MKK6/MEK6 Antibody

Western Blot: MKK6/MEK6 Antibody [NBP1-19267] - Analysis of mouse brain tissue extract, probed with MKK6 pAb.

Immunohistochemistry: MKK6/MEK6 Antibody [NBP1-19267] - Analysis of human breast cancer tissue with MKK6 pAb.

Immunohistochemistry: MKK6/MEK6 Antibody [NBP1-19267] - Analysis of MKK6. There is prominent MKK6 in association with neurons containing neurofibrillary pathology in hippocampal sections (CA1 area) from an AD patient with granular structure heavily stained (right). MKK6 is barely detected in control brain (left).

Product Discontinued

MKK6/MEK6 Antibody Summary

• Immunogen: Synthetic peptide derived from the sequence of human MEK6, conjugated to KLH
• Specificity: MKK6
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MAP2K6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1:100-1:2000

Reactivity Notes

Human, Mouse, Rat, Xenopus.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Borate buffered saline, pH 8.2, containing 50% glycerol
• Preservative: 0.09% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for MKK6/MEK6 Antibody

• MAP kinase kinase 6
• MAP2K6
• MAPK/ERK kinase 6
• MAPKK6dual specificity mitogen-activated protein kinase kinase 6
• MEK6
• MEK6MAPKK 6
• mitogen-activated protein kinase kinase 6
• MKK6
• MKK6MEK 6
• PRKMK6
• PRKMK6protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)
• SAPKK3
• SAPKK3EC 2.7.12.2

Background

Mitogen activated protein kinase kinase 6 (MEK6 or MKK6) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MEK6, closely related to MEK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38, thus activating it, in response to inflammatory cytokines and environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this protein is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MAP2K6
• Entrez:
  • 5608(Human)
  • 26399(Mouse)
  • 114495(Rat)