Tetanus Toxin Synthetic Peptide

• Applications: ELISA
• Concentration: 1 mg/ml

Tetanus Toxin Synthetic Peptide Summary

• Description: Synthetic tetanus toxin peptide is a 15 amino acid peptide corresponding to amino acid residues 1300-1314 located at the C-terminus of the Clostridium tetani tetanus toxin heavy chain according to entrez protein accession number CAA28033. Amino Acid Sequence: CDWYFVPTDEGWTND
• Preparation Method: Solid phase synthesis
• Source: Synthetic
• Protein/Peptide Type: Synthetic Peptide
• Gene: TETX

Applications/Dilutions

• Dilutions:
  • ELISA

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Preservative: No Preservative
• Concentration: 1 mg/ml

Alternate Names for Tetanus Toxin Synthetic Peptide

• Tentoxylysin

Background

Tetanus toxin, a member of the peptidase M27 family of proteins, is produced by the anaerobic spore-forming bacteria Clostridium tetani as a single-chain polypeptide that is 1315 amino acids (aa) in length. The protein is subsequently cleaved by an endogenous protease to yield the 52 kDa tetanus toxin light chain (TeNT-LC), which is 457 aa in length, and the 98 kDa tetanus toxin heavy chain that is 858 aa long. The light and heavy chains are linked by a disulfide bridge and are non-toxic after separation. Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neural synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the 76-Gln-|-Phe-77 bond of synaptobrevin-2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: TETX
• Entrez:
  • CAA28033(C. tetani)
• Uniprot:
  • P04958(C. tetani)