alpha Endosulfine Antibody (S08-1G6)

Western Blot: alpha Endosulfine Antibody (S08-1G6) [NBP3-14992] - Western blot detection of alpha Endosulfine in Rat Brain, C6, 3T3, Hela cell lysates using alpha Endosulfine Rabbit mAb (1:1000 diluted). Predicted band size: 13kDa. Observed band size: 15kDa.

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: S08-1G6
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated

alpha Endosulfine Antibody (S08-1G6) Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: A synthetic peptide of human alpha Endosulfine (Uniprot#: O43768)
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: ENSA
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1/1000-1/5000
• Theoretical MW: 15 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA
• Preservative: 0.01% Sodium Azide
• Purity: Affinity purified

Alternate Names for alpha Endosulfine Antibody (S08-1G6)

• alpha-endosulfine
• ARPP-19eMGC4319
• endosulfine alpha
• MGC78563
• MGC8394

Background

alpha Endosulfine is encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. alpha Endosulfine is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ENSA