TACE/ADAM17 Antibody Blocking Peptide

Western Blot: ADAM17 Peptide [NBP1-77044PEP] - TACE peptide is used for blocking the activity of Anti-TACE. Incubating the peptide with equal volume of antibody for 30 min at 37C usually completely blocks the activity of Anti-TACE in Western blotting.

• Reactivity: Hu
• Applications: AC
• Concentration: 0.2 mg/ml

TACE/ADAM17 Antibody Blocking Peptide Summary

• Description: A blocking peptide containing 17 amino acids near the carboxy terminus of human TACE.

  Source: Synthetic

  (Accession #: NP_003174)

• Source: Synthetic
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: ADAM17
• Purity: N/A

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This peptide is useful as a blocking peptide for NBP1-77044.
  
  For further blocking peptide related protocol, click here.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin.
• Preservative: 0.02% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: N/A

Alternate Names for TACE/ADAM17 Antibody Blocking Peptide

• ADAM 17
• ADAM metallopeptidase domain 17
• ADAM metallopeptidase domain 18
• ADAM17
• ADAM18
• CD156b antigen
• CD156b
• CSVP
• disintegrin and metalloproteinase domain-containing protein 17
• EC 3.4.24.86
• MGC71942
• Snake venom-like protease
• TACE
• TACEcSVP
• TNF-alpha convertase
• TNF-alpha converting enzyme
• TNF-alpha-converting enzyme
• tumor necrosis factor, alpha, converting enzyme

Background

ADAM17 encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: ADAM17