C-Reactive Protein/CRP Antibody Pair [HRP]

Sandwich ELISA: C-Reactive Protein/CRP Antibody Pair [HRP] [NBP2-79581] - This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP
• Standard Curve Range: 34.38-2200 pg/ml (example only; lot dependent)
• Sensitivity: 34.38 pg/ml (example only; lot dependent)

C-Reactive Protein/CRP Antibody Pair [HRP] Summary

• Description: Solid Phase sandwich ELISA for the quantitative determination of Mouse C-Reactive Protein/CRP.
• Specificity: This solid phase sandwich ELISA utilizes an antibody specific for Mouse C-Reactive Protein/CRP.
• Standard Curve Range: 34.38-2200 pg/ml (example only; lot dependent)
• Sensitivity: 34.38 pg/ml (example only; lot dependent)
• Assay Type: Sandwich ELISA
• Sample Volume: 100 ul
• Gene: CRP

Applications/Dilutions

• Dilutions:
  • ELISA
  • Sandwich ELISA

Packaging, Storage & Formulations

• Storage: Storage of components varies. See protocol for specific instructions.

Alternate Names for C-Reactive Protein/CRP Antibody Pair [HRP]

• C-Reactive Protein
• C-reactive protein, pentraxin-related
• CRP
• MGC88244
• pentraxin 1
• PTX1MGC149895

Background

C Reactive Protein is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is a pentraxin (cyclic pentameric protein) compound of five identical nonglycosylated subunits of 206 amino acids each (m.w. 24 kDa), that are bound noncovalently to form the physiologic CRP molecule (m.w. 117.5 kDa). C Reactive Protein mediates activities associated with preimmune nonspecific host resistance. It is opsonic, an initiator of the classical complement cascade and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. Studies have revealed that among other markers of inflammation, CRP shows the strongest association with cardiovascular events. Many clinical studies demonstrated that coronary mortality among patients with unstable angina and elevated CRP is significantly higher comparing with the patients without elevated CRP. Measurements of C reactive protein (hsCRP) in the patients with ischemic heart disease provide a novel method for detecting individuals at high risk of plaque rupture.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are guaranteed for 6 months from date of receipt.

Bioinformatics

• Gene Symbol: CRP