Glycogen Phosphorylase BB/GPBB Antibody

Immunohistochemistry-Paraffin: Glycogen Phosphorylase BB/GPBB Antibody [NB100-58759] - Analysis of anti-PYGB antibody with human brain at concentration 10 ug/ml.

Product Discontinued

Glycogen Phosphorylase BB/GPBB Antibody Summary

• Immunogen: Synthetic 10 amino acid peptide from internal region of human Glycogen Phosphorylase BB/GPBB.
• Specificity: Human PYGB. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Mouse (90%), Opossum (94%), Orangutan (100%), Hamster (90%), Bat (90%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PYGB
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 10 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Rat (80%), Canine (80%), Equine (80%), Rabbit (80%), Zebrafish (80%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Glycogen Phosphorylase BB/GPBB Antibody

• Brain glycogen phosphorylase
• EC 2.4.1.1
• Glycogen phosphorylase B
• Glycogen phosphorylase brain form
• Glycogen Phosphorylase Isoenzyme BB
• GPBB
• MGC9213
• Phosphorylase glycogen brain
• PYGB

Background

The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for Glycogen Phosphorylase BB/GPBB Antibody (NB100-58759). (Showing 1 - 1 of 1 FAQ).

1. Would it be possible to obtain information on whether the sequence indicated below for Drosophila melanogaster GLYP can be recognized by antibody GPBB Antibody (NB100-58759)? Drosophila Sequence: DGLYP MSKPQSDADRRKQISVRGIAEVGNVTEVKKNFNRHLHYTLVKDRNVSTLR DYYFALANTVKDNMVGRWIRTQQHYYEKDPKRVYYLSLEYYMGRSLTNTM INLGIQSECEEAMYQLGLDIENLEEMEEDAGLGNGGLGRLAACFLDSMAT LGLAAYGYGIRYEYGIFAQKIKNGEQVEEPDDWLRYGNPWEKARPEFMLP VNFYGRVIDTPEGKKWVDTQRVFAMPYDNPIPGYNNNHVNTLRLWSAKSP IDFNLKFFNDGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFM CAATLQDIIRRYKASKFGSREAVRNTFDHFPDKVAIQLNDTHPSLAIPEL MRILVDEEHLTWEKAWDITVRSCAYTNHTVLPEALERWPVSLLESILPRH LQIIYHINFLHMENVKKKFPDDLDRMRRMSMVEEDGEKRINMAHLSIVGS HAVNGVAAIHSQILKDSLFHDFYEMEPQKFQNKTNGITPRRWLLLCNPGL SDLIAEKIGDEWPVHLDQLVALKKWAKDPNFQRNVARVKQENKLKLAAIL EKDYGVKINPSSMFDIQVKRIHEYKRQLLNCLHIITLYNRIKKDPTANFT PRTIMIGGKAAPGYYVAKQIIKLICAVGNVVNNDPIVGDKLKVIFLENYR VTLAEKIMPAADLSEQISTAGTEASGTGNMKFQLNGALTIGTLDGANVEM AEEMGLDNIFIFGMTVDEVEALKKKGYNAYDYYNANPEVKQVIDQIQGGF FSPGNPNEFKNIADILLKYDHYYLLADYDAYIKAQDLVSKTYQNQAKWLE MSINNIASSGKFSSDRTIAEYAREIWGVEPTWEKLPAPEDQPQN
   • The sequence homology is around 80%, and we usually don't recommend antibodies for an untested species unless it's at least 85%. There's a chance that it will work for your customer, but I can't guarantee it.

Bioinformatics

• Gene Symbol: PYGB
• Entrez:
  • 5834(Human)
• Uniprot:
  • P11216(Human)