Mouse IFN-beta DuoSet ELISA, 5 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse IFN-beta DuoSet ELISA, 5 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IFN-beta DuoSet ELISA, 5 Plate

• Fibroblast interferon
• IFB
• IFBIFNB
• IFF
• IFNB
• IFNB1
• IFNbeta
• IFN-beta
• interferon beta
• interferon, beta 1, fibroblast
• MGC96956

Background

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

Publications for IFN-beta (DY8234-05)(49)

Publications using DY8234-05

• Chan, FHM;Yeap, HW;Liu, Z;Rosli, SN;Low, KE;Bonne, I;Wu, Y;Chong, SZ;Chen, KW; Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection Cell reports 2025-01-16 [PMID: 39823227] (Mouse)
• Wu, Y;Park, J;Le, Q;Byun, J;Choi, J;Xu, H;Lee, J;Oh, Y; NET formation-mediated in situ protein delivery to the inflamed central nervous system Nature communications 2024-12-30 [PMID: 39737919] (N/A)
• Olawuyi, IF;Heo, E;Jeong, M;Kim, JH;Park, JJ;Chae, J;Gwon, S;Do Lee, S;Kim, H;Ojulari, OV;Song, YB;Lee, BH;Gu, BB;Kim, SR;Lee, JH;Lee, W;Hwang, JS;Nam, JO;Hahn, D;Byun, S; Acidic polysaccharide from the edible insect Protaetia brevitarsis seulensis activates antiviral immunity to suppress norovirus infection Carbohydrate polymers 2025-01-01 [PMID: 39486915] (Mouse)
• Denz, PJ;Speaks, S;Kenney, AD;Eddy, AC;Papa, JL;Roettger, J;Scace, SC;Rubrum, A;Hemann, EA;Forero, A;Webby, RJ;Bowman, AS;Yount, JS; Innate immune control of influenza virus interspecies adaptation via IFITM3 Nature communications 2024-10-30 [PMID: 39477971] (Mouse, Transgenic Mouse)
• An, S;Oh, J;Shon, HJ;Song, J;Choi, YS;Kim, D; Co-adjuvanting Nod2-stimulating bacteria with a TLR7 agonist elicits potent protective immunity against respiratory virus infection International journal of antimicrobial agents 2024-10-28 [PMID: 39477030] (Mouse)
• Hong, NE;Chaplin, A;Di, L;Ravodina, A;Bevan, GH;Gao, H;Asase, C;Gangwar, RS;Cameron, MJ;Mignery, M;Cherepanova, O;Finn, AV;Nayak, L;Pieper, AA;Maiseyeu, A; Nanoparticle-based itaconate treatment recapitulates low-cholesterol/low-fat diet-induced atherosclerotic plaque resolution Cell reports 2024-10-27 [PMID: 39466775] (Mouse)
• Ainslie, K; Modifying Post-Surgical Immunity: Controlled Release of TLR7/8 Agonist for Immune Mediated Clearance of Glioblastoma Research square 2024-09-26 [PMID: 39399681] (Mouse)
• Taheri, M;Tehrani, HA;Farzad, SA;Korourian, A;Arefian, E;Ramezani, M; The potential of mesenchymal stem cell coexpressing cytosine deaminase and secretory IL18-FC chimeric cytokine in suppressing glioblastoma recurrence International immunopharmacology 2024-09-04 [PMID: 39236459] (Mouse)
• Jensen, SB;Jæhger, DE;Serrano-Chávez, E;Halldórsdóttir, HR;Engel, TB;Jørgensen, JS;Björgvinsdóttir, UJ;Kostrikov, S;Scheeper, MJ;Ringgaard, L;Bruun, LM;Stavnsbjerg, C;Christensen, E;Bak, M;Thuroczy, J;Balogh, L;Jensen, ATI;Melander, F;Kjaer, A;Henriksen, JR;Hansen, AE;Andresen, TL; An in situ depot for the sustained release of a TLR7/8 agonist in combination with a TGF? inhibitor promotes anti-tumor immune responses Nature communications 2024-09-03 [PMID: 39227589] (Mouse, Transgenic Mouse)
• Honwad, HH;Najibi, M;Koscso, B;Bogunovic, M;Irazoqui, JE; TFEB-Mediated Pro-inflammatory Response in Murine Macrophages Induced by Acute Alpha7 Nicotinic Receptor Activation bioRxiv : the preprint server for biology 2024-08-10 [PMID: 39211236] (Mouse)
• Gabele, L;Bochow, I;Rieke, N;Sieben, C;Michaelsen-Preusse, K;Hosseini, S;Korte, M; H7N7 viral infection elicits pronounced, sex-specific neuroinflammatory responses in vitro Frontiers in cellular neuroscience 2024-08-07 [PMID: 39171200] (Mouse)
• Huang, Q;Yang, G;Tang, C;Dou, B;Hu, Y;Liu, H;Wu, X;Zhang, H;Wang, H;Xu, L;Yang, XD;Xu, Y;Zheng, Y; Rujin Jiedu decoction protects against influenza virus infection by modulating gut microbiota Heliyon 2024-07-15 [PMID: 39071618] (Mouse)
• Li, J;Moresco, P;Fearon, DT; Intratumoral NKT cell accumulation promotes antitumor immunity in pancreatic cancer Proceedings of the National Academy of Sciences of the United States of America 2024-07-16 [PMID: 38980903] (Mouse)
• Miles, MA;Luong, R;To, EE;Erlich, JR;Liong, S;Liong, F;Logan, JM;O'Leary, J;Brooks, DA;Selemidis, S; TLR9 Monotherapy in Immune-Competent Mice Suppresses Orthotopic Prostate Tumor Development Cells 2024-01-02 [PMID: 38201300] (Mouse)
• Zhang, H;Xue, K;Li, W;Yang, X;Gou, Y;Su, X;Qian, F;Sun, L; Cullin5 drives experimental asthma exacerbations by modulating alveolar macrophage antiviral immunity Nature communications 2024-01-04 [PMID: 38177117] (Mouse, Transgenic Mouse)
• Heinzl, GC;Eriksen, DB;Johnsen, PR;Scarafoni, A;Frøkiær, H; Protein Concentration Affects the Food Allergen ?-Conglutin Uptake and Bacteria-Induced Cytokine Production in Dendritic Cells Biomolecules 2023-10-16 [PMID: 37892213] (Mouse)
• Wang, X;Wang, Y;Cao, A;Luo, Q;Chen, D;Zhao, W;Xu, J;Li, Q;Bu, X;Quan, J; Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation Nature communications 2023-10-02 [PMID: 37783727] (Mouse)
• Barasa, L;Chaudhuri, S;Zhou, JY;Jiang, Z;Choudhary, S;Green, RM;Wiggin, E;Cameron, M;Humphries, F;Fitzgerald, KA;Thompson, PR; Development of LB244, an Irreversible STING Antagonist Journal of the American Chemical Society 2023-09-20 [PMID: 37695732] (Mouse)
• Rasmussen, M;Alvik, K;Kannen, V;Olafsen, NE;Erlingsson, LAM;Grimaldi, G;Takaoka, A;Grant, DM;Matthews, J; Loss of PARP7 Increases Type I Interferon Signaling in EO771 Breast Cancer Cells and Prevents Mammary Tumor Growth by Increasing Antitumor Immunity Cancers 2023-07-20 [PMID: 37509350] (Mouse)
• Pérez-Cabello, JA;Silvera-Carrasco, L;Franco, JM;Capilla-González, V;Armaos, A;Gómez-Lima, M;García-García, R;Yap, XW;Leal-Lasarte, M;Lall, D;Baloh, RH;Martínez, S;Miyata, Y;Tartaglia, GG;Sawarkar, R;García-Domínguez, M;Pozo, D;Roodveldt, C; MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS Proceedings of the National Academy of Sciences of the United States of America 2023-07-11 [PMID: 37399380] (Mouse)
• Hu, Z;Xie, Y;Lu, J;Yang, J;Zhang, J;Jiang, H;Li, H;Zhang, Y;Wu, D;Zeng, K;Bai, X;Yu, X; VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation Science advances 2023-06-23 [PMID: 37352355] (Transgenic Mouse)
• Weilun Pang, Fenghua Hu C9ORF72 suppresses JAK-STAT mediated inflammation iScience 2023-05-19 [PMID: 37250330] (Mouse)
• D Levy, SN Abadchi, N Shababi, MR Ravari, NH Pirolli, C Bergeron, A Obiorah, F Mokhtari-E, S Gheshlaghi, JM Abraham, IM Smith, E Powsner, T Solomon, JW Harmon, SM Jay Induced pluripotent stem cell-derived extracellular vesicles promote wound repair in a diabetic mouse model via an anti-inflammatory immunomodulatory mechanism bioRxiv : the preprint server for biology, 2023-03-23;0(0):. 2023-03-23 [PMID: 36993554] (Mouse)
• R Falahat, A Berglund, P Perez-Vill, RM Putney, I Hamaidi, S Kim, S Pilon-Thom, GN Barber, JJ Mulé Epigenetic state determines the in vivo efficacy of STING agonist therapy Nature Communications, 2023-03-22;14(1):1573. 2023-03-22 [PMID: 36949064] (Mouse)
• S Speaks, A Zani, A Solstad, A Kenney, L Zhang, AC Eddy, AO Amer, R Robinson, C Cai, J Ma, EA Hemann, A Forero, JS Yount Loss of Gasdermin D is protective against influenza virus-induced inflammation and mortality bioRxiv : the preprint server for biology, 2023-04-07;0(0):. 2023-04-07 [PMID: 36945485] (Mouse)
• A Hooftman, CG Peace, DG Ryan, EA Day, M Yang, AF McGettrick, M Yin, EN Montano, L Huo, JE Toller-Kaw, V Zecchini, TAJ Ryan, A Bolado-Car, AM Casey, HA Prag, ASH Costa, G De Los San, M Ishimori, DJ Wallace, S Venuturupa, E Nikitopoul, N Frizzell, C Johansson, A Von Kriegs, MP Murphy, C Jefferies, C Frezza, LAJ O'Neill Macrophage fumarate hydratase restrains mtRNA-mediated interferon production Nature, 2023-03-08;615(7952):490-498. 2023-03-08 [PMID: 36890227] (Mouse, Transgenic Mouse)
• Y Wang, Y Wang, L Ding, X Ren, B Wang, L Wang, S Zhao, X Yue, Z Wu, C Li, X Liang, C Ma, L Gao Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages Cell Reports, 2022-11-29;41(9):111738. 2022-11-29 [PMID: 36450259] (Mouse, Transgenic Mouse)
• L Willemsen, KHM Prange, AE Neele, CPAA van Roomen, M Gijbels, GR Griffith, MD Toom, L Beckers, R Siebeler, NJ Spann, HJ Chen, LA Bosmans, A Gorbatenko, S van Wouw, N Zelcer, H Jacobs, F van Leeuwe, MPJ de Winther DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability Cell Reports, 2022-11-22;41(8):111703. 2022-11-22 [PMID: 36417856] (Transgenic Mouse)
• N Bartonicek, R Rouet, J Warren, C Loetsch, GS Rodriguez, S Walters, F Lin, D Zahra, J Blackburn, JM Hammond, ALM Reis, IW Deveson, N Zammit, M Zeraati, S Grey, D Christ, JS Mattick, T Chtanova, R Brink, ME Dinger, RJ Weatheritt, J Sprent, C King The retroelement Lx9 puts a brake on the immune response to virus infection Nature, 2022-08-10;0(0):. 2022-08-10 [PMID: 35948641] (Mouse)
• Z Qin, X Fang, W Sun, Z Ma, T Dai, S Wang, Z Zong, H Huang, H Ru, H Lu, B Yang, S Lin, F Zhou, L Zhang Deactylation by SIRT1 enables liquid-liquid phase separation of IRF3/IRF7 in innate antiviral immunity Nature Immunology, 2022-07-25;0(0):. 2022-07-25 [PMID: 35879450] (Mouse)
• M Perego, S Fu, Y Cao, A Kossenkov, M Yao, K Alicea-Tor, W Liu, Z Jiang, Z Chen, SY Fuchs, J Zhou, DI Gabrilovic Mechanisms regulating transitory suppressive activity of neutrophils in newborns: PMNs-MDSCs in newborns Oncogene, 2022-06-21;0(0):. 2022-06-21 [PMID: 35726818] (Mouse)
• CJ Batty, MD Gallovic, J Williams, TM Ross, EM Bachelder, KM Ainslie Multiplexed electrospray enables high throughput production of cGAMP microparticles to serve as an adjuvant for a broadly acting influenza vaccine International journal of pharmaceutics, 2022-05-24;622(0):121839. 2022-05-24 [PMID: 35623484] (Mouse)
• AD Kenney, SL Aron, C Gilbert, N Kumar, P Chen, A Eddy, L Zhang, A Zani, N Vargas-Mal, S Speaks, J Kawahara, PJ Denz, L Dorn, F Accornero, J Ma, H Zhu, MVS Rajaram, C Cai, RA Langlois, JS Yount Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis Science Advances, 2022-05-11;8(19):eabm5371. 2022-05-11 [PMID: 35544568] (Mouse)
• JT Hinkle, J Patel, N Panicker, SS Karuppagou, D Biswas, B Belingon, R Chen, S Brahmachar, O Pletnikova, JC Troncoso, VL Dawson, TM Dawson STING mediates neurodegeneration and neuroinflammation in nigrostriatal alpha-synucleinopathy Proceedings of the National Academy of Sciences of the United States of America, 2022-04-08;119(15):e2118819119. 2022-04-08 [PMID: 35394877] (Mouse)
• D Olmeda, D Cerezo-Wal, C Mucientes, TG Calvo, E Cañón, D Alonso-Cur, N Ibarz, J Muñoz, JL Rodriguez-, P Ortiz-Rome, S Ortega, MS Soengas Live imaging of neolymphangiogenesis identifies acute antimetastatic roles of dsRNA mimics Embo Molecular Medicine, 2021-11-11;0(0):e12924. 2021-11-11 [PMID: 34762341] (Mouse)
• DE Jæhger, ML Hübbe, MK Kræmer, G Clergeaud, AV Olsen, C Stavnsbjer, MN Wiinholt, A Kjær, JR Henriksen, AE Hansen, TL Andresen Enhancing adoptive CD8 T cell therapy by systemic delivery of tumor associated antigens Scientific Reports, 2021-10-05;11(1):19794. 2021-10-05 [PMID: 34611284] (Mouse)
• S Rastogi, S Ellinwood, J Augenstrei, KD Mayer-Barb, V Briken Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF PloS Pathogens, 2021-07-29;17(7):e1009712. 2021-07-29 [PMID: 34324582] (Mouse)
• Y Li, C Bax, J Patel, T Vazquez, A Ravishanka, MM Bashir, M Grinnell, D Diaz, VP Werth Plasma-derived DNA containing-extracellular vesicles induce STING-mediated proinflammatory responses in dermatomyositis Theranostics, 2021-05-21;11(15):7144-7158. 2021-05-21 [PMID: 34158841] (Mouse)
• J Chen, M Qiu, Z Ye, T Nyalile, Y Li, Z Glass, X Zhao, L Yang, J Chen, Q Xu In situ cancer vaccination using lipidoid nanoparticles Science Advances, 2021-05-05;7(19):. 2021-05-05 [PMID: 33952519] (Mouse)
• M Najibi, HH Honwad, JA Moreau, SM Becker, JE Irazoqui A NOVEL NOX/PHOX-CD38-NAADP-TFEB AXIS IMPORTANT FOR MACROPHAGE ACTIVATION DURING BACTERIAL PHAGOCYTOSIS Autophagy, 2021-04-13;0(0):. 2021-04-13 [PMID: 33818279] (Mouse)
• N Hijaze, M Ledersnaid, E Simanovich, S Kassem, MA Rahat Inducing regulated necrosis and shifting macrophage polarization with anti-EMMPRIN antibody (161-pAb) and complement factors J Leukoc Biol, 2020-11-17;0(0):. 2020-11-17 [PMID: 33205451] (Mouse)
• JC DuBois, AK Ray, P Davies, B Shafit-Zag Anti-Axl antibody treatment reduces the severity of experimental autoimmune encephalomyelitis J Neuroinflammation, 2020-10-29;17(1):324. 2020-10-29 [PMID: 33121494] (Mouse)
• M Sermershei, AD Kenney, PH Lin, TM McMichael, C Cai, K Gumpper, TMA Adesanya, H Li, X Zhou, KH Park, JS Yount, J Ma MG53 suppresses interferon-&beta and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling Nat Commun, 2020-07-17;11(1):3624. 2020-07-17 [PMID: 32681036] (Human)
• J Wu, N Weisshaar, A Hotz-Wagen, A Madi, S Ma, A Mieg, M Hering, K Mohr, T Schlimbach, H Borgers, G Cui Skeletal muscle antagonizes antiviral CD8+ T cell exhaustion Sci Adv, 2020-06-12;6(24):eaba3458. 2020-06-12 [PMID: 32582853] (Mouse)
• O Danov, L Lasswitz, H Obernolte, C Hesse, A Braun, S Wronski, K Sewald Rupintrivir reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo Respir. Res., 2019-10-22;20(1):228. 2019-10-22 [PMID: 31640701] (Mouse)
• L Yue, M Yan, ML Tremblay, TJ Lin, H Li, T Yang, X Song, T Xie, Z Xie PTP1B negatively regulates nitric oxide-mediated Pseudomonas aeruginosa killing by neutrophils PLoS ONE, 2019-09-18;14(9):e0222753. 2019-09-18 [PMID: 31532798] (Mouse)
• M Coorens, VAF Schneider, AM de Groot, A van Dijk, M Meijerink, JM Wells, MR Scheenstra, EJA Veldhuizen, HP Haagsman Cathelicidins Inhibit Escherichia coli-Induced TLR2 and TLR4 Activation in a Viability-Dependent Manner J. Immunol., 2017-07-14;0(0):. 2017-07-14 [PMID: 28710255] (Mouse)
• PC Campos, MT Gomes, ES Guimarães, G Guimarães, SC Oliveira TLR7 and TLR3 Sense Brucella abortus RNA to Induce Proinflammatory Cytokine Production but They Are Dispensable for Host Control of Infection Front Immunol, 2017-01-23;8(0):28. 2017-01-23 [PMID: 28167945] (Mouse)
• Joerg Mattes TRAIL signaling is pro-inflammatory and pro-viral in a murine model of rhinovirus 1B infection Am. J. Physiol. Lung Cell Mol. Physiol., 2016-11-11;0(0):ajplung.00200. 2016-11-11 [PMID: 27836899] (Mouse)