JNK2 [p Thr183, p Tyr185] Antibody

Product Discontinued

JNK2 [p Thr183, p Tyr185] Antibody Summary

• Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Thr183/Tyr185 of human SAPK/JNK.
• Modification: p Thr183, p Tyr185
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MAPK9
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2), 1% BSA, 50% Glycerol
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Affinity purified

Alternate Names for JNK2 [p Thr183, p Tyr185] Antibody

• c-Jun kinase 2
• c-Jun N-terminal kinase 2
• EC 2.7.11
• EC 2.7.11.24
• JNK2
• JNK2A
• JNK2BETA
• JNK2JNK2ALPHA
• JNK-55
• Jun kinase
• MAP kinase 9
• MAPK 9
• MAPK9
• mitogen-activated protein kinase 9
• p54a
• p54aSAPK
• PRKM9JNK2B
• SAPK
• SAPK1 alpha
• Stress-activated protein kinase JNK2

Background

JNK protein kinases are distantly related to mitogen-activated protein kinases (ERKs) and are activated by dual phosphorylation on Tyr and Thr. The JNK protein kinase group includes the 46-kDa isoform JNK1 and the 55-kDa protein kinase JNK2. The activities of both JNK isoforms are markedly increased by exposure of cells to UV radiation (1). JNK becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase MKK4 and MKK7 (2). JNK2 functions in a cell-type-specific and stimulus-dependent manner, being required for apoptosis of immature thymocytes induced by anti-CD3 antibody but not for apoptosis induced by anti-Fas antibody, UVC or dexamethasone. JNK2 is not required for activation-induced cell death of mature T cells (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for JNK2 Antibody (NBP1-45787)(1)

Publication using NBP1-45787

• Lv R, Zhao J, Lei M et al. IL-33 Attenuates Sepsis by Inhibiting IL-17 Receptor Signaling through Upregulation of SOCS3 Cell. Physiol. Biochem. 2017-08-09 [PMID: 28793286] (WB, Human)

Bioinformatics

• Gene Symbol: MAPK9
• Entrez:
  • 5601(Human)
• Uniprot:
  • NP_001128516(Human)