LOX-1/OLR1 Antibody (331212) [Janelia Fluor® 646]

• Reactivity: Hu
• Applications: WB, Flow, B/N, CyTOF-ready
• Clone: 331212
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 646

LOX-1/OLR1 Antibody (331212) [Janelia Fluor® 646] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human LOX-1/OLR1
  Ser61-Gln273
  Accession # P78380
• Specificity: Detects human LOX-1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody does not cross-react with recombinant mouse LOX‑1.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: OLR1
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Blockade of Receptor-ligand Interaction
  • CyTOF-ready
  • Flow Cytometry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for LOX-1/OLR1 Antibody (331212) [Janelia Fluor® 646]

• CLEC8A
• CLEC8ASLOX1
• C-type lectin domain family 8 member A
• hLOX-1
• Lectin-like oxidized LDL receptor 1
• Lectin-like oxLDL receptor 1
• Lectin-type oxidized LDL receptor 1
• LOX1
• LOX-1
• LOX1ox LDL receptor 1
• LOXIN
• OLR1
• oxidised low density lipoprotein (lectin-like) receptor 1
• oxidized low density lipoprotein (lectin-like) receptor 1
• oxidized low-density lipoprotein receptor 1
• oxidized low-density lipoprotein receptor 1, soluble form
• Ox-LDL receptor 1
• SCARE1
• scavenger receptor class E, member 1
• SR-E1

Background

LOX 1 belongs to the C type lectin like protein super family. This unique scavenger receptor plays important roles in atherogenesis. Like other scavenger receptors, LOX 1 has a wide spectrum of physiological ligands, including OxLDL, anionic phospholipids, aged/apoptotic cells, activated platelets, and bacteria. The LOX 1 gene is a so called immediate early gene that is dynamically modulated by several factors in vitro and in vivo. LOX 1 expression is induced by stimuli such as inflammatory cytokines, OxLDL, TNF alpha, TGF beta, and ANG II in vitro, and several proatherogenic factors in vivo.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: OLR1