CCR6 Antibody

Immunohistochemistry-Paraffin: CCR6 Antibody [NLS356] - IHC staining of human tonsil using this antibody at 2.5 ug/ml.

Product Discontinued

CCR6 Antibody Summary

• Immunogen: Synthetic 18 amino acid peptide from 2nd extracellular domain of human CCR6.
• Epitope: 2nd extracellular domain
• Specificity: Human CCR6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Primate (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CCR6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 2 ug/ml
• Control:

  CCR6 Overexpression Lysate

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (94%), Monkey (89%), Opossum (83%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for CCR6 Antibody

• BN-1
• CC-CKR-6
• CCR6
• CCR-6
• CD196 antigen
• CD196
• chemokine (C-C motif) receptor 6
• CKRL3
• CKR-L3
• CKR-L3G-protein coupled receptor 29
• CKRL3LARC receptor
• CMKBR6
• CMKBR6STRL22
• DRY6
• GPR29
• GPR29C-C CKR-6
• GPRCY4
• GPR-CY4
• GPRCY4DRY-6
• lymphocyte, 22
• STRL22

Background

CCR6 is a Chemokine Receptor that is activated by MIP3alpha/Larc binding. CCR6 has been shown to be upregulated in psoriatic skin. CCR6 has been reported to be expressed in intestine, colon, liver, lymph node, spleen, lung, blood, umbilical cord, placenta, skin, and pancreas. It has also been reported to be expressed in lymphocytes, T cells, and B cells but not in natural killer cells, monocytes, or granulocytes from spleen, lymph node, appendix, and fetal liver. ESTs have been isolated from liver/spleen, lymph, and fetal lung/testis/B cell libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Review for CCR6 Antibody (NLS356) (1)

Average Rating: 3

(Based on 1 review)

We have 1 review tested in 1 species: Human.

reviewed by: Verified Customer IHC-P Human 05/20/2016

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: skin
• Species: Human
• Lot: 6246

FAQs for CCR6 Antibody (NLS356). (Showing 1 - 1 of 1 FAQ).

1. I am looking for an anti-bovine CCR6 antibody and I see your antibody below was raised in goat so may cross react. Do you know if it can be used in cattle for flow cytometry? CCR6 Antibody (NB100-713)
   • Unfortunately, the species that the antibody is made in is no indicator of the species it will react to. In this case, the immunogen for NB100-713 shares just 57% similarity with bovine CCR6, so this antibody will almost certainly not cross-react with bovine. In this case, the immunogens for NLS356 and NBP1-88565 shares 79% similarity with bovine and have the highest chance of cross-reactivity of any antibodies we carry, although this is still below the 85% that we generally prefer to recommend for cross-reactivity. These are the best two we currently have for your species.

Bioinformatics

• Gene Symbol: CCR6
• Entrez:
  • 1235(Human)
• Uniprot:
  • P51684()