PRDM16/MEL1 Antibody - BSA Free

Western Blot: PRDM16/MEL1 Antibody - BSA Free [NBP1-71992] - Analysis of anti-PRDM16 antibody with rat brain tissue lysate.

Immunohistochemistry-Paraffin: PRDM16/MEL1 Antibody - BSA Free [NBP1-71992] - Analysis of anti-PRDM16 antibody with human skin at concentration 5 ug/ml.

Immunocytochemistry/Immunofluorescence: PRDM16/MEL1 Antibody - BSA Free [NBP1-71992] - Analysis of anti-PRDM16 antibody with human brain cells.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

PRDM16/MEL1 Antibody - BSA Free Summary

• Immunogen: A 17 aa synthetic peptide near the C-terminus of human PRDM16/MEL1. The immunogen is located within aa 1120 - 1170 of PRDM16/MEL1.
• Epitope: C-Terminus
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PRDM16
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100 - 1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/ml
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Western Blot 1-2 ug/ml
• Application Notes: .

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Peptide affinity purified

Alternate Names for PRDM16/MEL1 Antibody - BSA Free

• MDS1/EVI1-like gene 1
• MEL1
• MEL1KIAA1675PFM13MGC166915
• PFM13
• PR domain containing 16
• PR domain zinc finger protein 16
• PR domain-containing protein 16
• PRDM16
• Transcription factor MEL1

Background

The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PRDM16