Mouse TNF-alpha Quantikine ELISA Kit, 2 Plate

HFD-induced plasma saturated free fatty acid (FFA) and lactate trigger production of proinflammatory cytokines and VEGF in mouse chondrocytes.(a~d) Relative mRNA levels of IL-6 (a), TNF-alpha (b), IL-1 beta (c) and VEGF (d) in the mouse primary chondrocytes treated with full or fractionated (>3 KD or <3 KD) serum from the 8-week ND or HFD-feeding mice. (n = 3, *P < 0.05, **P < 0.01 and ***P < 0.005). (e~h) Relative mRNA levels of IL-6 (e), TNF-alpha (f), IL-1 beta (g) and VEGF (h) in the mouse primary chondrocytes treated with BSA (5%) or BSA-linked FFA (18:0, 200 μM) for 24 h. (n = 3, *P < 0.05 and **P < 0.01). (i~l) Relative mRNA expression of IL-6 (i), TNF-alpha (j), IL-1 beta (k) and VEGF (l) in the mouse primary chondrocytes treated with lactate (25 mM) or vehicle control for 24 h. (n = 3, *P < 0.05 and **P < 0.01). Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/26271607), licensed under a CC-BY license. Not internally tested by R&D Systems.

PYC suppressed LPS-induced proinflammatory cytokine production in BV2 microglia.Cells were incubated with the indicated concentrations of PYC or vehicle for 1h before LPS treatment (500ng/mL). After 24 h incubation, the culture supernatants were collected, and the amount of TNF-alpha , IL-6, IL-1 beta and IL-10 were measured by ELISA (A-D). Data are represented as mean ± SD from at least 3 independent experiments. *P< 0.05 compared with LPS alone. #P< 0.05. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/26367267), licensed under a CC-BY license. Not internally tested by R&D Systems.

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse TNF-alpha Quantikine ELISA Kit, 2 Plate Summary

• Background: The Quantikine Mouse TNF-alpha Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse TNF-alpha levels in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant mouse TNF-alpha and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse TNF-alpha accurately. Results obtai...ned using natural mouse TNF-alpha showed dose-response curves that were parallel to the standard curves obtained using the recombinant kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse TNF-alpha .
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• Specificity: Natural and recombinant mouse TNF-alpha .
• Source: N/A
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Tnf

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Interference observed with 1 or more available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse TNF-alpha Quantikine ELISA Kit, 2 Plate

• APC1 protein
• Cachectin
• Cachetin
• DIF
• TNF
• TNF, monocyte-derived
• TNFA
• TNF-A
• TNFalpha
• TNF-alpha
• TNF-alphacachectin
• TNFATNF, macrophage-derived
• TNFG1F
• TNFSF1A
• TNFSF2
• TNFSF2TNF superfamily, member 2
• tumor necrosis factor (TNF superfamily, member 2)
• tumor necrosis factor alpha
• Tumor necrosis factor ligand superfamily member 2
• tumor necrosis factor
• tumor necrosis factor-alpha

Background

Tumor necrosis factor alpha (TNF-alpha ), also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily (1). It is a pleiotropic molecule that plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism (2-5). TNF-alpha is also involved in a number of pathological conditions including asthma, Crohn's disease, rheumatoid arthritis, neuropathic pain, obesity, type 2 diabetes, septic shock, autoimmunity, and cancer (5-11).   

Mouse TNF-alpha is synthesized as a 26 kDa type II transmembrane protein that consists of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 179 aa extracellular domain (ECD) (12). Within the ECD, mouse TNF-alpha shares 95% aa identity with rat, and 80% aa identity with canine, equine, feline, human, rabbit, and porcine TNF-alpha . It is produced by a wide variety of immune, epithelial, endothelial, and tumor cells. TNF-alpha is assembled intracellularly to form a noncovalently linked homotrimer which is expressed on the cell surface (13). Cell surface TNF-alpha can both induce the lysis of tumor cells and virus infected cells, and generate its own downstream cell signaling following ligation by soluble TNF RI (14, 15). Shedding of membrane bound TNF-alpha by TACE/ADAM17 releases the bioactive cytokine, a 55 kDa soluble trimer containing the TNF-alpha extracellular domain (16-18).    

TNF-alpha binds the ubiquitous 55-60 kDa TNF RI (19, 20) and the hematopoietic cell-restricted 78-80 kDa TNF RII (21, 22), both of which are also expressed as homotrimers (1, 23). Both type I and type II receptors bind TNF-alpha with comparable affinity and can promote NFkB activation (24-27). Only TNF RI, however, contains a cytoplasmic death domain which triggers the activation of apoptosis (3, 28). Soluble forms of both types of receptors are released into human serum and urine, and can neutralize the biological activity of TNF (29-31).

&#9888; WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for TNF-alpha (MTA00B)(738)

Publications using MTA00B

• Zhao, Q;Wang, Q;Yao, Q;Yang, Z;Li, W;Cheng, X;Wen, Y;Chen, R;Xu, J;Wang, X;Qin, D;Zhu, S;He, L;Li, N;Wu, Y;Yu, Y;Cao, X;Wang, P; Nonenzymatic lysine D-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses Cell research 2025-01-06 [PMID: 39757301] (Mouse)
• Chen, YW;Wu, MY;Huang, NJ;Wu, MS;Hsu, YH;Liao, CT;Chen, CH; Therapeutic Potential of Oligo-Fucoidan in Mitigating Peritoneal Dialysis-Associated Fibrosis Marine drugs 2024-11-25 [PMID: 39728104] (Transgenic Mouse)
• Hu, X;Zhang, Y;Guo, L;Xiao, R;Yuan, L;Liu, F; Comprehensive Analysis of Bulk RNA-Seq and Single-Cell RNA-Seq Data Unveils Sevoflurane-Induced Neurotoxicity Through SLC7A11-Associated Ferroptosis Journal of cellular and molecular medicine 2024-12-01 [PMID: 39724413] (Mouse)
• Guo, C;Zhang, Y;Kong, C;Liu, W;Li, M;Yang, J;Sun, J;Wang, Y;Yu, J; Electroacupuncture pretreatment ameliorates Golgi stress and the inflammation response against endotoxin-induced lung injury International immunopharmacology 2024-12-20 [PMID: 39709911] (Mouse)
• Wang, L;Lin, B;Zhai, M;Hull, L;Cui, W;Xiao, M; Endothelial Dysfunction and Impaired Wound Healing Following Radiation Combined Skin Wound Injury International journal of molecular sciences 2024-11-21 [PMID: 39684207] (Mouse)
• Webber, CJ;van de Spek, SJF;Cruz, AL;Puri, S;Zhang, C;Aw, JTM;Papadimitriou, GZ;Roberts, R;Jiang, K;Tran, TN;Zhang, L;Taylor, A;Wang, Z;Porter, J;Sotiropoulos, I;Emili, A;Silva, J;Li, H;Wolozin, B; TIA1 Mediates Divergent Inflammatory Responses to Tauopathy in Microglia and Macrophages bioRxiv : the preprint server for biology 2024-11-07 [PMID: 39574689] (Transgenic Mouse)
• Nakano, T;Yoshida, E;Sasaki, Y;Kazama, S;Katami, F;Aoki, K;Fujie, T;Du, K;Hara, T;Yamamoto, C;Takahashi, T;Fujiwara, Y;Eto, K;Iwakura, Y;Shinoda, Y;Kaji, T; Mechanisms Underlying Sensory Nerve-Predominant Damage by Methylmercury in the Peripheral Nervous System International journal of molecular sciences 2024-10-30 [PMID: 39519224] (Mouse)
• Liao, R;Dewey, MJ;Rong, J;Johnson, SA;D'Angelo, WA;Hussey, GS;Badylak, SF; Matrix-bound nanovesicles alleviate particulate-induced periprosthetic osteolysis Science advances 2024-10-18 [PMID: 39423278] (Mouse)
• Shin, SH;Ye, MK;Chae, MH;Geum, SY;Aboraia, AS;Abdel-Aal, AM;Qayed, WS;El-Wahab, HAAA;Abou-Ghadir, OF;Aboul-Fadl, T; Anti-Allergic and Anti-Inflammatory Effects of Lidocaine-Derived Organic Compounds in a House Dust Mite-Induced Allergic Rhinitis Mouse Model Biomedicines 2024-08-29 [PMID: 39335479] (Mouse)
• Lee, SE;Kim, IH;Kang, YC;Kim, Y;Yu, SH;Yeo, JS;Kwon, I;Lim, JH;Kim, JH;Han, K;Kim, SH;Kim, CH; Mitochondrial transplantation attenuates lipopolysaccharide-induced acute respiratory distress syndrome BMC pulmonary medicine 2024-09-27 [PMID: 39334020] (Mouse)
• Yin, W;Rajvanshi, PK;Rogers, HM;Yoshida, T;Kopp, JB;An, X;Gassmann, M;Noguchi, CT; Erythropoietin regulates energy metabolism through EPO-EpoR-RUNX1 axis Nature communications 2024-09-16 [PMID: 39284834] (Mouse)
• Kim, J;Kadayat, TM;Lee, JE;Kwon, S;Jung, K;Hwang, JS;Kwon, OB;Kim, YJ;Choi, YK;Park, KG;Hwang, H;Cho, SJ;Lee, T;Jeon, YH;Chin, J; Discovery of the therapeutic potential of PPAR? agonist bearing 1,3,4- thiadiazole in inflammatory disorders European journal of medicinal chemistry 2024-09-12 [PMID: 39270454] (Mouse)
• Xu, N;Wan, J;Wang, C;Chen, L; Serum CIAPIN1 is lower in septic patients with cardiac dysfunction Peptides 2024-09-04 [PMID: 39241831] (Rat)
• Pacifico, T;Stolfi, C;Tomassini, L;Luiz-Ferreira, A;Franzè, E;Ortenzi, A;Colantoni, A;Sica, GS;Sambucci, M;Monteleone, I;Monteleone, G;Laudisi, F; Rafoxanide negatively modulates STAT3 and NF-?B activity and inflammation-associated colon tumorigenesis Cancer science 2024-09-06 [PMID: 39239848] (Mouse)
• Kikuchi, K;Kazuma, S;Yamakage, M; Recombinant thrombomodulin and recombinant antithrombin attenuate pulmonary endothelial glycocalyx degradation and neutrophil extracellular trap formation in ventilator-induced lung injury in the context of endotoxemia Respiratory research 2024-09-03 [PMID: 39227918] (Mouse)
• Xie, F;Kitagawa, Y;Ogata, H;Yasuhara, S;You, Z;Jeevendra Martyn, JA; Morphine induces inflammatory responses via both TLR4 and cGAS-STING signaling pathways Cytokine 2024-08-31 [PMID: 39217915] (Mouse)
• Walter Jackson Iii, ;Yang, Y;Salman, S;Dordai, D;Lyu, Y;Datan, E;Drehmer, D;Huang, TY;Hwang, Y;Semenza, GL; Pharmacologic HIF stabilization activates costimulatory receptor expression to increase antitumor efficacy of adoptive T cell therapy Science advances 2024-08-30 [PMID: 39196939] (Transgenic Mouse)
• Kim, H;Choi, J;Seo, J;Lim, H;Kang, SK; CKD-497 inhibits NF-kB signaling and ameliorates inflammation and pulmonary fibrosis in ovalbumin-induced asthma and particulate matter-induced airway inflammatory diseases Frontiers in pharmacology 2024-08-07 [PMID: 39170711] (Mouse)
• Bernard, A;Eggstein, C;Tang, L;Keller, M;Körner, A;Mirakaj, V;Rosenberger, P; Plexin C1 influences immune response to intracellular LPS and survival in murine sepsis Journal of biomedical science 2024-08-21 [PMID: 39169397] (Transgenic Mouse)
• Su, J;Chen, K;Sang, X;Feng, Z;Zhou, F;Zhao, H;Wu, S;Deng, X;Lin, C;Lin, X;Xie, L;Ye, H;Chen, Q; Huperzine a ameliorates sepsis-induced acute lung injury by suppressing inflammation and oxidative stress via ?7 nicotinic acetylcholine receptor International immunopharmacology 2024-08-18 [PMID: 39159557] (Mouse)
• Su, J;Xiao, J;Deng, X;Lin, X;Xie, L;Ye, H;Lin, C;Zhou, F;Wu, S; Combining Aloin with TIENAM ameliorates cecal ligation and puncture-induced sepsis in mice by attenuating inflammation and modulating abdominal cavity microbiota International immunopharmacology 2024-08-17 [PMID: 39154534] (Mouse)
• Luo, KH;Tu, HP;Chang, HC;Yang, CC;Weng, WC;Chen, TH;Yang, CH;Chuang, HY; Mediation analysis for TNF-? as a mediator between multiple metal exposure and kidney function Ecotoxicology and environmental safety 2024-08-08 [PMID: 39121655] (Human)
• Liu, X;Cui, L;Tao, Y;Xia, S;Hou, J;Cao, X;Xu, S; The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response Cell reports 2024-08-08 [PMID: 39120972] (Mouse)
• Li, Z;Wang, S;Han, J;Shi, C;Xi, L;Cui, Y;Zhang, H; Expression of cytokine and Apoptosis-Associated genes in mice bone Marrow-Derived Macrophages stimulated with Brucella recombinant type IV secretion effectors Cytokine 2024-08-01 [PMID: 39094437] (Mouse)
• Tian, R;Li, R;Chen, Y;Liu, D;Li, Y;He, S;Pan, T;Qu, H;Tan, R; Shenfu injection ameliorates endotoxemia-associated endothelial dysfunction and organ injury via inhibiting PI3K/Akt-mediated glycolysis Journal of ethnopharmacology 2024-07-30 [PMID: 39089657] (Mouse)
• Bouredji, A;Muresan, B;Truong, XT;Lumière, L;Pourchez, J;Forest, V; An in vitro comparison of the toxicological profiles of ground tire particles (TP) and actual tire and road wear particles (TRWP) emissions Environment international 2024-07-14 [PMID: 39024828] (Mouse)
• Liu, J;Huang, B;Rao, Y;Guo, L;Cai, C;Gao, D;Kong, D;Wang, G;Xiong, Y;Cui, R;Zhang, M;Chen, C; Intraductal photothermal ablation: a noninvasive approach for early breast cancer treatment and prevention Theranostics 2024-07-01 [PMID: 38994019] (Mouse)
• Choi, SH;Shin, J;Park, C;Lee, JU;Lee, J;Ambo, Y;Shin, W;Yu, R;Kim, JY;Lah, JD;Shin, D;Kim, G;Noh, K;Koh, W;Lee, CJ;Lee, JH;Kwak, M;Cheon, J; In vivo magnetogenetics for cell-type-specific targeting and modulation of brain circuits Nature nanotechnology 2024-07-02 [PMID: 38956320] (Transgenic Mouse)
• Qasim, R;Thiab, TA;Alhindi, T;Al-Hunaiti, A;Imraish, A; The Nurr1 ligand indole acetic acid hydrazide loaded onto ZnFe2O4 nanoparticles suppresses proinflammatory gene expressions in SimA9 microglial cells Scientific reports 2024-06-17 [PMID: 38886466] (Mouse)
• Liu, X;Liu, Y;Su, X;Jiang, L;Tang, G;Wang, Y; Geranylgeranylacetone mitigates sepsis-associated intestinal injury through CHIP-dependent anti-inflammation and anti-oxidative effect International immunopharmacology 2024-05-23 [PMID: 38788444] (Mouse)
• Roy, S;Roy, S;Halder, S;Jana, K;Ukil, A; Leishmania exploits host cAMP/EPAC/calcineurin signaling to induce an IL-33-mediated anti-inflammatory environment for the establishment of infection The Journal of biological chemistry 2024-05-13 [PMID: 38750790] (Mouse)
• Zhang, Y;Jiang, H;Dong, M;Min, J;He, X;Tan, Y;Liu, F;Chen, M;Chen, X;Yin, Q;Zheng, L;Shao, Y;Li, X;Chen, H; Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation Cell reports 2024-05-28 [PMID: 38733581] (Mouse)
• Deng, M;Hou, Y;Liu, J;He, J;Lan, Z;Xiao, H; Mesenchymal stem cell-derived exosomes overexpressing SRC-3 protect mice from cerebral ischemia by inhibiting ferroptosis Brain research bulletin 2024-04-16 [PMID: 38614406] (Mouse)
• Park, B;Lee, S;Jang, YN;Park, HY; Affective dysfunction mediates the link between neuroimmune markers and the default mode network functional connectivity, and the somatic symptoms in somatic symptom disorder Brain, behavior, and immunity 2024-02-13 [PMID: 38360374] (Human)
• Ouyang, P;Cai, Z;Peng, J;Lin, S;Chen, X;Chen, C;Feng, Z;Wang, L;Song, G;Zhang, Z; SELENOK-dependent CD36 palmitoylation regulates microglial functions and A? phagocytosis Redox biology 2024-02-01 [PMID: 38320455] (Mouse)
• Zhang, Y;Song, Y;Wang, X;Shi, M;Lin, Y;Tao, D;Han, S; An NFAT1-C3a-C3aR Positive Feedback Loop in Tumor-Associated Macrophages Promotes a Glioma Stem Cell Malignant Phenotype Cancer immunology research 2024-01-30 [PMID: 38289255] (Mouse)
• Ko, JS;Chang, BY;Choi, YJ;Choi, JS;Kwon, HY;Lee, JY;Kim, SY;Choung, SY; Ashwagandha Ethanol Extract Attenuates Sarcopenia-Related Muscle Atrophy in Aged Mice Nutrients 2024-01-03 [PMID: 38201986] (Mouse)
• Duan, H;Hu, J;Deng, Y;Zou, J;Ding, W;Peng, Q;Duan, R;Sun, J;Zhu, J; Berberine Mediates the Production of Butyrate to Ameliorate Cerebral Ischemia via the Gut Microbiota in Mice Nutrients 2023-12-19 [PMID: 38201839] (Mouse)
• Chen, L;Mei, W;Song, J;Chen, K;Ni, W;Wang, L;Li, Z;Ge, X;Su, L;Jiang, C;Liu, B;Dai, C; CD163 protein inhibits lipopolysaccharide-induced macrophage transformation from M2 to M1 involved in disruption of the TWEAK-Fn14 interaction Heliyon 2024-01-15 [PMID: 38148798] (Mouse)
• Ye, D;Miyoshi, A;Ushitani, T;Kadoya, M;Igeta, M;Konishi, K;Shoji, T;Yasuda, K;Kitaoka, S;Yagi, H;Kuroda, E;Yamamoto, Y;Cheng, J;Koyama, H; RAGE in circulating immune cells is fundamental for hippocampal inflammation and cognitive decline in a mouse model of latent chronic inflammation Brain, behavior, and immunity 2023-12-22 [PMID: 38142917] (Transgenic Mouse)
• Chung, YC;Song, SJ;Lee, A;Jang, CH;Kim, CS;Hwang, YH; Isobavachin, a main bioavailable compound in Psoralea corylifolia, alleviates lipopolysaccharide-induced inflammatory responses in macrophages and zebrafish by suppressing the MAPK and NF-?B signaling pathways Journal of ethnopharmacology 2023-11-25 [PMID: 38012970] (Mouse)
• Lee, SG;Park, CH;Kang, H; Effect of E. cava and C. indicum Complex Extract on Phorbol 12-Myristate 13-Acetate (PMA)-Stimulated Inflammatory Response in Human Pulmonary Epithelial Cells and Particulate Matter (PM)2.5-Induced Pulmonary Inflammation in Mice Pharmaceutics 2023-11-13 [PMID: 38004599] (Mouse)
• Jin, Y;Ge, X;Xu, Y;Wang, S;Lu, Q;Deng, A;Li, J;Gu, Z; A pH-Responsive DNA Tetrahedron/Methotrexate Drug Delivery System Used for Rheumatoid Arthritis Treatment Journal of functional biomaterials 2023-11-03 [PMID: 37998110] (Mouse)
• Xu, M;Shi, F;Gao, Y;Han, S;Huang, C;Hou, Q;Wen, X;Wang, B;Zhu, Z;Zou, L;Xiong, M;Dong, W;Tan, J; Arabinose confers protection against intestinal injury by improving integrity of intestinal mucosal barrier International immunopharmacology 2023-11-22 [PMID: 37995573] (Mouse)
• Jung, SH;Chung, KS;Na, CS;Ahn, HS;Shin, YK;Lee, KT; Ethanol Extracts from the Aerial Parts of Inula japonica and Potentilla chinensis Alleviate Airway Inflammation in Mice That Inhaled Particulate Matter 10 and Diesel Particulate Matter Nutrients 2023-10-29 [PMID: 37960252] (Mouse)
• Wang, J;Ling, D;Shi, L;Li, H;Peng, M;Wen, H;Liu, T;Liang, R;Lin, Y;Wei, L;Zhang, G;Chen, S; METTL3-mediated m6A methylation regulates ovarian cancer progression by recruiting myeloid-derived suppressor cells Cell & bioscience 2023-11-06 [PMID: 37932814]
• Yuen, CK;Wong, WM;Mak, LF;Lam, JY;Cheung, LY;Cheung, DT;Ng, YY;Lee, AC;Zhong, N;Yuen, KY;Kok, KH; An interferon-integrated mucosal vaccine provides pan-sarbecovirus protection in small animal models Nature communications 2023-10-24 [PMID: 37875475] (Mouse)
• Kang, Z;Lin, Y;Su, C;Li, S;Xie, W;Wu, X; Hsp70 ameliorates sleep deprivation-induced anxiety-like behavior and cognitive impairment in mice Brain research bulletin 2023-10-17 [PMID: 37858682] (Mouse)
• Sun, C;Peng, S;Lv, Z;Guo, T;Zhang, L; Research of STEAP3 interaction with Rab7A and RACK1 to modulate the MAPK and JAK/STAT signaling in Osteoarthritis International immunopharmacology 2023-10-09 [PMID: 37820423] (Rat)
• Wang, C;Feng, L;Zhu, L;Wu, L;Chen, B;Cui, C;Yang, M;Gao, Y;Jiang, P; Cerebral endothelial cell-derived extracellular vesicles regulate microglial polarization and promote autophagy via delivery of miR-672-5p Cell death & disease 2023-09-29 [PMID: 37773169] (Mouse)
• Su, J;Guan, B;Su, Q;Hu, S;Wu, S;Tong, Z;Zhou, F; Fucoxanthin Ameliorates Sepsis via Modulating Microbiota by Targeting IRF3 Activation International journal of molecular sciences 2023-09-07 [PMID: 37762104] (Mouse)
• Zhao, L;Song, R;Liu, Y; Glycolytic metabolite phosphoenolpyruvate protects host from viral infection through promoting AATK expression European journal of immunology 2023-09-19 [PMID: 37724936] (Mouse)
• Shlykova, O;Izmailova, O;Kabaliei, A;Palchyk, V;Shynkevych, V;Kaidashev, I; PPARG stimulation restored lung mRNA expression of core clock, inflammation- and metabolism-related genes disrupted by reversed feeding in male mice Physiological reports 2023-09-01 [PMID: 37704580] (Mouse)
• Sukkasem, K;Itharat, A;Thisayakorn, K;Tangsuphoom, N;Panthong, S;Makchuchit, S;Inprasit, J;Prommee, N;Khoenok, W;Sriyam, K;Pahusee, D;Tasanarong, A;Ooraikul, B;Davies, NM; Exploring in vitro and in vivo anti-inflammatory activities of the Thai traditional remedy Kheaw-Hom and its bioactive compound, ethyl p-methoxycinnamate, and ethnopharmacological analysis Journal of ethnopharmacology 2023-09-07 [PMID: 37689327] (Mouse)
• Lê, HG;Kang, JM;Võ, TC;Yoo, WG;Na, BK; Naegleria fowleri Extracellular Vesicles Induce Proinflammatory Immune Responses in BV-2 Microglial Cells International journal of molecular sciences 2023-09-03 [PMID: 37686429] (Mouse)
• Li, C;Liu, J;Zhang, C;Cao, L;Zou, F;Zhang, Z; Dihydroquercetin (DHQ) ameliorates LPS-induced acute lung injury by regulating macrophage M2 polarization through IRF4/miR-132-3p/FBXW7 axis Pulmonary pharmacology & therapeutics 2023-08-28 [PMID: 37648017] (Mouse)
• Schroer, AB;Ventura, PB;Sucharov, J;Misra, R;Chui, MKK;Bieri, G;Horowitz, AM;Smith, LK;Encabo, K;Tenggara, I;Couthouis, J;Gross, JD;Chan, JM;Luke, A;Villeda, SA; Platelet factors attenuate inflammation and rescue cognition in ageing Nature 2023-08-16 [PMID: 37587343] (Mouse)
• Abasubong, KP;Jiang, GZ;Guo, HX;Wang, X;Huang, YY;Dai, YJ;Li, XF;Yanzou, D;Gabriel, NN;Liu, WB; Oral bovine serum albumin administration alleviates inflammatory signals and improves antioxidant capacity and immune response under thioacetamide stress in blunt snout bream fed a high-calorie diet Fish & shellfish immunology 2023-08-12 [PMID: 37579810] (Fish)
• Jin, J;Fan, YJ;Nguyen, TV;Yu, ZN;Song, CH;Lee, SY;Shin, HS;Chai, OH; Fallopia japonica Root Extract Ameliorates Ovalbumin-Induced Airway Inflammation in a CARAS Mouse Model by Modulating the IL-33/TSLP/NF-?B Signaling Pathway International journal of molecular sciences 2023-08-07 [PMID: 37569890] (Mouse)
• Su, J;Chen, S;Xiao, J;Feng, Z;Hu, S;Su, Q;Chen, Q;Chen, D; Aloe-Emodin Ameliorates Cecal Ligation and Puncture-Induced Sepsis International journal of molecular sciences 2023-07-26 [PMID: 37569344] (Mouse)
• Hu, C;Zhang, B;Zhao, S; METTL3-mediated N6-methyladenosine modification stimulates mitochondrial damage and ferroptosis of kidney tubular epithelial cells following acute kidney injury by modulating the stabilization of MDM2-p53-LMNB1 axis European journal of medicinal chemistry 2023-11-05 [PMID: 37542992] (Mouse)
• Bagon, BB;Lee, J;Matienzo, ME;Lee, SJ;Pak, SW;Kim, K;Lee, J;Lee, CM;Shin, IS;Moon, C;Park, MJ;Kim, DI; Cold-induced adaptive thermogenesis is impaired by exposure of Asian sand dust in mice Journal of thermal biology 2023-07-26 [PMID: 37517326] (Mouse)
• Fan, H;Liu, S;Jiao, B;Liang, X; Low‑dose ionizing radiation attenuates high glucose‑induced hepatic apoptosis and immune factor release via modulation of a miR‑155‑SOCS1 axis Molecular medicine reports 2023-09-01 [PMID: 37503757] (Mouse)
• Bai, Y;Min, R;Chen, P;Mei, S;Deng, F;Zheng, Z;Jiang, C;Miao, R;Wu, Z;Zhang, P;Pan, Y;Lieberman, J;Liu, X; Disulfiram blocks inflammatory TLR4 signaling by targeting MD-2 Proceedings of the National Academy of Sciences of the United States of America 2023-08-01 [PMID: 37487070] (Mouse)
• Tawarayama, H;Umeki, K;Inoue-Yanagimachi, M;Takahashi, N;Hasegawa, H;Himori, N;Tsuda, S;Kunikata, H;Akaike, T;Nakazawa, T; Glutathione trisulfide prevents lipopolysaccharide-induced retinal inflammation via inhibition of proinflammatory cytokine production in glial cells Scientific reports 2023-07-17 [PMID: 37460786] (Mouse)
• Lin, JB;Mora, A;Wang, TJ;Santeford, A;Usmani, D;Ligon, MM;Mysorekar, IU;Apte, RS; Loss of stearoyl-CoA desaturase 2 disrupts inflammatory response in macrophages mBio 2023-07-07 [PMID: 37417745] (Mouse)
• Lee, HS;Kwon, YJ;Seo, EB;Kim, SK;Lee, H;Lee, JT;Chang, PS;Choi, YJ;Lee, SH;Ye, SK; Anti-inflammatory effects of Allium cepa L. peel extracts via inhibition of JAK-STAT pathway in LPS-stimulated RAW264.7 cells Journal of ethnopharmacology 2023-06-27 [PMID: 37385574] (Mouse)
• Dossou, AS;Mantsch, ME;Kapic, A;Burnett, WL;Sabnis, N;Coffer, JL;Berg, RE;Fudala, R;Lacko, AG; Mannose-Coated Reconstituted Lipoprotein Nanoparticles for the Targeting of Tumor-Associated Macrophages: Optimization, Characterization, and In Vitro Evaluation of Effectiveness Pharmaceutics 2023-06-08 [PMID: 37376134] (Mouse)
• Lin, CH;Kuo, YH;Shih, CC; Antidiabetic and Immunoregulatory Activities of Extract of Phyllanthus emblica L. in NOD with Spontaneous and Cyclophosphamide-Accelerated Diabetic Mice International journal of molecular sciences 2023-06-08 [PMID: 37373070] (Mouse)
• Fan, D;Jin, Z;Cao, J;Li, Y;He, T;Zhang, W;Peng, L;Liu, H;Wu, X;Chen, M;Fan, Y;He, B;Yu, W;Wang, H;Hu, X;Lu, Z; Leucine zipper protein 1 prevents doxorubicin-induced cardiotoxicity in mice Redox biology 2023-06-18 [PMID: 37354826] (Transgenic Mouse, Mouse)
• Matsumura, D;Kawao, N;Okumoto, K;Ohira, T;Mizukami, Y;Akagi, M;Kaji, H; Effects of elastase-induced emphysema on muscle and bone in mice PloS one 2023-06-23 [PMID: 37352205] (Mouse)
• Liu, PY;Chen, CY;Lin, YL;Lin, CM;Tsai, WC;Tsai, YL;Lin, GJ;Chen, YG;Wang, SY;Sun, RN;Huang, YC;Chang, H;Chen, YC; RNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injury Cell death & disease 2023-06-21 [PMID: 37344492] (Mouse)
• Youn, C;Pontaza, C;Wang, Y;Dikeman, DA;Joyce, DP;Alphonse, MP;Wu, MJ;Nolan, SJ;Anany, MA;Ahmadi, M;Young, J;Tocaj, A;Garza, LA;Wajant, H;Miller, LS;Archer, NK; Neutrophil-intrinsic TNF receptor signaling orchestrates host defense against Staphylococcus aureus Science advances 2023-06-16 [PMID: 37327341] (Mouse)
• Lou, C;Lin, C;Wang, W;Jiang, H;Cai, T;Lin, S;Xue, X;Lin, J;Pan, X; Extracts of Oldenlandia diffusa protects chondrocytes via inhibiting apoptosis and associated inflammatory response in osteoarthritis Journal of ethnopharmacology 2023-06-07 [PMID: 37295574] (Mouse)
• Piao, X;Duan, J;Jiang, N;Liu, S;Hou, N;Chen, Q; Schistosoma japonicum Tyrosine Hydroxylase is promising targets for immunodiagnosis and immunoprotection of Schistosomiasis japonica PLoS neglected tropical diseases 2023-06-05 [PMID: 37276235] (Mouse)
• Feng, W;Zhong, XQ;Zheng, XX;Liu, QP;Liu, MY;Liu, XB;Lin, CS;Xu, Q; The Underlying Mechanism of Duanteng Yimu Decoction in Inhibiting Synovial Hyperplasia in Rheumatoid Arthritis Journal of immunology research 2023-05-21 [PMID: 37252680] (Mouse)
• Su, P;Zhang, J;Wu, J;Chen, H;Luo, W;Hu, M; TREM2 expression on the microglia resolved lead exposure-induced neuroinflammation by promoting anti-inflammatory activities Ecotoxicology and environmental safety 2023-05-26 [PMID: 37245276] (Mouse)
• Geng, S;Hao, P;Wang, D;Zhong, P;Tian, F;Zhang, R;Qiao, J;Qiu, X;Bao, P; Zinc oxide nanoparticles have biphasic roles on Mycobacterium-induced inflammation by activating autophagy and ferroptosis mechanisms in infected macrophages Microbial pathogenesis 2023-05-16 [PMID: 37201638] (Mouse)
• Payne, A;Taka, E;Adinew, GM;Soliman, KFA; Molecular Mechanisms of the Anti-Inflammatory Effects of Epigallocatechin 3-Gallate (EGCG) in LPS-Activated BV-2 Microglia Cells Brain sciences 2023-04-07 [PMID: 37190597] (Mouse)
• S Piñeiro-He, G Bosso, R Sánchez-Vá, P Martínez, MA Blasco Telomerase deficiency and dysfunctional telomeres in the lung tumor microenvironment impair tumor progression in NSCLC mouse models and patient-derived xenografts Cell Death and Differentiation, 2023-04-21;0(0):. 2023-04-21 [PMID: 37085672] (Mouse)
• JY Sun, LJ Du, XR Shi, YY Zhang, Y Liu, YL Wang, BY Chen, T Liu, H Zhu, Y Liu, CC Ruan, Z Gan, H Ying, Z Yin, PJ Gao, X Yan, RG Li, SZ Duan An IL-6/STAT3/MR/FGF21 axis mediates heart-liver cross-talk after myocardial infarction Science Advances, 2023-04-05;9(14):eade4110. 2023-04-05 [PMID: 37018396] (Mouse)
• K Ann Shirey, W Lai, M Sunday, F Cuttitta, J Cg Blanco, SN Vogel Novel neuroendocrine role of gamma-aminobutyric acid and gastrin releasing peptide in the host response to influenza infection Mucosal Immunology, 2023-03-24;0(0):. 2023-03-24 [PMID: 36965691] (Mouse)
• L Xiao, L Li, J Huang, Y Luan, J Pan, Y Gai, Z Xu Salidroside attenuates lipopolysaccharide-induced neuroinflammation and cognitive impairment in septic encephalopathy mice International immunopharmacology, 2023-03-20;117(0):109975. 2023-03-20 [PMID: 36948107] (Mouse)
• A Naraiah Mu, R Petrut, R Goldfarb, E Leigh Bero, C Ho Leung, Z Khan, M Ailenberg, M Jerkic, AC Andreazza, SG Rhind, MG Jeschke, A Kapus, OD Rotstein Augmented Parkin-dependent mitophagy underlies the hepatoprotective effect of remote ischemic conditioning used prior to hemorrhagic shock Mitochondrion, 2023-03-10;70(0):20-30. 2023-03-10 [PMID: 36906251] (Mouse)
• LM Christman, GP Wang, TL Washington, L Gu Muscadine Grape (Vitis rotundifolia) and Wine Polyphenols Alleviated Arthritis and Restored the Gut Microbial Composition in Mice The Journal of nutritional biochemistry, 2023-03-04;0(0):109311. 2023-03-04 [PMID: 36878329] (Mouse)
• G Zhou, Q Ye, Y Xu, B He, L Wu, G Zhu, J Xie, L Yao, Z Xiao Mitochondrial calcium uptake 3 mitigates cerebral amyloid angiopathy-related neuronal death and glial inflammation by reducing mitochondrial dysfunction International immunopharmacology, 2023-03-04;117(0):109614. 2023-03-04 [PMID: 36878048] (Mouse)
• SY Park, MW Kim, JH Kang, HJ Jung, JH Hwang, SJ Yang, JK Woo, Y Jeon, H Lee, YS Yoon, JK Seong, SH Oh Novel NF-kappaB reporter mouse for the non-invasive monitoring of inflammatory diseases Scientific Reports, 2023-03-02;13(1):3556. 2023-03-02 [PMID: 36864088] (Mouse)
• HH Kim, YR Shim, SE Choi, TE Falana, JK Yoo, SH Ahn, M Park, H Seo, C Choi, WI Jeong Exosome-Based Delivery of Super-Repressor IkappaBalpha Alleviates Alcohol-Associated Liver Injury in Mice Pharmaceutics, 2023-02-14;15(2):. 2023-02-14 [PMID: 36839957] (Mouse)
• S Michurina, I Stafeev, M Boldyreva, VA Truong, E Ratner, M Menshikov, YC Hu, Y Parfyonova Transplantation of Adipose-Tissue-Engineered Constructs with CRISPR-Mediated UCP1 Activation International Journal of Molecular Sciences, 2023-02-14;24(4):. 2023-02-14 [PMID: 36835254] (Mouse)
• J Zhu, MJ Lee, JH An, E Oh, W Chung, JY Heo ATF5 Attenuates the Secretion of Pro-Inflammatory Cytokines in Activated Microglia International Journal of Molecular Sciences, 2023-02-07;24(4):. 2023-02-07 [PMID: 36834738] (Mouse)
• A Bright, F Li, M Movahed, H Shi, B Xue Chronic Exposure to Low-Molecular-Weight Polycyclic Aromatic Hydrocarbons Promotes Lipid Accumulation and Metabolic Inflammation Biomolecules, 2023-01-18;13(2):. 2023-01-18 [PMID: 36830566] (Mouse)
• DW Chen, T Kang, XZ Xu, WJ Xia, X Ye, YB Wu, YR Xu, J Liu, H Ren, J Deng, YK Chen, HQ Ding, M Aslam, WM Zelek, BP Morgan, R Kapur, S Santoso, YS Fu Mechanism and intervention of murine transfusion-related acute lung injury caused by anti-CD36 antibodies JCI Insight, 2023-03-22;0(0):. 2023-03-22 [PMID: 36809299] (Mouse)
• Y Fujino, S Kanmura, Y Morinaga, I Kojima, N Maeda, A Tanaka, H Maeda, K Kumagai, F Sasaki, S Tanoue, A Ido Hepatocyte growth factor ameliorates dextran sodium sulfate?induced colitis in a mouse model by altering the phenotype of intestinal macrophages Molecular Medicine Reports, 2023-02-17;27(3):. 2023-02-17 [PMID: 36799161] (Mouse)
• SR Giri, B Bhoi, C Trivedi, A Rath, R Rathod, A Sharma, R Ranvir, S Kadam, K Ingale, H Patel, A Nyska, MR Jain Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet BMC Cancer, 2023-01-17;23(1):59. 2023-01-17 [PMID: 36650455] (Mouse)
• HR Kim, EM Noh, SY Kim Anti-inflammatory effect and signaling mechanism of 8-shogaol and 10-shogaol in a dextran sodium sulfate-induced colitis mouse model Heliyon, 2023-01-05;9(1):e12778. 2023-01-05 [PMID: 36647352] (Mouse)
• L Interdonat, Y Marino, GA Franco, A Arangia, R D'Amico, R Siracusa, M Cordaro, D Impellizze, R Fusco, S Cuzzocrea, RD Paola A�ai Berry Administration Promotes Wound Healing through Wnt/beta-Catenin Pathway International Journal of Molecular Sciences, 2023-01-03;24(1):. 2023-01-03 [PMID: 36614291] (Mouse)
• M Soltani, M Pourfarzam, AH Sharifabad, AK Neisiani, MK Mousavi, M Aliomrani Effect of pretreatment with a synbiotic on Perfluorooctanoic acid-induced liver damage after sub-acute oral exposure in C57BL/6J mice Toxicology and Applied Pharmacology, 2022-12-23;459(0):116360. 2022-12-23 [PMID: 36572227] (Mouse)
• A Saga, M Koseki, K Kanno, J Chang, T Higo, D Okuzaki, T Okada, H Inui, M Asaji, K Tanaka, T Omatsu, S Nishihara, Y Zhu, K Ito, H Hattori, I Ichi, Y Kamada, M Ono, T Saibara, T Ohama, S Hikoso, M Nishida, S Yamashita, Y Sakata A Dietary Oxysterol, 7-Ketocholesterol, Exacerbates Imiquimod-Induced Psoriasis-like Dermatitis in Steatohepatitic Mice International Journal of Molecular Sciences, 2022-12-13;23(24):. 2022-12-13 [PMID: 36555497] (Mouse)
• N Cuesta, S Fernández-, C Punzón, C Moreno, B Barrocal, V Sreeramkum, M Desco, M Fresno Opposing Actions of TLR2 and TLR4 in Adipocyte Differentiation and Mature-Onset Obesity International Journal of Molecular Sciences, 2022-12-10;23(24):. 2022-12-10 [PMID: 36555322] (Mouse)
• H Gu, HJ An, MG Gwon, S Bae, CC Zouboulis, KK Park The Effects of Synthetic SREBP-1 and PPAR-gamma Decoy Oligodeoxynucleotide on Acne-like Disease In Vivo and In Vitro via Lipogenic Regulation Biomolecules, 2022-12-12;12(12):. 2022-12-12 [PMID: 36551286] (Mouse)
• YH Kwon, S Banskota, H Wang, L Rossi, JA Grondin, SA Syed, Y Yousefi, JD Schertzer, KM Morrison, MG Wade, AC Holloway, MG Surette, GR Steinberg, WI Khan Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice Nature Communications, 2022-12-20;13(1):7617. 2022-12-20 [PMID: 36539404] (Mouse)
• C Lu, S Li, M Jin Rapamycin Inhibits Light-Induced Necrosome Activation Occurring in Wild-Type, but not RPE65-Null, Mouse Retina Investigative Ophthalmology & Visual Science, 2022-12-01;63(13):19. 2022-12-01 [PMID: 36534385] (Mouse)
• V Martins, SS Santos, LOCP Rodrigues, R Salomao, L Liaudet, C Szabo Efficacy of Clinically Used PARP Inhibitors in a Murine Model of Acute Lung Injury Cells, 2022-11-26;11(23):. 2022-11-26 [PMID: 36497049] (Mouse)
• R Ohue-Kitan, H Nonaka, A Nishida, Y Masujima, D Takahashi, T Ikeda, A Uwamizu, M Tanaka, M Kohjima, M Igarashi, H Katoh, T Tanaka, A Inoue, T Suganami, K Hase, Y Ogawa, J Aoki, I Kimura Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84 JCI Insight, 2023-01-24;0(0):. 2023-01-24 [PMID: 36480287] (Mouse)
• Y Nishimoto, D Ando, K Irie, I Kainuma, Y Katayama, S Sato, T Suzuki, M Harada, T Yoshida, K Ito, Y Kizawa Dasatinib attenuates airway inflammation of asthma exacerbation in mice induced by house dust mites and dsRNA Biochemistry and Biophysics Reports, 2022-12-02;33(0):101402. 2022-12-02 [PMID: 36478895] (Mouse)
• TK Kim, EJ Bae, BC Jung, M Choi, SJ Shin, SJ Park, JT Kim, MK Jung, A Ulusoy, MY Song, JS Lee, HJ Lee, DA Di Monte, SJ Lee Inflammation promotes synucleinopathy propagation Experimental & Molecular Medicine, 2022-12-06;0(0):. 2022-12-06 [PMID: 36473937] (Mouse)
• J Yan, Y Zhang, H Yu, Y Zong, D Wang, J Zheng, L Jin, X Yu, C Liu, Y Zhang, F Jiang, R Zhang, X Fang, T Xu, M Li, J Di, Y Lu, X Ma, J Zhang, W Jia, C Hu GPSM1 impairs metabolic homeostasis by controlling a pro-inflammatory pathway in macrophages Nature Communications, 2022-11-25;13(1):7260. 2022-11-25 [PMID: 36434066] (Mouse)
• J Lee, S Kim, CH Kang Immunostimulatory Activity of Lactic Acid Bacteria Cell-Free Supernatants through the Activation of NF-kappaB and MAPK Signaling Pathways in RAW 264.7 Cells Microorganisms, 2022-11-13;10(11):. 2022-11-13 [PMID: 36422317] (Mouse)
• C Wang, X Li, B Xue, C Yu, L Wang, R Deng, H Liu, Z Chen, Y Zhang, S Fan, C Zuo, H Sun, H Zhu, J Wang, S Tang RasGRP1 promotes the acute inflammatory response and restricts inflammation-associated cancer cell growth Nature Communications, 2022-11-16;13(1):7001. 2022-11-16 [PMID: 36385095] (Mouse)
• J Luo, J Tan, J Zhao, L Wang, J Liu, X Dai, Y Sun, Q Kuang, J Hui, J Chen, G Kuang, S Chen, Y Wang, C Ge, M Xu Cynapanoside A exerts protective effects against obesity-induced diabetic nephropathy through ameliorating TRIM31-mediated inflammation, lipid synthesis and fibrosis International immunopharmacology, 2022-11-11;113(0):109395. 2022-11-11 [PMID: 36375322] (Mouse)
• GK Vivian, RO da Silva, ACA Santos, AA Hastreiter, CC Dias, EN Makiyama, P Borelli, C de Oliveir, RA Fock The interaction between aging and protein malnutrition modulates peritoneal macrophage function: An experimental study in male mice Experimental gerontology, 2022-11-11;171(0):112025. 2022-11-11 [PMID: 36372284] (Mouse)
• AJ Vesting, A Jais, P Klemm, L Steuernage, P Wienand, M Fog-Tonnes, H Hvid, AL Schumacher, C Kukat, H Nolte, T Georgomano, J Altmüller, M Pasparakis, A Schmidt, M Krüger, MS Supprian, A Waisman, BK Straub, N Raschzok, M Bernier, AL Birkenfeld, N Hövelmeyer, JC Brüning, FT Wunderlich NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition Molecular Metabolism, 2022-11-07;66(0):101626. 2022-11-07 [PMID: 36356831] (Mouse)
• P Selvam, CM Cheng, HU Dahms, VK Ponnusamy, YY Sun AhR Mediated Activation of Pro-Inflammatory Response of RAW 264.7 Cells Modulate the Epithelial-Mesenchymal Transition Toxics, 2022-10-27;10(11):. 2022-10-27 [PMID: 36355934] (Mouse)
• TK Kim, S Jeon, S Park, SK Sonn, S Seo, J Suh, J Jin, HY Kweon, S Kim, SH Moon, O Kweon, BH Koo, N Kim, HO Lee, YM Kim, YJ Kim, SH Park, GT Oh 2&#039;-5&#039; oligoadenylate synthetase?like 1 (OASL1) protects against atherosclerosis by maintaining endothelial nitric oxide synthase mRNA stability Nature Communications, 2022-11-04;13(1):6647. 2022-11-04 [PMID: 36333342] (Mouse)
• W Bi, J Zhang, Z Zeng, R Zhou, J Zhao, W Yan, L Wang, X Li, L Zhu Ubiquitin?specific protease 8 ameliorates lipopolysaccharide?induced spleen injury via suppression of NF?kappaB and MAPK signaling pathways Molecular Medicine Reports, 2022-11-02;26(6):. 2022-11-02 [PMID: 36321796] (Mouse)
• K Tange, S Yagi, E Takeshita, M Abe, Y Yamamoto, H Tomida, T Kawamura, M Hanayama, B Matsuura, Y Ikeda, Y Hiasa Oral administration of human carbonic anhydrase I suppresses colitis in a murine inflammatory bowel disease model Scientific Reports, 2022-10-26;12(1):17983. 2022-10-26 [PMID: 36289244] (Mouse)
• DK Lee, T Kim, J Byeon, M Park, S Kim, J Kim, S Choi, G Lee, C Park, KW Lee, YJ Kwon, JH Lee, YG Kwon, YM Kim REDD1 promotes obesity-induced metabolic dysfunction via atypical NF-kappaB activation Nature Communications, 2022-10-22;13(1):6303. 2022-10-22 [PMID: 36272977] (Mouse)
• C Ge, J Tan, X Dai, Q Kuang, S Zhong, L Lai, C Yi, Y Sun, J Luo, C Zhang, L Zhu, B Wang, M Xu Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by targeting FAK Oncogene, 2022-10-08;13(1):5945. 2022-10-08 [PMID: 36209205] (Mouse)
• D Wang, Y Lin, F Xu, H Zhang, X Zhu, Z Liu, Y Hu, G Dong, B Sun, Y Yu, G Ma, Z Tang, D Legarda, A Ting, Y Liu, J Hou, L Dong, H Xiong SIRPalpha maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis EBioMedicine, 2022-10-03;85(0):104278. 2022-10-03 [PMID: 36202053] (Mouse)
• M Jones-Muha, Q Shao, JP Warrington Increased seizure sensitivity in pregnant mice with genetic knockdown of acid sensing ion channel 2a is associated with impaired hippocampal inflammatory response Frontiers in Physiology, 2022-09-14;13(0):983506. 2022-09-14 [PMID: 36187797] (Mouse)
• A Hasan, S Devi Ms, G Sharma, V Narayanan, P Sathiyaraj, S Vinayak, S Sunil Vathasura Kudineer, an Andrographis based polyherbal formulation exhibits immunomodulation and inhibits chikungunya virus (CHIKV) under in-vitro conditions Journal of ethnopharmacology, 2022-09-29;0(0):115762. 2022-09-29 [PMID: 36181982] (Mouse)
• M Shayan, F Eslami, A Amanlou, S Solaimania, N Rahimi, A Rashidian, S Ejtemaei-M, M Ghasemi, AR Dehpour Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or KATP channels inhibitors Toxicology and Applied Pharmacology, 2022-09-23;454(0):116254. 2022-09-23 [PMID: 36155770] (Mouse)
• S Ortega-Peñ, M Chopin-Dor, A Tejeda-Fer, DM Giraldo-Gó, RM Salgado, E Krötzsch Dialkyl Carbamoyl Chloride-Coated Dressing Prevents Macrophage and Fibroblast Stimulation via Control of Bacterial Growth: An In Vitro Assay Microorganisms, 2022-09-13;10(9):. 2022-09-13 [PMID: 36144427] (Mouse)
• Y Guo, F Xu, SC Thomas, Y Zhang, B Paul, S Sakilam, S Chae, P Li, C Almeter, AR Kamer, P Arora, DT Graves, D Saxena, X Li Targeting the succinate receptor effectively inhibits periodontitis Cell Reports, 2022-09-20;40(12):111389. 2022-09-20 [PMID: 36130514] (Mouse)
• T Suda, T Hanawa, M Tanaka, Y Tanji, K Miyanaga, S Hasegawa-I, K Shirato, T Kizaki, T Matsuda Modification of the immune response by bacteriophages alters methicillin-resistant Staphylococcus aureus infection Scientific Reports, 2022-09-19;12(1):15656. 2022-09-19 [PMID: 36123529] (Mouse)
• K Thomas, L Zondler, N Ludwig, M Kardell, C Lüneburg, K Henke, S Mersmann, A Margraf, T Spieker, T Tekath, A Velic, R Holtmeier, J Hermann, V Jankowski, M Meersch, D Vestweber, M Westphal, J Roth, MA Schäfers, JA Kellum, CA Lowell, J Rossaint, A Zarbock Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells JCI Insight, 2022-11-08;7(21):. 2022-11-08 [PMID: 36107633] (Mouse)
• NJ Lai, EL Ngu, JR Pang, KH Wong, C Ardianto, LC Ming, SH Lim, SG Walvekar, A Anwar, YY Yow Carrageenophyte Kappaphycus malesianus Inhibits Microglia-Mediated Neuroinflammation via Suppression of AKT/NF-kappaB and ERK Signaling Pathways Marine Drugs, 2022-08-20;20(8):. 2022-08-20 [PMID: 36005538] (Mouse)
• H Kim, L Rahmawati, YH Hong, SY Choi, JY Cho NK cell-mediated immunostimulatory effects of ethanol extract of Morinda citrifolia (noni) fruit BMC complementary medicine and therapies, 2022-08-22;22(1):222. 2022-08-22 [PMID: 35996139] (Mouse)
• HG Lê, JM Kang, TC Võ, BK Na Naegleria fowleri Cathepsin B Induces a Pro-Inflammatory Immune Response in BV-2 Microglial Cells via NF-kappaB and AP-1 Dependent-MAPK Signaling Pathway International Journal of Molecular Sciences, 2022-07-29;23(15):. 2022-07-29 [PMID: 35955520] (Mouse)
• MK Abdel-Rafe, NM Thabet, MM Amin Concerted regulation of OPG/RANKL/ NF?kappaB/MMP-13 trajectories contribute to ameliorative capability of prodigiosin and/or low dose gamma-radiation against adjuvant- induced arthritis in rats International immunopharmacology, 2022-08-06;111(0):109068. 2022-08-06 [PMID: 35944459] (Mouse)
• Y Wang, Y Li, Z Chen, Y Yuan, Q Su, K Ye, C Chen, G Li, Y Song, H Chen, Y Xu GSDMD-dependent neutrophil extracellular traps promote macrophage-to-myofibroblast transition and renal fibrosis in obstructive nephropathy Cell Death & Disease, 2022-08-08;13(8):693. 2022-08-08 [PMID: 35941120] (Mouse)
• A Hudák, G Morgan, J Bacovsky, R Patai, TF Polgár, A Letoha, A Pettko-Sza, C Vizler, L Szilák, T Letoha Biodistribution and Cellular Internalization of Inactivated SARS-CoV-2 in Wild-Type Mice International Journal of Molecular Sciences, 2022-07-09;23(14):. 2022-07-09 [PMID: 35886958] (Mouse)
• Y Xia, P Meng, S Liu, Z Tan, X Yang, L Liang, F Xie, H Zhang, G Wang, Z Xiong, J Lo, L Ai Structural and Potential Functional Properties of Alkali-Extracted Dietary Fiber From Antrodia camphorata Frontiers in Microbiology, 2022-07-07;13(0):921164. 2022-07-07 [PMID: 35875549] (Mouse)
• S Pradhan, Snehlata, D Manna, S Karmakar, MK Singh, A Bhattachar, B Mukherjee, J Paul Activation of TLR-pathway to induce host Th1 immune response against visceral leishmaniasis: Involvement of galactosylated-flavonoids Heliyon, 2022-07-03;8(7):e09868. 2022-07-03 [PMID: 35847617] (Mouse)
• T Yamasaki, T Horie, S Koyama, T Nakao, O Baba, M Kimura, N Sowa, K Sakamoto, K Yamazaki, S Obika, Y Kasahara, J Kotera, K Oka, R Fujita, T Sasaki, A Takemiya, K Hasegawa, K Minatoya, T Kimura, K Ono Inhibition of microRNA-33b specifically ameliorates abdominal aortic aneurysm formation via suppression of inflammatory pathways Scientific Reports, 2022-07-14;12(1):11984. 2022-07-14 [PMID: 35835906] (Mouse)
• EJ Bae, M Choi, JT Kim, DK Kim, MK Jung, C Kim, TK Kim, JS Lee, BC Jung, SJ Shin, KH Rhee, SJ Lee TNF-alpha promotes alpha-synuclein propagation through stimulation of senescence-associated lysosomal exocytosis Oncogene, 2022-07-05;0(0):. 2022-07-05 [PMID: 35790884] (Mouse)
• E Hee Jo, J Eun Moon, M Han Chang, Y Jin Lim, J Hyun Park, S Hee Lee, Y Rae Cho, AE Cho, S Pil Pack, HW Kim, L Crowley, B Le, AB Nukhet, Y Chen, Y Zhong, J Zhao, Y Li, H Cha, J Hoon Pan, J Kyeom Kim, J Hyup Lee Sensitization of GSH synthesis by curcumin curtails acrolein-induced alveolar epithelial apoptosis via Keap1 cysteine conjugation: A randomized controlled trial and experimental animal model of pneumonitis Journal of advanced research, 2022-06-27;0(0):. 2022-06-27 [PMID: 35772713] (Mouse)
• AP Young, EM Denovan-Wr Synthetic cannabinoids reduce the inflammatory activity of microglia and subsequently improve neuronal survival in vitro Brain, Behavior, and Immunity, 2022-06-25;105(0):29-43. 2022-06-25 [PMID: 35764268] (Mouse)
• M Tlili, H Acevedo, A Descoteaux, M Germain, KM Heinonen Cell-intrinsic Wnt4 ligand regulates mitochondrial oxidative phosphorylation in macrophages The Journal of Biological Chemistry, 2022-06-25;0(0):102193. 2022-06-25 [PMID: 35764169] (Mouse)
• L Dayani, MS Dinani, M Aliomrani, H Hashempour, J Varshosaz, A Taheri Immunomodulatory effects of cyclotides isolated from Viola odorata in an experimental autoimmune encephalomyelitis animal model of multiple sclerosis Oncogene, 2022-06-10;64(0):103958. 2022-06-10 [PMID: 35716476] (Mouse)
• S Ambreen, S Fatima, A Elwakiel, R Rana, K Singh, A Gupta, D Gupta, H Khawaja, J Manoharan, C Besler, U Laufs, S Kohli, B Isermann, K Shahzad Hypercoagulability Impairs Plaque Stability in Diabetes-Induced Atherosclerosis Nutrients, 2022-05-10;14(10):. 2022-05-10 [PMID: 35631132] (Mouse)
• C Shi, S Wang, J Han, L Xi, M Li, Z Li, H Zhang Functional insights into Brucella transcriptional regulator ArsR Microbial pathogenesis, 2022-05-24;168(0):105557. 2022-05-24 [PMID: 35623565] (Mouse)
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• Megid J, Kaneno R, Nozaki CN, Brito CJ, Almeida MF Increased interleukin-10 associated with low IL-6 concentration correlated with greater survival rates in mice infected by rabies virus vaccinated against it and immunomodulated with P. acnes. Comp. Immunol. Microbiol. Infect. Dis., 2004-11-01;27(6):393-411. 2004-11-01 [PMID: 15325513] (Mouse)
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• Hao Z, Hampel B, Yagita H, Rajewsky K T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J. Exp. Med., 2004-05-17;199(10):1355-65. 2004-05-17 [PMID: 15148335] (Mouse)
• LaBue M, Colburn KK, Green LM Thyrocytes isolated from autoimmune-diseased thyroids secrete soluble tumor necrosis factor-R1 that is related to their elevated protein kinase C activity. Thyroid, 2004-04-01;14(4):249-62. 2004-04-01 [PMID: 15142358] (Mouse)
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FAQs for TNF-alpha (MTA00B). (Showing 1 - 4 of 4 FAQs).

1. I need to know about TNF-alpha antibody kits for mice.
   • We currently have two TNFalpha ELISA kits specific for mouse: catalog numbers KA0257 and NBP1-92670.
2. I would like to ask you for help. I need an antibody for Elisa to detect human TNF alpha in a supernatant from a cell culture (meaning supernatant after centrifugation of collected cell suspension from a plate well). Which of your antibodies against human tnf alpha would be suitable? I would like to buy only the primary antibody.
   • I would recommend catalog number NBP1-67821 or NB600-587; however, a full list of our anti-human TNF alpha antibodies suitable for use in ELISA can be found using this link.
3. I am interested in a TNF alpha antibody, cross reactive for human, rat and mouse (host species: rabbit). Could your product NBP1-19532 be used in western blotting applications? Or do you have a similar product in your catalog which could fit with my request?
   • The antibody you mention, NBP1-19532, has not yet been validated in Western blot. I would instead recommend either NBP1-67821 or NB600-587. These are both rabbit polyclonal antibodies that cross-reacts with human, mouse and rat and have been used in Western blotting.
4. Can your TNF-alpha products be used to treat TBI victims and therefore avoid the perispinal injections with Enbrel?
   • I am very sorry, but all of our products are for scientific research use only, and none are intended or approved for use in humans.

Bioinformatics

• Gene Symbol: Tnf