Human IFN-beta ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IFN-beta ELISA Kit Summary

• Additional Information: NEW Human IFN-beta Quantikine ELISA Kit is now available!
• Specificity: Human IFN-beta
• Source: N/A
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IFNB1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IFN-beta ELISA Kit

• Fibroblast interferon
• IFB
• IFBIFNB
• IFF
• IFNB
• IFNB1
• IFNbeta
• IFN-beta
• interferon beta
• interferon, beta 1, fibroblast
• MGC96956

Background

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

Publications for IFN-beta (41410-1)(31)

Publications using 41410-1

• Ferecsk�, AS;Smallwood, MJ;Moore, A;Liddle, C;Newcombe, J;Holley, J;Whatmore, J;Gutowski, NJ;Eggleton, P; STING-Triggered CNS Inflammation in Human Neurodegenerative Diseases Biomedicines 2023-05-05 [PMID: 37239045] (Human)
• X Kong, X Lu, S Wang, J Hao, D Guo, H Wu, Y Jiang, Y Sun, J Wang, G Zhang, Z Cai Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner Cell Reports, 2023-01-19;42(1):112002. 2023-01-19 [PMID: 36662617] (Mouse)
• RS Singh, V Vidhyasaga, S Yang, AB Arna, M Yadav, A Aggarwal, AN Aguilera, S Shinriki, KK Bhanumathy, K Pandey, A Xu, N Rapin, M Bosch, J DeCoteau, J Xiang, FJ Vizeacouma, Y Zhou, V Misra, H Matsui, SR Ross, Y Wu DDX41 is required for cGAS-STING activation against DNA virus infection Cell Reports, 2022-05-24;39(8):110856. 2022-05-24 [PMID: 35613581] (Human)
• J Wu, Y Shi, X Pan, S Wu, R Hou, Y Zhang, T Zhong, H Tang, W Du, L Wang, J Wo, J Mu, Y Qiu, K Yang, LK Zhang, BC Ye, N Qi SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO Cell Reports, 2021-02-03;34(7):108761. 2021-02-03 [PMID: 33567255] (Human)
• S Ding, J Diep, N Feng, L Ren, B Li, YS Ooi, X Wang, KF Brulois, LL Yasukawa, X Li, CJ Kuo, DA Solomon, JE Carette, HB Greenberg STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection Nat Commun, 2018-04-16;9(1):1485. 2018-04-16 [PMID: 29662124] (Human)
• M Bugge, B Bergstrom, OK Eide, H Solli, IF Kjønstad, J Stenvik, T Espevik, NJ Nilsen Surface Toll-Like Receptor 3 Expression in Metastatic Intestinal Epithelial Cells induces Inflammatory Cytokine Production and Promotes Invasiveness J. Biol. Chem., 2017-07-17;0(0):. 2017-07-17 [PMID: 28717003] (Human)
• Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production Proc Natl Acad Sci USA, 2016-09-06;113(38):10625-10630. 2016-09-06 [PMID: 27601648] (Human)
• Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5 PLoS ONE, 2016-08-09;11(8):e0160875. 2016-08-09 [PMID: 27504984] (Human)
• CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection PLoS Pathog, 2016-07-28;12(7):e1005770. 2016-07-28 [PMID: 27467705] (Mouse)
• M Tatematsu, R Yoshida, Y Morioka, N Ishii, K Funami, A Watanabe, K Saeki, T Seya, M Matsumoto Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization and TICAM-1 Signaling in a Cell Type-Specific Manner J Immunol, 2016-03-28;0(0):. 2016-03-28 [PMID: 27022195] (Human)
• Villenave R, Broadbent L, Douglas I, Lyons J, Coyle P, Teng M, Tripp R, Heaney L, Shields M, Power U Induction and Antagonism of Antiviral Responses in Respiratory Syncytial Virus-Infected Pediatric Airway Epithelium. J Virol, 2015-09-30;89(24):12309-18. 2015-09-30 [PMID: 26423940] (Human)
• Hosein A, Livingstone J, Buchanan M, Reid J, Hallett M, Basik M A functional in vitro model of heterotypic interactions reveals a role for interferon-positive carcinoma associated fibroblasts in breast cancer. BMC Cancer, 2015-03-15;15(0):130. 2015-03-15 [PMID: 25884794] (Human)
• Scheuplein V, Seifried J, Malczyk A, Miller L, Hocker L, Vergara-Alert J, Dolnik O, Zielecki F, Becker B, Spreitzer I, Konig R, Becker S, Waibler Z, Muhlebach M High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus. J Virol, 2015-01-21;89(7):3859-69. 2015-01-21 [PMID: 25609809] (Human)
• Wu Z, Sinzger C, Reichel J, Just M, Mertens T Natural killer cells can inhibit the transmission of human cytomegalovirus in cell culture by using mechanisms from innate and adaptive immune responses. J Virol, 2014-12-24;89(5):2906-17. 2014-12-24 [PMID: 25540381] (Human)
• Ranjan P, Singh N, Kumar A, Neerincx A, Kremmer E, Cao W, Davis W, Katz J, Gangappa S, Lin R, Kufer T, Sambhara S NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection. Eur J Immunol, 2014-12-23;45(3):758-72. 2014-12-23 [PMID: 25404059] (Human)
• Zhang Y, Yeruva L, Marinov A, Prantner D, Wyrick P, Lupashin V, Nagarajan U The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-beta during Chlamydia trachomatis infection. J Immunol, 2014-07-28;193(5):2394-404. 2014-07-28 [PMID: 25070851] (Human)
• Liu H, Chen K, Feng W, Guo J, Li H HSV-2 increases TLR4-dependent phosphorylated IRFs and IFN-beta induction in cervical epithelial cells. PLoS ONE, 2014-04-10;9(4):e94806. 2014-04-10 [PMID: 24722640] (Human)
• Xia , Mao, Gonzalez , Patrick, Li , Chunyan, Meng , Gang, Jiang , Aiqin, Wang , Hongwei, Gao , Qian, Debatin , Klaus-Mi, Beltinger , Christia, Wei , Jiwu Mitophagy enhances oncolytic measles virus replication by mitigating DDX58/RIG-I-like receptor signaling. J Virol, 2014-02-26;88(9):5152-64. 2014-02-26 [PMID: 24574393] (Human)
• Stone , Amy E L, Giugliano , Silvia, Schnell , Gretja, Cheng , Linling, Leahy , Katelyn, Golden-Mason , Lucy, Gale , Michael, Rosen , Hugo R Hepatitis C virus pathogen associated molecular pattern (PAMP) triggers production of lambda-interferons by human plasmacytoid dendritic cells. PLoS Pathog, 2013-04-18;9(4):e1003316. 2013-04-18 [PMID: 23637605] (Human)
• Osterlund P, Strengell M, Sarin L, Poranen M, Fagerlund R, Melen K, Julkunen I Incoming influenza A virus evades early host recognition, while influenza B virus induces interferon expression directly upon entry. J Virol, 2012;86(20):11183-93. 2012 [PMID: 22855501] (Human)
• Patel MV, Ghosh M, Fahey JV, Wira CR Uterine epithelial cells specifically induce interferon-stimulated genes in response to polyinosinic-polycytidylic acid independently of estradiol. PLoS ONE, 2012-04-25;7(4):e35654. 2012-04-25 [PMID: 22558189] (Human)
• Wang P, Arjona A, Zhang Y Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Nat. Immunol., 2010-09-05;11(10):912-9. 2010-09-05 [PMID: 20818395] (Mouse)
• Liang X, Moseman EA, Farrar MA Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells. Blood, 2010-03-25;115(24):5041-52. 2010-03-25 [PMID: 20339095] (Human)
• Beck LA, Boguniewicz M, Hata T, Schneider LC, Hanifin J, Gallo R, Paller AS, Lieff S, Reese J, Zaccaro D, Milgrom H, Barnes KC, Leung DY Phenotype of atopic dermatitis subjects with a history of eczema herpeticum. J. Allergy Clin. Immunol., 2009-06-27;124(2):260-9, 269.e1. 2009-06-27 [PMID: 19541356] (Human)
• Schirmer SH, van Royen N, Moerland PD, Fledderus JO, Henriques JP, van der Schaaf RJ, Vis MM, Baan J, Koch KT, Horrevoets AJ, Hoefer IE, Piek JJ Local cytokine concentrations and oxygen pressure are related to maturation of the collateral circulation in humans. J. Am. Coll. Cardiol., 2009-06-09;53(23):2141-7. 2009-06-09 [PMID: 19497439] (Human)
• Lee SH, Kim JS, Jun HK The major outer membrane protein of a periodontopathogen induces IFN-beta and IFN-stimulated genes in monocytes via lipid raft and TANK-binding kinase 1/IFN regulatory factor-3. J. Immunol., 2009-05-01;182(9):5823-35. 2009-05-01 [PMID: 19380831] (Human)
• Chase JC, Celli J, Bosio CM Direct and indirect impairment of human dendritic cell function by virulent Francisella tularensis Schu S4. Infect. Immun., 2008-11-03;77(1):180-95. 2008-11-03 [PMID: 18981246] (Human)
• Newcomb DC, Sajjan US, Nagarkar DR, Goldsmith AM, Bentley JK, Hershenson MB Cooperative effects of rhinovirus and TNF-{alpha} on airway epithelial cell chemokine expression. Am. J. Physiol. Lung Cell Mol. Physiol., 2007-07-13;293(4):L1021-8. 2007-07-13 [PMID: 17631613] (Human)
• Lee MT, Hooper LC, Kump L, Hayashi K, Nussenblatt R, Hooks JJ, Detrick B Interferon-beta and adhesion molecules (E-selectin and s-intracellular adhesion molecule-1) are detected in sera from patients with retinal vasculitis and are induced in retinal vascular endothelial cells by Toll-like receptor 3 signalling. Clin. Exp. Immunol., 2007-01-01;147(1):71-80. 2007-01-01 [PMID: 17177965] (Human)
• Emori Y, Ikeda T, Ohashi T, Masuda T, Kurimoto T, Takei M, Kannagi M Inhibition of human immunodeficiency virus type 1 replication by Z-100, an immunomodulator extracted from human-type tubercle bacilli, in macrophages. J. Gen. Virol., 2004-09-01;85(0):2603-13. 2004-09-01 [PMID: 15302954] (Human)
• Schmidt KN, Leung B, Kwong M, Zarember KA, Satyal S, Navas TA, Wang F, Godowski PJ APC-independent activation of NK cells by the Toll-like receptor 3 agonist double-stranded RNA. J. Immunol., 2004-01-01;172(1):138-43. 2004-01-01 [PMID: 14688319] (Human)

Bioinformatics

• Gene Symbol: IFNB1