TRPM7 Antibody (M573)

Western Blot: TRPM7 Antibody (M573) [NBP3-23439] - Western blot image of TRPM7 expression in human MCF-7 cell lysate. The blot was probed with mouse monoclonal anti-TRPM7 (Extracellular region) M573 at a dilution of 1:250.

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: M573
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

TRPM7 Antibody (M573) Summary

• Description: Stable for at least 1 year at -20°C.
• Immunogen: Clone M573 was generated from TRPM7 synthetic peptide (coupled to carrier) corresponding to amino acids in the extracellular region of human TRPM7. This site is well conserved in rat and mouse TRPM7, but has low homology to other TRPM family members. [UniProt# Q96QT4]
• Specificity: This antibody detects a 220 kDa protein on SDS-PAGE immunoblots of human MCF7 cells.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: TRPM7
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500
• Theoretical MW: 220 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C.
• Buffer: PBS, 1 mg/ml BSA and 50% glycerol
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Alternate Names for TRPM7 Antibody (M573)

• CHAK
• CHAK1FLJ25718
• Channel-kinase 1
• EC 2.7.11.1
• Long transient receptor potential channel 7
• LTRPC ion channel family member 7
• LTrpC7
• LTrpC-7
• LTRPC7FLJ20117
• transient receptor potential cation channel subfamily M member 7
• transient receptor potential cation channel, subfamily M, member 7
• transient receptor potential-phospholipase C-interacting kinase
• TRP-PLIK

Background

The TRPM7 (Transient Receptor Protein-PhosphoLipase C-Interacting Kinase) protein is a member of the ion channel proteins. It regulates the calcium concentration in cells, which is imperative for such functions as muscle contractions and neuronal firing. TRPM7, however, is unique among the TRP channel proteins because it is bi-functional. It not only controls ion channels but it also acts as a kinase by phosphorylating proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TRPM7