Claudin-1 Antibody

Immunohistochemistry-Paraffin: Claudin-1 Antibody [NB120-15098] - Formalin fixed paraffin embedded human skin stained with Claudin 1 antibody (NB120-15098).

Product Discontinued

Claudin-1 Antibody Summary

• Immunogen: Synthetic peptide (Human) (C terminal).
• Localization: Cell Membrane, Cytoplasmic
• Specificity: Claudin 1
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CLDN1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:50-1:100
  • Immunohistochemistry-Paraffin 1:50-1:100
• Application Notes: IHC-P: recommended pretreatment of citrate buffer, pH 6.0. Recommended incubation time of 30 min at RT.
• Control:

  Claudin-1 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS (pH 7.4), 0.2% BSA, Tween-20
• Preservative: 0.05% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: Affinity purified

Alternate Names for Claudin-1 Antibody

• claudin 1
• Claudin1
• Claudin-1
• CLD1
• CLDN1
• ILVASCSenescence-associated epithelial membrane protein
• SEMP1
• SEMP1senescence-associated epithelial membrane protein 1

Background

Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact; made up of networking strands to act as a molecular gasket for preventing the leakage of ions, water etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CLDN1
• Entrez:
  • 9076(Human)
  • 12737(Mouse)
  • 65129(Rat)