndoj, P González-A, C Nikolaidis, J Abbott, DS Rogawski, MA Potopnyk, K Kempinska, H Miao, T Purohit, A Henderson, A Mapp, ML Sulis, A Ferrando, J Grembecka, T Cierpicki Covalent inhibition of NSD1 histone methyltransferase Nat. Chem. Biol., 2020-08-31;0(0):. 2020-08-31 [PMID: 32868895] (Bioassay, Mouse)
• JM Inclan-Ric, JJ Ponessa, N Valero-Pac, CM Hernandez, CB Sy, AD Lemenze, AM Beaulieu, MC Siracusa Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition Nat. Immunol., 2020-08-17;0(0):. 2020-08-17 [PMID: 32807943] (Bioassay, Mouse)
• A Ní Chealla, SE Guimond, S Oscarson, GJ Miller Chemical synthesis of a sulfated d-glucosamine library and evaluation of cell proliferation capabilities Carbohydr. Res., 2020-07-12;495(0):108085. 2020-07-12 [PMID: 32807354] (Bioassay, Mouse)
• A Jandke, D Melandri, L Monin, DS Ushakov, AG Laing, P Vantourout, P East, T Nitta, T Narita, H Takayanagi, R Feederle, A Hayday Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial &amp;gamma&amp;delta T cell compartments Nat Commun, 2020-07-28;11(1):3769. 2020-07-28 [PMID: 32724083] (Cell Culture, Mouse)
• H Seo, H Masuda, K Asagoshi, T Uchiki, S Kawata, G Sasaki, T Yabuki, S Miyai, N Takahashi, SI Hashimoto, A Sawada, A Takaiwa, C Koyama, K Tamai, K Kurosawa, KY Lin, K Ohta, Y Nakazaki Streamlined human antibody generation and optimization by exploiting designed immunoglobulin loci in a B cell line Cell. Mol. Immunol., 2020-05-26;0(0):. 2020-05-26 [PMID: 32457406] (Cell Culture, Mouse)
• S Kreutmair, C Klingeberg, T Poggio, G Andrieux, A Keller, C Miething, M Follo, D Pfeifer, K Shoumariye, C Lengerke, I Gonzalez-M, F Fend, R Zeiser, SD Turner, L Quintanill, M Boerries, J Duyster, AL Illert Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model Leukemia, 2020-03-17;0(0):. 2020-03-17 [PMID: 32203142] (Cell Culture, Mouse)
• A Yoshimi, TM Trippett, N Zhang, X Chen, AV Penson, ME Arcila, J Pichardo, J Baik, A Sigler, H Harada, DC Fajgenbaum, A Dogan, O Abdel-Waha, W Xiao Genetic basis for iMCD-TAFRO Oncogene, 2020-02-12;0(0):. 2020-02-12 [PMID: 32051554] (Bioassay, Mouse)
• SG Rudd, N Tsesmetzis, K Sanjiv, CB Paulin, L Sandhow, J Kutzner, I Hed Myrber, SS Bunten, H Axelsson, SM Zhang, A Rasti, P Mäkelä, SA Coggins, S Tao, S Suman, RM Branca, G Mermelekas, E Wiita, S Lee, J Walfridsso, RF Schinazi, B Kim, J Lehtiö, GZ Rassidakis, K Pokrovskaj, U Warpman-Be, M Heyman, D Grandér, S Lehmann, T Lundbäck, H Qian, JI Henter, T Schaller, T Helleday, N Herold Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy EMBO Mol Med, 2020-01-17;12(3):e10419. 2020-01-17 [PMID: 31950591] (Cell Culture, Mouse)
• MM de Rezende, JP Ng-Blichfe, GZ Justo, EJ Paredes-Ga, R Gosens Divergent effects of Wnt5b on IL-3- and GM-CSF-induced myeloid differentiation Cell. Signal., 2019-12-17;67(0):109507. 2019-12-17 [PMID: 31857239] (Bioassay, Mouse)
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• Yu , Chuanjia, Kancha , Rama Kri, Duyster , Justus Targeting oncoprotein stability overcomes drug resistance caused by FLT3 kinase domain mutations. PLoS ONE, 2014-05-21;9(5):e97116. 2014-05-21 [PMID: 24849514] (Bioassay, Mouse)
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• Zhang H, Nieves J, Fraser S, Isern J, Douvaras P, Papatsenko D, D'Souza S, Lemischka I, Dyer M, Baron M Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm. Stem Cells, 2014-01-01;32(1):191-203. 2014-01-01 [PMID: 24022884] (Bioassay, Mouse)
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• Pope , Nathanie, Bresnick , Emery H Establishment of a cell-type-specific genetic network by the mediator complex component Med1. Mol Cell Biol, 2013-03-04;33(10):1938-55. 2013-03-04 [PMID: 23459945] (Bioassay, Mouse)
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• Gautier E, Westerterp M, Bhagwat N, Cremers S, Shih A, Abdel-Wahab O, Lutjohann D, Randolph G, Levine R, Tall A, Yvan-Charvet L HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders. J Exp Med, 2013-01-14;210(2):339-53. 2013-01-14 [PMID: 23319699] (Bioassay, Mouse)
• Jeong H, Oh H, Nam S, Han N, Kim Y, Kim J, Lee S, Kim M, Moon P, Kim H, Oh H The critical role of mast cell-derived hypoxia-inducible factor-1alpha in human and mice melanoma growth. Int J Cancer, 2012-12-03;132(11):2492-501. 2012-12-03 [PMID: 23161568] (Bioassay, Mouse)
• Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)
• Matsushita H, Endo S, Kobayashi E, Sakamoto Y, Kobayashi K, Kitaguchi K, Kuroki K, Soderhall A, Maenaka K, Nakamura A, Strittmatter SM, Takai T Differential but competitive binding of Nogo protein and class i major histocompatibility complex (MHCI) to the PIR-B ectodomain provides an inhibition of cells. J. Biol. Chem., 2011-06-02;286(29):25739-47. 2011-06-02 [PMID: 21636572] (Bioassay, Mouse)
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• Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J. Virol., 2010-09-29;84(24):12703-12. 2010-09-29 [PMID: 20881038] (In Vivo, Mouse)
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• Perrigoue JG, Saenz SA, Siracusa MC, Allenspach EJ, Taylor BC, Giacomin PR, Nair MG, Du Y, Zaph C, Van Rooijen N, Comeau MR, Pearce EJ, Laufer TM, Artis D MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat. Immunol., 2009-05-24;10(7):697-705. 2009-05-24 [PMID: 19465906] (Bioassay, Mouse)
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• Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J, Joe GJ, Hexner E, Choi Y, Taichman RS, Emerson SG Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Blood, 2007-01-16;109(9):3706-12. 2007-01-16 [PMID: 17227831] (Bioassay, Mouse)
• Bao YC, Nomura Y, Moon Y, Tonozuka Y, Minoshima Y, Hatori T, Tsuchiya A, Kiyono M, Nosaka T, Nakajima H Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors. J. Cell Biol., 2006-12-18;175(6):937-46. 2006-12-18 [PMID: 17178910] (Bioassay, Mouse)
• Yuan W, Payton JE, Holt MS, Link DC, Watson MA, DiPersio JF, Ley TJ Commonly dysregulated genes in murine APL cells. Blood, 2006-09-28;109(3):961-70. 2006-09-28 [PMID: 17008535] (In Vivo, Mouse)
• Yilmaz OH, Kiel MJ, Morrison SJ SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood, 2005-10-11;107(3):924-30. 2005-10-11 [PMID: 16219798] (Bioassay, Mouse)
• Yoshihiro Ueda, Motonari Kondo, Garnett Kelsoe Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow The Journal of Experimental Medicine 2005-06-06 [PMID: 15939792] (Bioassay, Mouse)
• Dikov MM, Ohm JE, Ray N, Tchekneva EE, Burlison J, Moghanaki D, Nadaf S, Carbone DP Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation. J. Immunol., 2005-01-01;174(1):215-22. 2005-01-01 [PMID: 15611243] (Bioassay, Mouse)
• Cox GN, Smith DJ, Carlson SJ, Bendele AM, Chlipala EA, Doherty DH Enhanced circulating half-life and hematopoietic properties of a human granulocyte colony-stimulating factor/immunoglobulin fusion protein. Exp. Hematol., 2004-05-01;32(5):441-9. 2004-05-01 [PMID: 15145212] (Bioassay, Mouse)
• Armstrong SA, Kung AL, Mabon ME, Silverman LB, Stam RW, Den Boer ML, Pieters R, Kersey JH, Sallan SE, Fletcher JA, Golub TR, Griffin JD, Korsmeyer SJ Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. Cancer Cell, 2003-02-01;3(2):173-83. 2003-02-01 [PMID: 12620411] (Bioassay, Mouse)
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Bioinformatics

• Gene Symbol: Il3
• Uniprot:
  • NP_034686()