Uteroglobin/SCGB1A1 Antibody (AY1E6)

Product Discontinued

Uteroglobin/SCGB1A1 Antibody (AY1E6) Summary

• Immunogen: anti-inflammatory mediator Clara cell protein (CC16)
• Specificity: The monoclonal antibody AY1E6 recognizes the anti-inflammatory mediator Clara cell protein (CC16).
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: SCGB1A1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunoassay
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:100-1:2000
• Application Notes: For immunohistology and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: 0.2 um filtered solution in PBS and 0.1% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.1 mg/ml
• Purity: Protein A or G purified

Alternate Names for Uteroglobin/SCGB1A1 Antibody (AY1E6)

• Blastokinin
• CC10
• CC10Urine protein 1
• CC16
• CCPBP
• CCSP
• CCSPCCPBP
• Clara cell phospholipid-binding protein
• Clara cells 10 kDa secretory protein
• Clara
• PCB-BP
• SCGB1A1
• Secretoglobin family 1A member 1
• secretoglobin, family 1A, member 1 (uteroglobin)
• UGB
• UGBUP-1
• UP1
• Urinary protein 1
• Uteroglobin

Background

The monoclonal antibody AY1E6 recognizes the anti-inflammatory mediator Clara cell protein (CC16). Clara cell protein or urinary protein 1 is a homodimeric protein of 16 kD and is secreted predominantly by Clara cells in terminal bronchioles and from puberty on in the male urogenital tract. CC16 is formed by two chains, each with a molecular weight of 7.9 kD. CC16 occurs in very high concentrations in respiratory tract derived fluids such as sputum or bronchoalveolar lavage fluid. CC16 occurs also in urogenital secretions, such as amniotic fluid, urine and semen. The protein difusses passively into serum. CC16 behaves like an anti-cytokine by downregulating the production of IFN-gamma, IL-1 and TNF-alpha by stimulated leukocytes. Besides this, CC16 reduces the antiviral activity and the augmentation of phagocytosis induced by IFN-gamma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SCGB1A1
• Entrez:
  • 7356(Human)