GnRH Antibody (5-1#) - BSA Free

Western Blot: GnRH Antibody (5-1#) [NBP3-41594] - Sample: Recombinant GnRH, Rat.

• Reactivity: Mu, Rt
• Applications: WB
• Clone: 5-1#
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

GnRH Antibody (5-1#) - BSA Free Summary

• Immunogen: Immunized with recombinant Rat GnRH (Uniprot#: P07490; His25-Met92 (Uniprot#: P07490)
• Isotype: IgG
• Clonality: Monoclonal
• Host: Mouse
• Gene: GNRH1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.5-2ug/mL

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 0.01M PBS, pH7.4, 50% glycerol
• Preservative: 0.05% Proclin 300
• Concentration: 1 mg/ml
• Purity: Protein A or G purified

Alternate Names for GnRH Antibody (5-1#) - BSA Free

• GNRH
• GnRH-associated peptide 1
• gonadotropin-releasing hormone 1 (leutinizing-releasing hormone)
• gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
• GRH
• LHRH
• LNRH
• luliberin I
• Progonadoliberin I
• progonadoliberin-1
• prolactin release-inhibiting factor

Background

Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle.Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GNRH1