Mouse IL-6 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse IL-6 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il6

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-6 DuoSet ELISA, 15 Plate

• B-cell differentiation factor
• B-cell stimulatory factor 2
• BSF2
• BSF-2
• CDF
• CTL differentiation factor
• HSF
• hybridoma growth factor
• IFNB2
• IFN-beta-2
• IL6
• IL-6
• Interferon beta-2
• interleukin 6 (interferon, beta 2)
• interleukin BSF-2
• interleukin-6
• MGI-2A

Background

Interleukin 6 (IL-6) is a pleiotropic, a-helical, 22-28 kDa phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. Mature human IL-6 is 183 amino acids (aa) in length and shares 39% aa sequence identity with mouse and rat IL-6. Alternative splicing generates several isoforms with internal deletions, some of which exhibit antagonistic properties. Cells known to express IL-6 include CD8+ T cells, fibroblasts, synoviocytes, adipocytes, osteoblasts, megakaryocytes, endothelial cells (under the influence of endothelins), sympathetic neurons, cerebral cortex neurons, adrenal medulla chromaffin cells, retinal pigment cells, mast cells, keratinocytes, Langerhans cells, fetal and adult astrocytes, neutrophils, monocytes, eosinophils, colonic epithelial cells, B1 B cells and pancreatic islet beta cells. IL-6 production is generally correlated with cell activation and is normally kept in control by glucocorticoids, catecholamines, and secondary sex steroids. Normal human circulating IL-6 is in the 1 pg/mL range, with slight elevations during the menstrual cycle, modest elevations in certain cancers, and large elevations after surgery.

IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R alpha) and a signal transducing subunit (gp130). IL-6 binds to IL-6 Ra, triggering IL-6 Ra association with gp130 and gp130 dimerization. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 Ra are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 Ra elicit responses from gp130-expressing cells that lack cell surface IL-6 Ra. Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 Ra is predominantly restricted to hepatocytes, monocytes, and resting lymphocytes. Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 Ra but not from other cytokines that use gp130 as a co-receptor. 

IL-6, along with TNF-a and IL-1, drives the acute inflammatory response. IL-6 is almost solely responsible for fever and the acute phase response in the liver, and it is important in the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in conditions such as obesity, insulin resistance, inflammatory bowel disease, arthritis, and sepsis. IL-6 modulates bone resorption and is a major effector of inflammatory joint destruction in rheumatoid arthritis through its promotion of Th17 cell development and activity. It contributes to atherosclerotic plaque development and destabilization as well as the development of inflammation-associated carcinogenesis.

Publications for IL-6 (DY406)(648)

Publications using DY406

• Milligan, C;Cowley, DO;Stewart, W;Curry, AM;Forbes, E;Rector, B;Hastie, A;Liu, L;Hawkins, GA; Enhanced Interleukin 6 Trans-Signaling Modulates Disease Process in Amyotrophic Lateral Sclerosis Mouse Models Brain sciences 2025-01-17 [PMID: 39851451] (Transgenic Mouse)
• Hamadi, N;Al?Salam, S;Beegam, S;Zaaba, N;Elzaki, O;Nemmar, A; Chronic Exposure to Two Regimens of Waterpipe Smoke Elicits Lung Injury, Genotoxicity, and Mitochondrial Impairment with the Involvement of MAPKs Activation in Mice International journal of molecular sciences 2025-01-06 [PMID: 39796284] (Mouse)
• Chin, J;Abeydeera, N;Repasy, T;Rivera-Lugo, R;Mitchell, G;Nguyen, VQ;Zheng, W;Richards, A;Swaney, DL;Krogan, NJ;Ernst, JD;Cox, JS;Budzik, JM; Tax1bp1 enhances bacterial virulence and promotes inflammatory responses during Mycobacterium tuberculosis infection of alveolar macrophages bioRxiv : the preprint server for biology 2024-12-16 [PMID: 39763950] (Transgenic Mouse)
• Santamaria, C;Biegas, KJ;Kim, CY;Cabral, J;Lee, JR;Swarts, BM;Siegrist, MS; Trehalose dimycolate inhibits phagosome maturation and promotes intracellular M. tuberculosis growth via noncanonical SNARE interaction bioRxiv : the preprint server for biology 2024-12-16 [PMID: 39763847] (Mouse)
• Wu, Y;Park, J;Le, Q;Byun, J;Choi, J;Xu, H;Lee, J;Oh, Y; NET formation-mediated in situ protein delivery to the inflamed central nervous system Nature communications 2024-12-30 [PMID: 39737919] (Mouse)
• Liu, J;Jiang, Y;Diao, Z;Chen, D;Xia, R;Wang, B;Yang, S;Yin, Z; Gasdermin D-mediated neutrophil pyroptosis drives inflammation in psoriasis eLife 2024-12-24 [PMID: 39717896] (Mouse, Transgenic Mouse)
• Carloni, S;Nasoni, MG;Casabianca, A;Orlandi, C;Capobianco, L;Iaconisi, GN;Cerioni, L;Burattini, S;Benedetti, S;Reiter, RJ;Balduini, W;Luchetti, F; Melatonin Reduces Mito-Inflammation in Ischaemic Hippocampal HT22 Cells and Modulates the cGAS-STING Cytosolic DNA Sensing Pathway and FGF21 Release Journal of cellular and molecular medicine 2024-12-01 [PMID: 39707673] (Mouse)
• Perez-Penco, M;Byrdal, M;Lara de la Torre, L;Ballester, M;Khan, S;Siersbæk, M;Lecoq, I;Madsen, CO;Kjeldsen, JW;Svane, IM;Hansen, M;Donia, M;Johansen, JS;Olsen, LR;Grøntved, L;Chen, IM;Arnes, L;Holmström, MO;Andersen, MH; The antitumor activity of TGF?-specific T cells is dependent on IL-6 signaling Cellular and Molecular Immunology 2024-12-09 [PMID: 39653766] (Mouse)
• Wang, S;Hu, L;Fu, Y;Xu, F;Shen, Y;Liu, H;Zhu, L; Inhibition of IRE1?/XBP1 axis alleviates LPS-induced acute lung injury by suppressing TXNIP/NLRP3 inflammasome activation and ERK/p65 signaling pathway Respiratory research 2024-11-27 [PMID: 39604886] (Mouse)
• Wen, S;Arakawa, H;Yokoyama, S;Shirasaka, Y;Higashida, H;Tamai, I; Functional identification of soluble uric acid as an endogenous inhibitor of CD38 eLife 2024-11-11 [PMID: 39527634] (Mouse)
• da S Santos, FR;Valadão, DF;Bambirra, JL;Moreira, TP;de Souza, CDF;Passos, IBS;Queiroz-Junior, CM;Fagundes, CT;Teixeira, MM;Costa, VV;Souza, DG; Targeting PI3K? Pathway for Treating Dengue virus Infection Microbial pathogenesis 2024-10-25 [PMID: 39490942] (Mouse, Transgenic Mouse)
• Denz, PJ;Speaks, S;Kenney, AD;Eddy, AC;Papa, JL;Roettger, J;Scace, SC;Rubrum, A;Hemann, EA;Forero, A;Webby, RJ;Bowman, AS;Yount, JS; Innate immune control of influenza virus interspecies adaptation via IFITM3 Nature communications 2024-10-30 [PMID: 39477971] (Mouse, Transgenic Mouse)
• An, S;Oh, J;Shon, HJ;Song, J;Choi, YS;Kim, D; Co-adjuvanting Nod2-stimulating bacteria with a TLR7 agonist elicits potent protective immunity against respiratory virus infection International journal of antimicrobial agents 2024-10-28 [PMID: 39477030] (Mouse)
• Samukha, V;Fantasma, F;D'Urso, G;Colarusso, E;Schettino, A;Marigliano, N;Chini, MG;Saviano, G;De Felice, V;Lauro, G;Maione, F;Bifulco, G;Casapullo, A;Iorizzi, M; Chemical Profiling of Polar Lipids and the Polyphenolic Fraction of Commercial Italian Phaseolus Seeds by UHPLC-HRMS and Biological Evaluation Biomolecules 2024-10-20 [PMID: 39456269] (Mouse)
• Chen, K;Han, H;Zhao, S;Xu, B;Yin, B;Lawanprasert, A;Trinidad, M;Burgstone, BW;Murthy, N;Doudna, JA; Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR-Cas9 ribonucleoprotein Nature biotechnology 2024-10-16 [PMID: 39415058] (Mouse)
• da Silva, CP;Silva, MDS;Santana, HM;Paloschi, MV;Ferreira E Ferreira, AA;Brilhante, LMV;Cruz, LF;Serrath, SN;Eulálio, MMC;Setúbal, SDS;Vallochi, AL;Nery, NM;Zuliani, JP; Bothrops atrox snake venom decreased MHC-II and CD86 expression in bone marrow-derived dendritic cells Acta tropica 2024-10-10 [PMID: 39393479] (Mouse)
• Romero, J;Toral-Rios, D;Yu, J;Paul, SM;Cashikar, AG; 25-hydroxycholesterol promotes brain cytokine production and leukocyte infiltration in a mouse model of lipopolysaccharide-induced neuroinflammation Journal of neuroinflammation 2024-10-05 [PMID: 39369253] (Mouse, Transgenic Mouse)
• Diercks, AH;Podolskaia, IS;Murray, TA;Jahn, AN;Mai, D;Liu, D;Amon, LM;Nakagawa, Y;Shimano, H;Aderem, A;Gold, ES; Oxysterol binding protein regulates the resolution of TLR-induced cytokine production in macrophages Proceedings of the National Academy of Sciences of the United States of America 2024-08-13 [PMID: 39361877] (Mouse)
• Kwon, JW;Lee, K;Kim, SW;Park, J;Hong, JJ;Che, JH; Therapeutic potential of histamine H4 receptor antagonist as a preventive treatment for diabetic retinopathy in mice Scientific Reports 2024-01-01 [PMID: 39349555] (Mouse)
• Ikegawa, M;Kano, N;Ori, D;Fukuta, M;Hirano, M;Hewson, R;Yoshii, K;Kawai, T;Kawasaki, T; HuR (ELAVL1) regulates the CCHFV minigenome and HAZV replication by associating with viral genomic RNA PLoS neglected tropical diseases 2024-09-01 [PMID: 39348382] (Mouse)
• de Oliveira, LD;de Carvalho, LS;Xavier, ACC;de Oliveira, FE;Leão, MVP;Diamantino, MGG;Khoury, RD;Valera, MC;Carvalho, CAT;Abu Hasna, A; In Vitro Evaluation of Sodium Hypochlorite, Chlorhexidine, Propolis, and Calcium Hydroxide Effect on Lipoteichoic-Acid-Induced Proinflammatory Cytokines Production Dentistry journal 2024-09-05 [PMID: 39329852] (Mouse)
• Klein, R;Onyuru, J;Viera, EM;Putnam, CD;Hoffman, HM;Hastings, ML; Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation bioRxiv : the preprint server for biology 2024-09-06 [PMID: 39282364] (Mouse)
• Guo, ZF;Tongmuang, N;Li, C;Zhang, C;Hu, L;Capreri, D;Zuo, MX;Summer, R;Sun, J; Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice JCI insight 2024-09-10 [PMID: 39253972] (Mouse, Transgenic Mouse)
• Nayer, B;Tan, JL;Alshoubaki, YK;Lu, YZ;Legrand, JMD;Lau, S;Hu, N;Park, AJ;Wang, XN;Amann-Zalcenstein, D;Hickey, PF;Wilson, T;Kuhn, GA;Müller, R;Vasanthakumar, A;Akira, S;Martino, MM; Local administration of regulatory T cells promotes tissue healing Nature communications 2024-09-09 [PMID: 39251592] (Mouse)
• Hussain, S;Majumder, N;Mazumder, MHH;Lewis, SE;Olapeju, O;Velayutham, M;Amin, MS;Brundage, K;Kelley, EE;Vanoirbeek, J; Intermittent ozone inhalation during house dust mite-induced sensitization primes for adverse asthma phenotype Redox biology 2024-10-01 [PMID: 39244793] (Mouse)
• Maruthupandy, M;Jeon, JH;Noh, J;Yang, SI;Cho, WS; Mitigated toxicity of polystyrene nanoplastics in combination exposure with copper ions by transformation into copper (I) oxide: Inhibits the oxidative potential of nanoplastics Chemosphere 2024-09-05 [PMID: 39243901] (Mouse)
• Taheri, M;Tehrani, HA;Farzad, SA;Korourian, A;Arefian, E;Ramezani, M; The potential of mesenchymal stem cell coexpressing cytosine deaminase and secretory IL18-FC chimeric cytokine in suppressing glioblastoma recurrence International immunopharmacology 2024-09-04 [PMID: 39236459] (Mouse)
• Roumelioti, F;Tzaferis, C;Konstantopoulos, D;Papadopoulou, D;Prados, A;Sakkou, M;Liakos, A;Chouvardas, P;Meletakos, T;Pandis, Y;Karagianni, N;Denis, MC;Fousteri, M;Armaka, M;Kollias, G; Mir221/222 drive synovial hyperplasia and arthritis by targeting cell cycle inhibitors and chromatin remodeling components eLife 2024-09-05 [PMID: 39235454] (Mouse)
• Honwad, HH;Najibi, M;Koscso, B;Bogunovic, M;Irazoqui, JE; TFEB-Mediated Pro-inflammatory Response in Murine Macrophages Induced by Acute Alpha7 Nicotinic Receptor Activation bioRxiv : the preprint server for biology 2024-08-10 [PMID: 39211236] (Mouse)
• Yadav, P;Ortega, JG;Tamaki, W;Chien, C;Chang, KC;Biswas, N;Pan, S;Nilsson, J;Yin, X;Bhattacharyya, A;Boostanpour, K;Jujaray, T;Wang, J;Tsukui, T;Sheppard, D;Li, B;Maishan, M;Taenaka, H;Matthay, MA;Muramatsu, R;Maliskova, L;Ghosh, A;Eckalbar, WL;Molofsky, AB;Wolters, PJ;Tamaki, SJ;Bivona, T;Abate, AR;Wagner, A;Tharp, KM;Bhattacharya, M; Macrophage-fibroblast crosstalk drives Arg1-dependent lung fibrosis via ornithine loading bioRxiv : the preprint server for biology 2024-07-31 [PMID: 39211079] (Mouse, Transgenic Mouse)
• Loaiza, R;Fattahi, F;Kalbitz, M;Grailer, JJ;Russell, MW;Jalife, J;Valdivia, HH;Zetoune, FS;Ward, PA; The Impact of Extracellular Histones and Absence of Toll-like Receptors on Cardiac Functional and Electrical Disturbances in Mouse Hearts International journal of molecular sciences 2024-08-08 [PMID: 39201339] (Mouse, Transgenic Mouse)
• Pouxvielh, K;Marotel, M;Drouillard, A;Villard, M;Moreews, M;Bossan, A;Poiget, M;Khoryati, L;Benezech, S;Fallone, L;Hamada, S;Rousseaux, N;Picq, L;Rocca, Y;Berton, A;Teixeira, M;Mathieu, AL;Ainouze, M;Hasan, U;Fournier, A;Thaunat, O;Marçais, A;Walzer, T; Tumor-induced natural killer cell dysfunction is a rapid and reversible process uncoupled from the expression of immune checkpoints Science advances 2024-08-30 [PMID: 39196934] (Mouse)
• Gabele, L;Bochow, I;Rieke, N;Sieben, C;Michaelsen-Preusse, K;Hosseini, S;Korte, M; H7N7 viral infection elicits pronounced, sex-specific neuroinflammatory responses in vitro Frontiers in cellular neuroscience 2024-08-07 [PMID: 39171200] (Mouse)
• Ohm, M;Hosseini, S;Lonnemann, N;He, W;More, T;Goldmann, O;Medina, E;Hiller, K;Korte, M; The potential therapeutic role of itaconate and mesaconate on the detrimental effects of LPS-induced neuroinflammation in the brain Journal of neuroinflammation 2024-08-20 [PMID: 39164713] (Mouse)
• Sun, L;Apweiler, M;Tirkey, A;Klett, D;Normann, C;Dietz, GPH;Lehner, MD;Fiebich, BL; Anti-Neuroinflammatory Effects of Ginkgo biloba Extract EGb 761 in LPS-Activated BV2 Microglial Cells International journal of molecular sciences 2024-07-25 [PMID: 39125680] (Mouse)
• Wang, EY;Chen, HS;Wu, MC;Yang, YL;Wang, HL;Liu, CW;Lai, TW; Microglia through MFG-E8 signaling decrease the density of degenerating neurons and protect the brain from the development of cortical infarction after stroke PloS one 2024-08-07 [PMID: 39110702] (Mouse)
• Map Schuh, C;Ezquer, F;Mamani, S;Campodónico, PR;Cárcamo, C;Martinez-Gómez, F;Aburto, I;Ezquer, M;Morales, B;Olivares, B; A Natural deep eutectic solvent as an effective material for dual debridement and antibiofilm effects in chronic wound treatment International journal of pharmaceutics 2024-08-03 [PMID: 39103063] (Mouse)
• Zou, Z;Singh, P;Pinkner, JS;Obernuefemann, CLP;Xu, W;Nye, TM;Dodson, KW;Almqvist, F;Hultgren, SJ;Caparon, MG; Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treat Streptococcus pyogenes skin and soft tissue infection Science advances 2024-08-02 [PMID: 39093975] (Mouse)
• Huang, Q;Yang, G;Tang, C;Dou, B;Hu, Y;Liu, H;Wu, X;Zhang, H;Wang, H;Xu, L;Yang, XD;Xu, Y;Zheng, Y; Rujin Jiedu decoction protects against influenza virus infection by modulating gut microbiota Heliyon 2024-07-15 [PMID: 39071618] (Mouse)
• Hering, M;Madi, A;Sandhoff, R;Ma, S;Wu, J;Mieg, A;Richter, K;Mohr, K;Knabe, N;Stichling, D;Poschet, G;Bestvater, F;Frank, L;Utikal, J;Umansky, V;Cui, G; Sphinganine recruits TLR4 adaptors in macrophages and promotes inflammation in murine models of sepsis and melanoma Nature communications 2024-07-18 [PMID: 39025856] (Mouse)
• Abarikwu, SO;Coimbra, JLP;Campolina-Silva, G;Rocha, ST;Costa, VV;Lacerda, SMSN;Costa, GMJ; Acute effects of atrazine on the immunoexpressions of Sertoli and germ cells molecular markers, cytokines, chemokines, and sex hormones levels in mice testes and epididymides Chemosphere 2024-07-15 [PMID: 39019188] (Mouse)
• Rizzo, GP;Sanches, RC;Chavero, C;Bianchi, DS;Apuzzo, E;Herrera, SE;Agazzi, ML;Keitelman, IA;Trevani, AS;Oliveira, SC;Azzaroni, O;Smaldini, PL;Docena, GH; Poly(allylamine)-tripolyphosphate polymeric nanoparticle as an NLRP3-dependent systemic adjuvant for the vaccine development bioRxiv : the preprint server for biology 2024-07-04 [PMID: 39005275] (Mouse)
• Katsoulis, O;Toussaint, M;Jackson, MM;Mallia, P;Footitt, J;Mincham, KT;Meyer, GFM;Kebadze, T;Gilmour, A;Long, M;Aswani, AD;Snelgrove, RJ;Johnston, SL;Chalmers, JD;Singanayagam, A; Neutrophil extracellular traps promote immunopathogenesis of virus-induced COPD exacerbations Nature communications 2024-07-09 [PMID: 38982052] (Mouse)
• Lim, PN;Cervantes, MM;Pham, LK;Doherty, S;Tufts, A;Dubey, D;Mai, D;Aderem, A;Diercks, AH;Rothchild, AC; Absence of c-Maf and IL-10 enables Type I IFN enhancement of innate responses to low-dose LPS in alveolar macrophages bioRxiv : the preprint server for biology 2024-05-26 [PMID: 38826239] (Mouse)
• Salesse, L;Duval, A;Sauvanet, P;Da Silva, A;Barnich, N;Godfraind, C;Dalmasso, G;Nguyen, HTT; ATG16L1 in myeloid cells limits colorectal tumor growth in ApcMin/+ mice infected with colibactin-producing Escherichia coli via decreasing inflammasome activation Autophagy 2024-05-31 [PMID: 38818900] (Mouse)
• Flores-Valdez, MA;Peterson, EJR;Aceves-Sánchez, MJ;Baliga, NS;Morita, YS;Sparks, IL;Saini, DK;Yadav, R;Lang, R;Mata-Espinosa, D;León-Contreras, JC;Hernández-Pando, R; Comparison of the transcriptome, lipidome, and c-di-GMP production between BCG?BCG1419c and BCG, with Mincle- and Myd88-dependent induction of proinflammatory cytokines in murine macrophages Scientific reports 2024-05-24 [PMID: 38789479] (Mouse, Transgenic Mouse)
• Lee, J;Kim, MY;Kim, HJ;Choi, WS;Kim, HS; Impaired autophagy in myeloid cells aggravates psoriasis-like skin inflammation through the IL-1?/CXCL2/neutrophil axis Cell & bioscience 2024-05-04 [PMID: 38704587] (Transgenic Mouse)
• Moon, S;Han, S;Jang, IH;Ryu, J;Rha, MS;Cho, HJ;Yoon, SS;Nam, KT;Kim, CH;Park, MS;Seong, JK;Lee, WJ;Yoon, JH;Chung, YW;Ryu, JH; Airway epithelial CD47 plays a critical role in inducing influenza virus-mediated bacterial super-infection Nature communications 2024-04-30 [PMID: 38693120] (Mouse)
• Sun, L;Wilke Saliba, S;Apweiler, M;Akmermer, K;Herlan, C;Grathwol, C;de Oliveira, ACP;Normann, C;Jung, N;Bräse, S;Fiebich, BL; Anti-Neuroinflammatory Effects of a Macrocyclic Peptide-Peptoid Hybrid in Lipopolysaccharide-Stimulated BV2 Microglial Cells International journal of molecular sciences 2024-04-18 [PMID: 38674048] (Mouse)
• Falvey, A;Palandira, SP;Chavan, SS;Brines, M;Dantzer, R;Tracey, KJ;Pavlov, VA; Electrical stimulation of the dorsal motor nucleus of the vagus in male mice can regulate inflammation without affecting the heart rate Brain, behavior, and immunity 2024-04-24 [PMID: 38670240] (Mouse)
• Krishnamohan, M;Kaplanov, I;Maudi-Boker, S;Yousef, M;Machluf-Katz, N;Cohen, I;Elkabets, M;Titus, J;Bersudsky, M;Apte, RN;Voronov, E;Braiman, A; Tumor Cell-Associated IL-1? Affects Breast Cancer Progression and Metastasis in Mice through Manipulation of the Tumor Immune Microenvironment International journal of molecular sciences 2024-04-02 [PMID: 38612760] (Mouse, Transgenic Mouse)
• Wang, Y;Gao, JZ;Sakaguchi, T;Maretzky, T;Gurung, P;Narayanan, NS;Short, S;Xiong, Y;Kang, Z; LRRK2 G2019S Promotes Colon Cancer Potentially via LRRK2-GSDMD Axis-Mediated Gut Inflammation Cells 2024-03-23 [PMID: 38607004] (Transgenic Mouse)
• Zhang, N;Zhang, J;Yang, Y;Shan, H;Hou, S;Fang, H;Ma, M;Chen, Z;Tan, L;Xu, D; A palmitoylation-depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis Nature cell biology 2024-03-27 [PMID: 38538834] (Mouse)
• Du, Y;Kusama, K;Hama, K;Chen, X;Tahara, Y;Kajiwara, S;Shibata, S;Orihara, K; Protective Effects of Inulin on Stress-Recurrent Inflammatory Bowel Disease International journal of molecular sciences 2024-02-21 [PMID: 38473746] (Mouse)
• Anees, F;Montoya, DA;Pisetsky, DS;Payne, CK; DNA corona on nanoparticles leads to an enhanced immunostimulatory effect with implications for autoimmune diseases Proceedings of the National Academy of Sciences of the United States of America 2024-03-12 [PMID: 38442162] (Mouse)
• Zhang, Y;Bharathi, V;Dokoshi, T;de Anda, J;Ursery, LT;Kulkarni, NN;Nakamura, Y;Chen, J;Luo, EWC;Wang, L;Xu, H;Coady, A;Zurich, R;Lee, MW;Matsui, T;Lee, H;Chan, LC;Schepmoes, AA;Lipton, MS;Zhao, R;Adkins, JN;Clair, GC;Thurlow, LR;Schisler, JC;Wolfgang, MC;Hagan, RS;Yeaman, MR;Weiss, TM;Chen, X;Li, MMH;Nizet, V;Antoniak, S;Mackman, N;Gallo, RL;Wong, GCL; Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes Proceedings of the National Academy of Sciences of the United States of America 2024-02-06 [PMID: 38306481] (Mouse)
• Zou, Z;Obernuefemann, CLP;Singh, P;Pinkner, JS;Xu, W;Nye, TM;Dodson, KW;Almqvist, F;Hultgren, SJ;Caparon, MG; Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treat Streptococcus pyogenes skin and soft tissue infection bioRxiv : the preprint server for biology 2024-01-03 [PMID: 38260261] (Mouse)
• Sluiter, TJ;Tillie, RJHA;de Jong, A;de Bruijn, JBG;Peters, HAB;van de Leijgraaf, R;Halawani, R;Westmaas, M;Starink, LIW;Quax, PHA;Sluimer, JC;de Vries, MR; Myeloid PHD2 Conditional Knockout Improves Intraplaque Angiogenesis and Vascular Remodeling in a Murine Model of Venous Bypass Grafting Journal of the American Heart Association 2024-01-23 [PMID: 38258662] (Transgenic Mouse)
• Li, XM;Yang, Y;Jiang, FQ;Hu, G;Wan, S;Yan, WY;He, XS;Xiao, F;Yang, XM;Guo, X;Lu, JH;Yang, XQ;Chen, JJ;Ye, WL;Liu, Y;He, K;Duan, HX;Zhou, YJ;Gan, WJ;Liu, F;Wu, H; Histone lactylation inhibits RAR? expression in macrophages to promote colorectal tumorigenesis through activation of TRAF6-IL-6-STAT3 signaling Cell reports 2024-01-19 [PMID: 38245869] (Mouse)
• Liu, Y;Kors, L;Butter, LM;Stokman, G;Claessen, N;Zuurbier, CJ;Girardin, SE;Leemans, JC;Florquin, S;Tammaro, A; NLRX1 Prevents M2 Macrophage Polarization and Excessive Renal Fibrosis in Chronic Obstructive Nephropathy Cells 2023-12-21 [PMID: 38201227] (Mouse)
• Ká?erová, S;Muchová, M;Doudová, H;Münster, L;Hanulíková, B;Valášková, K;Kašpárková, V;Ku?itka, I;Humpolí?ek, P;Víchová, Z;Vaší?ek, O;Vícha, J; Chitosan/dialdehyde cellulose hydrogels with covalently anchored polypyrrole: Novel conductive, antibacterial, antioxidant, immunomodulatory, and anti-inflammatory materials Carbohydrate polymers 2024-03-01 [PMID: 38171669] (Mouse)
• Nakajima, S;Demers, G;Machuca-Parra, AI;Pour, ZD;Bairamian, D;Bouyakdan, K;Fisette, A;Kabahizi, A;Robb, J;Rodaros, D;Laurent, C;Ferreira, G;Arbour, N;Alquier, T;Fulton, S; Central activation of the fatty acid sensor GPR120 suppresses microglia reactivity and alleviates sickness- and anxiety-like behaviors Journal of neuroinflammation 2023-12-19 [PMID: 38111048] (Mouse)
• Morais, MÍ;Braga, AV;Silva, RRL;Barbosa, BCM;Costa, SOAM;Rodrigues, FF;Melo, ISF;Matos, RC;Carobin, NV;Sabino, AP;Coelho, MM;Machado, RR; Metformin inhibits paclitaxel-induced mechanical allodynia by activating opioidergic pathways and reducing cytokines production in the dorsal root ganglia and thalamus Cytokine 2023-12-14 [PMID: 38101167] (Mouse)
• Zhu, W;Han, L;Wu, Y;Tong, L;He, L;Wang, Q;Yan, Y;Pan, T;Shen, J;Song, Y;Shen, Y;Zhu, Q;Zhou, J; Keratin 15 protects against cigarette smoke-induced epithelial mesenchymal transformation by MMP-9 Respiratory research 2023-11-25 [PMID: 38007424] (Mouse, Transgenic Mouse)
• Korábková, E;Kašpárková, V;Vaší?ek, O;Víchová, Z;Ká?erová, S;Valášková, K;Urbánková, L;Vícha, J;Münster, L;Skopalová, K;Humpolí?ek, P; Pickering emulsions as an effective route for the preparation of bioactive composites: A study of nanocellulose/polyaniline particles with immunomodulatory effect Carbohydrate polymers 2024-01-01 [PMID: 37940298] (Mouse)
• Pereira, RDD;Rabelo, RAN;Oliveira, NFM;Porto, SLT;Andrade, ACDSP;Queiroz-Junior, CM;Barbosa, CLN;de Souza-Costa, LP;Santos, FRDS;Oliveira, FBR;da Silva, BLV;Umezu, HL;Ferreira, R;da Silva, GSF;Cruz, JS;Teixeira, MM;Costa, VV;Machado, FS; A 5-Lipoxygenase Inhibitor, Zileuton, Modulates Host Immune Responses and Improves Lung Function in a Model of Severe Acute Respiratory Syndrome (SARS) Induced by Betacoronavirus Viruses 2023-10-04 [PMID: 37896826]
• Guo, ZF;Tongmuang, N;Li, C;Zhang, C;Hu, L;Capreri, D;Zuo, MX;Summer, R;Sun, J; Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice bioRxiv : the preprint server for biology 2023-09-29 [PMID: 37808846] (Mouse)
• Alchawoosh, A;Hashimoto, K;Kawashima, N;Noda, S;Nozaki, K;Okiji, T; Hydraulic calcium silicate-based root canal sealers mitigate proinflammatory cytokine synthesis and promote osteogenesis in vitro Journal of dental sciences 2023-10-01 [PMID: 37799856] (Mouse)
• Ribeiro, R;Silva, EG;Moreira, FC;Gomes, GF;Cussat, GR;Silva, BSR;da Silva, MCM;de Barros Fernandes, H;de Sena Oliveira, C;de Oliveira Guarnieri, L;Lopes, V;Ferreira, CN;de Faria, AMC;Maioli, TU;Ribeiro, FM;de Miranda, AS;Moraes, GSP;de Oliveira, ACP;Vieira, LB; Chronic hyperpalatable diet induces impairment of hippocampal-dependent memories and alters glutamatergic and fractalkine axis signaling Scientific reports 2023-09-29 [PMID: 37773430] (Mouse)
• Gruol, DL;Calderon, D;Huitron-Resendiz, S;Cates-Gatto, C;Roberts, AJ; Impact of Elevated Brain IL-6 in Transgenic Mice on the Behavioral and Neurochemical Consequences of Chronic Alcohol Exposure Cells 2023-09-19 [PMID: 37759527] (Mouse)
• Joo, MK;Shin, YJ;Kim, DH; Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice Scientific reports 2023-09-19 [PMID: 37726354] (Mouse)
• Fechtner, S;Allen, BE;Chriswell, ME;Jubair, WK;Robertson, CE;Kofonow, JN;Frank, DN;Holers, VM;Kuhn, KA; 3,3-dimethyl-1-butanol and its metabolite 3,3-dimethylbutyrate ameliorate collagen-induced arthritis independent of choline trimethylamine lyase activity Research square 2023-09-05 [PMID: 37720032] (Mouse)
• Barasa, L;Chaudhuri, S;Zhou, JY;Jiang, Z;Choudhary, S;Green, RM;Wiggin, E;Cameron, M;Humphries, F;Fitzgerald, KA;Thompson, PR; Development of LB244, an Irreversible STING Antagonist Journal of the American Chemical Society 2023-09-20 [PMID: 37695732] (Mouse)
• Denz, PJ;Speaks, S;Kenney, AD;Eddy, AC;Papa, JL;Roettger, J;Scace, SC;Hemann, EA;Forero, A;Webby, RJ;Bowman, AS;Yount, JS; Innate immune control of influenza virus interspecies adaptation bioRxiv : the preprint server for biology 2023-08-23 [PMID: 37662304] (Mouse)
• Schädel, P;Wichmann-Costaganna, M;Czapka, A;Gebert, N;Ori, A;Werz, O; Short-Term Caloric Restriction and Subsequent Re-Feeding Compromise Liver Health and Associated Lipid Mediator Signaling in Aged Mice Nutrients 2023-08-21 [PMID: 37630850] (Mouse)
• Torazza, C;Provenzano, F;Gallia, E;Cerminara, M;Balbi, M;Bonifacino, T;Tessitore, S;Ravera, S;Usai, C;Musante, I;Puliti, A;Van Den Bosch, L;Jafar-Nejad, P;Rigo, F;Milanese, M;Bonanno, G; Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes Cells 2023-07-27 [PMID: 37566031] (Mouse)
• Kelestemur, T;Németh, ZH;Pacher, P;Beesley, J;Robson, SC;Eltzschig, HK;Haskó, G; Adenosine metabolized from extracellular ATP ameliorates organ injury by triggering A2BR signaling Respiratory research 2023-07-13 [PMID: 37438813] (Mouse)
• Wang, Y;Gao, JZ;Sakaguchi, T;Maretzky, T;Gurung, P;Short, S;Xiong, Y;Kang, Z; LRRK2 G2019S promotes the development of colon cancer via modulating intestinal inflammation bioRxiv : the preprint server for biology 2023-06-30 [PMID: 37425755] (Mouse)
• Lee, CK;Oliveira, LVN;Akalin, A;Specht, CA;Lourenco, D;Gomez, CL;Ramirez-Ortiz, ZG;Wang, JP;Levitz, SM; Dysregulated Pulmonary Inflammatory Responses Exacerbate the Outcome of Secondary Aspergillosis Following Influenza bioRxiv : the preprint server for biology 2023-06-30 [PMID: 37425745] (Mouse)
• Oummadi, A;Menuet, A;Méresse, S;Laugeray, A;Guillemin, G;Mortaud, S; The herbicides glyphosate and glufosinate and the cyanotoxin ?-N-methylamino-l-alanine induce long-term motor disorders following postnatal exposure: the importance of prior asymptomatic maternal inflammatory sensitization Frontiers in neuroscience 2023-06-09 [PMID: 37360165] (Mouse)
• Amo-Aparicio, J;Daly, J;Højen, JF;Dinarello, CA; Pharmacologic inhibition of NLRP3 reduces the levels of ?-synuclein and protects dopaminergic neurons in a model of Parkinson's disease Journal of neuroinflammation 2023-06-22 [PMID: 37349821] (Mouse)
• Pinto, EP;da Costa, SOAM;D'Haese, C;Nysten, B;Machado, FP;Rocha, LM;de Souza, TM;Beloqui, A;Machado, RR;Araújo, RS; Poly-?-caprolactone nanocapsules loaded with copaiba essential oil reduce inflammation and pain in mice International journal of pharmaceutics 2023-06-17 [PMID: 37336298] (Mouse)
• Kinsella, RL;Kimmey, JM;Smirnov, A;Woodson, R;Gaggioli, MR;Chavez, SM;Kreamalmeyer, D;Stallings, CL; Autophagy prevents early proinflammatory responses and neutrophil recruitment during Mycobacterium tuberculosis infection without affecting pathogen burden in macrophages PLoS biology 2023-06-15 [PMID: 37319285] (Mouse)
• Hopkin, SJ;Pezhman, L;Begum, J;Kavanagh, D;McGettrick, HM;Iqbal, AJ;Chimen, M; Aging modulates homeostatic leukocyte trafficking to the peritoneal cavity in a sex-specific manner Journal of leukocyte biology 2023-06-13 [PMID: 37309034] (Mouse)
• Falvey, A;Palandira, SP;Chavan, SS;Brines, M;Tracey, KJ;Pavlov, VA; Electrical stimulation of the dorsal motor nucleus of the vagus regulates inflammation without affecting the heart rate bioRxiv : the preprint server for biology 2023-05-20 [PMID: 37292846] (Mouse)
• Kim, TW; Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer International journal of molecular sciences 2023-05-22 [PMID: 37240422] (Mouse)
• Tarkany Basting, R;Henrique Napimoga, M;Ant�nio Trindade Silva, C;Ballassini Abdalla, H;Campos Durso, B;Henrique Barboza Martins, L;de Abreu Cavalcanti, H;Hammock, BD;Trindade Clemente-Napimoga, J; Soluble epoxide hydrolase inhibitor blockage microglial cell activation in subnucleus caudalis in a persistent model of arthritis International immunopharmacology 2023-05-23 [PMID: 37230034] (Mouse)
• James, CA;Baer, JM;Zuo, C;Panni, UY;Knolhoff, BL;Hogg, GD;Kingston, NL;Kang, LI;Lander, VE;Luo, J;Tao, Y;Watson, MA;Aft, R;Fields, RC;Hawkins, WG;DeNardo, DG; Systemic Alterations in Type-2 Conventional Dendritic Cells Leads to Impaired Tumor Immunity in Pancreatic Cancer Cancer immunology research 2023-05-25 [PMID: 37229629] (Mouse)
• Li, C;Ture, SK;Nieves-Lopez, B;Blick-Nitko, SK;Maurya, P;Livada, AC;Stahl, TJ;Kim, M;Pietropaoli, AP;Morrell, CN; Thrombocytopenia Independently Leads to Monocyte Immune Dysfunction bioRxiv : the preprint server for biology 2023-05-12 [PMID: 37214993] (Mouse)
• Hamadi, N;Beegam, S;Zaaba, NE;Elzaki, O;Altamimi, MA;Nemmar, A; Neuroinflammation, Oxidative Stress, Apoptosis, Microgliosis and Astrogliosis in the Cerebellum of Mice Chronically Exposed to Waterpipe Smoke Biomedicines 2023-04-06 [PMID: 37189722] (Mouse)
• Niknam, B;Baghaei, K;Mahmoud Hashemi, S;Hatami, B;Reza Zali, M;Amani, D; Human Wharton's jelly mesenchymal stem cells derived-exosomes enriched by miR-124 promote an anti-fibrotic response in an experimental model of liver fibrosis International immunopharmacology 2023-05-09 [PMID: 37167639] (Mouse)
• Guo, Y;Gu, D;Huang, T;Li, A;Zhou, Y;Kang, X;Meng, C;Xiong, D;Song, L;Jiao, X;Pan, Z; Salmonella Enteritidis T1SS protein SiiD inhibits NLRP3 inflammasome activation via repressing the mtROS-ASC dependent pathway PLoS pathogens 2023-05-08 [PMID: 37155697] (Transgenic Mouse, Mouse)
• YJ Chen, GN Li, XJ Li, LX Wei, MJ Fu, ZL Cheng, Z Yang, GQ Zhu, XD Wang, C Zhang, JY Zhang, YP Sun, H Saiyin, J Zhang, WR Liu, WW Zhu, KL Guan, Y Xiong, Y Yang, D Ye, LL Chen Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy Science Advances, 2023-04-28;9(17):eadg0654. 2023-04-28 [PMID: 37115931] (Mouse)
• T Tominaga, J Huang, S Wang, M Noguchi, Y Tong, M Asano-Orit, K Suzuki Collagen-Derived Dipeptides and Amino Acids Have Immunomodulatory Effects in M1-Differentiated RAW264.7 Cells and PBMC International Journal of Molecular Sciences, 2023-04-08;24(8):. 2023-04-08 [PMID: 37108094] (Mouse)
• P Schädel, A Czapka, N Gebert, ID Jacobsen, A Ori, O Werz Metabololipidomic and proteomic profiling reveals aberrant macrophage activation and interrelated immunomodulatory mediator release during aging Aging Cell, 2023-04-26;0(0):e13856. 2023-04-26 [PMID: 37101405] (Mouse)
• C Zhang, ZF Guo, W Liu, K Kazama, L Hu, X Sun, L Wang, H Lee, L Lu, XF Yang, R Summer, J Sun PIMT is a novel and potent suppressor of endothelial activation Elife, 2023-04-18;12(0):. 2023-04-18 [PMID: 37070640] (Mouse)
• M Baran, C Feriotti, A McGinley, SR Carlile, Z Jiang, R Calderon-G, A Dumigan, J Sá-Pessoa, CE Sutton, J Kearney, RM McLoughlin, KHG Mills, KA Fitzgerald, JA Bengeochea, AG Bowie PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection Cell Reports, 2023-04-04;42(4):112341. 2023-04-04 [PMID: 37018072] (Mouse)
• D Levy, SN Abadchi, N Shababi, MR Ravari, NH Pirolli, C Bergeron, A Obiorah, F Mokhtari-E, S Gheshlaghi, JM Abraham, IM Smith, E Powsner, T Solomon, JW Harmon, SM Jay Induced pluripotent stem cell-derived extracellular vesicles promote wound repair in a diabetic mouse model via an anti-inflammatory immunomodulatory mechanism bioRxiv : the preprint server for biology, 2023-03-23;0(0):. 2023-03-23 [PMID: 36993554] (Mouse)
• G Feigelman, E Simanovich, P Brockmeyer, MA Rahat Knocking-Down CD147/EMMPRIN Expression in CT26 Colon Carcinoma Forces the Cells into Cellular and Angiogenic Dormancy That Can Be Reversed by Interactions with Macrophages Biomedicines, 2023-03-02;11(3):. 2023-03-02 [PMID: 36979746] (Mouse)
• P De Cicco, G Ercolano, C Sirignano, V Rubino, D Rigano, A Ianaro, C Formisano Chamomile essential oils exert anti-inflammatory effects involving human and murine macrophages: Evidence to support a therapeutic action Journal of ethnopharmacology, 2023-03-21;0(0):116391. 2023-03-21 [PMID: 36948263] (Mouse)
• VP Skulachev, MY Vyssokikh, BV Chernyak, OA Averina, AA Andreev-An, RA Zinovkin, KG Lyamzaev, MV Marey, MV Egorov, OJ Frolova, DB Zorov, MV Skulachev, VA Sadovnichi Mitochondrion-targeted antioxidant SkQ1 prevents rapid animal death caused by highly diverse shocks Scientific Reports, 2023-03-15;13(1):4326. 2023-03-15 [PMID: 36922552] (Human)
• JH Park, JH Kim, JY Shin, ES Kang, BO Cho Anti-inflammatory effects of Peucedanum japonicum Thunberg leaves extract in Lipopolysaccharide-stimulated RAW264.7�cells Journal of ethnopharmacology, 2023-03-10;309(0):116362. 2023-03-10 [PMID: 36907479] (Mouse)
• A Hooftman, CG Peace, DG Ryan, EA Day, M Yang, AF McGettrick, M Yin, EN Montano, L Huo, JE Toller-Kaw, V Zecchini, TAJ Ryan, A Bolado-Car, AM Casey, HA Prag, ASH Costa, G De Los San, M Ishimori, DJ Wallace, S Venuturupa, E Nikitopoul, N Frizzell, C Johansson, A Von Kriegs, MP Murphy, C Jefferies, C Frezza, LAJ O'Neill Macrophage fumarate hydratase restrains mtRNA-mediated interferon production Nature, 2023-03-08;615(7952):490-498. 2023-03-08 [PMID: 36890227] (Mouse)
• L Panahipour, A Oladzad Ab, R Gruber Oral Cell Lysates Reduce the Inflammatory Response of Activated Macrophages Journal of Clinical Medicine, 2023-02-20;12(4):. 2023-02-20 [PMID: 36836236] (Mouse)
• Y González, R Mojica-Flo, D Moreno-Lab, L Cubilla-Ri, KSJ Rao, PL Fernández, OV Larionov, J Lakey-Beit Polyphenols with Anti-Inflammatory Properties: Synthesis and Biological Activity of Novel Curcumin Derivatives International Journal of Molecular Sciences, 2023-02-12;24(4):. 2023-02-12 [PMID: 36835104] (Mouse)
• Q Fei, EM Shalosky, R Barnes, VC Shukla, MN Ballinger, L Farkas, RJ Lee, SN Ghadiali, JA Englert Macrophage-targeted lipid nanoparticle delivery of microRNA-146a to mitigate hemorrhagic shock-induced acute respiratory distress syndrome bioRxiv : the preprint server for biology, 2023-02-19;0(0):. 2023-02-19 [PMID: 36824913] (Mouse)
• T Wei, K Wang, S Liu, Y Fang, Z Hong, Y Liu, H Zhang, C Yang, G Ouyang, T Wu Periostin deficiency reduces PD-1+ tumor-associated macrophage infiltration and enhances anti-PD-1 efficacy in colorectal cancer Cell Reports, 2023-02-09;42(2):112090. 2023-02-09 [PMID: 36773295] (Mouse)
• HJ Lee, HJ Kim, JH Ko, JY Oh Myeloid cells protect corneal nerves against sterile injury through negative-feedback regulation of TLR2-IL-6 axis Journal of Neuroinflammation, 2023-02-07;20(1):27. 2023-02-07 [PMID: 36750851] (Mouse)
• P Jordan, A Costa, E Specker, O Popp, A Volkamer, R Piske, T Obrusnik, S Kleissle, K Stuke, A Rex, M Neuenschwa, JP von Kries, M Nazare, P Mertins, H Kettenmann, SA Wolf Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation PLoS ONE, 2023-02-06;18(2):e0278325. 2023-02-06 [PMID: 36745631] (Mouse)
• L Tang, M Zhu, X Che, X Yang, Y Xu, Q Ma, M Zhang, Z Ni, X Shao, S Mou Astragaloside IV Targets Macrophages to Alleviate Renal Ischemia-Reperfusion Injury via the Crosstalk between Hif-1alpha and NF-kappaB (p65)/Smad7 Pathways Journal of personalized medicine, 2022-12-27;13(1):. 2022-12-27 [PMID: 36675720] (Mouse)
• A Oun, E Hoeksema, A Soliman, F Brouwer, F García-Rey, H Pots, M Trombetta-, A Kortholt, AM Dolga Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW Macrophages International Journal of Molecular Sciences, 2023-01-13;24(2):. 2023-01-13 [PMID: 36675159] (Mouse)
• TTT Nguyen, YH Choi, WK Lee, Y Ji, E Chun, YH Kim, JE Lee, HS Jung, JH Suh, S Kim, M Jin Tryptophan-dependent and -independent secretions of tryptophanyl- tRNA synthetase mediate innate inflammatory responses Cell Reports, 2022-12-30;42(1):111905. 2022-12-30 [PMID: 36640342] (Mouse)
• TFR Costa, A Goundry, A Morrot, DJ Grab, JC Mottram, APCA Lima Trypanosoma brucei rhodesiense Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response International Journal of Molecular Sciences, 2022-12-30;24(1):. 2022-12-30 [PMID: 36614101] (Mouse)
• H Yu, Z Zhang, G Li, Y Feng, L Xian, F Bakhsh, D Xu, C Xu, T Vong, B Wu, FM Selaru, F Wan, M Donowitz, GW Wong Adipokine C1q/Tumor necrosis factor- Related Protein 3 (CTRP3) Attenuates Intestinal Inflammation via Sirtuin 1 / NF-kappaB Signaling Cellular and Molecular Gastroenterology and Hepatology, 2022-12-30;0(0):. 2022-12-30 [PMID: 36592863] (Mouse)
• Y Lin, X Cui, Q Cao, R Bi, Y Liu, D Jing, C Yue, Q Zhao, Y Wang, S Liu, Y Su, K Formoso, S Susperregu, L Birnbaumer, M Freichel, Y Yang, L You, X Gao TRPC absence induces pro-inflammatory macrophages and gut microbe disorder, sensitizing mice to colitis International immunopharmacology, 2022-12-31;115(0):109655. 2022-12-31 [PMID: 36592529] (Mouse)
• DC Sarver, C Xu, LM Velez, S Aja, AE Jaffe, MM Seldin, RH Reeves, GW Wong Dysregulated systemic metabolism in a Down syndrome mouse model Molecular Metabolism, 2022-12-29;68(0):101666. 2022-12-29 [PMID: 36587842] (Mouse)
• K Chen, LY Cheong, Y Gao, Y Zhang, T Feng, Q Wang, L Jin, E Honoré, KSL Lam, W Wang, X Hui, A Xu Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects Nature Communications, 2022-12-20;13(1):7838. 2022-12-20 [PMID: 36539421] (Mouse)
• PF Kinoshita, AM Orellana, DZ Andreotti, GA de Souza, NP de Mello, L de Sá Lima, EM Kawamoto, C Scavone Consequences of the Lack of TNFR1 in Ouabain Response in the Hippocampus of C57BL/6J Mice Biomedicines, 2022-11-15;10(11):. 2022-11-15 [PMID: 36428505] (Mouse)
• JS Park, SC Yang, HY Jeong, SY Lee, JG Ryu, JW Choi, HY Kang, SM Kim, SH Hwang, ML Cho, SH Park EC-18 prevents autoimmune arthritis by suppressing inflammatory cytokines and osteoclastogenesis Arthritis Research & Therapy, 2022-11-17;24(1):254. 2022-11-17 [PMID: 36397156] (Mouse)
• CS Rigazio, N Mariz-Pont, EP Caballero, FN Penas, NB Goren, MH Santamaría, RS Corral Involvement of glycoinositolphospholipid from Trypanosoma cruzi and macrophage migration inhibitory factor in proinflammatory mechanisms promoting cardiovascular injury mechanisms promoting cardiovascular inflammation tThe combined action of glycoinositolphospholipid from Trypanosoma cruzi and macrophage migration inhibitory factor increases proinflammatory mediator production by cardiomyocytes and vascular endothelial cells Microbial pathogenesis, 2022-11-12;0(0):105881. 2022-11-12 [PMID: 36379373] (Mouse)
• S Giofrè, A Renda, S Sesana, B Formicola, B Vergani, BE Leone, V Denti, G Paglia, S Groppuso, V Romeo, L Muzio, A Balboni, A Menegon, A Antoniou, A Amenta, D Passarella, P Seneci, S Pellegrino, F Re Dual Functionalized Liposomes for Selective Delivery of Poorly Soluble Drugs to Inflamed Brain Regions Pharmaceutics, 2022-11-07;14(11):. 2022-11-07 [PMID: 36365220] (Mouse)
• Z Pan, B Mao, Q Zhang, X Tang, B Yang, J Zhao, S Cui, H Zhang Postbiotics Prepared Using Lactobacillus paracasei CCFM1224 Prevent Nonalcoholic Fatty Liver Disease by Modulating the Gut Microbiota and Liver Metabolism International Journal of Molecular Sciences, 2022-11-04;23(21):. 2022-11-04 [PMID: 36362307] (Mouse)
• AE Pottash, D Levy, A Jeyaram, L Kuo, SM Kronstadt, W Chao, SM Jay Combinatorial microRNA Loading into Extracellular Vesicles for Increased Anti-Inflammatory Efficacy Non-coding RNA, 2022-10-21;8(5):. 2022-10-21 [PMID: 36287123] (Mouse)
• H Wang, Y Li, Z Yue, Y Liu, Q Chen, D Hu, J Han Adipose-Derived Stem Cell Exosomes Inhibit Hypertrophic Scaring Formation by Regulating Th17/Treg Cell Balance BioMed Research International, 2022-10-12;2022(0):9899135. 2022-10-12 [PMID: 36277890] (Mouse)
• J Liu, L Shi, W Huang, Z Zheng, X Huang, Y Su Homoharringtonine Attenuates Dextran Sulfate Sodium-Induced Colitis by Inhibiting NF-kappaB Signaling Mediators of Inflammation, 2022-09-29;2022(0):3441357. 2022-09-29 [PMID: 36211988] (Mouse)
• J Wang, Q Zhu, R Li, J Zhang, X Ye, X Li YAP1 protects against septic liver injury via ferroptosis resistance Cell & bioscience, 2022-10-01;12(1):163. 2022-10-01 [PMID: 36182901] (Mouse)
• JK Allen, TC Sutherland, AR Prater, CG Geoffroy, JP Pellois In vivo peptide-based delivery of a gene-modifying enzyme into cells of the central nervous system Science Advances, 2022-09-28;8(39):eabo2954. 2022-09-28 [PMID: 36170360] (Mouse)
• P Boroumand, DC Prescott, T Mukherjee, PJ Bilan, M Wong, J Shen, I Tattoli, Y Zhou, A Li, T Sivasubram, N Shi, LY Zhu, Z Liu, C Robbins, DJ Philpott, SE Girardin, A Klip Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity Elife, 2022-09-20;11(0):. 2022-09-20 [PMID: 36125130] (Mouse)
• AM Mello, T Ngodup, Y Lee, KL Donahue, J Li, A Rao, ES Carpenter, HC Crawford, M Pasca di M, KE Lee Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer Oncogenesis, 2022-09-15;11(1):56. 2022-09-15 [PMID: 36109493] (Mouse)
• CWS Wanderley, A Maganin, B Adjafre, AS Mendes, CE Anibal Sil, AU Quadros, JPM Luiz, CMS Silva, NR Silva, FF Oliveira, FIF Gomes, JLJ Restrepo, CA Speck-Hern, F Turaça, GVL Silva, GR Pigatto, HI Nakaya, JM Mota, R Barroso-So, JC Alves-Filh, TM Cunha, FQ Cunha PD-1/PD-L1 inhibition enhances chemotherapy-induced neuropathic pain by suppressing neuroimmune antinociceptive signaling Cancer Immunology Research, 2022-11-02;0(0):. 2022-11-02 [PMID: 36083496] (Mouse)
• Y Zhang, L Zhu, J Hong, C Chen Extracellular matrix of early pulmonary fibrosis modifies the polarization of alveolar macrophage International immunopharmacology, 2022-08-24;111(0):109179. 2022-08-24 [PMID: 36029666] (Mouse)
• SJ Matissek, M Karbalivan, W Han, A Boutilier, E Yzar-Garci, LL Kehoe, DS Gardner, A Hage, K Fleck, V Jeffers, R Rajsbaum, SF Elsawa A novel mechanism of regulation of the oncogenic transcription factor GLI3 by toll-like receptor signaling Oncotarget, 2022-08-03;13(0):944-959. 2022-08-03 [PMID: 35937499] (Human)
• J Hu, Y Zhang, S Yi, C Wang, X Huang, S Pan, J Yang, G Yuan, S Tan, H Li Lithocholic acid inhibits dendritic cell activation by reducing intracellular glutathione via TGR5 signaling International journal of biological sciences, 2022-07-11;18(11):4545-4559. 2022-07-11 [PMID: 35864954] (Mouse)
• PS Woods, LM Kimmig, KA Sun, AY Meliton, OR Shamaa, Y Tian, R Cetin-Atal, WW Sharp, RB Hamanaka, GM Mutlu HIF-1alpha induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury Elife, 2022-07-13;11(0):. 2022-07-13 [PMID: 35822617] (Mouse)
• W Chen, S Chen, C Yan, Y Zhang, R Zhang, M Chen, S Zhong, W Fan, S Zhu, D Zhang, X Lu, J Zhang, Y Huang, L Zhu, X Li, D Lv, Y Fu, H Iv, Z Ling, L Ma, H Jiang, G Long, J Zhu, D Wu, B Wu, B Sun Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion Nature Immunology, 2022-07-06;23(7):1021-1030. 2022-07-06 [PMID: 35794369] (Mouse)
• HOJ Morad, S Luqman, LG Pinto, KP Cunningham, B Vilar, G Clayton, M Shankar-Ha, PA McNaughton Artemisinin inhibits neutrophil and macrophage chemotaxis, cytokine production and NET release Scientific Reports, 2022-06-30;12(1):11078. 2022-06-30 [PMID: 35773325] (Mouse)
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• A Moshensky, CS Brand, H Alhaddad, J Shin, JA Masso-Silv, I Advani, D Gunge, A Sharma, S Mehta, A Jahan, S Nilaad, J Olay, W Gu, T Simonson, D Almarghala, J Pham, S Perera, K Park, R Al-Kolla, H Moon, S Das, M Byun, Z Shah, Y Sari, J Heller Bro, LE Crotty Ale Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice Elife, 2022-04-12;11(0):. 2022-04-12 [PMID: 35411847] (Mouse)
• YH Su, JY Lin Menthone Inhalation Alleviates Local and Systemic Allergic Inflammation in Ovalbumin-Sensitized and Challenged Asthmatic Mice International Journal of Molecular Sciences, 2022-04-04;23(7):. 2022-04-04 [PMID: 35409371] (Mouse)
• KC Ngamsri, A Fuhr, K Schindler, M Simelitidi, M Hagen, Y Zhang, J Gamper-Tsi, FM Konrad Sevoflurane Dampens Acute Pulmonary Inflammation via the Adenosine Receptor A2B and Heme Oxygenase-1 Cells, 2022-03-24;11(7):. 2022-03-24 [PMID: 35406657] (Mouse)
• C Lemberg, K Martinez d, R Fróis-Mart, S Altmeier, VDT Tran, S Mertens, S Amorim-Vaz, LS Rai, C d'Enfert, M Pagni, D Sanglard, S LeibundGut Candida albicans commensalism in the oral mucosa is favoured by limited virulence and metabolic adaptation PloS Pathogens, 2022-04-11;18(4):e1010012. 2022-04-11 [PMID: 35404986] (Mouse)
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• Y Hiramatsu, K Suzuki, T Nishida, N Onoda, T Satoh, S Akira, M Ikawa, H Ikeda, J Kamei, S Derouiche, M Tominaga, Y Horiguchi The Mechanism of Pertussis Cough Revealed by the Mouse-Coughing Model MBio, 2022-03-31;0(0):e0319721. 2022-03-31 [PMID: 35357202] (Mouse)
• GS McElroy, RP Chakrabart, KB D'Alessand, K Vasan, J Tan, JS Stoolman, SE Weinberg, EM Steinert, PA Reyfman, BD Singer, WC Ladiges, L Gao, J Lopéz-Barn, GRS Budinger, NS Chandel Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice Scientific Reports, 2022-03-25;12(1):5196. 2022-03-25 [PMID: 35338200] (Mouse)
• E Singh, RAM Osmani, R Banerjee, AS Abu Lila, A Moin, K Almansour, HH Arab, HF Alotaibi, ES Khafagy Poly epsilon-Caprolactone Nanoparticles for Sustained Intra-Articular Immune Modulation in Adjuvant-Induced Arthritis Rodent Model Pharmaceutics, 2022-02-26;14(3):. 2022-02-26 [PMID: 35335895] (Mouse)
• W Kazana, D Jakubczyk, K Pacyga-Pru, K Leszczy?sk, S Górska, J Siednienko, J Maca?a, G Piechowiak, A Zab?ocka A Novel Mechanism of Macrophage Activation by the Natural Yolkin Polypeptide Complex from Egg Yolk International Journal of Molecular Sciences, 2022-03-14;23(6):. 2022-03-14 [PMID: 35328547] (Mouse)
• C Iuliano, M Absmaier-K, T Sinnberg, N Hoffard, M Hils, M Köberle, F Wölbing, E Shumilina, N Heise, B Fehrenbach, M Schaller, F Lang, S Kaesler, T Biedermann Fetal Tissue-Derived Mast Cells (MC) as Experimental Surrogate for In Vivo Connective Tissue MC Cells, 2022-03-08;11(6):. 2022-03-08 [PMID: 35326379] (Mouse)
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• MA Pallett, Y Lu, GL Smith DDX50 Is a Viral Restriction Factor That Enhances IRF3 Activation Viruses, 2022-02-03;14(2):. 2022-02-03 [PMID: 35215908] (Mouse)
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• S Lee, BG Seok, SJ Lee, SW Chung Inhibition of mitoNEET attenuates LPS-induced inflammation and oxidative stress Cell Death & Disease, 2022-02-08;13(2):127. 2022-02-08 [PMID: 35136051] (Mouse)
• RM van Harten, JLM Tjeerdsma-, A de Greeff, MD Balhuizen, A van Dijk, EJA Veldhuizen, HP Haagsman, MR Scheenstra d-enantiomers of CATH-2 enhance the response of macrophages against Streptococcus suis serotype 2 Journal of advanced research, 2021-05-26;36(0):101-112. 2021-05-26 [PMID: 35127168] (Mouse)
• PATS Castro, GM Barbosa, DH Machanocke, RS Peres, TM Cunha, JE Cunha, FFB Oliveira, FS Ramalho, TL Russo, FQ Cunha, TF Salvini Clinical-like cryotherapy in acute knee arthritis of the knee improves inflammation signs, pain, joint swelling, and motor performance in mice PLoS ONE, 2022-01-21;17(1):e0261667. 2022-01-21 [PMID: 35061737] (Mouse)
• R Pohl, S Feder, EM Haberl, L Rein-Fisch, TS Weiss, M Spirk, A Bruckmann, N McMullen, CJ Sinal, C Buechler Chemerin Overexpression in the Liver Protects against Inflammation in Experimental Non-Alcoholic Steatohepatitis Biomedicines, 2022-01-07;10(1):. 2022-01-07 [PMID: 35052810] (Mouse)
• A Nemmar, S Beegam, NE Zaaba, S Alblooshi, S Alseiari, BH Ali The Salutary Effects of Catalpol on Diesel Exhaust Particles-Induced Thrombogenic Changes and Cardiac Oxidative Stress, Inflammation and Apoptosis Biomedicines, 2022-01-04;10(1):. 2022-01-04 [PMID: 35052780] (Mouse)
• Y Gu, J Chen, Q Huang, Y Zhan, T Wang, J Wu, J Zhao, Z Zeng, Y Lv, C Xiao, J Xie MTMR14 Alleviates Chronic Obstructive Pulmonary Disease as a Regulator in Inflammation and Emphysema Oxidative Medicine and Cellular Longevity, 2022-01-07;2022(0):9300269. 2022-01-07 [PMID: 35035670] (Mouse)
• I Park, ME Goddard, JE Cole, N Zanin, LP Lyytikäine, T Lehtimäki, E Andreakos, M Feldmann, I Udalova, I Drozdov, C Monaco C-type lectin receptor CLEC4A2 promotes tissue adaptation of macrophages and protects against atherosclerosis Nature Communications, 2022-01-11;13(1):215. 2022-01-11 [PMID: 35017526] (Mouse)
• KC Ngamsri, RA Putri, C Jans, K Schindler, A Fuhr, Y Zhang, J Gamper-Tsi, S Ehnert, FM Konrad CXCR4 and CXCR7 Inhibition Ameliorates the Formation of Platelet-Neutrophil Complexes and Neutrophil Extracellular Traps through Adora2b Signaling International Journal of Molecular Sciences, 2021-12-17;22(24):. 2021-12-17 [PMID: 34948374] (Mouse)
• J Tomala, P Weberova, B Tomalova, Z Jiraskova, L Sivak, J Kovarova, M Kovar IL-2/JES6-1 mAb complexes dramatically increase sensitivity to LPS through IFN-gamma production by CD25+Foxp3- T cells Elife, 2021-12-21;10(0):. 2021-12-21 [PMID: 34932467] (Mouse)
• BY Lee, EKJ Hogg, CR Below, A Kononov, A Blanco-Gom, F Heider, J Xu, C Hutton, X Zhang, T Scheidt, K Beattie, A Lamarca, M McNamara, JW Valle, C Jørgensen Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis Nature Communications, 2021-12-17;12(1):7336. 2021-12-17 [PMID: 34921158] (Mouse)
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• P Sun, J Zhong, H Liao, P Loughran, J Mulla, G Fu, D Tang, J Fan, TR Billiar, W Gao, MJ Scott Hepatocytes are resistant to cell death from canonical and non-canonical inflammasome-activated pyroptosis Cellular and Molecular Gastroenterology and Hepatology, 2021-12-07;0(0):. 2021-12-07 [PMID: 34890842] (Mouse)
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• J Lücht, N Rolfs, SJ Wowro, F Berger, KRL Schmitt, G Tong Cooling and Sterile Inflammation in an Oxygen-Glucose-Deprivation/Reperfusion Injury Model in BV-2 Microglia Mediators of Inflammation, 2021-11-05;2021(0):8906561. 2021-11-05 [PMID: 34776788] (Mouse)
• MC Kiritsy, K McCann, D Mott, SM Holland, SM Behar, CM Sassetti, AJ Olive Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells Elife, 2021-11-02;10(0):. 2021-11-02 [PMID: 34726598] (Mouse)
• P Rozier, M Maumus, ATJ Maria, K Toupet, C Jorgensen, P Guilpain, D Noël Lung Fibrosis Is Improved by Extracellular Vesicles from IFNgamma-Primed Mesenchymal Stromal Cells in Murine Systemic Sclerosis Cells, 2021-10-13;10(10):. 2021-10-13 [PMID: 34685707] (Mouse)
• SR Bruno, A Kumar, ZF Mark, R Chandrasek, E Nakada, N Chamberlai, B Mihavics, J Walzer, J Cahoon, AE Dixon, B Cunniff, V Anathy DRP1-Mediated Mitochondrial Fission Regulates Lung Epithelial Response to Allergen International Journal of Molecular Sciences, 2021-10-15;22(20):. 2021-10-15 [PMID: 34681784] (Mouse)
• S Li, Y Lei, J Lei, H Li All?trans retinoic acid promotes macrophage phagocytosis and decreases inflammation via inhibiting CD14/TLR4 in acute lung injury Molecular Medicine Reports, 2021-10-22;24(6):. 2021-10-22 [PMID: 34676874] (Mouse)
• JR Santin, L Benvenutti, MF Broering, R Nunes, FC Goldoni, YBK Patel, JA de Souza, MAT Kopp, P de Souza, RCV da Silva, MVD Pastor, AB de Souza, LD Testoni, AG Couto, TMB Bresolin, NLM Quintão Sambucus nigra: A traditional medicine effective in reducing inflammation in mice Journal of ethnopharmacology, 2021-10-11;283(0):114736. 2021-10-11 [PMID: 34648899] (Mouse)
• N Majumder, M Velayutham, D Bitounis, VK Kodali, MH Hasan Mazu, J Amedro, VV Khramtsov, A Erdely, T Nurkiewicz, P Demokritou, EE Kelley, S Hussain Oxidized carbon black nanoparticles induce endothelial damage through C-X-C chemokine receptor 3-mediated pathway Redox Biology, 2021-10-04;47(0):102161. 2021-10-04 [PMID: 34624601] (Mouse)
• AV Ferreira, RF Uijen, O Bulut, MI de Jonge, J Domínguez-, MG Netea Limited role of the spleen in a mouse model of trained immunity: Impact on neutrophilia Journal of leukocyte biology, 2021-10-01;0(0):. 2021-10-01 [PMID: 34596266] (Mouse)
• J Hu, C Wang, X Huang, S Yi, S Pan, Y Zhang, G Yuan, Q Cao, X Ye, H Li Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling Cell Reports, 2021-09-21;36(12):109726. 2021-09-21 [PMID: 34551302] (Mouse)
• S Droho, CM Cuda, H Perlman, JA Lavine Macrophage-derived interleukin-6 is necessary and sufficient for choroidal angiogenesis Scientific Reports, 2021-09-10;11(1):18084. 2021-09-10 [PMID: 34508129] (Mouse, Transgenic Mouse)
• WJ Melvin, CO Audu, FM Davis, SB Sharma, A Joshi, A DenDekker, S Wolf, E Barrett, K Mangum, X Zhou, M Bame, A Ruan, A Obi, SL Kunkel, BB Moore, KA Gallagher Coronavirus induces diabetic macrophage-mediated inflammation via SETDB2 Proceedings of the National Academy of Sciences of the United States of America, 2021-09-21;118(38):. 2021-09-21 [PMID: 34479991] (Mouse)
• VC Bobbo, DF Engel, CP Jara, NF Mendes, R Haddad-Tov, TP Prado, D Sidarta-Ol, J Morari, LA Velloso, EP Araujo Interleukin-6 actions in the hypothalamus protects against obesity and is involved in the regulation of neurogenesis Journal of Neuroinflammation, 2021-08-31;18(1):192. 2021-08-31 [PMID: 34465367] (Mouse)
• W Wang, M Kong, Y Dou, S Xue, Y Liu, Y Zhang, W Chen, Y Li, X Dai, J Meng, J Wang Selective Expression of a SNARE-Cleaving Protease in Peripheral Sensory Neurons Attenuates Pain-Related Gene Transcription and Neuropeptide Release International Journal of Molecular Sciences, 2021-08-17;22(16):. 2021-08-17 [PMID: 34445536] (Mouse)
• SKH Chow, C Cui, KYK Cheng, YN Chim, J Wang, CHW Wong, KW Ng, RMY Wong, WH Cheung Acute Inflammatory Response in Osteoporotic Fracture Healing Augmented with Mechanical Stimulation is Regulated In Vivo through the p38-MAPK Pathway International Journal of Molecular Sciences, 2021-08-13;22(16):. 2021-08-13 [PMID: 34445423] (Mouse)
• N Majumder, WT Goldsmith, VK Kodali, M Velayutham, SA Friend, VV Khramtsov, TR Nurkiewicz, A Erdely, PC Zeidler-Er, V Castranova, JR Harkema, EE Kelley, S Hussain Oxidant-induced epithelial alarmin pathway mediates lung inflammation and functional decline following ultrafine carbon and ozone inhalation co-exposure Redox Biology, 2021-08-05;46(0):102092. 2021-08-05 [PMID: 34418598] (Mouse)
• SG Lee, DG Lee, YH Joo, N Chung Synergistic inhibitory effects of the oxyresveratrol and dacarbazine combination against melanoma cells Oncology Letters, 2021-07-14;22(3):667. 2021-07-14 [PMID: 34386089] (Mouse)
• H Ahn, G Lee, J Kim, J Park, SG Kang, SI Yoon, E Lee, GS Lee NLRP3 Triggers Attenuate Lipocalin-2 Expression Independent with Inflammasome Activation Cells, 2021-07-02;10(7):. 2021-07-02 [PMID: 34359830] (Mouse)
• L Benvenutti, R Nunes, I Venturi, SA Ramos, MF Broering, FC Goldoni, SE Pavan, MVD Pastor, A Malheiros, NLM Quintão, ES Fernandes, JR Santin Anti-Inflammatory and Healing Activity of the Hydroalcoholic Fruit Extract of Solanum diploconos (Mart.) Bohs Journal of Immunology Research, 2021-07-19;2021(0):9957451. 2021-07-19 [PMID: 34337087] (Mouse)
• S Rastogi, S Ellinwood, J Augenstrei, KD Mayer-Barb, V Briken Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF PloS Pathogens, 2021-07-29;17(7):e1009712. 2021-07-29 [PMID: 34324582] (Mouse)
• CC Lin, YR Shen, CC Chang, XY Guo, YY Young, TY Lai, IS Yu, CY Lee, TH Chuang, HY Tsai, LC Hsu Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation Nature Communications, 2021-06-29;12(1):3878. 2021-06-29 [PMID: 34188032] (Mouse)
• K Matsushita, X Li, Y Nakamura, D Dong, K Mukai, M Tsai, SB Montgomery, SJ Galli The role of Sp140 revealed in IgE and mast cell responses in Collaborative Cross mice JCI Insight, 2021-06-22;6(12):. 2021-06-22 [PMID: 34156030] (Mouse)
• DJ Levy, A Goundry, RSS Laires, TFR Costa, CM Novo, DJ Grab, JC Mottram, APCA Lima Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host PloS Neglected Tropical Diseases, 2021-06-21;15(6):e0009526. 2021-06-21 [PMID: 34153047] (Mouse)
• A Doni, R Parente, I Laface, E Magrini, C Cunha, FS Colombo, JF Lacerda, A Campos, SN Mapelli, F Petroni, R Porte, T Schorn, A Inforzato, T Mercier, K Lagrou, J Maertens, JD Lambris, B Bottazzi, C Garlanda, M Botto, A Carvalho, A Mantovani Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus Nature Communications, 2021-06-18;12(1):3739. 2021-06-18 [PMID: 34145258] (Mouse)
• A Ulu, A Burr, AJ Heires, J Pavlik, T Larsen, PA Perez, C Bravo, NV DiPatrizio, M Baack, DJ Romberger, TM Nordgren A high docosahexaenoic acid diet alters lung inflammation and recovery following repetitive exposure to aqueous organic dust extracts: Role of DHA in repetitive organic dust exposure The Journal of nutritional biochemistry, 2021-06-12;0(0):108797. 2021-06-12 [PMID: 34126202] (Mouse)
• N Lee, YJ Heo, SE Choi, JY Jeon, SJ Han, DJ Kim, Y Kang, KW Lee, HJ Kim Anti-inflammatory Effects of Empagliflozin and Gemigliptin on LPS-Stimulated Macrophage via the IKK/NF-&kappaB, MKK7/JNK, and JAK2/STAT1 Signalling Pathways Journal of Immunology Research, 2021-06-02;2021(0):9944880. 2021-06-02 [PMID: 34124273] (Mouse)
• LG Lima, S Ham, H Shin, EPZ Chai, ESH Lek, RJ Lobb, AF Müller, S Mathivanan, B Yeo, Y Choi, BS Parker, A Möller Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution Nature Communications, 2021-06-10;12(1):3543. 2021-06-10 [PMID: 34112803] (Mouse)
• HJ Shin, SH Kim, HJ Park, MS Shin, I Kang, MJ Kang Nucleotide-binding domain and leucine-rich-repeat-containing protein X1 deficiency induces nicotinamide adenine dinucleotide decline, mechanistic target of rapamycin activation, and cellular senescence and accelerates aging lung-like changes Aging Cell, 2021-06-04;0(0):e13410. 2021-06-04 [PMID: 34087956] (Mouse)
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• MG Granja, LP Alves, M Leardini-T, ME Saul, LC Bortoni, FM de Moraes, EC Ferreira, BPT de Moraes, VZ da Silva, AFR Dos Santos, AR Silva, CF Gonçalves-, V Bambini-Ju, AS Weyrich, MT Rondina, GA Zimmerman, HC de Castro- Inflammatory, synaptic, motor, and behavioral alterations induced by gestational sepsis on the offspring at different stages of life Journal of Neuroinflammation, 2021-02-25;18(1):60. 2021-02-25 [PMID: 33632243] (Mouse)
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• KP Foley, Y Chen, NG Barra, M Heal, K Kwok, AK Tamrakar, W Chi, BM Duggan, BD Henriksbo, Y Liu, JD Schertzer Inflammation promotes adipocyte lipolysis via IRE1 kinase The Journal of Biological Chemistry, 2021-02-19;0(0):100440. 2021-02-19 [PMID: 33610548] (Mouse)
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• M Grancieri, HSD Martino, E Gonzalez d Protein Digests and Pure Peptides from Chia Seed Prevented Adipogenesis and Inflammation by Inhibiting PPAR&gamma and NF-&kappaB Pathways in 3T3L-1 Adipocytes Nutrients, 2021-01-08;13(1):. 2021-01-08 [PMID: 33430086] (Mouse)
• F Botelho, A Dubey, EA Ayaub, R Park, A Yip, A Humbles, R Kolbeck, CD Richards IL-33 Mediates Lung Inflammation by the IL-6-Type Cytokine Oncostatin M Mediators of Inflammation, 2020-11-28;2020(0):4087315. 2020-11-28 [PMID: 33376451] (Mouse)
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• SS Chiang, LS Chen, CY Chu Active food ingredients production from cold pressed processing residues of Camellia oleifera and Camellia sinensis seeds for regulation of blood pressure and vascular function Chemosphere, 2020-12-11;267(0):129267. 2020-12-11 [PMID: 33338714] (Mouse)
• DO Kim, JE Byun, WS Kim, MJ Kim, JH Choi, H Kim, E Choi, TD Kim, SR Yoon, JY Noh, YJ Park, J Lee, HJ Cho, HG Lee, SH Min, I Choi, H Jung TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-&gamma Production during Bacterial Infection International Journal of Molecular Sciences, 2020-12-14;21(24):. 2020-12-14 [PMID: 33327533] (Mouse)
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• FM de Jesus O, CF Gonçalves-, IMM de Moraes, PA Reis, VN Rocha, PT Bozza, AR Silva, HC de Castro Simvastatin Posttreatment Controls Inflammation and Improves Bacterial Clearance in Experimental Sepsis Mediators Inflamm, 2020-10-14;2020(0):1839762. 2020-10-14 [PMID: 33110395] (Mouse)
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• F Yang, P Huang, L Shi, F Liu, A Tang, S Xu Phoenixin 14 Inhibits High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Experimental Mice Drug Des Devel Ther, 2020-09-22;14(0):3865-3874. 2020-09-22 [PMID: 33061293] (Mouse)
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• B Cuffaro, ALW Assohoun, D Boutillier, L Súkeníková, J Desramaut, S Boudebbouz, S Salomé-Des, J Hrdý, AJ Waligora-D, E Maguin, C Grangette In Vitro Characterization of Gut Microbiota-Derived Commensal Strains: Selection of Parabacteroides distasonis Strains Alleviating TNBS-Induced Colitis in Mice Cells, 2020-09-16;9(9):. 2020-09-16 [PMID: 32947881] (Mouse)
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FAQs for IL-6 (DY406). (Showing 1 - 1 of 1 FAQs).

1. I was wondering if you know of any blocking antibodies against IL-6 or VEGF-C that can be used in cell culture to quench these cytokines?
   • We have no antibodies that are currently known to show blocking antibodies to VEGF-C. Please see this link to our IL-6 antibodies with blocking/neutralizing activity can be found at this link.

Bioinformatics

• Gene Symbol: Il6