MTHFD2 Antibody - BSA Free

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Immunohistochemistry: MTHFD2 Antibody [NBP2-33575] - Staining of human kidney shows strong cytoplasmic positivity in tubule cells.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Format
BSA Free

Order Details

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Catalog# & Formulation Size Price

MTHFD2 Antibody - BSA Free Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: PASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVDGLL
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
MTHFD2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
MTHFD2 Protein (NBP2-33575PEP)

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (88%), Rat (85%)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for MTHFD2 Antibody - BSA Free

  • bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase
  • methenyltetrahydrofolate cyclohydrolase
  • methylene tetrahydrofolate dehydrogenase (NAD+ dependent)
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2
  • mitochondrial
  • NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase
  • NMDMC

Background

MTHFD2 encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in multiple transcripts encoding different isoforms. This gene has a pseudogene on chromosome 7.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol MTHFD2
Uniprot