This TGF-β Signaling Pathway poster provides an outline of canonical/SMAD-dependent and non-canonical/SMAD-independent signaling executed by Transforming Growth Factor Beta (TGF-β). This poster also highlights TGF-β’s context dependent signaling (normal vs cancer), small molecule inhibitors, and target genes which regulate various biological processes, such as cell proliferation, cell death, angiogenesis, epithelial to mesenchymal transition (EMT) and stemness.
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Canonical/SMAD - Dependent TGF-β Signaling
Non-canonical/ SMAD - Independent TGF-β Signaling
Contextual TGF-β Signaling in Cancer and Normal Cells