Recombinant Human TNF-alpha Protein, CF

Recombinant Human TNF-alpha (Catalog # 210‑TA/CF) induces cytotoxicity in the L-929 mouse fibroblast cell line in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is 25‑100 pg/mL.

Recombinant Human TNF-alpha (Catalog # 210‑TA/CF) induces cytotoxicity in the L-929 mouse fibroblast cell line in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is 25‑100 pg/mL.

1 µg/lane of Recombinant Human TNF-alpha was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa.

• Reactivity: Hu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Human TNF-alpha Protein, CF Summary

• Additional Information: A new economically priced TNF-alpha is available! The new protein is HEK293 expressed!
• Details of Functionality: Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. Matthews, N. and M.L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 221. The ED₅₀ for this effect is 25-100 pg/mL.
• Source: E. coli-derived human TNF-alpha protein
  Val77-Leu233, with and without an N-terminal Met
• Accession #: P01375
• N-terminal Sequence: Met & Val77
• Protein/Peptide Type: Recombinant Proteins
• Gene: TNF
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 17 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 17 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS. *Small pack size (5 & 20 µg) is supplied as a 0.2 µm filtered solution in PBS.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 0.1-1 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human TNF-alpha Protein, CF

• APC1 protein
• Cachectin
• Cachetin
• DIF
• TNF
• TNF, monocyte-derived
• TNFA
• TNF-A
• TNFalpha
• TNF-alpha
• TNF-alphacachectin
• TNFATNF, macrophage-derived
• TNFG1F
• TNFSF1A
• TNFSF2
• TNFSF2TNF superfamily, member 2
• tumor necrosis factor (TNF superfamily, member 2)
• tumor necrosis factor alpha
• Tumor necrosis factor ligand superfamily member 2
• tumor necrosis factor
• tumor necrosis factor-alpha

Background

Tumor necrosis factor alpha (TNF-alpha ), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism (1, 2). Human TNF-alpha consisits of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 177 aa extracellular domain (ECD) (3). Within the ECD, human TNF-alpha shares 97% aa sequence identity with rhesus and 71%-92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-alpha . TNF-alpha is produced by a wide variety of immune, epithelial, endothelial, and tumor cells (1, 2). TNF-alpha is assembled intracellularly to form a noncovalently linked homotrimer which is expressed on the cell surface (4). Cell surface TNF-alpha can induce the lysis of neighboring tumor cells and virus infected cells, and it can generate its own downstream cell signaling following ligation by soluble TNFR I (2, 5). Shedding of membrane bound TNF-alpha by TACE/ADAM17 releases the bioactive cytokine, a 55 kDa soluble trimer of the TNF-alpha extracellular domain (6-8). TNF-alpha binds the ubiquitous 55-60 kDa TNF RI (9, 10) and the hematopoietic cell-restricted 80 kDa TNF RII (11, 12), both of which are also expressed as homotrimers (1, 2, 13). Both type I and type II receptors bind TNF-alpha with comparable affinity (14), although only TNF RI contains a cytoplasmic death domain which triggers the activation of apoptosis. Soluble forms of both types of receptors are released and can neutralize the biological activity of TNF-alpha (15).

1. Zelova, H. and J. Hosek (2013) Inflamm. Res. 62:641.
2. Juhasz, K. et al. (2013) Expert Rev. Clin. Immunol. 9:335.
3. Pennica, D. et al. (1984) Nature 312:724.
4. Tang, P. et al. (1996) Biochemistry 35:8216.
5. Perez, C. et al. (1990) Cell 63:251.
6. Black, R.A. et al. (1997) Nature 385:729.
7. Moss, M.L. et al. (1997) Nature 385:733.
8. Gearing, A.J.H. et al. (1994) Nature 370:555.
9. Schall, T.J. et al. (1990) Cell 61:361.
10. Loetscher, H. et al. (1990) Cell 61:351.
11. Dembic, Z. et al. (1990) Cytokine 2:231.
12. Smith, C.A. et al. (1990) Science 248:1019.
13. Loetscher, H. et al. (1991) J. Biol. Chem. 266:18324.
14. Pinckard, J.K. et al. (1997) J. Biol. Chem. 272:10784.
15. Engelmann, H. et al. (1990) J. Biol. Chem. 265:1531.

Show all background references

Publications for TNF-alpha (210-TA/CF)(773)

Publications using 210-TA/CF

• Ma, HY;Li, Q;Wong, WR;N'Diaye, EN;Caplazi, P;Bender, H;Huang, Z;Arlantico, A;Jeet, S;Wong, A;Emson, C;Brightbill, H;Tam, L;Newman, R;Roose-Girma, M;Sandoval, W;Ding, N; LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lung Science advances 2023-05-26 [PMID: 37235663] (Bioassay, Human)
• Cheng, RYS;Ridnour, LA;Wink, AL;Gonzalez, AL;Femino, EL;Rittscher, H;Somasundaram, V;Heinz, WF;Coutinho, L;Rangel, MC;Edmondson, EF;Butcher, D;Kinders, RJ;Li, X;Wong, STC;McVicar, DW;Anderson, SK;Pore, M;Hewitt, SM;Billiar, TR;Glynn, SA;Chang, JC;Lockett, SJ;Ambs, S;Wink, DA; Interferon-gamma is quintessential for NOS2 and COX2 expression in ER- breast tumors that lead to poor outcome Cell death & disease 2023-05-11 [PMID: 37169743] (Bioassay, Human)
• P Dörschmann, C Seeba, T Thalenhors, J Roider, A Klettner Anti-inflammatory properties of antiangiogenic fucoidan in retinal pigment epithelium cells Heliyon, 2023;9(4):e15202. 2023 [PMID: 37123974] (Cell Culture, Porcine)
• P Dörschmann, C Seeba, T Thalenhors, J Roider, A Klettner Anti-inflammatory properties of antiangiogenic fucoidan in retinal pigment epithelium cells Heliyon, 2023-04-10;9(4):e15202. 2023-04-10 [PMID: 37123974] (Cell Culture, Porcine)
• IN Boys, AG Johnson, M Quinlan, PJ Kranzusch, NC Elde Structural homology screens reveal poxvirus-encoded proteins impacting inflammasome-mediated defenses bioRxiv : the preprint server for biology, 2023-04-03;0(0):. 2023-04-03 [PMID: 36909515] (Bioassay, Human)
• Y Nie, L Mou, Q Long, D Deng, R Hu, J Cheng, J Wu SARS-CoV-2 ORF3a positively regulates NF-kappaB activity by enhancing IKKbeta-NEMO interaction Virus research, 2023-03-13;328(0):199086. 2023-03-13 [PMID: 36894068] (Bioassay, Human)
• T Zyrianova, K Zou, B Lopez, A Liao, C Gu, R Olcese, A Schwingsha Activation of Endothelial Large Conductance Potassium Channels Protects against TNF-alpha-Induced Inflammation International Journal of Molecular Sciences, 2023-02-17;24(4):. 2023-02-17 [PMID: 36835507] (Bioassay, Human)
• F Parween, SP Singh, HH Zhang, N Kathuria, FA Otaizo-Car, A Shamsaddin, PJ Gardina, S Ganesan, J Kabat, HA Lorenzi, TG Myers, JM Farber Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells bioRxiv : the preprint server for biology, 2023-02-13;0(0):. 2023-02-13 [PMID: 36789428] (Bioassay, Human)
• DI Cho, MJ Ahn, HH Cho, M Cho, JH Jun, BG Kang, SY Lim, SJ Yoo, MR Kim, HS Kim, SJ Lee, LT Dat, C Lee, YS Kim, Y Ahn ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation Experimental & Molecular Medicine, 2023-02-13;0(0):. 2023-02-13 [PMID: 36782020] (Bioassay, Human)
• RD de Ruiter, LE Wisse, T Schoenmake, M Yaqub, G Sánchez-Du, EMW Eekhoff, D Micha TGF-Beta Induces Activin A Production in Dermal Fibroblasts Derived from Patients with Fibrodysplasia Ossificans Progressiva International Journal of Molecular Sciences, 2023-01-24;24(3):. 2023-01-24 [PMID: 36768622] (Bioassay, Human)
• J Nassour, LG Aguiar, A Correia, TT Schmidt, L Mainz, S Przetocka, C Haggblom, N Tadepalle, A Williams, MN Shokhirev, SC Akincilar, V Tergaonkar, GS Shadel, J Karlseder Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis Nature, 2023-02-08;614(7949):767-773. 2023-02-08 [PMID: 36755096] (Bioassay, Human)
• W Zhu, H Chu, Y Zhang, T Luo, H Yu, H Zhu, Y Liu, H Gao, Y Zhao, Q Li, X Wang, G Li, W Yang Fructose-1,6-bisphosphatase 1 dephosphorylates IkappaBalpha and suppresses colorectal tumorigenesis Cell Research, 2023-01-16;0(0):. 2023-01-16 [PMID: 36646759] (Bioassay, Human)
• H Ben Halima, N Zine, J Bausells, N Jaffrezic-, A Errachid A Novel Cortisol Immunosensor Based on a Hafnium Oxide/Silicon Structure for Heart Failure Diagnosis Micromachines, 2022-12-16;13(12):. 2022-12-16 [PMID: 36557534] (Bioassay, Human)
• D Cai, M Fraunfelde, SY Chen Blood serum analysis: A modified sandwich enzyme-linked immunosorbent assay protocol MethodsX, 2022-11-22;9(0):101923. 2022-11-22 [PMID: 36483291] (ELISA Control, Human)
• HJ Kim, SH Kim, YS Oh, SR Lee, HD Chae Dienogest May Reduce Estradiol- and Inflammatory Cytokine-Induced Cell Viability and Proliferation and Inhibit the Pathogenesis of Endometriosis: A Cell Culture- and Mouse Model-Based Study Biomedicines, 2022-11-21;10(11):. 2022-11-21 [PMID: 36428561] (Cell Culture, Human)
• K Li, Y Zhu, P Zhang, M Alini, S Grad, Z Li Anti-inflammatory and pro-anabolic effects of 5-aminosalicylic acid on human inflammatory osteoarthritis models Journal of Orthopaedic Translation, 2022-10-29;38(0):106-116. 2022-10-29 [PMID: 36381242] (Cell Culture, Human)
• B Saravi, Z Li, V Basoli, S Grad, S Häckel, CE Albers, M Alini, H Schmal, P Obid, G Lang In Vitro Characterization of a Tissue Renin-Angiotensin System in Human Nucleus Pulposus Cells Cells, 2022-10-28;11(21):. 2022-10-28 [PMID: 36359814] (Bioassay, Human)
• DR Calabrese, T Tsao, M Magnen, C Valet, Y Gao, B Mallavia, JJ Tian, EA Aminian, KM Wang, A Shemesh, EB Punzalan, A Sarma, CS Calfee, SA Christenso, CR Langelier, SR Hays, JA Golden, LE Leard, ME Kleinhenz, NA Kolaitis, RJ Shah, A Venado, LL Lanier, JR Greenland, DM Sayah, A Ardehali, J Kukreja, SS Weigt, JA Belperio, JP Singer, MR Looney NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes JCI Insight, 2022-12-22;0(0):. 2022-12-22 [PMID: 36346670] (Bioassay, Human)
• S Hayashi, CK Muraleedha, M Oku, S Tomar, SP Hogan, M Quiros, CA Parkos, A Nusrat Intestinal epithelial BLT1 promotes mucosal repair JCI Insight, 2022-12-08;0(0):. 2022-12-08 [PMID: 36301666] (Bioassay, Human)
• Bhuyan S, Pal B, Pathak L, Saikia P, Mitra S, Gayan S, Mokhtari R, Li H, Ramana C, Baishya D, Das B Targeting hypoxia-induced tumor stemness by activating pathogen-induced stem cell niche defense. Front Immunol, 2022-09-29;13(0):933329. 2022-09-29 [PMID: 36248858] (Bioassay, Complex Species Category)
• P Pavlidis, A Tsakmaki, A Treveil, K Li, D Cozzetto, F Yang, U Niazi, BH Hayee, M Saqi, J Friedman, T Korcsmaros, G Bewick, N Powell Cytokine responsive networks in human colonic epithelial organoids unveil a molecular classification of inflammatory bowel disease Cell Reports, 2022-09-27;40(13):111439. 2022-09-27 [PMID: 36170836] (Bioassay, Human)
• H Iwanishi, O Yamanaka, T Sumioka, S Yasuda, M Miyajima, S Saika Delayed regression of laser-induced choroidal neovascularization in TNFalpha-null mice Journal of Cellular and Molecular Medicine, 2022-09-20;0(0):. 2022-09-20 [PMID: 36127870] (Bioassay, Human)
• AA Hariri, SS Newman, S Tan, D Mamerow, AM Adams, N Maganzini, BL Zhong, M Eisenstein, AR Dunn, HT Soh Improved immunoassay sensitivity and specificity using single-molecule colocalization Nature Communications, 2022-09-12;13(1):5359. 2022-09-12 [PMID: 36097164] (Bioassay, Human)
• V Catalán, P Domench, J Gómez-Ambr, B Ramírez, S Becerril, A Mentxaka, A Rodríguez, V Valentí, R Moncada, J Baixauli, C Silva, J Escalada, G Frühbeck Dermatopontin Influences the Development of Obesity-Associated Colon Cancer by Changes in the Expression of Extracellular Matrix Proteins International Journal of Molecular Sciences, 2022-08-17;23(16):. 2022-08-17 [PMID: 36012487] (Stimulation, Human)
• DC Humphries, R Mills, C Boz, BJ McHugh, N Hirani, AG Rossi, A Pedersen, HT Schambye, RJ Slack, H Leffler, UJ Nilsson, W Wang, T Sethi, AC Mackinnon Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation Frontiers in Pharmacology, 2022-08-08;13(0):949264. 2022-08-08 [PMID: 36003515] (Bioassay, Human)
• YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells Science Advances, 2022-08-24;8(34):eabn5522. 2022-08-24 [PMID: 36001668] (Bioassay, Human)
• S Ng, S Lim, ACN Sim, R Mangadu, A Lau, C Zhang, SB Martinez, A Chandramoh, UM Lim, SSW Ho, SC Chang, P Gopal, LZ Hong, A Schwaid, AZ Fernandis, A Loboda, C Li, U Phan, B Henry, AW Partridge STUB1 is an intracellular checkpoint for interferon gamma sensing Scientific Reports, 2022-08-18;12(1):14087. 2022-08-18 [PMID: 35982220] (Bioassay, Human)
• Z Cai, S Tian, T Klein, L Tu, LW Geenen, T Koudstaal, AE van den Bo, YB de Rijke, IKM Reiss, E Boersma, C van der Le, M Van Faasse, I Kema, DJ Duncker, KA Boomars, K Tran-Lundm, C Guignabert, D Merkus Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Ralpha Scientific Reports, 2022-07-19;12(1):12326. 2022-07-19 [PMID: 35853948] (Bioassay, Human)
• XJ Mi, JK Kim, S Lee, SK Moon, YJ Kim, H Kim In vitro assessment of the anti-inflammatory and skin-moisturizing effects of Filipendula palmata (Pall.) Maxim. On human keratinocytes and identification of its bioactive phytochemicals Journal of ethnopharmacology, 2022-07-07;296(0):115523. 2022-07-07 [PMID: 35809756] (Bioassay, Human)
• MD Gundersen, KB Larsen, KM Johnsen, R Goll, J Florholmen, G Haraldsen Hypo-osmotic stress induces the epithelial alarmin IL-33 in the colonic barrier of ulcerative colitis Scientific Reports, 2022-07-07;12(1):11550. 2022-07-07 [PMID: 35798804] (Bioassay, Human)
• CW Lee, YF Chen, AW Hsiao, AY Wang, OY Shen, BY Wang, LWC Ho, WT Lin, CHJ Choi, OK Lee Demystifying the long noncoding RNA landscape of small EVs derived from human mesenchymal stromal cells Journal of advanced research, 2021-11-19;39(0):73-88. 2021-11-19 [PMID: 35777918] (Bioassay, Human)
• S Wang, B Li, V Solomon, A Fonteh, SI Rapoport, DA Bennett, Z Arvanitaki, HC Chui, PM Sullivan, HN Yassine Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4 Molecular Neurodegeneration, 2022-06-15;17(1):42. 2022-06-15 [PMID: 35705959] (Bioassay, Mouse)
• E Iverson, K Griswold, D Song, TB Gagliardi, K Hamidzadeh, M Kesimer, S Sinha, M Perry, GA Duncan, MA Scull Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium MBio, 2022-06-14;0(0):e0105522. 2022-06-14 [PMID: 35699372] (Bioassay, Human)
• S Hong, EY Kim, SE Lim, JH Kim, Y Sohn, HS Jung Dendrobium nobile Lindley Administration Attenuates Atopic Dermatitis-like Lesions by Modulating Immune Cells International Journal of Molecular Sciences, 2022-04-18;23(8):. 2022-04-18 [PMID: 35457288] (Bioassay, Human)
• R Giri, EC Hoedt, S Khushi, AA Salim, AS Bergot, V Schreiber, R Thomas, MA McGuckin, TH Florin, M Morrison, RJ Capon, P Ó Cuív, J Begun Secreted NF-kappaB suppressive microbial metabolites modulate gut inflammation Cell Reports, 2022-04-12;39(2):110646. 2022-04-12 [PMID: 35417687] (Bioassay, Human)
• S Banjonjit, M Taweechoti, S Rungsiyano Effect of probiotic Lactobacillus paracasei on tumor necrosis factor-alpha level in gingival crevicular fluid of patients undergoing impacted third molar removal Journal of oral science, 2022-04-08;0(0):. 2022-04-08 [PMID: 35400713] (ELISA Standard, Human)
• P Sekhri, DK Ledezma, A Shukla, EE Sweeney, R Fernandes The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells Cancers, 2022-03-11;14(6):. 2022-03-11 [PMID: 35326601] (Cell Culture, Human)
• CC Yang, LD Hsiao, YF Shih, HH Lin, CM Yang 5,8-Dihydroxy-4 &#039;, 7-dimethoxyflavone Attenuates TNF-alpha-Induced Expression of Vascular Cell Adhesion Molecule-1 through EGFR/PKCalpha/PI3K/Akt/Sp1-Dependent Induction of Heme Oxygenase-1 in Human Cardiac Fibroblasts Oxidative Medicine and Cellular Longevity, 2022-03-04;2022(0):1372958. 2022-03-04 [PMID: 35281466] (Bioassay, Human)
• H Farese, Farese H, M Noack, Noack M, P Miossec Synoviocytes from pigmented villonodular synovitis are less sensitive to cadmium-induced cell death than synoviocytes from rheumatoid arthritis. Sci Rep, 2022-03-09;12(1):3832. 2022-03-09 [PMID: 35264617] (Bioassay, Human)
• D Stacey, L Chen, PJ Stanczyk, JMM Howson, AM Mason, S Burgess, S MacDonald, J Langdown, H McKinney, K Downes, N Farahi, JE Peters, S Basu, JS Pankow, W Tang, N Pankratz, M Sabater-Ll, PS de Vries, NL Smith, CHARGE Hem, AD Gelinas, DJ Schneider, N Janjic, NJ Samani, S Ye, C Summers, ER Chilvers, J Danesh, DS Paul Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus Nature Communications, 2022-03-09;13(1):1222. 2022-03-09 [PMID: 35264566] (Bioassay, Human)
• C Stene, A Röme, I Palmquist, C Linninge, G Molin, S Ahrné, LB Johnson, B Jeppsson Administration of probiotics to healthy volunteers: effects on reactivity of intestinal mucosa and systemic leukocytes BMC gastroenterology, 2022-03-05;22(1):100. 2022-03-05 [PMID: 35247974] (Cell Culture, Human)
• C Ge, J Tan, D Lou, L Zhu, Z Zhong, X Dai, Y Sun, Q Kuang, J Zhao, L Wang, J Liu, B Wang, M Xu Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling Redox Biology, 2022-02-24;51(0):102274. 2022-02-24 [PMID: 35240537] (Bioassay, Human)
• K Harhouri, P Cau, F Casey, KM Guedenon, Y Doubaj, L Van Malder, G Mejia-Balt, C Bartoli, A De Sandre-, N Lévy MG132 Induces Progerin Clearance and Improves Disease Phenotypes in HGPS-like Patients&#039; Cells Cells, 2022-02-10;11(4):. 2022-02-10 [PMID: 35203262] (Bioassay, Human)
• MA Shandell, AL Capatina, SM Lawrence, WJ Brackenbur, D Lagos Inhibition of the Na+/K+-ATPase by cardiac glycosides suppresses expression of the IDO1 immune checkpoint in cancer cells by reducing STAT1 activation The Journal of Biological Chemistry, 2022-02-09;0(0):101707. 2022-02-09 [PMID: 35150740] (Bioassay, Human)
• AM Abu El-Asr, A Ahmad, MI Nawaz, MM Siddiquei, A De Zutter, L Vanbrabant, PW Gikandi, G Opdenakker, S Struyf Tissue Inhibitor of Metalloproteinase-3 Ameliorates Diabetes-Induced Retinal Inflammation Frontiers in Physiology, 2022-01-10;12(0):807747. 2022-01-10 [PMID: 35082694] (Bioassay, Human)
• JJ Lenoir, JP Parisien, CM Horvath Immune regulator LGP2 targets Ubc13/UBE2N to mediate widespread interference with K63 polyubiquitination and NF-kappaB activation Cell Reports, 2021-12-28;37(13):110175. 2021-12-28 [PMID: 34965427] (Bioassay, Human)
• L Toma, T Barb?lat?, GM Sanda, LS Niculescu, AV Sima, CS Stancu CRISPR/dCas9 Transcriptional Activation of Endogenous Apolipoprotein AI and Paraoxonase 1 in Enterocytes Alleviates Endothelial Cell Dysfunction Biomolecules, 2021-11-25;11(12):. 2021-11-25 [PMID: 34944413] (Bioassay, Human)
• R Sagawa, S Sakata, B Gong, Y Seto, A Takemoto, S Takagi, H Ninomiya, N Yanagitani, M Nakao, M Mun, K Uchibori, M Nishio, Y Miyazaki, Y Shiraishi, S Ogawa, K Kataoka, N Fujita, K Takeuchi, R Katayama Soluble PD-L1 through alternative polyadenylation works as a decoy in lung cancer immunotherapy JCI Insight, 2022-01-11;0(0):. 2022-01-11 [PMID: 34874919] (Bioassay, Human)
• Y Hu, H Zhang, N Xie, D Liu, Y Jiang, Z Liu, D Ye, S Liu, X Chen, C Li, Q Wang, X Huang, Y Liu, Y Shi, X Zhang Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1 Cell Death and Differentiation, 2021-12-01;0(0):. 2021-12-01 [PMID: 34853447] (Bioassay, Mouse)
• A Fu, L van Rooyen, L Evans, N Armstrong, D Avizonis, T Kin, GH Bird, A Reddy, ET Chouchani, M Liesa-Roig, LD Walensky, AMJ Shapiro, NN Danial Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets Cell Reports, 2021-11-23;37(8):110037. 2021-11-23 [PMID: 34818536] (Bioassay, Human)
• C Xu, J Tang, Q Yang, H Zhao, Y Liu, J Cao, Y Zhou, X Chen, J Chen Histone deacetylase 5 deacetylates the phosphatase PP2A for positively regulating NF-kappaB signaling The Journal of Biological Chemistry, 2021-11-03;0(0):101380. 2021-11-03 [PMID: 34740611] (Bioassay, Human)
• M McAleavy, Q Zhang, PJ Ehmann, J Xu, MF Wipperman, D Ajithdoss, L Pan, M Wakai, R Simonson, A Gadi, A Oyejide, SC Hamon, A Boyapati, LG Morton, T Shavlakadz, CA Kyratsous, DJ Glass The Activin/FLRG pathway associates with poor COVID-19 outcomes in hospitalized patients Molecular and Cellular Biology, 2021-11-01;0(0):MCB0046721. 2021-11-01 [PMID: 34723652] (Bioassay, Human)
• Y Xing, Y Lin, Y Zhang, J Hu, J Liu, Y Tian, J Zhao, W Chen, B Han Novel cytoplasmic lncRNA IKBKBAS promotes lung adenocarcinoma metastasis by upregulating IKKbeta and consequential activation of NF-kappaB signaling pathway Cell Death & Disease, 2021-10-26;12(11):1004. 2021-10-26 [PMID: 34702815] (Bioassay, Human)
• G Panattoni, R Amoriello, C Memo, A Thalhammer, C Ballerini, L Ballerini Diverse inflammatory threats modulate astrocytes Ca2+ signaling via connexin43 hemichannels in organotypic spinal slices Molecular Brain, 2021-10-25;14(1):159. 2021-10-25 [PMID: 34696792] (Bioassay, Mouse)
• VA Samara, S Das, MA Reddy, VS Tanwar, K Stapleton, A Leung, M Abdollahi, R Ganguly, L Lanting, R Natarajan Angiotensin II-Induced Long Non-Coding RNA Alivec Regulates Chondrogenesis in Vascular Smooth Muscle Cells Cells, 2021-10-09;10(10):. 2021-10-09 [PMID: 34685676] (Cell Culture, Rat)
• S Kochumon, A Al-Sayyar, T Jacob, A Hasan, F Al-Mulla, S Sindhu, R Ahmad TNF-alpha Increases IP-10 Expression in MCF-7 Breast Cancer Cells via Activation of the JNK/c-Jun Pathways Biomolecules, 2021-09-13;11(9):. 2021-09-13 [PMID: 34572567] (Bioassay, Human)
• I Papazian, E Tsoukala, A Boutou, M Karamita, K Kambas, L Iliopoulou, R Fischer, RE Kontermann, MC Denis, G Kollias, H Lassmann, L Probert Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKbeta promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice Journal of Neuroinflammation, 2021-09-26;18(1):222. 2021-09-26 [PMID: 34565380] (Bioassay, Mouse)
• S Shao, J Chen, WR Swindell, LC Tsoi, X Xing, F Ma, R Uppala, MK Sarkar, O Plazyo, AC Billi, R Wasikowski, KM Smith, P Honore, VE Scott, E Maverakis, JM Kahlenberg, G Wang, NL Ward, PW Harms, JE Gudjonsson Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris JCI Insight, 2021-10-22;0(0):. 2021-10-22 [PMID: 34491907] (Bioassay, Human)
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• SI Jeong, JW Kim, KP Ko, BK Ryu, MG Lee, HJ Kim, SG Chi XAF1 forms a positive feedback loop with IRF-1 to drive apoptotic stress response and suppress tumorigenesis Cell Death Dis, 2018-07-24;9(8):806. 2018-07-24 [PMID: 30042418] (Bioassay, Human)
• JJ Seeley, RG Baker, G Mohamed, T Bruns, MS Hayden, SD Deshmukh, DE Freedberg, S Ghosh Induction of innate immune memory via microRNA targeting of chromatin remodelling factors Nature, 2018-06-27;559(7712):114-119. 2018-06-27 [PMID: 29950719] (Bioassay, Mouse)
• G Genard, AC Wera, C Huart, B Le Calve, S Penninckx, A Fattacciol, T Tabarrant, C Demazy, N Ninane, AC Heuskin, S Lucas, C Michiels Proton irradiation orchestrates macrophage reprogramming through NF?B signaling Cell Death Dis, 2018-06-27;9(7):728. 2018-06-27 [PMID: 29950610] (Bioassay, Human)
• W Feng, Y Wu, G Chen, S Fu, B Li, B Huang, D Wang, W Wang, J Liu Sodium Butyrate Attenuates Diarrhea in Weaned Piglets and Promotes Tight Junction Protein Expression in Colon in a GPR109A-Dependent Manner Cell. Physiol. Biochem., 2018-06-27;47(4):1617-1629. 2018-06-27 [PMID: 29949795] (Bioassay, Human)
• Michael J Workman, John P Gleeson, Elissa J Troisi, Hannah Q Estrada, S Jordan Kerns, Christopher D Hinojosa, Geraldine A Hamilton, Stephan R Targan, Clive N Svendsen, Robert J Barrett Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips. Cellular and Molecular Gastroenterology and Hepatology, 2017-12-29;0(0):2352-345X. 2017-12-29 [PMID: 29930984] (Bioassay, Human)
• A Gaudin, M Tolar, OA Peters Lipoxin A4 Attenuates the Inflammatory Response in Stem Cells of the Apical Papilla via ALX/FPR2 Sci Rep, 2018-06-11;8(1):8921. 2018-06-11 [PMID: 29892010] (Bioassay, Human)
• JA Marwick, R Mills, O Kay, K Michail, J Stephen, AG Rossi, I Dransfield, N Hirani Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-?B activation Cell Death Dis, 2018-06-04;9(6):665. 2018-06-04 [PMID: 29867198] (Bioassay, Human)
• SU Seo, SM Woo, HS Lee, SH Kim, KJ Min, TK Kwon mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy Oncogene, 2018-05-30;0(0):. 2018-05-30 [PMID: 29849119] (Bioassay, Human)
• S Hemmati-Sa, J Ringe, T Dehne, R Haag, M Sittinger Hyaluronic Acid Influence on Normal and Osteoarthritic Tissue-Engineered Cartilage Int J Mol Sci, 2018-05-19;19(5):. 2018-05-19 [PMID: 29783732] (Bioassay, Human)
• E Vorkapic, A Kunath, D Wågsäter Effects of osteoprotegerin/TNFRSF11B in two models of abdominal aortic aneurysms Mol Med Rep, 2018-04-27;0(0):. 2018-04-27 [PMID: 29749489] (Bioassay, Human)
• AE Dodi, IO Ajayi, C Chang, M Beard, SL Ashley, SK Huang, VJ Thannickal, DJ Tschumperl, TH Sisson, JC Horowitz Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli Respir. Res., 2018-05-10;19(1):91. 2018-05-10 [PMID: 29747634] (Bioassay, Human)
• BN Nakamura, A Glazier, MG Kattah, B Duong, Y Jia, D Campo, L Shao A20 regulates canonical wnt-signaling through an interaction with RIPK4 PLoS ONE, 2018-05-02;13(5):e0195893. 2018-05-02 [PMID: 29718933] (Bioassay, Human)
• M Boyd, M Thodberg, M Vitezic, J Bornholdt, K Vitting-Se, Y Chen, M Coskun, Y Li, BZS Lo, P Klausen, P Jan Schwei, AG Pedersen, N Rapin, K Skovgaard, K Dahlgaard, R Andersson, TB Terkelsen, B Lilje, JT Troelsen, AM Petersen, KB Jensen, I Gögenur, P Thielsen, JB Seidelin, OH Nielsen, JT Bjerrum, A Sandelin Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies Nat Commun, 2018-04-25;9(1):1661. 2018-04-25 [PMID: 29695774] (Bioassay, Human)
• A Beringer, N Thiam, J Molle, B Bartosch, P Miossec Synergistic effect of interleukin-17 and tumor necrosis factor-α on inflammatory response in hepatocytes through interleukin-6 dependent and independent pathways Clin. Exp. Immunol., 2018-05-31;0(0):. 2018-05-31 [PMID: 29676779] (Bioassay, Human)
• H Kim, SR Kim, J Je, K Jeong, S Kim, HJ Kim, KC Chang, SW Park The proximal tubular ?7 nicotinic acetylcholine receptor attenuates ischemic acute kidney injury through Akt/PKC signaling-mediated HO-1 induction Exp. Mol. Med., 2018-04-20;50(4):40. 2018-04-20 [PMID: 29674665] (Bioassay, Human)
• JP Parisien, JJ Lenoir, R Mandhana, KR Rodriguez, K Qian, AM Bruns, CM Horvath RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling EMBO Rep., 2018-04-16;0(0):. 2018-04-16 [PMID: 29661858] (Bioassay, Human)
• M Brown, LA Johnson, DA Leone, P Majek, K Vaahtomeri, D Senfter, N Bukosza, H Schachner, G Asfour, B Langer, R Hauschild, K Parapatics, YK Hong, KL Bennett, R Kain, M Detmar, M Sixt, DG Jackson, D Kerjaschki Lymphatic exosomes promote dendritic cell migration along guidance cues J. Cell Biol., 2018-04-12;0(0):. 2018-04-12 [PMID: 29650776] (Bioassay, Human)
• J Weiler, M Mohr, KS Zänker, T Dittmar Matrix metalloproteinase-9 (MMP9) is involved in the TNF-α-induced fusion of human M13SV1-Cre breast epithelial cells and human MDA-MB-435-pFDR1 cancer cells Cell Commun. Signal, 2018-04-10;16(1):14. 2018-04-10 [PMID: 29636110] (Bioassay, Human)
• C Lema, RY Reins, RL Redfern High-Mobility Group Box 1 in Dry Eye Inflammation Invest. Ophthalmol. Vis. Sci., 2018-04-01;59(5):1741-1750. 2018-04-01 [PMID: 29610858] (Bioassay, Human)
• R Drolia, S Tenguria, AC Durkes, JR Turner, AK Bhunia Listeria Adhesion Protein Induces Intestinal Epithelial Barrier Dysfunction for Bacterial Translocation Cell Host Microbe, 2018-04-05;0(0):. 2018-04-05 [PMID: 29606495] (Bioassay, Human)
• M Gabl, M Sundqvist, A Holdfeldt, S Lind, J Mårtensson, K Christenso, T Marutani, C Dahlgren, H Mukai, H Forsman Mitocryptides from Human Mitochondrial DNA-Encoded Proteins Activate Neutrophil Formyl Peptide Receptors: Receptor Preference and Signaling Properties J. Immunol., 2018-03-30;0(0):. 2018-03-30 [PMID: 29602776] (Bioassay, Human)
• O Sokolova, T Kähne, K Bryan, M Naumann Interactome analysis of transforming growth factor-?-activated kinase 1 inHelicobacter pylori-infected cells revealed novel regulators tripartite motif 28 and CDC37 Oncotarget, 2018-02-21;9(18):14366-14381. 2018-02-21 [PMID: 29581850] (Bioassay, Human)
• L Gao, MM Liu, HM Zang, QY Ma, Q Yang, L Jiang, GL Ren, HD Li, WF Wu, JN Wang, B Wei, XQ Liu, C Jiang, C Huang, J Li, XM Meng Restoration of E-cadherin by PPBICA protects against cisplatin-induced acute kidney injury by attenuating inflammation and programmed cell death Lab. Invest., 2018-03-26;0(0):. 2018-03-26 [PMID: 29581579] (Bioassay, Mouse)
• D Sireesh, U Dhamodhara, K Ezhilarasi, V Vijay, KM Ramkumar Association of NF-E2 Related Factor 2 (Nrf2) and inflammatory cytokines in recent onset Type 2 Diabetes Mellitus Sci Rep, 2018-03-23;8(1):5126. 2018-03-23 [PMID: 29572460] (Bioassay, Human)
• C Napoletano, S Mattiucci, A Colantoni, F Battisti, IG Zizzari, H Rahimi, M Nuti, A Rughetti Anisakis pegreffii impacts differentiation and function of human dendritic cells Parasite Immunol., 2018-05-01;0(0):e12527. 2018-05-01 [PMID: 29569735] (Bioassay, Human)
• CM Dickinson, BW LeBlanc, MM Edhi, DS Heffernan, MH Faridi, V Gupta, WG Cioffi, X O'Brien, JS Reichner Leukadherin-1 ameliorates endothelial barrier damage mediated by neutrophils from critically ill patients J Intensive Care, 2018-03-15;6(0):19. 2018-03-15 [PMID: 29568527] (Bioassay, Human)
• S Ikeya, JI Sakabe, T Yamada, T Naito, Y Tokura Voriconazole-induced photocarcinogenesis is promoted by aryl hydrocarbon receptor-dependent COX-2 upregulation Sci Rep, 2018-03-22;8(1):5050. 2018-03-22 [PMID: 29568008] (Bioassay, Human)
• M Toutfaire, E Dumortier, A Fattacciol, MV Steenbrugg, CM Proby, F Debacq-Cha Unraveling the interplay between senescent dermal fibroblasts and cutaneous squamous cell carcinoma cell lines at different stages of tumorigenesis Int. J. Biochem. Cell Biol., 2018-03-14;0(0):. 2018-03-14 [PMID: 29550586] (Bioassay, Human)
• S Modi, N Yaluri, T Kokkola Strigolactone GR24 and pinosylvin attenuate adipogenesis and inflammation of white adipocytes Biochem. Biophys. Res. Commun., 2018-03-21;0(0):. 2018-03-21 [PMID: 29550483] (Bioassay, Mouse)
• KA Jhang, JS Park, HS Kim, YH Chong Sulforaphane rescues amyloid-? peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages J Neuroinflammation, 2018-03-12;15(1):75. 2018-03-12 [PMID: 29530050] (Bioassay, Human)
• K Flentie, C Gonzalez, B Kocher, Y Wang, H Zhu, J Marasa, D Piwnica-Wo Nucleoside Diphosphate Kinase-3 (NME3) Enhances TLR5-Induced NF-?B Activation Mol. Cancer Res., 2018-03-09;0(0):. 2018-03-09 [PMID: 29523766] (Bioassay, Human)
• Y Wang, Y Liu, M Zhang, L Lv, X Zhang, P Zhang, Y Zhou LRRC15 promotes osteogenic differentiation of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation Stem Cell Res Ther, 2018-03-09;9(1):65. 2018-03-09 [PMID: 29523191] (Bioassay, Human)
• E Canto, N Isobe, A Didonna, SL Hauser, JR Oksenberg Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients J Neuroinflammation, 2018-03-07;15(1):72. 2018-03-07 [PMID: 29514694] (Bioassay, Human)
• S Wink, SW Hiemstra, S Huppelscho, JE Klip, B van de Wat Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury Arch. Toxicol., 2018-03-03;0(0):. 2018-03-03 [PMID: 29502165] (Bioassay, Human)
• JG Chen, X Liu, M Munshi, L Xu, N Tsakmaklis, MG Demos, A Kofides, ML Guerrera, GG Chan, CJ Patterson, KE Meid, J Gustine, T Dubeau, P Severns, JJ Castillo, ZR Hunter, J Wang, SJ Buhrlage, NS Gray, SP Treon, G Yang BTKCys481Serdrives ibrutinib resistance via ERK1/2, and protects BTKWild-TypeMYD88 mutated cells by a paracrine mechanism Blood, 2018-03-01;0(0):. 2018-03-01 [PMID: 29496671] (Bioassay, Human)
• P Singhirunn, B Moolmuang, K Lirdprapam, M Ruchirawat Arsenite exposure potentiates apoptosis-inducing effects of tumor necrosis factor-alpha- through reactive oxygen species J Toxicol Sci, 2018-01-01;43(2):159-169. 2018-01-01 [PMID: 29479036] (Bioassay, Human)
• CH Lee, HH Zhang, SP Singh, L Koo, J Kabat, H Tsang, TP Singh, JM Farber C/EBP? drives interactions between human MAIT cells and endothelial cells that are important for extravasation Elife, 2018-02-22;7(0):. 2018-02-22 [PMID: 29469805] (Bioassay, Human)
• LH Wright, DJ Herr, SS Brown, H Kasiganesa, DR Menick Angiokine Wisp-1 is increased in myocardial infarction and regulates cardiac endothelial signaling JCI Insight, 2018-02-22;3(4):. 2018-02-22 [PMID: 29467324] (Bioassay, Human)
• Y Wang, VM Abrahams, G Luo, NG Norwitz, VV Snegovskik, SW Ng, ER Norwitz Progesterone Inhibits Apoptosis in Fetal Membranes by Altering Expression of Both Pro- and Antiapoptotic Proteins Reprod Sci, 2018-02-20;0(0):1933719118759. 2018-02-20 [PMID: 29463188] (Bioassay, Human)
• A Lundin, L Delsing, M Clausen, P Ricchiuto, J Sanchez, A Sabirsh, M Ding, J Synnergren, H Zetterberg, G Brolén, R Hicks, A Herland, A Falk Human iPS-Derived Astroglia from a Stable Neural Precursor State Show Improved Functionality Compared with Conventional Astrocytic Models Stem Cell Reports, 2018-02-15;0(0):. 2018-02-15 [PMID: 29456185] (Bioassay, Human)
• G Bi, L Wu, P Huang, S Islam, DP Heruth, LQ Zhang, DY Li, V Sampath, W Huang, BA Simon, RB Easley, SQ Ye Up-regulation of SFTPB expression and attenuation of acute lung injury by pulmonary epithelial cell-specific NAMPT knockdown FASEB J., 2018-02-08;0(0):fj201701059R. 2018-02-08 [PMID: 29452569] (Bioassay, Human)
• AJ Lakhter, RE Pratt, RE Moore, KK Doucette, BF Maier, LA DiMeglio, EK Sims Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes Diabetologia, 2018-02-14;0(0):. 2018-02-14 [PMID: 29445851] (Cell Culture, Human, Mouse)
• TD Jung, SI Choi, SH Choi, BY Cho, WS Sim, SJ Lee, SJ Park, DB Kim, YC Kim, JH Lee, OH Lee Changes in the Anti-Allergic Activities of Sesame by Bioconversion Nutrients, 2018-02-14;10(2):. 2018-02-14 [PMID: 29443928] (Bioassay, Human)
• AW Clarke, L Poulton, D Shim, D Mabon, D Butt, M Pollard, V Pande, J Husten, J Lyons, C Tian, AG Doyle An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease MAbs, 2018-03-05;0(0):1-43. 2018-03-05 [PMID: 29436901] (Surface Plasmon Resonance (SPR, Human)
• WR Swindell, MA Beamer, MK Sarkar, S Loftus, J Fullmer, X Xing, NL Ward, LC Tsoi, MJ Kahlenberg, Y Liang, JE Gudjonsson RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature Front Immunol, 2018-01-29;9(0):80. 2018-01-29 [PMID: 29434599] (Cell Culture, Human)
• M Frank-Bert, DS Pisetsky, C Kolling, BA Michel, RE Gay, A Jüngel, S Gay TLR3 Ligand Poly(I:C) Exerts Distinct Actions in Synovial Fibroblasts When Delivered by Extracellular Vesicles Front Immunol, 2018-01-29;9(0):28. 2018-01-29 [PMID: 29434584] (Bioassay, Human)
• M Armaka, C Ospelt, M Pasparakis, G Kollias The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts Nat Commun, 2018-02-12;9(1):618. 2018-02-12 [PMID: 29434332] (Bioassay, Human)
• MA Rapsomanik, XK Lun, S Woerner, M Laumanns, B Bodenmille, MR Martínez CellCycleTRACER accounts for cell cycle and volume in mass cytometry data Nat Commun, 2018-02-12;9(1):632. 2018-02-12 [PMID: 29434325] (Bioassay, Human)
• M Miyauchi, M Ao, H Furusho, C Chea, A Nagasaki, S Sakamoto, T Ando, T Inubushi, K Kozai, T Takata Galectin-3 Plays an Important Role in Preterm Birth Caused by Dental Infection of Porphyromonas gingivalis Sci Rep, 2018-02-12;8(1):2867. 2018-02-12 [PMID: 29434245] (Bioassay, Human)
• W Klement, R Garbelli, E Zub, L Rossini, L Tassi, B Girard, M Blaquiere, F Bertaso, J Perroy, F de Bock, N Marchi Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature Neurobiol. Dis., 2018-02-09;0(0):. 2018-02-09 [PMID: 29432809] (Cell Culture, Human)
• M Oshima, KP Knoch, M Diedisheim, A Petzold, P Cattan, M Bugliani, P Marchetti, P Choudhary, GC Huang, SR Bornstein, M Solimena, O Albagli-Cu, R Scharfmann Virus-like infection induces human ? cell dedifferentiation JCI Insight, 2018-02-08;3(3):. 2018-02-08 [PMID: 29415896] (Bioassay, Human)
• L Chung, ET Orberg, AL Geis, JL Chan, K Fu, CED Shields, CM Dejea, P Fathi, J Chen, BB Finard, AJ Tam, FM McAllister, H Fan, X Wu, S Ganguly, A Lebid, P Metz, SW Van Meerbe, DL Huso, EC Wick, DM Pardoll, F Wan, S Wu, CL Sears, F Housseau Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells Cell Host Microbe, 2018-02-01;0(0):. 2018-02-01 [PMID: 29398651] (Bioassay, Human)
• K Ouhara, S Munenaga, M Kajiya, K Takeda, S Matsuda, Y Sato, Y Hamamoto, T Iwata, S Yamasaki, K Akutagawa, N Mizuno, T Fujita, E Sugiyama, H Kurihara The induced RNA-binding protein, HuR targets 3&#039;-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis Clin. Exp. Immunol., 2018-03-08;0(0):. 2018-03-08 [PMID: 29393507] (Bioassay, Human)
• F Zhang, G Liu, D Li, C Wei, J Hao DDIT4 and Associated lncDDIT4 Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway J. Immunol., 2018-01-29;0(0):. 2018-01-29 [PMID: 29378913] (Bioassay, Human)
• JS Edmisson, S Tian, CL Armstrong, A Vashishta, CK Klaes, I Miralda, E Jimenez-Fl, J Le, Q Wang, RJ Lamont, SM Uriarte Filifactor alocis modulates human neutrophil antimicrobial functional responses Cell. Microbiol., 2018-02-12;0(0):. 2018-02-12 [PMID: 29377528] (Cell Culture, Human)
• A Rutkowska, DR Shimshek, AW Sailer, KK Dev EBI2 regulates pro-inflammatory signalling and cytokine release in astrocytes Neuropharmacology, 2018-01-31;133(0):121-128. 2018-01-31 [PMID: 29374507] (Bioassay, Human, Mouse, Rat)
• L Bin, X Li, B Richers, JE Streib, JW Hu, P Taylor, DYM Leung ANKRD1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum J. Allergy Clin. Immunol., 2018-01-31;0(0):. 2018-01-31 [PMID: 29371118] (Cell Culture, Human)
• L Tengroth, J Arebro, O Larsson, C Bachert, SK Georén, LO Cardell Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps Sci Rep, 2018-01-24;8(1):1561. 2018-01-24 [PMID: 29367682] (Bioassay, Human)
• X Zhang, Y Zhang, J Xu, H Wang, X Zheng, Y Lou, B Han Antigen presentation of the Oct4 and Sox2 peptides by CD154-activated B lymphocytes enhances the killing effect of cytotoxic T lymphocytes on tumor stem-like cells derived from cisplatin-resistant lung cancer cells J Cancer, 2018-01-01;9(2):367-374. 2018-01-01 [PMID: 29344283] (Bioassay, Human)
• R Jalili, J Horecka, JR Swartz, RW Davis, HHJ Persson Streamlined circular proximity ligation assay provides high stringency and compatibility with low-affinity antibodies Proc. Natl. Acad. Sci. U.S.A., 2018-01-16;0(0):. 2018-01-16 [PMID: 29339495] (Bioassay)
• M Medelin, V Giacco, A Aldinucci, G Castronovo, E Bonechi, A Sibilla, M Tanturli, M Torcia, L Ballerini, F Cozzolino, C Ballerini Bridging pro-inflammatory signals, synaptic transmission and protection in spinal explants in vitro Mol Brain, 2018-01-15;11(1):3. 2018-01-15 [PMID: 29334986] (Bioassay, Mouse)
• TA Nakada, P Wacharasin, JA Russell, JH Boyd, E Nakada, SA Thair, T Shimada, KR Walley The IL20 Genetic Polymorphism Is Associated with Altered Clinical Outcome in Septic Shock J Innate Immun, 2018-01-16;0(0):. 2018-01-16 [PMID: 29334679] (Bioassay, Human)
• HD Brightbill, E Suto, N Blaquiere, N Ramamoorth, S Sujatha-Bh, EB Gogol, GM Castanedo, BT Jackson, YC Kwon, S Haller, J Lesch, K Bents, C Everett, PB Kohli, S Linge, L Christian, K Barrett, A Jaochico, LM Berezhkovs, PW Fan, Z Modrusan, K Veliz, MJ Townsend, J DeVoss, AR Johnson, R Godemann, WP Lee, CD Austin, BS McKenzie, JA Hackney, JJ Crawford, ST Staben, MH Alaoui Ism, LC Wu, N Ghilardi NF-?B inducing kinase is a therapeutic target for systemic lupus erythematosus Nat Commun, 2018-01-12;9(1):179. 2018-01-12 [PMID: 29330524] (Bioassay, Human)
• Y Zhang, S Wang, H Dong, X Yi, J Zhang, X Liu, R Zhuang, Y Ding LAIR-1 shedding from human fibroblast-like synoviocytes in rheumatoid arthritis following TNF-? stimulation Clin. Exp. Immunol., 2018-02-20;0(0):. 2018-02-20 [PMID: 29328500] (Bioassay, Human)
• B Jeong, HR Kim, NS Choi, BS Park, H Eom, JW Park, JG Kim, BJ Lee Role of thyroid transcription factor-1 in transcriptional regulation of heme oxygenase-1 Biochem. Biophys. Res. Commun., 2018-01-04;0(0):. 2018-01-04 [PMID: 29305861] (Bioassay, In Vivo, Mouse, Rat)
• X Zhong, HN Lee, YJ Surh RvD1 inhibits TNF?-induced c-Myc expression in normal intestinal epithelial cells and destabilizes hyper-expressed c-Myc in colon cancer cells Biochem. Biophys. Res. Commun., 2018-01-03;0(0):. 2018-01-03 [PMID: 29305860] (Bioassay, Human)
• TD Zaikos, MM Painter, NT Sebastian, VH Terry, KL Collins Class 1-selective histone deacetylase inhibitors enhance HIV latency reversal while preserving the activity of HDAC isoforms necessary for maximal HIV gene expression J. Virol., 2018-02-26;0(0):. 2018-02-26 [PMID: 29298886] (Bioassay, Human)
• YJ Choi, SJ Park, YS Park, HS Park, KM Yang, K Heo EpCAM peptide-primed dendritic cell vaccination confers significant anti-tumor immunity in hepatocellular carcinoma cells PLoS ONE, 2018-01-03;13(1):e0190638. 2018-01-03 [PMID: 29298343] (Bioassay, Human)
• S Gogia, A Kelkar, C Zhang, KM Dayananda, S Neelamegha Role of calcium in regulating the intra- and extracellular cleavage of von Willebrand factor by the protease ADAMTS13 Blood Adv, 2017-10-20;1(23):2063-2074. 2017-10-20 [PMID: 29296853] (Western Blot)
• N Cheng, Y Guo Long noncoding RNA NEAT1 promotes nasopharyngeal carcinoma progression through regulation of miR-124/NF-?B pathway Onco Targets Ther, 2017-12-11;10(0):5843-5853. 2017-12-11 [PMID: 29270022] (Bioassay, Human)
• AM Abu El-Asr, K Alam, M Garcia-Ram, A Ahmad, MM Siddiquei, G Mohammad, A Mousa, G De Hertogh, G Opdenakker, R Simó Association of HMGB1 with oxidative stress markers and regulators in PDR Mol. Vis., 2017-12-05;23(0):853-871. 2017-12-05 [PMID: 29259392] (Bioassay, Human)
• T Tanaka, Y Zhou, T Ozawa, R Okizono, A Banba, T Yamamura, E Oga, A Muraguchi, H Sakurai Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation J. Biol. Chem., 2017-12-18;0(0):. 2017-12-18 [PMID: 29255092] (Bioassay, Human)
• AT Holdbrooks, CM Britain, SL Bellis ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptor J. Biol. Chem., 2017-12-12;0(0):. 2017-12-12 [PMID: 29233887] (Bioassay, Human)
• Y Xu, S Xu, P Liu, M Koroleva, S Zhang, S Si, ZG Jin Suberanilohydroxamic Acid as a Pharmacological Kruppel-Like Factor 2 Activator That Represses Vascular Inflammation and Atherosclerosis J Am Heart Assoc, 2017-11-30;6(12):. 2017-11-30 [PMID: 29191808] (Bioassay, Human)
• N Han, L Shi, Q Guo, W Sun, Y Yu, L Yang, X Zhang, M Zhang HAT1 induces lung cancer cell apoptosis via up regulating Fas Oncotarget, 2017-09-23;8(52):89970-89977. 2017-09-23 [PMID: 29163803] (Bioassay, Human)
• WS Yang, SY Moon, MJ Lee, EK Lee, SK Park Diosgenin, an Activator of 1,25D3-MARRS Receptor/ERp57, Attenuates the Effects of TNF-? by Causing ADAM10-Dependent Ectodomain Shedding of TNF Receptor 1 Cell. Physiol. Biochem., 2017-10-27;43(6):2434-2445. 2017-10-27 [PMID: 29073626] (Bioassay, Human)
• D Yee, KM Shah, MC Coles, TV Sharp, D Lagos MicroRNA-155 induction via TNF-? and IFN-? suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells J. Biol. Chem., 2017-10-24;292(50):20683-20693. 2017-10-24 [PMID: 29066622] (Bioassay, Human)
• NN Mehta, HL Teague, WR Swindell, Y Baumer, NL Ward, X Xing, B Baugous, A Johnston, AA Joshi, J Silverman, DH Barnes, L Wolterink, RP Nair, PE Stuart, M Playford, JJ Voorhees, MK Sarkar, JT Elder, K Gallagher, SK Ganesh, JE Gudjonsson IFN-? and TNF-? synergism may provide a link between psoriasis and inflammatory atherogenesis Sci Rep, 2017-10-23;7(1):13831. 2017-10-23 [PMID: 29062018] (Bioassay, Human)
• MA Peplowski, AJ Vegso, V Iablokov, M Dicay, RS Zaheer, B Renaux, D Proud, MD Hollenberg, PL Beck, WK MacNaughto Tumor necrosis factor ? decreases aquaporin 3 expression in intestinal epithelial cells through inhibition of constitutive transcription Physiol Rep, 2017-10-16;5(19):. 2017-10-16 [PMID: 29038361] (Bioassay, Human)
• H Mogami, A Hari Kisho, Y Akgul, RA Word Healing of Preterm Ruptured Fetal Membranes Sci Rep, 2017-10-13;7(1):13139. 2017-10-13 [PMID: 29030612] (Bioassay, Human)
• S Ebtehaj, EG Gruppen, M Parvizi, UJF Tietge, RPF Dullaart The anti-inflammatory function of HDL is impaired in type 2 diabetes: role of hyperglycemia, paraoxonase-1 and low grade inflammation Cardiovasc Diabetol, 2017-10-12;16(1):132. 2017-10-12 [PMID: 29025405] (Bioassay, Human)
• Z Wang, MY Li, C Mi, KS Wang, J Ma, X Jin Mollugin Has an Anti-Cancer Therapeutic Effect by Inhibiting TNF-?-Induced NF-?B Activation Int J Mol Sci, 2017-07-26;18(8):. 2017-07-26 [PMID: 28933726] (Bioassay, Human)
• L Qiang, A Sample, CR Shea, K Soltani, KF Macleod, YY He Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis Autophagy, 2017-01-01;0(0):0. 2017-01-01 [PMID: 28933598] (Bioassay, Human)
• D Korenfeld, L Gorvel, A Munk, J Man, A Schaffer, T Tung, C Mann, E Klechevsky A type of human skin dendritic cell marked by CD5 is associated with the development of inflammatory skin disease JCI Insight, 2017-09-21;2(18):. 2017-09-21 [PMID: 28931765] (Bioassay, Human)
• ML Palisoul, JM Quinn, E Schepers, IS Hagemann, L Guo, K Reger, AR Hagemann, CK McCourt, PH Thaker, MA Powell, DG Mutch, KC Fuh Inhibition of the Receptor Tyrosine Kinase AXL Restores Paclitaxel Chemosensitivity in Uterine Serous Cancer Mol. Cancer Ther., 2017-09-13;0(0):. 2017-09-13 [PMID: 28904132] (Bioassay, Human)
• N Akbar, JE Digby, TJ Cahill, AN Tavare, AL Corbin, S Saluja, S Dawkins, L Edgar, N Rawlings, K Ziberna, E McNeill, E Johnson, AA Aljabali, RA Dragovic, M Rohling, TG Belgard, IA Udalova, DR Greaves, KM Channon, PR Riley, DC Anthony, RP Choudhury Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction JCI Insight, 2017-09-07;2(17):. 2017-09-07 [PMID: 28878126] (Bioassay, Human)
• M Matsushita, K Ozawa, T Suzuki, M Nakamura, N Nakano, S Kanchi, D Ichikawa, E Matsuki, M Sakurai, D Karigane, H Kasahara, N Tsukamoto, T Shimizu, T Mori, H Nakajima, S Okamoto, Y Kawakami, Y Hattori CXorf48 is a potential therapeutic target for achieving treatment-free remission in CML patients Blood Cancer J, 2017-09-01;7(9):e601. 2017-09-01 [PMID: 28862699] (Bioassay, Human)
• YK Lee, SW Kim, JY Park, WC Kang, YJ Kang, D Khang Suppression of human arthritis synovial fibroblasts inflammation using dexamethasone-carbon nanotubes via increasing caveolin-dependent endocytosis and recovering mitochondrial membrane potential Int J Nanomedicine, 2017-08-10;12(0):5761-5779. 2017-08-10 [PMID: 28848352] (Bioassay, Human)
• N Starc, D Ingo, A Conforti, V Rossella, L Tomao, A Pitisci, F De Mattia, I Brigida, M Algeri, M Montanari, G Palumbo, P Merli, P Rossi, A Aiuti, F Locatelli, ME Bernardo Biological and functional characterization of bone marrow-derived mesenchymal stromal cells from patients affected by primary immunodeficiency Sci Rep, 2017-08-15;7(1):8153. 2017-08-15 [PMID: 28811575] (Bioassay, Human)
• KA Bailey, FG Haj, SI Simon, AG Passerini Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation Sci Rep, 2017-08-15;7(1):8196. 2017-08-15 [PMID: 28811527] (Bioassay, Human)
• BK Hong, S You, SA Yoo, D Park, D Hwang, CS Cho, WU Kim MicroRNA-143 and -145 modulate the phenotype of synovial fibroblasts in rheumatoid arthritis Exp. Mol. Med., 2017-08-04;49(8):e363. 2017-08-04 [PMID: 28775366] (Bioassay, Human)
• AE van der Wi, IMC Vogels, CJF van Noorde, I Klaassen, RO Schlingema TNF?-Induced Disruption of the Blood-Retinal Barrier In Vitro Is Regulated by Intracellular 3&#039;,5&#039;-Cyclic Adenosine Monophosphate Levels Invest. Ophthalmol. Vis. Sci., 2017-07-01;58(9):3496-3505. 2017-07-01 [PMID: 28715583] (Bioassay, Human)
• E Couderc, F Morel, P Levillain, A Buffière-M, M Camus, C Paquier, C Bodet, JF Jégou, M Pohin, L Favot, M Garcia, V Huguier, J Mcheik, C Lacombe, H Yssel, G Guillet, FX Bernard, JC Lecron Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis PLoS ONE, 2017-07-14;12(7):e0181486. 2017-07-14 [PMID: 28708859] (Bioassay, Human)
• Y Haim, M Blüher, D Konrad, N Goldstein, N Klöting, I Harman-Boe, B Kirshtein, D Ginsberg, T Tarnovscki, Y Gepner, I Shai, A Rudich ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype Mol Metab, 2017-05-06;6(7):725-736. 2017-05-06 [PMID: 28702328] (Bioassay, Human)
• R Ahmad, B Rah, D Bastola, P Dhawan, AB Singh Obesity-induces Organ and Tissue Specific Tight Junction Restructuring and Barrier Deregulation by Claudin Switching Sci Rep, 2017-07-11;7(1):5125. 2017-07-11 [PMID: 28698546] (Bioassay, Human)
• J Yuzugulen, JA Douthwaite, EG Wood, IC Villar, NSA Patel, J Jegard, H Gaertner, I Rossitto-B, K Rose, O Hartley, PR Cutillas, A Ahluwalia, R Corder Characterisation of preproendothelin-1 derived peptides identifies Endothelin-Like Domain Peptide as a modulator of Endothelin-1 Sci Rep, 2017-07-10;7(1):4956. 2017-07-10 [PMID: 28694457] (Bioassay, Human)
• SS Chung, Y Wu, Q Okobi, D Adekoya, M Atefi, O Clarke, P Dutta, JV Vadgama Proinflammatory Cytokines IL-6 and TNF-? Increased Telomerase Activity through NF-?B/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells Mediators Inflamm., 2017-06-06;2017(0):5958429. 2017-06-06 [PMID: 28676732] (Bioassay, Human)
• R Connor, LD Jones, X Qiu, J Thakar, SB Maggirwar Frontline Science: c-Myc regulates P-selectin glycoprotein ligand-1 expression in monocytes during HIV-1 infection J. Leukoc. Biol., 2017-06-29;0(0):. 2017-06-29 [PMID: 28663244] (Bioassay, Human)
• L Šenolt, K Prajzlerov, H Hulejová, B Šumová, M Filková, D Veigl, K Pavelka, J Vencovský Interleukin-20 is triggered by TLR ligands and associates with disease activity in patients with rheumatoid arthritis Cytokine, 2017-06-26;97(0):187-192. 2017-06-26 [PMID: 28662439] (Bioassay, Human)
• JD Graci, D Michaels, G Chen, GM Schiralli, S Nodder, M Weetall, GM Karp, Z Gu, JM Colacino, AJ Henderson Identification of benzazole compounds that induce HIV-1 transcription PLoS ONE, 2017-06-28;12(6):e0179100. 2017-06-28 [PMID: 28658263] (Bioassay, Human)
• TL Liao, YM Chen, CW Hsieh, HH Chen, HC Lee, WT Hung, KT Tang, DY Chen Upregulation of circulating microRNA-134 in adult-onset Still&#039;s disease and its use as potential biomarker Sci Rep, 2017-06-23;7(1):4214. 2017-06-23 [PMID: 28646209] (Bioassay, Human)
• S Weis, AR Carlos, MR Moita, S Singh, B Blankenhau, S Cardoso, R Larsen, S Rebelo, S Schäuble, L Del Barrio, G Mithieux, F Rajas, S Lindig, M Bauer, MP Soares Metabolic Adaptation Establishes Disease Tolerance to Sepsis Cell, 2017-06-15;169(7):1263-1275.e14. 2017-06-15 [PMID: 28622511] (Bioassay, Human)
• A Pavesi, AT Tan, S Koh, A Chia, M Colombo, E Antonecchi, C Miccolis, E Ceccarello, G Adriani, MT Raimondi, RD Kamm, A Bertoletti A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors JCI Insight, 2017-06-15;2(12):. 2017-06-15 [PMID: 28614795] (Bioassay, Human)
• JS Reyat, M Chimen, PJ Noy, J Szyroka, GE Rainger, MG Tomlinson ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration J. Immunol., 2017-06-09;0(0):. 2017-06-09 [PMID: 28600292] (Bioassay, Human)
• M Fardoun, T Al-Shehabi, A El-Yazbi, K Issa, F Zouein, D Maaliki, R Iratni, AH Eid Ziziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells Oxid Med Cell Longev, 2017-05-15;2017(0):4134093. 2017-05-15 [PMID: 28593025] (Bioassay, Human)
• Z Zhang, Z Stickney, N Duong, K Curley, B Lu AAV-based dual-reporter circuit for monitoring cell signaling in living human cells J Biol Eng, 2017-06-05;11(0):18. 2017-06-05 [PMID: 28592991] (Bioassay, Human)
• R Santos, KC Vadodaria, BN Jaeger, A Mei, S Lefcochilo, APD Mendes, G Erikson, M Shokhirev, L Randolph-M, C Fredlender, S Dave, R Oefner, C Fitzpatric, M Pena, JJ Barron, M Ku, AM Denli, BE Kerman, P Charnay, JR Kelsoe, MC Marchetto, FH Gage Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells Stem Cell Reports, 2017-06-06;8(6):1757-1769. 2017-06-06 [PMID: 28591655] (Bioassay, Human)
• NT Hogan, MB Whalen, LK Stolze, NK Hadeli, MT Lam, JR Springstea, CK Glass, CE Romanoski Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells Elife, 2017-06-06;6(0):. 2017-06-06 [PMID: 28585919] (Bioassay, Human)
• GG Jinesh, AM Kamat RalBP1 and p19-VHL play an oncogenic role, and p30-VHL plays a tumor suppressor role during the blebbishield emergency program Cell Death Discov, 2017-05-29;3(0):17023. 2017-05-29 [PMID: 28580172] (Bioassay, Human)
• D Sagar, NP Singh, R Ginwala, X Huang, R Philip, M Nagarkatti, P Nagarkatti, K Neumann, J Ruland, AM Andrews, SH Ramirez, ZK Khan, P Jain Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity Sci Rep, 2017-06-02;7(1):2707. 2017-06-02 [PMID: 28578388] (Bioassay, Human)
• C Zhang, Z Chen, X Meng, M Li, L Zhang, A Huang The involvement and possible mechanism of pro-inflammatory tumor necrosis factor alpha (TNF-?) in thoracic ossification of the ligamentum flavum PLoS ONE, 2017-06-02;12(6):e0178986. 2017-06-02 [PMID: 28575129] (Bioassay, Human)
• S Khiar, M Lucas-Hour, S Nisole, N Smith, O Helynck, M Bourgine, C Ruffié, JP Herbeuval, H Munier-Leh, F Tangy, PO Vidalain Identification of a small molecule that primes the type I interferon response to cytosolic DNA Sci Rep, 2017-05-31;7(1):2561. 2017-05-31 [PMID: 28566766] (Bioassay, Human)
• K Kinnunen, N Piippo, S Loukovaara, M Hytti, K Kaarnirant, A Kauppinen Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs) J Cell Commun Signal, 2017-05-25;0(0):. 2017-05-25 [PMID: 28547650] (Bioassay, Human)
• M Shioda, T Muneta, K Tsuji, M Mizuno, K Komori, H Koga, I Sekiya TNF? promotes proliferation of human synovial MSCs while maintaining chondrogenic potential PLoS ONE, 2017-05-18;12(5):e0177771. 2017-05-18 [PMID: 28542363] (Bioassay, Human)
• CH Lo, N Vunnam, AK Lewis, TL Chiu, BE Brummel, TM Schaaf, BD Grant, P Bawaskar, DD Thomas, JN Sachs An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors SLAS Discov, 2017-05-22;0(0):2472555217706. 2017-05-22 [PMID: 28530838] (Bioassay, Human)
• Yunbo Ke, Noureddine Zebda, Olga Oskolkova, Taras Afonyushk, Evgeny Berdyshev, Yufeng Tian, Fanyong Meng, Nicolene Sarich, Valery N Bochkov, Ji Ming Wang, Anna A Birukova, Konstantin G Birukov Anti-Inflammatory Effects of OxPAPC Involve Endothelial Cell-Mediated Generation of LXA4. Circulation Research, 2017-05-18;0(0):1524-4571. 2017-05-18 [PMID: 28522438] (Bioassay, Human)
• A Alquraini, M Jamal, L Zhang, T Schmidt, GD Jay, KA Elsaid The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes Arthritis Res. Ther., 2017-05-08;19(1):89. 2017-05-08 [PMID: 28482921] (Bioassay, Human)
• GW He, C Günther, V Thonn, YQ Yu, E Martini, B Buchen, MF Neurath, M Stürzl, C Becker Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice J. Exp. Med., 2017-05-05;0(0):. 2017-05-05 [PMID: 28476895] (Bioassay, Human)
• X Wang, R Wilkinson, K Kildey, J Potriquet, J Mulvenna, RJ Lobb, A Möller, N Cloonan, P Mukhopadhy, AJ Kassianos, H Healy Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions J Extracell Vesicles, 2017-04-21;6(1):1314073. 2017-04-21 [PMID: 28473886] (Bioassay, Human)
• YS Jung, SO Lee Apomorphine suppresses TNF-?-induced MMP-9 expression and cell invasion through inhibition of ERK/AP-1 signaling pathway in MCF-7 cells Biochem. Biophys. Res. Commun., 2017-05-02;0(0):. 2017-05-02 [PMID: 28465234] (Bioassay, Human)
• H Choi, RMC Ignacio, ES Lee, AJ Wilson, D Khabele, DS Son Augmented Serum Amyloid A1/2 Mediated by TNF-induced NF-?B in Human Serous Ovarian Epithelial Tumors Immune Netw, 2017-04-20;17(2):121-127. 2017-04-20 [PMID: 28458624] (Bioassay, Human)
• B Wang, Z Chen, X Meng, M Li, X Yang, C Zhang iTRAQ quantitative proteomic study in patients with thoracic ossification of the ligamentum flavum Biochem. Biophys. Res. Commun., 2017-04-26;0(0):. 2017-04-26 [PMID: 28455229] (Bioassay, Human)
• P Huang, MW Lee, K Sadrerafi, DP Heruth, LQ Zhang, D Maulik, SQ Ye MC-PPEA as a new and more potent inhibitor of CLP-induced sepsis and pulmonary inflammation than FK866 Drug Des Devel Ther, 2017-03-03;11(0):629-641. 2017-03-03 [PMID: 28424540] (Bioassay, Human)
• H Al Faruque, JH Kang, SR Hwang, S Sung, MM Alam, KH Sa, EJ Nam, YR Byun, YM Kang Stepwise inhibition of T cell recruitment at post-capillary venules by orally active desulfated heparins in inflammatory arthritis PLoS ONE, 2017-04-18;12(4):e0176110. 2017-04-18 [PMID: 28419144] (Bioassay, Human)
• KJ Chung, A Chatzigeor, M Economopou, R Garcia-Mar, VI Alexaki, I Mitroulis, M Nati, J Gebler, T Ziemssen, SE Goelz, J Phieler, JH Lim, KP Karalis, T Papayannop, M Blüher, G Hajishenga, T Chavakis A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity Nat. Immunol., 2017-04-17;0(0):. 2017-04-17 [PMID: 28414311] (Bioassay, Human)
• BS Patel, MJ Kugel, G Baehring, AJ Ammit Doxofylline does not increase formoterol-induced cAMP nor MKP-1 expression in ASM cells resulting in lack of anti-inflammatory effect Pulm Pharmacol Ther, 2017-04-13;0(0):. 2017-04-13 [PMID: 28414142] (Bioassay, Human)
• E Redondo-Ca, C Cunningham, J Miller, L Martuscell, S Aoulad-Ali, NJ Rothwell, CM Kielty, SM Allan, E Pinteaux Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro Stem Cell Res Ther, 2017-04-17;8(1):79. 2017-04-17 [PMID: 28412968] (Bioassay, Human)
• E Krayukhina, M Noda, K Ishii, T Maruno, H Wakabayash, M Tada, T Suzuki, A Ishii-Wata, M Kato, S Uchiyama Analytical ultracentrifugation with fluorescence detection system reveals differences in complex formation between recombinant human TNF and different biological TNF antagonists in various environments MAbs, 2017-03-03;9(4):664-679. 2017-03-03 [PMID: 28387583] (Bioassay)
• JW Lee, J Lee, SH Um, EY Moon Synovial cell death is regulated by TNF-?-induced expression of B-cell activating factor through an ERK-dependent increase in hypoxia-inducible factor-1? Cell Death Dis, 2017-04-06;8(4):e2727. 2017-04-06 [PMID: 28383556] (Bioassay, Human)
• H Munir, LS Ward, L Sheriff, S Kemble, S Nayar, F Barone, GB Nash, HM McGettrick Adipogenic differentiation of MSC alters their immunomodulatory properties in a tissue-specific manner Stem Cells, 2017-04-24;0(0):. 2017-04-24 [PMID: 28376564] (Bioassay, Human)
• F Pan, H Xiang, J Yan, L Hong, L Zhang, Y Liu, X Feng, C Cai Dendritic cells from rheumatoid arthritis patient peripheral blood induce Th17 cell differentiation via miR-363/Integrin ?v/TGF-? axis Scand. J. Immunol., 2017-06-01;0(0):. 2017-06-01 [PMID: 28376277] (Bioassay, Human)
• R Havunen, M Siurala, S Sorsa, S Grönberg-V, M Behr, S Tähtinen, JM Santos, P Karell, J Rusanen, DM Nettelbeck, A Ehrhardt, A Kanerva, A Hemminki Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy Mol Ther Oncolytics, 2016-12-31;4(0):77-86. 2016-12-31 [PMID: 28345026] (Bioassay, Mouse)
• Z Zhang, Q He, Y Tao, J Guo, F Xu, LY Wu, YS Zhao, D Wu, LY Zhou, JY Su, LX Song, C Xiao, X Li, CK Chang Decitabine treatment sensitizes tumor cells to T-cell-mediated cytotoxicity in patients with myelodysplastic syndromes Am J Transl Res, 2017-02-15;9(2):454-465. 2017-02-15 [PMID: 28337274] (Bioassay, Human)
• Y Kokubu, T Yamaguchi, K Kawabata In�vitro model of cerebral ischemia by using brain microvascular endothelial cells derived from human induced pluripotent stem cells Biochem. Biophys. Res. Commun, 2017-03-21;0(0):. 2017-03-21 [PMID: 28336435] (Bioassay, Human)
• M Frank-Bert, M Trenkmann, K Klein, E Karouzakis, H Rehrauer, A Bratus, C Kolling, M Armaka, A Filer, BA Michel, RE Gay, CD Buckley, G Kollias, S Gay, C Ospelt Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions Nat Commun, 2017-03-23;8(0):14852. 2017-03-23 [PMID: 28332497] (Bioassay, Human)
• M Silva, RK Fung, CB Donnelly, PA Videira, R Sackstein Cell-Specific Variation in E-Selectin Ligand Expression among Human Peripheral Blood Mononuclear Cells: Implications for Immunosurveillance and Pathobiology J. Immunol, 2017-03-22;0(0):. 2017-03-22 [PMID: 28330896] (Bioassay, Human)
• HA Ebhardt, S Degen, V Tadini, A Schilb, N Johns, CA Greig, KC Fearon, R Aebersold, C Jacobi Comprehensive proteome analysis of human skeletal muscle in cachexia and sarcopenia: A pilot study J Cachexia Sarcopenia Muscle, 2017-03-15;0(0):. 2017-03-15 [PMID: 28296247] (Bioassay, Human)
• JS Ainscough, T Macleod, D McGonagle, R Brakefield, JM Baron, A Alase, M Wittmann, M Stacey Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36? Proc. Natl. Acad. Sci. U.S.A, 2017-03-13;114(13):E2748-E2757. 2017-03-13 [PMID: 28289191] (Bioassay, Human)
• J Retzlaff, K Thamm, CC Ghosh, W Ziegler, H Haller, SM Parikh, S David Flunarizine suppresses endothelial Angiopoietin-2 in a calcium - dependent fashion in sepsis Sci Rep, 2017-03-09;7(0):44113. 2017-03-09 [PMID: 28276491] (Bioassay, Human)
• J Arebro, S Ekstedt, E Hjalmarsso, O Winqvist, S Kumlien Ge, LO Cardell A possible role for neutrophils in allergic rhinitis revealed after cellular subclassification Sci Rep, 2017-03-08;7(0):43568. 2017-03-08 [PMID: 28272395] (Bioassay, Human)
• MH Hancock, LM Hook, J Mitchell, JA Nelson Human Cytomegalovirus MicroRNAs miR-US5-1 and miR-UL112-3p Block Proinflammatory Cytokine Production in Response to NF-?B-Activating Factors through Direct Downregulation of IKK? and IKK? MBio, 2017-03-07;8(2):. 2017-03-07 [PMID: 28270578] (Bioassay, Human)
• JA Schwartz, KL Clayton, S Mujib, H Zhang, AK Rahman, J Liu, FY Yue, E Benko, C Kovacs, MA Ostrowski Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9 J. Immunol, 2017-03-06;0(0):. 2017-03-06 [PMID: 28264968] (Bioassay, Human)
• BF Wang, PP Cao, ZC Wang, ZY Li, ZZ Wang, J Ma, B Liao, YK Deng, XB Long, K Xu, H Wang, H Wang, M Zeng, X Lu, Z Liu Interferon-? induced insufficient autophagy contributes to p62-dependent apoptosis of epithelial cells in chronic rhinosinusitis with nasal polyps Allergy, 2017-04-04;0(0):. 2017-04-04 [PMID: 28258963] (Bioassay, Human)
• F Salazar, D Awuah, OH Negm, F Shakib, AM Ghaemmagha The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs Sci Rep, 2017-03-03;7(0):43337. 2017-03-03 [PMID: 28256612] (Bioassay, Complex Species Category)
• WY Kuo, L Hwu, CY Wu, JS Lee, CW Chang, RS Liu STAT3/NF-?B-Regulated Lentiviral TK/GCV Suicide Gene Therapy for Cisplatin-Resistant Triple-Negative Breast Cancer Theranostics, 2017-01-15;7(3):647-663. 2017-01-15 [PMID: 28255357] (Bioassay, Human)
• Y Zou, S Zeng, M Huang, Q Qiu, Y Xiao, M Shi, Z Zhan, L Liang, X Yang, H Xu Inhibition of 6-phosphofructo-2-kinase suppresses fibroblast-like synoviocytes- mediated synovial inflammation and joint destruction in rheumatoid arthritis Br. J. Pharmacol, 2017-03-27;0(0):. 2017-03-27 [PMID: 28239846] (Bioassay, Human)
• SR DiNapoli, AM Ortiz, F Wu, K Matsuda, HL Twigg, VM Hirsch, K Knox, JM Brenchley Tissue-resident macrophages can contain replication-competent virus in antiretroviral-naive, SIV-infected Asian macaques JCI Insight, 2017-02-23;2(4):e91214. 2017-02-23 [PMID: 28239657] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))
• L Israel, Y Wang, K Bulek, E Della Mina, Z Zhang, V Pedergnana, M Chrabieh, NA Lemmens, V Sancho-Shi, M Descatoire, T Lasseau, E Israelsson, L Lorenzo, L Yun, A Belkadi, A Moran, LE Weisman, F Vandenesch, F Batteux, S Weller, M Levin, J Herberg, A Abhyankar, C Prando, Y Itan, WJB van Wamel, C Picard, L Abel, D Chaussabel, X Li, B Beutler, PD Arkwright, JL Casanova, A Puel Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity Cell, 2017-02-23;168(5):789-800.e10. 2017-02-23 [PMID: 28235196] (Bioassay, Cell Culture, Human)
• JS Muhammad, S Nanjo, T Ando, S Yamashita, T Maekita, T Ushijima, Y Tabuchi, T Sugiyama Autophagy Impairment by Helicobacter pylori-induced Methylation Silencing of MAP1LC3Av1 Promotes Gastric Carcinogenesis Int. J. Cancer, 2017-03-14;0(0):. 2017-03-14 [PMID: 28214334] (Bioassay, Rat)
• NV Sankpal, TP Fleming, PK Sharma, HJ Wiedner, WE Gillanders A double-negative feedback loop between EpCAM and ERK contributes to the regulation of epithelial-mesenchymal transition in cancer Oncogene, 2017-02-13;0(0):. 2017-02-13 [PMID: 28192403] (Bioassay, Human)
• S Kim, J Piao, Y Son, HS Hong Substance P enhances proliferation and paracrine potential of adipose-derived stem cells in�vitro Biochem. Biophys. Res. Commun, 2017-02-10;0(0):. 2017-02-10 [PMID: 28192115] (Bioassay, Human)
• M Tanaka, H Tashiro, B Omer, N Lapteva, J Ando, M Ngo, B Mehta, G Dotti, PR Kinchingto, AM Leen, C Rossig, CM Rooney Vaccination targeting native receptors to enhance the function and proliferation of chimeric antigen receptor (CAR)-modified T cells Clin. Cancer Res, 2017-02-09;0(0):. 2017-02-09 [PMID: 28183713] (Bioassay, Human)
• S Zhu, Q Zhang, X Sun, HJ Zeh, MT Lotze, R Kang, D Tang HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells Cancer Res, 2017-01-27;0(0):. 2017-01-27 [PMID: 28130223] (Bioassay, Human)
• A Smole, D Lain??ek, U Bezeljak, S Horvat, R Jerala A Synthetic Mammalian Therapeutic Gene Circuit for Sensing and Suppressing Inflammation Mol. Ther, 2017-01-04;25(1):102-119. 2017-01-04 [PMID: 28129106] (Bioassay, In Vivo, Human, Mouse)
• Bo Ra You, Bo Ram Han, Woo Hyun Park Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-? through up-regulation of TNF receptor 1 in lung cancer cells. Oncotarget, 2017-03-14;0(0):1949-2553. 2017-03-14 [PMID: 28099148] (Bioassay, Human)
• AC Lundell, I Nordstr”m, K Andersson, C Lundqvist, E Telemo, S Nava, H Kaipe, A Rudin IFN type I and II induce BAFF secretion from human decidual stromal cells Sci Rep, 2017-01-06;7(0):39904. 2017-01-06 [PMID: 28057926] (Bioassay, Human)
• Anja Kerstein Environmental factor and inflammation-driven alteration of the total peripheral T-cell compartment in granulomatosis with polyangiitis J. Autoimmun, 2016-12-28;0(0):. 2016-12-28 [PMID: 28040323] (Bioassay, Human)
• Eric Chu Bradykinin stimulates protein kinase D-mediated colonic myofibroblast migration via cyclooxygenase-2 and heat shock protein 27 J. Surg. Res, 2016-10-20;209(0):191-198. 2016-10-20 [PMID: 28032559] (Bioassay, Human)
• Martin F Reiner Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression Cardiovasc. Res, 2016-11-15;0(0):. 2016-11-15 [PMID: 28028070] (Bioassay, Human)
• Shailesh Dudhgaonka Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity J. Immunol, 2016-12-21;0(0):. 2016-12-21 [PMID: 28003376] (Bioassay, Human)
• Brijeshkumar S Patel Roflumilast N-oxide in Combination with Formoterol Enhances the Anti-inflammatory Effect of Dexamethasone in ASM Cells Am. J. Respir. Cell Mol. Biol, 2017-04-01;0(0):. 2017-04-01 [PMID: 27997807] (Bioassay, Human)
• Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling Sci Rep, 2016-12-19;6(0):39190. 2016-12-19 [PMID: 27991524] (Bioassay, Human)
• Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency Proc. Natl. Acad. Sci. U.S.A, 2016-12-07;0(0):. 2016-12-07 [PMID: 27930337] (Bioassay, Human)
• Wijtske Annema HDL function is impaired in acute myocardial infarction independent of plasma HDL cholesterol levels J Clin Lipidol, 2016-08-17;10(6):1318-1328. 2016-08-17 [PMID: 27919348] (Bioassay, Human)
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• Benjamin Malard Adsorption as a Contributor for Inflammatory Mediators Removal by Different Hemofiltration Membranes: A Pilot Study Artif Organs, 2016-12-02;0(0):. 2016-12-02 [PMID: 27911005] (Hemofiltration Procedure, Human)
• Prenylated Polyphenols from Clusiaceae and Calophyllaceae with Immunomodulatory Activity on Endothelial Cells PLoS ONE, 2016-12-01;11(12):e0167361. 2016-12-01 [PMID: 27907087] (Bioassay, Human)
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• Nathalie Castex-Riz Anti-inflammatory and immunomodulatory effects of Aquaphilus dolomiae extract on in vitro models Clin Cosmet Investig Dermatol, 2016-11-10;9(0):421-434. 2016-11-10 [PMID: 27877060] (Bioassay, Human)
• Jong Baeck Lim Identificaiton of Novel Immunogenic Human Papillomavirus Type 16 E7-Specific Epitopes Restricted to HLA-A*33;03 for Cervical Cancer Immunotherapy Yonsei Med. J., 2017-01-01;58(1):43-50. 2017-01-01 [PMID: 27873494] (Bioassay, Human)
• Andrea Todisco Regulation and function of Bone Morphogenetic Protein signaling in colonic injury and inflammation Am. J. Physiol. Gastrointest. Liver Physiol., 2016-11-17;0(0):ajpgi.00169.2. 2016-11-17 [PMID: 27856416] (Bioassay, Human)
• John Deanfield Anti-inflammatory treatment improves high-density lipoprotein function in rheumatoid arthritis Heart, 2016-11-16;0(0):. 2016-11-16 [PMID: 27852695] (Bioassay, Human)
• Robert Sabat MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations Mediators Inflamm., 2016-10-23;2016(0):4097574. 2016-10-23 [PMID: 27843200] (Bioassay, Human)
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• Niklas Czeloth Bioequivalence, safety and immunogenicity of BI 695501, an adalimumab biosimilar candidate, compared with the reference biologic in a randomized, double-blind, active-comparator Phase I clinical study (VOLTAIRE�-PK) in healthy subjects Expert Opin Investig Drugs, 2016-12-01;0(0):. 2016-12-01 [PMID: 27813422] (Bioassay)
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• IRAK1, a Target of miR-146b, Reduces Cell Aggressiveness of Human Papillary Thyroid Carcinoma J Clin Endocrinol Metab, 2016-08-17;0(0):jc20162276. 2016-08-17 [PMID: 27533309] (Bioassay, Human)
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• Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis Cell Death Dis, 2016-06-30;7(6):e2287. 2016-06-30 [PMID: 27362805] (Bioassay, Human)
• Michael A Schmid Mosquito Saliva Increases Endothelial Permeability in the Skin, Immune Cell Migration, and Dengue Pathogenesis during Antibody-Dependent Enhancement PLoS Pathog, 2016-06-16;12(6):e1005676. 2016-06-16 [PMID: 27310141] (Bioassay, Human)
• Interferon-? and Tumor Necrosis Factor-? Polarize Bone Marrow Stromal Cells Uniformly to a Th1 Phenotype Sci Rep, 2016-05-23;6(0):26345. 2016-05-23 [PMID: 27211104] (Bioassay, Human)
• Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells PLoS ONE, 2016-05-20;11(5):e0156145. 2016-05-20 [PMID: 27203692] (Bioassay, Human)
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• IL-3 Decreases Cartilage Degeneration by Downregulating Matrix Metalloproteinases and Reduces Joint Destruction in Osteoarthritic Mice J Immunol, 2016-05-13;0(0):. 2016-05-13 [PMID: 27183574] (Bioassay, Human)
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• Ji , Weidong, Yang , Mei, Praggastis , Alexandr, Li , Yonghao, Zhou , Huanjiao, He , Yun, Ghazvinian , Roxanne, Cincotta , Dylan J, Rice , Kevin P, Min , Wang Carbamoylating activity associated with the activation of the antitumor agent laromustine inhibits angiogenesis by inducing ASK1-dependent endothelial cell death. PLoS ONE, 2014-07-28;9(7):e103224. 2014-07-28 [PMID: 25068797] (Bioassay, Bovine, Human)
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• Guedes R, Csizmadia E, Moll H, Ma A, Ferran C, da Silva C A20 deficiency causes spontaneous neuroinflammation in mice. J Neuroinflammation, 2014-07-16;11(0):122. 2014-07-16 [PMID: 25026958] (Stimulation, Mouse)
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• Rabeony H, Petit-Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, Jegou J, Guillet G, Huguier V, Lecron J, Bernard F, Morel F Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1alpha, TNFalpha and oncostatin M. PLoS ONE, 2014-07-10;9(7):e101937. 2014-07-10 [PMID: 25010647] (Bioassay, Human)
• Jin H, Lee W, Eun S, Jung J, Park H, Kim G, Choi Y, Ryu C, Jung J, Hong S, Shin S, Kim H Morin, a flavonoid from Moraceae, suppresses growth and invasion of the highly metastatic breast cancer cell line MDA-MB231 partly through suppression of the Akt pathway. Int J Oncol, 2014-07-04;45(4):1629-37. 2014-07-04 [PMID: 24993541] (Bioassay, Human)
• Lewis , Nuruddee, Patnaude , Lori A, Pelletier , Josephin, Souza , Donald J, Lukas , Susan M, King , F James, Hill , Jonathan, Stefanopoulos , Dimitria, Ryan , Kelli, Desai , Sudha, Skow , Donna, Kauschke , Stefan G, Broermann , Andre, Kuzmich , Daniel, Harcken , Christia, Hickey , Eugene R, Modis , Louise K A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo. PLoS ONE, 2014-06-26;9(6):e100883. 2014-06-26 [PMID: 24967665] (Bioassay, Human)
• Chiang , En-Pei I, Tsai , Shu-Yao, Kuo , Yueh-Hsi, Pai , Man-Hui, Chiu , Hsi-Lin, Rodriguez , Raymond, Tang , Feng-Yao Caffeic acid derivatives inhibit the growth of colon cancer: involvement of the PI3-K/Akt and AMPK signaling pathways. PLoS ONE, 2014-06-24;9(6):e99631. 2014-06-24 [PMID: 24960186] (Bioassay, Human)
• Kastrati I, Canestrari E, Frasor J PHLDA1 expression is controlled by an estrogen receptor-NFkappaB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres. Oncogene, 2014-06-23;34(18):2309-16. 2014-06-23 [PMID: 24954507] (Bioassay, Human)
• Shindo Y, Hazama S, Maeda Y, Matsui H, Iida M, Suzuki N, Yoshimura K, Ueno T, Yoshino S, Sakai K, Suehiro Y, Yamasaki T, Hinoda Y, Oka M Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer. J Transl Med, 2014-06-19;12(0):175. 2014-06-19 [PMID: 24947606] (Bioassay, Human)
• Mimura N, Hideshima T, Shimomura T, Suzuki R, Ohguchi H, Rizq O, Kikuchi S, Yoshida Y, Cottini F, Jakubikova J, Cirstea D, Gorgun G, Minami J, Tai Y, Richardson P, Utsugi T, Iwama A, Anderson K Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition. Cancer Res, 2014-06-16;74(16):4458-69. 2014-06-16 [PMID: 24934808] (Bioassay, Human)
• Zhao C, Pavicic P, Datta S, Sun D, Novotny M, Hamilton T Cellular stress amplifies TLR3/4-induced CXCL1/2 gene transcription in mononuclear phagocytes via RIPK1. J Immunol, 2014-06-11;193(2):879-88. 2014-06-11 [PMID: 24920846] (Bioassay, Human)
• Cubbon R, Yuldasheva N, Viswambharan H, Mercer B, Baliga V, Stephen S, Askham J, Sukumar P, Skromna A, Mughal R, Walker A, Bruns A, Bailey M, Galloway S, Imrie H, Gage M, Rakobowchuk M, Li J, Porter K, Ponnambalam S, Wheatcroft S, Beech D, Kearney M Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential. Stem Cells, 2014-10-01;32(10):2714-23. 2014-10-01 [PMID: 24916783] (Bioassay, Human)
• Volpe E, Pattarini L, Martinez-Cingolani C, Meller S, Donnadieu M, Bogiatzi S, Fernandez M, Touzot M, Bichet J, Reyal F, Paronetto M, Chiricozzi A, Chimenti S, Nasorri F, Cavani A, Kislat A, Homey B, Soumelis V Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis. J Allergy Clin Immunol, 2014-06-06;134(2):373-81. 2014-06-06 [PMID: 24910175] (Bioassay, Human)
• Zhao Y, Xiao X, Frank S, Lin H, Xia Y Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-alpha, and IL-1beta. Am J Physiol Endocrinol Metab, 2014-06-03;307(2):E186-98. 2014-06-03 [PMID: 24895283] (Bioassay, Human)
• Tengroth L, Millrud C, Kvarnhammar A, Kumlien Georen S, Latif L, Cardell L Functional effects of Toll-like receptor (TLR)3, 7, 9, RIG-I and MDA-5 stimulation in nasal epithelial cells. PLoS ONE, 2014-06-02;9(6):e98239. 2014-06-02 [PMID: 24886842] (Bioassay, Human)
• Kim , Dae Won, Zloza , Andrew, Broucek , Joseph, Schenkel , Jason M, Ruby , Carl, Samaha , Georges, Kaufman , Howard L Interleukin-2 alters distribution of CD144 (VE-cadherin) in endothelial cells. J Transl Med, 2014-05-06;12(0):113. 2014-05-06 [PMID: 24885155] (Bioassay, Human)
• Schafer P, Parton A, Capone L, Cedzik D, Brady H, Evans J, Man H, Muller G, Stirling D, Chopra R Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity. Cell Signal, 2014-05-29;26(9):2016-29. 2014-05-29 [PMID: 24882690] (Bioassay, Human)
• Montespan F, Deschaseaux F, Sensebe L, Carosella E, Rouas-Freiss N Osteodifferentiated mesenchymal stem cells from bone marrow and adipose tissue express HLA-G and display immunomodulatory properties in HLA-mismatched settings: implications in bone repair therapy. J Immunol Res, 2014-04-30;2014(0):230346. 2014-04-30 [PMID: 24877156] (Bioassay, Human)
• Backman S, Kollara A, Haw R, Stein L, Brown T Glucocorticoid-induced reversal of interleukin-1beta-stimulated inflammatory gene expression in human oviductal cells. PLoS ONE, 2014-05-21;9(5):e97997. 2014-05-21 [PMID: 24848801] (Bioassay, Human)
• Cupi M, Sarra M, Marafini I, Monteleone I, Franze E, Ortenzi A, Colantoni A, Sica G, Sileri P, Rosado M, Carsetti R, MacDonald T, Pallone F, Monteleone G Plasma cells in the mucosa of patients with inflammatory bowel disease produce granzyme B and possess cytotoxic activities. J Immunol, 2014-05-16;192(12):6083-91. 2014-05-16 [PMID: 24835396] (Bioassay, Human)
• Zhou M, Liu R, Su D, Feng X, Li X TL1A increased the differentiation of peripheral Th17 in rheumatoid arthritis. Cytokine, 2014-05-13;69(1):125-30. 2014-05-13 [PMID: 24832108] (Bioassay, Human)
• Herr F, Lemoine R, Gouilleux F, Meley D, Kazma I, Heraud A, Velge-Roussel F, Baron C, Lebranchu Y IL-2 phosphorylates STAT5 to drive IFN-gamma production and activation of human dendritic cells. J Immunol, 2014-05-14;192(12):5660-70. 2014-05-14 [PMID: 24829413] (Bioassay, Human)
• You D, Park C, Lee H, Moon M, Kang J, Lee C, Oh S, Ahn C, Seong J, Hwang J A splicing variant of NME1 negatively regulates NF-kappaB signaling and inhibits cancer metastasis by interacting with IKKbeta. J Biol Chem, 2014-05-08;289(25):17709-20. 2014-05-08 [PMID: 24811176] (Bioassay, Human)
• Catanzaro J, Sheshadri N, Pan J, Sun Y, Shi C, Li J, Powers R, Crawford H, Zong W Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4. Nat Commun, 2014-04-23;5(0):3729. 2014-04-23 [PMID: 24759783] (Bioassay, Human)
• Harris D, Bandyopadhyay S, Maxwell T, Willard B, DiCorleto P Tumor necrosis factor (TNF)-alpha induction of CXCL10 in endothelial cells requires protein arginine methyltransferase 5 (PRMT5)-mediated nuclear factor (NF)-kappaB p65 methylation. J Biol Chem, 2014-04-21;289(22):15328-39. 2014-04-21 [PMID: 24753255] (Bioassay, Human)
• Singer B, Opp L, Heinrich A, Schreiber F, Binding-Liermann R, Berrocal-Almanza L, Heyl K, Muller M, Weimann A, Zweigner J, Slevogt H Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses. PLoS ONE, 2014-04-17;9(4):e94106. 2014-04-17 [PMID: 24743304] (Bioassay, Human)
• Mambetsariev I, Tian Y, Wu T, Lavoie T, Solway J, Birukov K, Birukova A Stiffness-activated GEF-H1 expression exacerbates LPS-induced lung inflammation. PLoS ONE, 2014-04-16;9(4):e92670. 2014-04-16 [PMID: 24739883] (Bioassay, Human)
• Ugarte-Berzal E, Bailon E, Amigo-Jimenez I, Albar J, Garcia-Marco J, Garcia-Pardo A A novel CD44-binding peptide from the pro-matrix metalloproteinase-9 hemopexin domain impairs adhesion and migration of chronic lymphocytic leukemia (CLL) cells. J Biol Chem, 2014-04-16;289(22):15340-9. 2014-04-16 [PMID: 24739387] (Bioassay, Human)
• Singh , Meera V, Davidson , Donna C, Jackson , Joseph W, Singh , Vir B, Silva , Jharon, Ramirez , Servio H, Maggirwar , Sanjay B Characterization of platelet-monocyte complexes in HIV-1-infected individuals: possible role in HIV-associated neuroinflammation. J Immunol, 2014-04-11;192(10):4674-84. 2014-04-11 [PMID: 24729609] (Bioassay, Human)
• Liu J, Ren Y, Kang L, Zhang L Overexpression of CCN3 inhibits inflammation and progression of atherosclerosis in apolipoprotein E-deficient mice. PLoS ONE, 2014-04-10;9(4):e94912. 2014-04-10 [PMID: 24722330] (Bioassay, Human)
• Beigel F, Friedrich M, Probst C, Sotlar K, Goke B, Diegelmann J, Brand S Oncostatin M mediates STAT3-dependent intestinal epithelial restitution via increased cell proliferation, decreased apoptosis and upregulation of SERPIN family members. PLoS ONE, 2014-04-07;9(4):e93498. 2014-04-07 [PMID: 24710357] (Western Blot)
• Hamada K, Osaka M, Yoshida M Cell density impacts epigenetic regulation of cytokine-induced E-selectin gene expression in vascular endothelium. PLoS ONE, 2014-04-01;9(4):e90502. 2014-04-01 [PMID: 24690766] (Bioassay, Human)
• Negm O, Mannsperger H, McDermott E, Drewe E, Powell R, Todd I, Fairclough L, Tighe P A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS). Eur J Immunol, 2014-06-10;44(7):2096-110. 2014-06-10 [PMID: 24668260] (Bioassay, Human)
• Ohlsson S, Ohlsson S, Soderberg D, Gunnarsson L, Pettersson A, Segelmark M, Hellmark T Neutrophils from vasculitis patients exhibit an increased propensity for activation by anti-neutrophil cytoplasmic antibodies. Clin Exp Immunol, 2014-06-01;176(3):363-72. 2014-06-01 [PMID: 24666336] (Bioassay, Human)
• Du J, An R, Chen L, Shen Y, Chen Y, Cheng L, Jiang Z, Zhang A, Yu L, Chu D, Shen Y, Luo Q, Chen H, Wan L, Li M, Xu X, Shen J Toxoplasma gondii virulence factor ROP18 inhibits the host NF-kappaB pathway by promoting p65 degradation. J Biol Chem, 2014-03-19;289(18):12578-92. 2014-03-19 [PMID: 24648522] (Bioassay, Human)
• Rahman M, Alkhouri H, Tang F, Che W, Ge Q, Ammit A Sphingosine 1-phosphate induces neutrophil chemoattractant IL-8: repression by steroids. PLoS ONE, 2014-03-19;9(3):e92466. 2014-03-19 [PMID: 24647471] (Bioassay, Human)
• Hsiao B, Chang T, Wu I, Chen M Rad GTPase inhibits the NFkappaB pathway through interacting with RelA/p65 to impede its DNA binding and target gene transactivation. Cell Signal, 2014-03-13;26(7):1437-44. 2014-03-13 [PMID: 24632303] (Bioassay, Human)
• You B, Park W Suberoylanilide hydroxamic acid-induced HeLa cell death is closely correlated with oxidative stress and thioredoxin 1 levels. Int J Oncol, 2014-03-12;44(5):1745-55. 2014-03-12 [PMID: 24626405] (Bioassay, Human)
• Lopez-Ramirez M, Wu D, Pryce G, Simpson J, Reijerkerk A, King-Robson J, Kay O, de Vries H, Hirst M, Sharrack B, Baker D, Male D, Michael G, Romero I MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation. FASEB J, 2014-03-06;28(6):2551-65. 2014-03-06 [PMID: 24604078] (Bioassay, Human)
• Weng Z, Patel A, Vasiadi M, Therianou A, Theoharides T Luteolin inhibits human keratinocyte activation and decreases NF-kappaB induction that is increased in psoriatic skin. PLoS ONE, 2014-02-28;9(2):e90739. 2014-02-28 [PMID: 24587411] (Bioassay, Human)
• Kankaanranta H, Ilmarinen P, Zhang X, Adcock I, Lahti A, Barnes P, Giembycz M, Lindsay M, Moilanen E Tumour necrosis factor-alpha regulates human eosinophil apoptosis via ligation of TNF-receptor 1 and balance between NF-kappaB and AP-1. PLoS ONE, 2014-02-28;9(2):e90298. 2014-02-28 [PMID: 24587316] (Bioassay, Human)
• Lessey-Morillon E, Osborne L, Monaghan-Benson E, Guilluy C, O'Brien E, Superfine R, Burridge K The RhoA guanine nucleotide exchange factor, LARG, mediates ICAM-1-dependent mechanotransduction in endothelial cells to stimulate transendothelial migration. J Immunol, 2014-02-28;192(7):3390-8. 2014-02-28 [PMID: 24585879] (Bioassay, Human)
• Rawnaq T, Dietrich L, Wolters-Eisfeld G, Uzunoglu F, Vashist Y, Bachmann K, Simon R, Izbicki J, Bockhorn M, Gungor C The multifunctional growth factor midkine promotes proliferation and migration in pancreatic cancer. Mol Cancer Res, 2014-02-24;12(5):670-80. 2014-02-24 [PMID: 24567526] (Bioassay, Human)
• Zhao N, Wang R, Zhou L, Zhu Y, Gong J, Zhuang S MicroRNA-26b suppresses the NF-kappaB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3. Mol Cancer, 2014-02-24;13(0):35. 2014-02-24 [PMID: 24565101] (Bioassay, Human)
• Magri G, Miyajima M, Bascones S, Mortha A, Puga I, Cassis L, Barra C, Comerma L, Chudnovskiy A, Gentile M, Llige D, Cols M, Serrano S, Arostegui J, Juan M, Yague J, Merad M, Fagarasan S, Cerutti A Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells. Nat Immunol, 2014-02-23;15(4):354-64. 2014-02-23 [PMID: 24562309] (Bioassay, Human)
• Proenca-Ferreira R, Brugnerotto A, Garrido V, Dominical V, Vital D, Ribeiro M, dos Santos M, Traina F, Olalla-Saad S, Costa F, Conran N Endothelial activation by platelets from sickle cell anemia patients. PLoS ONE, 2014-02-13;9(2):e89012. 2014-02-13 [PMID: 24551209] (Bioassay, Human)
• Llop-Guevara A, Chu D, Walker T, Goncharova S, Fattouh R, Silver J, Moore C, Xie J, O'Byrne P, Coyle A, Kolbeck R, Humbles A, Stampfli M, Jordana M A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure. PLoS ONE, 2014-02-14;9(2):e88714. 2014-02-14 [PMID: 24551140] (Bioassay, Human)
• Jung C, Lee M, Kang Y, Lee Y, Yoon H, Kang S, Lee W, Park J Vaspin inhibits cytokine-induced nuclear factor-kappa B activation and adhesion molecule expression via AMP-activated protein kinase activation in vascular endothelial cells. Cardiovasc Diabetol, 2014-02-12;13(0):41. 2014-02-12 [PMID: 24517399] (Bioassay, Human)
• Tannheimer S, Sorensen E, Cui Z, Kim M, Patel L, Baker W, Phillips G, Wright C, Salmon M The in vitro pharmacology of GS-5759, a novel bifunctional phosphodiesterase 4 inhibitor and long acting beta2-adrenoceptor agonist. J Pharmacol Exp Ther, 2014-02-10;349(1):85-93. 2014-02-10 [PMID: 24513870] (Bioassay, Human)
• Tsai C, Chen W, Hsieh H, Chi P, Hsiao L, Yang C TNF-alpha induces matrix metalloproteinase-9-dependent soluble intercellular adhesion molecule-1 release via TRAF2-mediated MAPKs and NF-kappaB activation in osteoblast-like MC3T3-E1 cells. J Biomed Sci, 2014-02-05;21(0):12. 2014-02-05 [PMID: 24502696] (Bioassay, Mouse)
• Parlato M, Souza-Fonseca-Guimaraes F, Philippart F, Misset B, Adib-Conquy M, Cavaillon J CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis. J Immunol, 2014-02-05;192(5):2449-59. 2014-02-05 [PMID: 24501201] (Bioassay, Human)
• Milwid , Jack M, Elman , Jessica, Li , Matthew, Shen , Keyue, Manrai , Arjun, Gabow , Aaron, Yarmush , Joshua, Jiao , Yunxin, Fletcher , Anne, Lee , Jungwoo, Cima , Michael, Yarmush , Martin L, Parekkadan , Biju Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators. Mol Ther, 2014-02-05;22(5):999-1007. 2014-02-05 [PMID: 24496384] (Bioassay, Human)
• Morlino G, Barreiro O, Baixauli F, Robles-Valero J, Gonzalez-Granado J, Villa-Bellosta R, Cuenca J, Sanchez-Sorzano C, Veiga E, Martin-Cofreces N, Sanchez-Madrid F Miro-1 links mitochondria and microtubule Dynein motors to control lymphocyte migration and polarity. Mol Cell Biol, 2014-02-03;34(8):1412-26. 2014-02-03 [PMID: 24492963] (Bioassay, Human)
• Evans H, Roostalu U, Walter G, Gullick N, Frederiksen K, Roberts C, Sumner J, Baeten D, Gerwien J, Cope A, Geissmann F, Kirkham B, Taams L TNF-alpha blockade induces IL-10 expression in human CD4+ T cells. Nat Commun, 2014-01-01;5(0):3199. 2014-01-01 [PMID: 24492460] (Bioassay, Human)
• Chiliveru S, Rahbek S, Jensen S, Jorgensen S, Nissen S, Christiansen S, Mogensen T, Jakobsen M, Iversen L, Johansen C, Paludan S Inflammatory cytokines break down intrinsic immunological tolerance of human primary keratinocytes to cytosolic DNA. J Immunol, 2014-01-31;192(5):2395-404. 2014-01-31 [PMID: 24489095] (Bioassay, Human)
• Lo H, Lai T, Li C, Wu W TNF-alpha induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways. Acta Pharmacol Sin, 2014-02-03;35(3):339-50. 2014-02-03 [PMID: 24487964] (Bioassay, Human)
• Haseeb A, Makki M, Haqqi T Modulation of ten-eleven translocation 1 (TET1), Isocitrate Dehydrogenase (IDH) expression, alpha-Ketoglutarate (alpha-KG), and DNA hydroxymethylation levels by interleukin-1beta in primary human chondrocytes. J Biol Chem, 2014-01-27;289(10):6877-85. 2014-01-27 [PMID: 24469454] (Bioassay, Human)
• Liu F, Wu X, Zhang Y, Wang Y, Jiang F TRAIL/DR5 signaling promotes macrophage foam cell formation by modulating scavenger receptor expression. PLoS ONE, 2014-01-22;9(1):e87059. 2014-01-22 [PMID: 24466325] (Bioassay, Human)
• van Bergen , Cornelis, Verdegaal , Elisabet, Honders , M Wilhel, Hoogstraten , Conny, Steijn-van Tol , A Q M Je, de Quartel , Linda, de Jong , Joan, Meyering , Maaike, Falkenburg , J H Fred, Griffioen , Marieke, Osanto , Susanne Durable remission of renal cell carcinoma in conjuncture with graft versus host disease following allogeneic stem cell transplantation and donor lymphocyte infusion: rule or exception? PLoS ONE, 2014-01-15;9(1):e85198. 2014-01-15 [PMID: 24454818] (Bioassay, Human)
• Liu C, Chen X, Yang L, Kisseleva T, Brenner D, Seki E Transcriptional repression of the transforming growth factor beta (TGF-beta) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor kappaB (NF-kappaB) p50 enhances TGF-beta signaling in hepatic stellate cells. J Biol Chem, 2014-01-21;289(10):7082-91. 2014-01-21 [PMID: 24448807] (Bioassay, Human)
• Sawada H, Saito T, Nickel N, Alastalo T, Glotzbach J, Chan R, Haghighat L, Fuchs G, Januszyk M, Cao A, Lai Y, Perez V, Kim Y, Wang L, Chen P, Spiekerkoetter E, Mitani Y, Gurtner G, Sarnow P, Rabinovitch M Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension. J Exp Med, 2014-01-20;211(2):263-80. 2014-01-20 [PMID: 24446489] (Bioassay, Human)
• Hu M, Yang Q, Zhang J, Liu S, Zhang Y, Lin H, Huang Z, Wang Y, Zhang X, Zhong B, Shu H TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A, 2014-01-13;111(4):1509-14. 2014-01-13 [PMID: 24434549] (Bioassay, Human)
• Ahmad T, Mukherjee S, Pattnaik B, Kumar M, Singh S, Kumar M, Rehman R, Tiwari B, Jha K, Barhanpurkar A, Wani M, Roy S, Mabalirajan U, Ghosh B, Agrawal A Miro1 regulates intercellular mitochondrial transport &amp; enhances mesenchymal stem cell rescue efficacy. EMBO J, 2014-01-15;33(9):994-1010. 2014-01-15 [PMID: 24431222] (Bioassay, Human)
• Tilstra J, Gaddy D, Zhao J, Dave S, Niedernhofer L, Plevy S, Robbins P Pharmacologic IKK/NF-kappaB inhibition causes antigen presenting cells to undergo TNFalpha dependent ROS-mediated programmed cell death. Sci Rep, 2014-01-10;4(0):3631. 2014-01-10 [PMID: 24406986] (Bioassay, Human)
• Chinnadurai R, Copland I, Patel S, Galipeau J IDO-independent suppression of T cell effector function by IFN-gamma-licensed human mesenchymal stromal cells. J Immunol, 2014-01-08;192(4):1491-501. 2014-01-08 [PMID: 24403533] (Bioassay, Human)
• Suzuki , Hitoshi, Raska , Milan, Yamada , Koshi, Moldoveanu , Zina, Julian , Bruce A, Wyatt , Robert J, Tomino , Yasuhiko, Gharavi , Ali G, Novak , Jan Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes. J Biol Chem, 2014-01-07;289(8):5330-9. 2014-01-07 [PMID: 24398680] (Bioassay, Human)
• Narayanan R, Yepuru M, Coss C, Wu Z, Bauler M, Barrett C, Mohler M, Wang Y, Kim J, Snyder L, He Y, Levy N, Miller D, Dalton J Discovery and preclinical characterization of novel small molecule TRK and ROS1 tyrosine kinase inhibitors for the treatment of cancer and inflammation. PLoS ONE, 2013-12-26;8(12):e83380. 2013-12-26 [PMID: 24386191] (Bioassay, Human, Mouse)
• Fiorcari S, Brown W, McIntyre B, Estrov Z, Maffei R, O'Brien S, Sivina M, Hoellenriegel J, Wierda W, Keating M, Ding W, Kay N, Lannutti B, Marasca R, Burger J The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells. PLoS ONE, 2013-12-23;8(12):e83830. 2013-12-23 [PMID: 24376763] (Bioassay, Human)
• Li W, Okuda A, Yamamoto H, Yamanishi K, Terada N, Yamanishi H, Tanaka Y, Okamura H Regulation of development of CD56 bright CD11c + NK-like cells with helper function by IL-18. PLoS ONE, 2013-12-20;8(12):e82586. 2013-12-20 [PMID: 24376549] (Human)
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• Dalli , Jesmond, Norling , Lucy V, Montero-Melendez , Trinidad, Federici Canova , Donata, Lashin , Hazem, Pavlov , Anton M, Sukhorukov , Gleb B, Hinds , Charles, Perretti , Mauro Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. EMBO Mol Med, 2013-12-15;6(1):27-42. 2013-12-15 [PMID: 24357647] (Bioassay, Human)
• Sommerfelt R, Feuerherm A, Jones K, Johansen B Cytosolic phospholipase A2 regulates TNF-induced production of joint destructive effectors in synoviocytes. PLoS ONE, 2013-12-12;8(12):e83555. 2013-12-12 [PMID: 24349530] (Bioassay, Human)
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• Dave SH, Tilstra JS, Matsuoka K, Li F, DeMarco RA, Beer-Stolz D, Sepulveda AR, Fink MP, Lotze MT, Plevy SE Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis. J. Leukoc. Biol., 2009-05-19;86(3):633-43. 2009-05-19 [PMID: 19454652] (Bioassay, Human)
• Kato N, Yuzawa Y, Kosugi T The E-selectin ligand basigin/CD147 is responsible for neutrophil recruitment in renal ischemia/reperfusion. J. Am. Soc. Nephrol., 2009-05-14;20(7):1565-76. 2009-05-14 [PMID: 19443639] (Bioassay, Human)
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• Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts. Bone, 2009-03-02;44(6):1143-50. 2009-03-02 [PMID: 19264156] (Bioassay, Human)
• Hao Q, Wang L, Tang H Vascular endothelial growth factor induces protein kinase D-dependent production of proinflammatory cytokines in endothelial cells. Am. J. Physiol., Cell Physiol., 2009-01-28;296(4):C821-7. 2009-01-28 [PMID: 19176759] (Bioassay, Human)
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• Mabilleau G, Sabokbar A Interleukin-32 promotes osteoclast differentiation but not osteoclast activation. PLoS ONE, 2009-01-12;4(1):e4173. 2009-01-12 [PMID: 19137064] (Human)
• Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, Fortugno P, Gonzalvo-Feo S, Franssen JD, Parmentier M, De Pita O, Girolomoni G, Sozzani S Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. J. Exp. Med., 2008-12-29;206(1):249-58. 2008-12-29 [PMID: 19114666] (Bioassay, Human)
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• Hirosako S, Goto E, Fujii K, Tsumori K, Hirata N, Tsumura S, Kamohara H, Kohrogi H Human bronchial intraepithelial T cells produce interferon-gamma and stimulate epithelial cells. Clin. Exp. Immunol., 2008-11-26;155(2):266-74. 2008-11-26 [PMID: 19040600] (Bioassay, Human)
• Hama S, Takeichi O, Fujisaki K, Tanabe N, Maeno M, Ochiai K Nitric oxide attenuates vascular endothelial cadherin-mediated vascular integrity in human chronic inflammation. Clin. Exp. Immunol., 2008-12-01;154(3):384-90. 2008-12-01 [PMID: 19037921] (Bioassay, Human)
• Kwan Tat S, Pelletier JP, Amiable N, Boileau C, Lajeunesse D, Duval N, Martel-Pelletier J Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts. Arthritis Rheum., 2008-12-01;58(12):3820-30. 2008-12-01 [PMID: 19035475] (Bioassay, Human)
• Chang SY, Su PF, Lee TC Ectopic expression of interleukin-1 receptor type II enhances cell migration through activation of the pre-interleukin 1alpha pathway. Cytokine, 2008-11-20;45(1):32-8. 2008-11-20 [PMID: 19026558] (Bioassay, Human)
• Sandberg WJ, Halvorsen B, Yndestad A, Smith C, Otterdal K, Brosstad FR, Froland SS, Olofsson PS, Damas JK, Gullestad L, Hansson GK, Oie E, Aukrust P Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis. Circ. Res., 2008-11-20;104(1):60-8. 2008-11-20 [PMID: 19023130] (Bioassay, Human)
• Watanabe H, Kawaguchi M, Fujishima S, Ogura M, Matsukura S, Takeuchi H, Ohba M, Sueki H, Kokubu F, Hizawa N, Adachi M, Huang SK, Iijima M Functional characterization of IL-17F as a selective neutrophil attractant in psoriasis. J. Invest. Dermatol., 2008-10-02;129(3):650-6. 2008-10-02 [PMID: 18830271] (Bioassay, Human)
• Secchiero P, Melloni E, Corallini F, Beltrami AP, Alviano F, Milani D, D'Aurizio F, di Iasio MG, Cesselli D, Bagnara GP, Zauli G Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells. Stem Cells, 2008-09-04;26(11):2955-63. 2008-09-04 [PMID: 18772312] (Bioassay, Human)
• Wente MN, Gaida MM, Mayer C, Michalski CW, Haag N, Giese T, Felix K, Bergmann F, Giese NA, Friess H Expression and potential function of the CXC chemokine CXCL16 in pancreatic ductal adenocarcinoma. Int. J. Oncol., 2008-08-01;33(2):297-308. 2008-08-01 [PMID: 18636150] (Bioassay, Human)
• Barbaroux JB, Beleut M, Brisken C, Mueller CG, Groves RW Epidermal receptor activator of NF-kappaB ligand controls Langerhans cells numbers and proliferation. J. Immunol., 2008-07-15;181(2):1103-8. 2008-07-15 [PMID: 18606662] (Bioassay, Human)
• Gerber SA, Pober JS IFN-alpha induces transcription of hypoxia-inducible factor-1alpha to inhibit proliferation of human endothelial cells. J. Immunol., 2008-07-15;181(2):1052-62. 2008-07-15 [PMID: 18606657] (Bioassay, Human)
• Rhee CK, Kang CM, You MB, Yoon HK, Kim YK, Kim KH, Moon HS, Park SH, Song JS Effect of fudosteine on mucin production. Eur. Respir. J., 2008-06-25;32(5):1195-202. 2008-06-25 [PMID: 18579549] (Bioassay, Human)
• Cherry WB, Yoon J, Bartemes KR, Iijima K, Kita H A novel IL-1 family cytokine, IL-33, potently activates human eosinophils. J. Allergy Clin. Immunol., 2008-06-01;121(6):1484-90. 2008-06-01 [PMID: 18539196] (Bioassay, Human)
• Jasny E, Eisenblatter M, Matz-Rensing K, Tenner-Racz K, Tenbusch M, Schrod A, Stahl-Hennig C, Moos V, Schneider T, Racz P, Uberla K, Kaup FJ, Ignatius R IL-12-impaired and IL-12-secreting dendritic cells produce IL-23 upon CD154 restimulation. J. Immunol., 2008-05-15;180(10):6629-39. 2008-05-15 [PMID: 18453582] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))
• Crocker SJ, Frausto RF, Whitton JL, Milner R A novel method to establish microglia-free astrocyte cultures: comparison of matrix metalloproteinase expression profiles in pure cultures of astrocytes and microglia. Glia, 2008-08-15;56(0):1187-98. 2008-08-15 [PMID: 18449943] (Bioassay, Human)
• Gonzalez RM, Seurynck-Servoss SL, Crowley SA Development and validation of sandwich ELISA microarrays with minimal assay interference. J. Proteome Res., 2008-04-19;7(6):2406-14. 2008-04-19 [PMID: 18422355] (ELISA (Standard))
• Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps. J. Allergy Clin. Immunol., 2008-04-14;121(6):1385-92, 1392. 2008-04-14 [PMID: 18410958] (Bioassay, Human)
• Ishitsuka K, Hideshima T, Neri P, Vallet S, Shiraishi N, Okawa Y, Shen Z, Raje N, Kiziltepe T, Ocio EM, Chauhan D, Tassone P, Munshi N, Campbell RM, Dios AD, Shih C, Starling JJ, Tamura K, Anderson KC p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications. Br. J. Haematol., 2008-04-07;141(5):598-606. 2008-04-07 [PMID: 18397345] (Bioassay, Human)
• Stanczyk J, Pedrioli DM, Brentano F, Sanchez-Pernaute O, Kolling C, Gay RE, Detmar M, Gay S, Kyburz D Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum., 2008-04-01;58(4):1001-9. 2008-04-01 [PMID: 18383392] (Bioassay, Human)
• Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS Res. Hum. Retroviruses, 2008-03-01;24(3):453-62. 2008-03-01 [PMID: 18327985] (ELISA (Standard))
• Wolk K, Witte K, Witte E, Proesch S, Schulze-Tanzil G, Nasilowska K, Thilo J, Asadullah K, Sterry W, Volk HD, Sabat R Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes. J. Leukoc. Biol., 2008-02-15;83(5):1181-93. 2008-02-15 [PMID: 18281438] (Bioassay, Human)
• Joubert P, Lajoie-Kadoch S, Welman M, Dragon S, Letuvee S, Tolloczko B, Halayko AJ, Gounni AS, Maghni K, Hamid Q Expression and regulation of CCR1 by airway smooth muscle cells in asthma. J. Immunol., 2008-01-15;180(2):1268-75. 2008-01-15 [PMID: 18178867] (Bioassay, Human)
• Tjwa M, Bellido-Martin L, Lin Y, Lutgens E, Plaisance S, Bono F, Delesque-Touchard N, Herve C, Moura R, Billiau AD, Aparicio C, Levi M, Daemen M, Dewerchin M, Lupu F, Arnout J, Herbert JM, Waer M, Garcia de Frutos P, Dahlback B, Carmeliet P, Hoylaerts MF, Moons L Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes. Blood, 2007-12-21;111(8):4096-105. 2007-12-21 [PMID: 18156494] (Bioassay, Human)
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• Dahm F, Bielawska A, Nocito A, Georgiev P, Szulc ZM, Bielawski J, Jochum W, Dindo D, Hannun YA, Clavien PA Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice. Br. J. Cancer, 2007-11-20;98(1):98-105. 2007-11-20 [PMID: 18026195] (Bioassay, Mouse)
• Secchiero P, Corallini F, Rimondi E, Chiaruttini C, di Iasio MG, Rustighi A, Del Sal G, Zauli G Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells. Blood, 2007-11-13;111(3):1287-94. 2007-11-13 [PMID: 18000166] (Bioassay, Human)
• Rao DA, Tracey KJ, Pober JS IL-1alpha and IL-1beta are endogenous mediators linking cell injury to the adaptive alloimmune response. J. Immunol., 2007-11-15;179(10):6536-46. 2007-11-15 [PMID: 17982042] (Bioassay, Human)
• Lee SK, Pi SH, Kim SH, Min KS, Lee HJ, Chang HS, Kang KH, Kim HR, Shin HI, Lee SK, Kim EC Substance P regulates macrophage inflammatory protein 3alpha/chemokine C-C ligand 20 (CCL20) with heme oxygenase-1 in human periodontal ligament cells. Clin. Exp. Immunol., 2007-10-09;150(3):567-75. 2007-10-09 [PMID: 17924972] (Bioassay, Human)
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• Hall JP, Kurdi Y, Hsu S, Cuozzo J, Liu J, Telliez JB, Seidl KJ, Winkler A, Hu Y, Green N, Askew GR, Tam S, Clark JD, Lin LL Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. J. Biol. Chem., 2007-09-11;282(46):33295-304. 2007-09-11 [PMID: 17848581] (Bioassay, Human)
• Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration. J. Biol. Chem., 2007-08-24;282(43):31643-55. 2007-08-24 [PMID: 17720976] (Bioassay, Human)
• Wosik K, Cayrol R, Dodelet-Devillers A, Berthelet F, Bernard M, Moumdjian R, Bouthillier A, Reudelhuber TL, Prat A Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis. J. Neurosci., 2007-08-22;27(34):9032-42. 2007-08-22 [PMID: 17715340] (Bioassay, Human)
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• Zalevsky J, Secher T, Ezhevsky SA, Janot L, Steed PM, O'Brien C, Eivazi A, Kung J, Nguyen DH, Doberstein SK, Erard F, Ryffel B, Szymkowski DE Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection. J. Immunol., 2007-08-01;179(3):1872-83. 2007-08-01 [PMID: 17641054] (Bioassay, Human)
• Kato A, Favoreto S, Avila PC, Schleimer RP TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells. J. Immunol., 2007-07-15;179(2):1080-7. 2007-07-15 [PMID: 17617600] (Bioassay, Human)
• Luty WH, Rodeberg D, Parness J, Vyas YM Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates. J. Immunol., 2007-07-15;179(2):819-29. 2007-07-15 [PMID: 17617572] (Bioassay, Human)
• Facco M, Baesso I, Miorin M, Bortoli M, Cabrelle A, Boscaro E, Gurrieri C, Trentin L, Zambello R, Calabrese F, Cassatella MA, Semenzato G, Agostini C Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis. J. Leukoc. Biol., 2007-07-05;82(4):946-55. 2007-07-05 [PMID: 17615381] (Bioassay, Human)
• Yoo SA, Park BH, Yoon HJ, Lee JY, Song JH, Kim HA, Cho CS, Kim WU Calcineurin modulates the catabolic and anabolic activity of chondrocytes and participates in the progression of experimental osteoarthritis. Arthritis Rheum., 2007-07-01;56(7):2299-311. 2007-07-01 [PMID: 17599750] (Bioassay, Human)
• Scaldaferri F, Sans M, Vetrano S, Graziani C, De Cristofaro R, Gerlitz B, Repici A, Arena V, Malesci A, Panes J, Grinnell BW, Danese S Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease. J. Clin. Invest., 2007-07-01;117(7):1951-60. 2007-07-01 [PMID: 17557119] (Bioassay, Human)
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• Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1. AIDS, 2007;21(10):1263-72. 2007 [PMID: 17545702] (ELISA (Standard), N/A)
• Silverman MD, Haas CS, Rad AM, Arbab AS, Koch AE The role of vascular cell adhesion molecule 1/ very late activation antigen 4 in endothelial progenitor cell recruitment to rheumatoid arthritis synovium. Arthritis Rheum., 2007-06-01;56(6):1817-26. 2007-06-01 [PMID: 17530710] (Bioassay, Human)
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• Zhang K, Shan L, Rahman MS, Unruh H, Halayko AJ, Gounni AS Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease. Am. J. Physiol. Lung Cell Mol. Physiol., 2007-05-18;293(2):L375-82. 2007-05-18 [PMID: 17513456] (Bioassay, Human)
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• Caruso R, Fina D, Peluso I, Fantini MC, Tosti C, Del Vecchio Blanco G, Paoluzi OA, Caprioli F, Andrei F, Stolfi C, Romano M, Ricci V, MacDonald TT, Pallone F, Monteleone G IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis. J. Immunol., 2007-05-01;178(9):5957-65. 2007-05-01 [PMID: 17442980] (Bioassay, Human)
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• Girard BM, Young BA, Buttolph TR, White SL, Parsons RL Regulation of neuronal pituitary adenylate cyclase-activating polypeptide expression during culture of guinea-pig cardiac ganglia. Neuroscience, 2007-03-23;146(2):584-93. 2007-03-23 [PMID: 17367946] (Bioassay, Guinea Pig)
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• Brechter AB, Lerner UH Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression. Arthritis Rheum., 2007-03-01;56(3):910-23. 2007-03-01 [PMID: 17328065] (Bioassay, Human)
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• Sawant KV, McMurray DN Guinea pig neutrophils infected with Mycobacterium tuberculosis produce cytokines which activate alveolar macrophages in noncontact cultures. Infect. Immun., 2007-02-05;75(4):1870-7. 2007-02-05 [PMID: 17283104] (ELISA (Standard))
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• Babinska A, Azari BM, Salifu MO, Liu R, Jiang XC, Sobocka MB, Boo D, Al Khoury G, Deitch JS, Marmur JD, Ehrlich YH, Kornecki E The F11 receptor (F11R/JAM-A) in atherothrombosis: overexpression of F11R in atherosclerotic plaques. Thromb. Haemost., 2007-02-01;97(2):272-81. 2007-02-01 [PMID: 17264957] (Bioassay, Human)
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• Daryadel A, Grifone RF, Simon HU, Yousefi S Apoptotic neutrophils release macrophage migration inhibitory factor upon stimulation with tumor necrosis factor-alpha. J. Biol. Chem., 2006-07-21;281(37):27653-61. 2006-07-21 [PMID: 16861224] (Bioassay, Human)
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• Filer A, Parsonage G, Smith E, Osborne C, Thomas AM, Curnow SJ, Rainger GE, Raza K, Nash GB, Lord J, Salmon M, Buckley CD Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils. Arthritis Rheum., 2006-07-01;54(7):2096-108. 2006-07-01 [PMID: 16802344] (Bioassay, Human)
• Monteleone G, Caruso R, Fina D, Peluso I, Gioia V, Stolfi C, Fantini MC, Caprioli F, Tersigni R, Alessandroni L, MacDonald TT, Pallone F Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Gut, 2006-05-08;55(12):1774-80. 2006-05-08 [PMID: 16682426] (Bioassay, Human)
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• Nguyen AN, Stebbins EG, Henson M, O&amp;apos;Young G, Choi SJ, Quon D, Damm D, Reddy M, Ma JY, Haghnazari E, Kapoun AM, Medicherla S, Protter A, Schreiner GF, Kurihara N, Anderson J, Roodman GD, Navas TA, Higgins LS Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation. Exp. Cell Res., 2006-04-04;312(10):1909-23. 2006-04-04 [PMID: 16600214] (Bioassay, Human)
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• Wunder DM, Mueller MD, Birkhauser MH, Bersinger NA Increased ENA-78 in the follicular fluid of patients with endometriosis. Acta Obstet Gynecol Scand, 2006-01-01;85(3):336-42. 2006-01-01 [PMID: 16553183] (ELISA (Standard))
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• Vergne-Salle</LastName><F P</Initial, Vergne-Salle P, Leger DY, Bertin P, Treves R, Beneytout JL, Liagre B Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes. Cytokine, 2005-09-07;31(5):335-48. 2005-09-07 [PMID: 16099671] (Bioassay, Human)
• Ameredes BT, Calhoun WJ Modulation of GM-CSF release by enantiomers of beta-agonists in human airway smooth muscle. J. Allergy Clin. Immunol., 2005-07-01;116(1):65-72. 2005-07-01 [PMID: 15990776] (Bioassay, Human)
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• Mozaffarian D, Rimm EB, King IB, Lawler RL, McDonald GB, Levy WC trans fatty acids and systemic inflammation in heart failure. Am. J. Clin. Nutr., 2004-12-01;80(6):1521-5. 2004-12-01 [PMID: 15585763] (ELISA (Standard))
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• Johansson MW, Lye MH, Barthel SR, Duffy AK, Annis DS, Mosher DF Eosinophils adhere to vascular cell adhesion molecule-1 via podosomes. Am. J. Respir. Cell Mol. Biol., 2004-06-25;31(4):413-22. 2004-06-25 [PMID: 15220135] (Bioassay, Human)
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• Satchell SC, Anderson KL, Mathieson PW Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties. J. Am. Soc. Nephrol., 2004-03-01;15(3):566-74. 2004-03-01 [PMID: 14978158] (Bioassay, Human)
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• Sade H, Krishna S, Sarin A The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells. J. Biol. Chem., 2003-10-28;279(4):2937-44. 2003-10-28 [PMID: 14583609] (Bioassay, Human, Mouse)
• Cardones AR, Murakami T, Hwang ST CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin. Cancer Res., 2003-10-15;63(20):6751-7. 2003-10-15 [PMID: 14583470] (Bioassay, Human)
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• Park JS, 107290, Kim YS, Jee YK, Myong NH, Lee KY Interleukin-8 production in tuberculous pleurisy: role of mesothelial cells stimulated by cytokine network involving tumour necrosis factor-alpha and interleukin-1 beta. Active immunotherapy against pathogenic Cis pT231-tau suppresses neurodegeneration in traumatic brain injury mouse models, 2003-05-01;57(5):463-9. 2003-05-01 [PMID: 12753503] (Bioassay, Human)
• Hikichi Y, Tsuji I, Shintani Y LIGHT, a member of the tumor necrosis factor ligand superfamily, prevents tumor necrosis factor-alpha-mediated human primary hepatocyte apoptosis, but not Fas-mediated apoptosis. J. Biol. Chem., 2002-10-18;277(51):50054-61. 2002-10-18 [PMID: 12393901] (Bioassay, Human)
• Favre D, Blouin V, Provost N, Spisek R, Porrot F, Bohl D, Marme F, Cherel Y, Salvetti A, Hurtrel B, Heard JM, Riviere Y, Moullier P Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus. J. Virol., 2002-11-01;76(22):11605-11. 2002-11-01 [PMID: 12388721] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• Messmer D, Jacque JM, Santisteban C, Bristow C, Han SY, Villamide-Herrera L, Mehlhop E, Marx PA, Steinman RM, Gettie A, Pope M Endogenously expressed nef uncouples cytokine and chemokine production from membrane phenotypic maturation in dendritic cells. J. Immunol., 2002-10-15;169(8):4172-82. 2002-10-15 [PMID: 12370346] (Bioassay, Human, Primate - Macaca mulatta (Rhesus Macaque))
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• Mitsiades CS, Mitsiades N, Poulaki V, Schlossman R, Akiyama M, Chauhan D, Hideshima T, Treon SP, Munshi NC, Richardson PG, Anderson KC Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications. Oncogene, 2002-08-22;21(37):5673-83. 2002-08-22 [PMID: 12173037] (Bioassay, Human)
• Cheong YC, Laird SM, Shelton JB, Ledger WL, Li TC, Cooke ID The correlation of adhesions and peritoneal fluid cytokine concentrations: a pilot study. Hum. Reprod., 2002-04-01;17(4):1039-45. 2002-04-01 [PMID: 11925402] (Bioassay, Human)
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FAQs for TNF-alpha (210-TA/CF). (Showing 1 - 4 of 4 FAQs).

1. I need to know about TNF-alpha antibody kits for mice.  ..show answer..
   • We currently have two TNFalpha ELISA kits specific for mouse: catalog numbers KA0257 and NBP1-92670.
2. I would like to ask you for help. I need an antibody for Elisa to detect human TNF alpha in a supernatant from a cell culture (meaning supernatant after centrifugation of collected cell suspension from a plate well). Which of your antibodies against human tnf alpha would be suitable? I would like to buy only the primary antibody.  ..show answer..
   • I would recommend catalog number NBP1-67821 or NB600-587; however, a full list of our anti-human TNF alpha antibodies suitable for use in ELISA can be found using this link.
3. I am interested in a TNF alpha antibody, cross reactive for human, rat and mouse (host species: rabbit). Could your product NBP1-19532 be used in western blotting applications? Or do you have a similar product in your catalog which could fit with my request?  ..show answer..
   • The antibody you mention, NBP1-19532, has not yet been validated in Western blot. I would instead recommend either NBP1-67821 or NB600-587. These are both rabbit polyclonal antibodies that cross-reacts with human, mouse and rat and have been used in Western blotting.
4. Can your TNF-alpha products be used to treat TBI victims and therefore avoid the perispinal injections with Enbrel?  ..show answer..
   • I am very sorry, but all of our products are for scientific research use only, and none are intended or approved for use in humans.

Bioinformatics

• Gene Symbol: TNF
• Uniprot:
  • P01375()