MSH2 Antibody (RM375)

Western Blot: MSH2 Antibody (RM375) [NBP2-77433] - Western Blot of HeLa lysate using NBP2-77433.

Immunohistochemistry: MSH2 Antibody (RM375) [NBP2-77433] - Immunohistochemical staining of formalin fixed and paraffin embedded human colon cancer tissue section using NBP2-77433.

• Reactivity: Hu
• Applications: WB, IHC
• Clone: RM375
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated

MSH2 Antibody (RM375) Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: A mammalian cells expressed recombinant protein fragment within 500 amino acids of the N-terminus of human MSH2
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: MSH2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:200 - 1:1000
  • Western Blot 1:400 - 1:2000

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 50% Glycerol/PBS, 1% BSA
• Preservative: 0.09% Sodium Azide
• Purity: Protein A purified

Alternate Names for MSH2 Antibody (RM375)

• COCA1
• DNA mismatch repair protein Msh2
• FCC1
• hMSH2
• HNPCC
• HNPCC1
• HNPCC1mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1)
• LCFS2
• MSH2
• mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
• MutS protein homolog 2

Background

MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MSH2