Mouse IL-12 p70 Quantikine ELISA Kit, 2 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse IL-12 p70 Quantikine ELISA Kit, 2 Plate Summary

• Background: The Quantikine Mouse IL-12 p70 Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse IL-12 p70 in cell culture supernates and mouse serum. It contains recombinant mouse IL-12 expressed in Sf 21 insect cells using a baculovirus expression vector and antibodies raised against recombinant mouse IL-12. This immunoassay has been shown to accurately quantitate the recombin...ant factor. Results obtained using natural mouse IL-12 showed linear curves that were parallel to the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse IL-12 p70.
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• Specificity: Natural and recombinant mouse IL-12 p70
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il12a

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-12 p70 Quantikine ELISA Kit, 2 Plate

• CLMF p35
• Cytotoxic lymphocyte maturation factor 35 kDa subunit
• IL12 p70
• IL-12 p70
• IL-12 subunit p35
• IL-12, subunit p35
• interleukin 12, p35
• interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocytematuration factor 1, p35)
• interleukin-12 alpha chain
• interleukin-12 subunit alpha
• natural killer cell stimulatory factor 1, 35 kD subunit
• NF cell stimulatory factor chain 1
• NK cell stimulatory factor chain 1
• NKSF1
• p35

Background

Interleukin 12 (IL-12), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. The IL-12 p40 subunit is shared by IL-23, another heterodimeric cytokine that has biological activities similar to, as well as distinct from, IL-12. IL-12 is produced by macrophages and B cells and has been shown to have multiple effects on T cells and natural killer (NK) cells. While mouse IL-12 is active on both human and mouse cells, human IL-12 is not active on mouse cells.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for IL-12 p70/IL-12A (M1270)(122)

Publications using M1270

• Albarracin, L;Dentice Maidana, S;Fukuyama, K;Elean, M;Argañaraz Aybar, JN;Suda, Y;Nishiyama, K;Kitazawa, H;Villena, J; Orally Administered Lactobacilli Strains Modulate Alveolar Macrophages and Improve Protection Against Respiratory Superinfection Biomolecules 2024-12-14 [PMID: 39766307] (Mouse)
• Gil-de-Gómez, L;Mattei, JJ;Lee, JH;Grupp, SA;Reid, GSD;Seif, AE; CD4+ T Cells Mediate Dendritic Cell Licensing to Promote Multi-Antigen Anti-Leukemic Immune Response Cancer medicine 2025-01-01 [PMID: 39727041] (Mouse)
• Blanco, T;Nakagawa, H;Musayeva, A;Krauthammer, M;Singh, RB;Narimatsu, A;Ge, H;Shoushtari, SI;Dana, R; Acquired Immunostimulatory Phenotype of Migratory CD103+ Dendritic Cells Promotes Alloimmunity Following Corneal Transplantation JCI insight 2024-09-05 [PMID: 39235864] (Mouse)
• Bova, V;Basilotta, R;Casili, G;Lanza, M;Filippone, A;Campolo, M;Capra, AP;Vitale, G;Chisari, G;Colarossi, C;Giuffrida, D;Paterniti, I;Esposito, E; The Protective Role of Troxerutin (Trox) in Counteracting Anaplastic Thyroid Carcinoma (ATC) Progression Biomedicines 2024-08-05 [PMID: 39200219] (Human)
• Roy, S;Roy, S;Halder, S;Jana, K;Ukil, A; Leishmania exploits host cAMP/EPAC/calcineurin signaling to induce an IL-33-mediated anti-inflammatory environment for the establishment of infection The Journal of biological chemistry 2024-05-13 [PMID: 38750790] (Mouse)
• Wang, Z;Chen, Y;Wu, H;Wang, M;Mao, L;Guo, X;Zhu, J;Ye, Z;Luo, X;Yang, X;Liu, X;Yang, J;Sheng, Z;Lee, J;Guo, Z;Liu, Y; Intravenous administration of IL-12 encoding self-replicating RNA-lipid nanoparticle complex leads to safe and effective antitumor responses Scientific reports 2024-03-28 [PMID: 38548896] (Mouse)
• Vannini, A;Parenti, F;Forghieri, C;Vannini, G;Barboni, C;Zaghini, A;Gianni, T;Campadelli-Fiume, G; Decrease in Heparan Sulphate Binding in Tropism-Retargeted Oncolytic Herpes Simplex Virus (ReHV) Delays Blood Clearance and Improves Systemic Anticancer Efficacy Cancers 2024-03-13 [PMID: 38539478] (Mouse)
• Zhang, Y;Song, Y;Wang, X;Shi, M;Lin, Y;Tao, D;Han, S; An NFAT1-C3a-C3aR Positive Feedback Loop in Tumor-Associated Macrophages Promotes a Glioma Stem Cell Malignant Phenotype Cancer immunology research 2024-01-30 [PMID: 38289255] (Mouse)
• Wang, J;Ling, D;Shi, L;Li, H;Peng, M;Wen, H;Liu, T;Liang, R;Lin, Y;Wei, L;Zhang, G;Chen, S; METTL3-mediated m6A methylation regulates ovarian cancer progression by recruiting myeloid-derived suppressor cells Cell & bioscience 2023-11-06 [PMID: 37932814] (Mouse, Transgenic Mouse)
• You, Y;Kim, SH;Kim, CH;Kim, IH;Shin, Y;Kim, TR;Sohn, M;Park, J; Immune-Stimulating Potential of Lacticaseibacillus rhamnosus LM1019 in RAW 264.7 Cells and Immunosuppressed Mice Induced by Cyclophosphamide Microorganisms 2023-09-13 [PMID: 37764156] (Mouse)
• Jin, J;Fan, YJ;Nguyen, TV;Yu, ZN;Song, CH;Lee, SY;Shin, HS;Chai, OH; Fallopia japonica Root Extract Ameliorates Ovalbumin-Induced Airway Inflammation in a CARAS Mouse Model by Modulating the IL-33/TSLP/NF-?B Signaling Pathway International journal of molecular sciences 2023-08-07 [PMID: 37569890] (Mouse)
• Nikolas T. Martin, Mathieu J. F. Crupi, Zaid Taha, Joanna Poutou, Jack T. Whelan, Sydney Vallati et al. Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy Pharmaceuticals (Basel) 2023-05-07 [PMID: 37242495] (Mouse)
• KJ Smith, D Minns, BJ McHugh, RK Holloway, R O'Connor, A Williams, L Melrose, R McPherson, VE Miron, DJ Davidson, E Gwyer Find The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation PloS Biology, 2022-08-26;20(8):e3001554. 2022-08-26 [PMID: 36026478] (Mouse)
• S Pradhan, Snehlata, D Manna, S Karmakar, MK Singh, A Bhattachar, B Mukherjee, J Paul Activation of TLR-pathway to induce host Th1 immune response against visceral leishmaniasis: Involvement of galactosylated-flavonoids Heliyon, 2022-07-03;8(7):e09868. 2022-07-03 [PMID: 35847617] (Mouse)
• CY Shen, CF Lee, WT Chou, JJ Hwang, YS Tyan, HY Chuang Liposomal beta-Sitosterol Suppresses Metastasis of CT26/luc Colon Carcinoma via Inhibition of MMP-9 and Evoke of Immune System Pharmaceutics, 2022-06-07;14(6):. 2022-06-07 [PMID: 35745788] (Mouse)
• C Shi, S Wang, J Han, L Xi, M Li, Z Li, H Zhang Functional insights into Brucella transcriptional regulator ArsR Microbial pathogenesis, 2022-05-24;168(0):105557. 2022-05-24 [PMID: 35623565] (Mouse)
• E Sugisawa, T Kondo, Y Kumagai, H Kato, Y Takayama, K Isohashi, E Shimosegaw, N Takemura, Y Hayashi, T Sasaki, MM Martino, M Tominaga, K Maruyama Nociceptor-derived Reg3gamma prevents endotoxic death by targeting kynurenine pathway in microglia Cell Reports, 2022-03-08;38(10):110462. 2022-03-08 [PMID: 35263589] (Mouse)
• Jamilah Abusarah, Fatemeh Khodayarian, Nehme El-Hachem, Natasha Salame, Martin Olivier, Mohammad Balood, Katiane Roversi, Sebastien Talbot, Jean-Pierre Bikorimana, Jingkui Chen, Mario Jolicoeur, Louis-Eric Trudeau, Samaneh Kamyabiazar, Borhane Annabi, Francis Robert, Jerry Pelletier, Abed-El-Hakim El-Kadiry, Riam Shammaa, Moutih Rafei Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice Cell Rep Med 2021-12-21 [PMID: 35028603] (Mouse)
• S Kos, M Bosnjak, T Jesenko, B Markelc, U Kamensek, K Znidar, U Matkovic, A Rencelj, G Sersa, R Hudej, A Tuljak, M Peterka, M Cemazar Non-Clinical In Vitro Evaluation of Antibiotic Resistance Gene-Free Plasmids Encoding Human or Murine IL-12 Intended for First-in-Human Clinical Study Pharmaceutics, 2021-10-19;13(10):. 2021-10-19 [PMID: 34684032] (Mouse)
• QR Li, SR Tan, L Yang, W He, L Chen, FX Shen, Z Wang, HF Wang Mechanism of chlorogenic acid in alveolar macrophage polarization in Klebsiella pneumoniae-induced pneumonia Journal of leukocyte biology, 2021-09-29;0(0):. 2021-09-29 [PMID: 34585429] (Mouse)
• JT Zou, HM Jing, Y Yuan, LH Lei, ZF Chen, Q Gou, QS Xiong, XL Zhang, Z Zhao, XK Zhang, H Zeng, QM Zou, JY Zhang Pore-forming alpha-hemolysin efficiently improves the immunogenicity and protective efficacy of protein antigens PloS Pathogens, 2021-07-21;17(7):e1009752. 2021-07-21 [PMID: 34288976] (Mouse)
• HH Ahn, C Carrington, Y Hu, HW Liu, C Ng, H Nam, A Park, C Stace, W West, HQ Mao, MG Pomper, CG Ullman, I Minn Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers Scientific Reports, 2021-05-06;11(1):9733. 2021-05-06 [PMID: 33958660] (Mouse)
• Y Yuan, Y Ren, M Dijk, GI Geertsema-, J Atema-Smit, HJ Busscher, HC van der Me Phagocytosis and macrophage polarization on bacterially contaminated dental implant materials and effects on tissue integration European cells & materials, 2021-03-30;41(0):421-430. 2021-03-30 [PMID: 33782938] (Mouse)
• MR Charan Raj, A Kar, S Srinivasan, D Chellappan, J Debnath, S Kar Mahapa Oral administration of eugenol oleate cures experimental visceral leishmaniasis through cytokines abundance Cytokine, 2020-10-28;0(0):155301. 2020-10-28 [PMID: 33127258] (Mouse)
• J Xiao, G Zhang, S Gao, J Shen, H Feng, Z He, C Xu Combined administration of SHP2 inhibitor SHP099 and the &alpha7nAChR agonist PNU282987 protect mice against DSS?induced colitis Mol Med Rep, 2020-07-10;22(3):2235-2244. 2020-07-10 [PMID: 32705242] (Mouse)
• K Maruyama, H Kidoya, N Takemura, E Sugisawa, O Takeuchi, T Kondo, MMA Eid, H Tanaka, MM Martino, N Takakura, Y Takayama, S Akira, A Vandenbon, Y Kumagai Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages Cell Rep, 2020-07-14;32(2):107906. 2020-07-14 [PMID: 32668247] (Mouse)
• T Kawabe, J Yi, A Kawajiri, K Hilligan, D Fang, N Ishii, H Yamane, J Zhu, D Jankovic, KS Kim, G Trinchieri, A Sher Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state Nat Commun, 2020-07-06;11(1):3366. 2020-07-06 [PMID: 32632165] (Mouse)
• R Leylek, M Alcántara-, Z Lanzar, A Lüdtke, OA Perez, B Reizis, J Idoyaga Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population Cell Rep, 2019-12-10;29(11):3736-3750.e8. 2019-12-10 [PMID: 31825848] (Mouse)
• VA Balaji Rag, M Anwar, MZ Akhter, A Chavez, Y Mao, V Natarajan, S Lakshmikan, M Chrzanowsk, AZ Dudek, L Claesson-W, JK Kitajewski, KK Wary, AB Malik, D Mehta Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling Cell Rep, 2019-12-10;29(11):3472-3487.e4. 2019-12-10 [PMID: 31825830] (Mouse)
• T Iida, Daisuke Hi, N Minami, M Matsuura, K Wagatsuma, K Kawakami, K Nagaishi, M Nojima, H Ikeuchi, S Hirota, R Shirakawa, H Horiuchi, H Nakase Downregulation of RalGTPase-activating protein promotes colitis-associated cancer via NLRP3 inflammasome activation Cell Mol Gastroenterol Hepatol, 2019-10-15;0(0):. 2019-10-15 [PMID: 31622786] (Mouse)
• S Esaki, F Goshima, H Ozaki, G Takano, Y Hatano, D Kawakita, K Ijichi, T Watanabe, Y Sato, T Murata, H Iwata, Y Shibamoto, S Murakami, Y Nishiyama, H Kimura Oncolytic activity of HF10 in head and neck squamous cell carcinomas Cancer Gene Ther., 2019-09-03;0(0):. 2019-09-03 [PMID: 31477804] (Mouse)
• Z Li, Y Lin, S Zhang, L Zhou, G Yan, Y Wang, M Zhang, M Wang, H Lin, Q Tong, Y Duan, G Du Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis J Transl Med, 2019-03-18;17(1):90. 2019-03-18 [PMID: 30885207] (Mouse)
• J Zhang, H Li, Q Wu, Y Chen, Y Deng, Z Yang, L Zhang, B Liu Tumoral NOX4 recruits M2 tumor-associated macrophages via ROS/PI3K signaling-dependent various cytokine production to promote NSCLC growth Redox Biol, 2019-02-06;22(0):101116. 2019-02-06 [PMID: 30769285] (Mouse)
• S Simonetti, ABB Seijas, A Natalini, S Vitale, D Runci, A Soriani, A Di Virgili, E Aricò, L Gabriele, A Santoni, F Di Rosa Dendritic cells modulate c-kit expression on the edge between activation and death Eur. J. Immunol., 2019-02-25;0(0):. 2019-02-25 [PMID: 30758056] (Mouse)
• G Garaulet, G Pérez-Chac, H Alarcón, A Alfranca, F Mulero, J Martínez-T, JM Zapata, A Rodríguez Intratumoral expression using a NFkB-based promoter enhances IL12 antitumor efficacy Cancer Gene Ther., 2019-01-09;0(0):. 2019-01-09 [PMID: 30622324] (Mouse)
• A Mohebbi, MS Ebrahimzad, S Baghban Ra, M Saeidi, A Tabarraei, SR Mohebbi, S Shirian, A Gorji, A Ghaemi Non-replicating Newcastle Disease Virus as an adjuvant for DNA vaccine enhances antitumor efficacy through the induction of TRAIL and granzyme B expression Virus Res., 2018-12-29;261(0):72-80. 2018-12-29 [PMID: 30599161] (Mouse)
• K Abdi, K Laky, K Padhan, C Petrovas, J Skinner, J Kabat, DW Dorward, J Brzostowsk, EO Long, G Trinchieri, R Varma Cutting Edge: Quantitative Determination of CD40L Threshold for IL-12 and IL-23 Production from Dendritic Cells J. Immunol., 2018-10-12;0(0):. 2018-10-12 [PMID: 30315139] (Mouse)
• RH Du, Y Zhou, ML Xia, M Lu, JH Ding, G Hu ?-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering ?-arrestin2-TAB1 interaction in astrocytes J Neuroinflammation, 2018-09-10;15(1):258. 2018-09-10 [PMID: 30200997] (Mouse)
• JA Barrett, H Cai, J Miao, PD Khare, P Gonzalez, J Dalsing-He, G Sharma, T Chan, LJN Cooper, F Lebel Regulated intratumoral expression of IL-12 using a RheoSwitch Therapeutic System� (RTS�) gene switch as gene therapy for the treatment of glioma Cancer Gene Ther., 2018-05-14;0(0):. 2018-05-14 [PMID: 29755109] (Mouse)
• HM Song, X Li, YY Liu, WP Lu, ZH Cui, L Zhou, D Yao, HM Zhang Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS Int. J. Mol. Med., 2018-03-27;0(0):. 2018-03-27 [PMID: 29620148] (Mouse)
• BG Lania, J Morari, AL Souza, MND Silva, AR de Almeida, G Veira-Dami, SM Alegre, CL César, LA Velloso, ML Cintra, NB Maia, PENF Velho Topical use and systemic action of green and roasted coffee oils and ground oils in a cutaneous incision model in rats (Rattus norvegicus albinus) PLoS ONE, 2017-12-13;12(12):e0188779. 2017-12-13 [PMID: 29236720] (Rat)
• YT Lee, CT Wu, HL Sun, JL Ko, KH Lue Fungal immunomodulatory protein-fve could modulate airway remodel through by affect IL17 cytokine J Microbiol Immunol Infect, 2017-06-29;0(0):. 2017-06-29 [PMID: 28709839] (Mouse)
• U Lampreht T, L Loiacono, M Cemazar, U Kamensek, VM Fazio, G Sersa, E Signori Gene Electrotransfer of Plasmid-Encoding IL-12 Recruits the M1 Macrophages and Antigen-Presenting Cells Inducing the Eradication of Aggressive B16F10 Murine Melanoma Mediators Inflamm., 2017-05-16;2017(0):5285890. 2017-05-16 [PMID: 28596641] (Mouse)
• MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection J. Immunol., 2017-06-02;0(0):. 2017-06-02 [PMID: 28576981] (Mouse)
• S Ishikawa, T Ishikawa, C Tezuka, K Asano, M Sunagawa, T Hisamitsu Efficacy of Juzentaihoto for Tumor Immunotherapy in B16 Melanoma Metastasis Model Evid Based Complement Alternat Med, 2017-02-12;2017(0):6054706. 2017-02-12 [PMID: 28286532] (Mouse)
• L Li, W Wang, H Pan, G Ma, X Shi, H Xie, X Liu, Q Ding, W Zhou, S Wang Microwave ablation combined with OK-432 induces Th1-type response and specific antitumor immunity in a murine model of breast cancer J Transl Med, 2017-01-31;15(1):23. 2017-01-31 [PMID: 28137271] (Mouse)
• Maja Cemazar Tailor-made fibroblast-specific and antibiotic-free interleukin 12 plasmid for gene electrotransfer-mediated cancer immunotherapy Plasmid, 2016-11-24;89(0):9-15. 2016-11-24 [PMID: 27890562] (Human, Mouse)
• Supeng Yin Subtilisin-like protease-1 secreted through type IV secretion system contributes to high virulence of Streptococcus suis 2 Sci Rep, 2016-06-08;6(0):27369. 2016-06-08 [PMID: 27270879] (Mouse)
• Gallagher K, Joshi A, Carson W, Schaller M, Allen R, Mukerjee S, Kittan N, Feldman E, Henke P, Hogaboam C, Burant C, Kunkel S Epigenetic changes in bone marrow progenitor cells influence the inflammatory phenotype and alter wound healing in type 2 diabetes. Diabetes, 2014-11-03;64(4):1420-30. 2014-11-03 [PMID: 25368099] (Mouse)
• Saha A, Biswas A, Srivastav S, Mukherjee M, Das P, Ukil A Prostaglandin E2 negatively regulates the production of inflammatory cytokines/chemokines and IL-17 in visceral leishmaniasis. J Immunol, 2014-07-21;193(5):2330-9. 2014-07-21 [PMID: 25049356] (Mouse)
• de Oliveira D, Hastreiter A, Mello A, de Oliveira Beltran J, Oliveira Santos E, Borelli P, Fock R The effects of protein malnutrition on the TNF-RI and NF-kappaB expression via the TNF-alpha signaling pathway. Cytokine, 2014-07-06;69(2):218-25. 2014-07-06 [PMID: 25005154] (Mouse)
• Gupta P, Giri J, Srivastav S, Chande A, Mukhopadhyaya R, Das P, Ukil A Leishmania donovani targets tumor necrosis factor receptor-associated factor (TRAF) 3 for impairing TLR4-mediated host response. FASEB J, 2014-01-03;28(4):1756-68. 2014-01-03 [PMID: 24391131] (Mouse)
• Kamensek , Urska, Sersa , Gregor, Cemazar , Maja Evaluation of p21 promoter for interleukin 12 radiation induced transcriptional targeting in a mouse tumor model. Mol Cancer, 2013-11-12;12(1):136. 2013-11-12 [PMID: 24219565] (Mouse)
• Maina , Virginia, Marrella , Veronica, Mantero , Stefano, Cassani , Barbara, Fontana , Elena, Anselmo , Achille, Del Prete , Annalisa, Sozzani , Silvano, Vezzoni , Paolo, Poliani , Pietro L, Villa , Anna Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration. J Leukoc Biol, 2013-09-19;94(6):1221-30. 2013-09-19 [PMID: 24052573] (Mouse)
• Toki S, Goleniewska K, Huckabee M, Zhou W, Newcomb D, FitzGerald G, Lawson W, Peebles R PGI(2) signaling inhibits antigen uptake and increases migration of immature dendritic cells. J Leukoc Biol, 2013-04-26;94(1):77-88. 2013-04-26 [PMID: 23625201] (Mouse)
• Guo Z, Wen Z, Qin A, Zhou Y, Liao Z, Liu Z, Liang Y, Ren T, Xu L Antisense oligonucleotide treatment enhances the recovery of acute lung injury through IL-10-secreting M2-like macrophage-induced expansion of CD4+ regulatory T cells. J Immunol, 2013-03-20;190(8):4337-48. 2013-03-20 [PMID: 23514739] (Mouse)
• Lipinski T, Fitieh A, St Pierre J, Ostergaard H, Bundle D, Touret N Enhanced immunogenicity of a tricomponent mannan tetanus toxoid conjugate vaccine targeted to dendritic cells via Dectin-1 by incorporating beta-glucan. J Immunol, 2013-03-20;190(8):4116-28. 2013-03-20 [PMID: 23514738] (Mouse)
• Owens BM, Beattie L, Moore JW, Brown N, Mann JL, Dalton JE, Maroof A, Kaye PM IL-10-Producing Th1 Cells and Disease Progression Are Regulated by Distinct CD11c+ Cell Populations during Visceral Leishmaniasis. PLoS Pathog., 2012-07-26;8(7):e1002827. 2012-07-26 [PMID: 22911108] (Mouse)
• Calderon J, Maganto-Garcia E, Punzon C, Carrion J, Terhorst C, Fresno M The Receptor Slamf1 on the Surface of Myeloid Lineage Cells Controls Susceptibility to Infection by Trypanosoma cruzi. PLoS Pathog., 2012-07-12;8(7):e1002799. 2012-07-12 [PMID: 22807679] (Mouse)
• TLR-mediated distinct IFN-gamma/IL-10 pattern induces protective immunity against murine visceral leishmaniasis. Eur. J. Immunol., 2012-08-01;42(8):2087-99. 2012-08-01 [PMID: 22622993] (Mouse)
• Noh KT, Son KH, Jung ID, Kang HK, Hwang SA, Lee WS, You JC, Park YM Protein kinase C delta (PKCdelta)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia. J. Biol. Chem., 2012-03-05;287(17):14226-33. 2012-03-05 [PMID: 22393041] (Mouse)
• Ghose P, Ali AQ, Fang R, Forbes D, Ballard B, Ismail N The interaction between IL-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria. J. Immunol., 2011-06-29;187(3):1333-46. 2011-06-29 [PMID: 21715688] (Mouse)
• Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2. Am. J. Pathol., 2011-05-10;179(1):302-14. 2011-05-10 [PMID: 21703412] (Mouse)
• Reim D, Rossmann-Bloeck T, Jusek G, Prazeres da Costa O, Holzmann B Improved host defense against septic peritonitis in mice lacking MyD88 and TRIF is linked to a normal interferon response. J. Leukoc. Biol., 2011-05-31;90(3):613-20. 2011-05-31 [PMID: 21628330] (Mouse)
• Diao J, Zhao J, Winter E Tumors Suppress In Situ Proliferation of Cytotoxic T Cells by Promoting Differentiation of Gr-1+ Conventional Dendritic Cells through IL-6. J. Immunol., 2011-03-23;186(9):5058-67. 2011-03-23 [PMID: 21430223] (Mouse)
• Rau CR, Hein K, Sattler MB, Kretzschmar B, Hillgruber C, McRae BL, Diem R, Bahr M Anti-inflammatory effects of FTY720 do not prevent neuronal cell loss in a rat model of optic neuritis. Am. J. Pathol., 2011-02-26;178(4):1770-81. 2011-02-26 [PMID: 21406175] (Rat)
• Vultaggio A, Nencini F, Pratesi S, Maggi L, Guarna A, Annunziato F, Romagnani S, Parronchi P, Maggi E The TLR7 ligand 9-benzyl-2-butoxy-8-hydroxy adenine inhibits IL-17 response by eliciting IL-10 and IL-10-inducing cytokines. J. Immunol., 2011-03-09;186(8):4707-15. 2011-03-09 [PMID: 21389257] (Mouse)
• Wang H, Cheng F Histone Deacetylase Inhibitor LAQ824 Augments Inflammatory Responses in Macrophages through Transcriptional Regulation of IL-10. J. Immunol., 2011-03-02;186(0):3986. 2011-03-02 [PMID: 21368229] (Mouse)
• Veltman JD, Lambers ME, van Nimwegen M Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma. Br. J. Cancer, 2010-07-27;103(5):629-41. 2010-07-27 [PMID: 20664588] (Mouse)
• Filardy AA, Pires DR, Nunes MP, Takiya CM, Freire-de-Lima CG, Ribeiro-Gomes FL, DosReis GA Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages. J. Immunol., 2010-07-21;185(4):2044-50. 2010-07-21 [PMID: 20660352] (Mouse)
• Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Hasler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J. Exp. Med., 2010-07-05;207(8):1617-24. 2010-07-05 [PMID: 20603312] (Mouse)
• Jung ID, Noh KT, Lee CM, Chun SH, Jeong SK, Park JW, Park WS, Kim HW, Yun CH, Shin YK, Park YM Oncostatin M induces dendritic cell maturation and Th1 polarization. Biochem. Biophys. Res. Commun., 2010-03-04;394(2):272-8. 2010-03-04 [PMID: 20206608] (Mouse)
• Alm AS, Li K, Yang D, Andersson R, Lu Y, Wang X Varying susceptibility of pulmonary cytokine production to lipopolysaccharide in mice. Cytokine, 2009-12-29;49(3):256-63. 2009-12-29 [PMID: 20042347] (Mouse)
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Bioinformatics

• Gene Symbol: Il12a