CCR4 Antibody - BSA Free

Immunohistochemistry-Paraffin: CCR4 Antibody [NBP1-86584] - Staining of human cerebral cortex shows no positivity in neurons as expected.

Immunohistochemistry-Paraffin: CCR4 Antibody [NBP1-86584] - Staining of human rectum shows strong cytoplasmic positivity in lymphoid cells.

Immunohistochemistry-Paraffin: CCR4 Antibody [NBP1-86584] - Staining of human skeletal muscle shows no positivity in striated muscle fibers, as expected.

Immunohistochemistry-Paraffin: CCR4 Antibody [NBP1-86584] - Staining of human tonsil shows moderate to strong cytoplasmic positivity in a subset of lymphoid cells.

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

CCR4 Antibody - BSA Free Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: LQIYSADTPSSSYTQSTMDHDLHDAL
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CCR4
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:20 - 1:50
  • Immunohistochemistry-Paraffin 1:20 - 1:50
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  CCR4 Protein (NBP1-86584PEP)

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rat (81%)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for CCR4 Antibody - BSA Free

• C-C chemokine receptor type 4
• C-C CKR-4
• CC-CKR-4HGCN:14099
• CCR4
• CCR-4
• CD194 antigen
• CD194
• chemokine (C-C motif) receptor 4
• chemokine (C-C) receptor 4
• ChemR13
• CKR4MGC88293
• CMKBR4k5-5
• K5-5

Background

Chemokine receptors are G protein-coupled receptors (GPCRs) that play a key role in inflammation and are characterized by similar sequences with a 4 cysteine motif. The C-C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation. Receptors for the C-C chemokine family include CCR-1, CCR-2A, CCR-3, CCR-4, CCR-5 and the Duffy blood group antigen.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CCR4 Antibody (NBP1-86584)(3)

Publications using NBP1-86584

• Liu Q, Zhang S, Wang Q et al. Single-cell transcriptomic analysis revealed the tumor-associated microenvironment of papillary thyroid carcinoma with metastasis Research Square 2023-04-25
• Enriquez JS, Wang X, Velatooru LR et al. Small-Molecule CCR4 Antagonists in Cutaneous T-cell Lymphoma Cancer Research Communications 2024-10-01 [PMID: 39302105]
• Zhiyuan Wang, Xiaoyu Ji, Ye Zhang, Fan Yang, Hongyue Su, Hao Zhang, Zhendong Li, Wenqian Zhang, Wei Sun Interactions between LAMP3+ dendritic cells and T-cell subpopulations promote immune evasion in papillary thyroid carcinoma Journal for Immunotherapy of Cancer 2024-01-01 [PMID: 38816233]

Bioinformatics

• Gene Symbol: CCR4
• Entrez:
  • 1233(Human)
• Uniprot:
  • P51679()