HMGB1/HMG-1 Antibody Blocking Peptide

• Reactivity: Mu
• Applications: AC
• Concentration: 1.0 mg/ml

HMGB1/HMG-1 Antibody Blocking Peptide Summary

• Description: A HMGB1 antibody blocking peptide.
• Specificity: This peptide is specific for NB100-2322 only.
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: HMGB1

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This peptide is useful as a blocking peptide for NB100-2322. For further blocking peptide related protocol, click here.

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: Peptide dissolved in dH2O. Contains no BSA.
• Preservative: No Preservative
• Concentration: 1.0 mg/ml

Alternate Names for HMGB1/HMG-1 Antibody Blocking Peptide

• Amphoterin
• high mobility group box 1
• High mobility group protein 1
• high mobility group protein B1
• high-mobility group (nonhistone chromosomal) protein 1
• high-mobility group box 1
• HMG1
• HMG-1
• HMG1DKFZp686A04236
• HMG3
• HMGB1
• SBP-1
• Sulfoglucuronyl carbohydrate binding protein

Background

HMGB1 and HMGB2 are part of the chromatin non-histone high mobility group proteins 1 and 2. HMGB1 and HMGB2 (containing multiple HMG-boxes) are conserved domains of 80 amino acids which mediate the DNA binding of many proteins. HMG box domains recognize DNA structure. Both HMGB1 and HMGB2 contain a N-terminal HMG box, a central HMG box, and an acidic carboxy terminus. The acidic tails of HMGB1 and HMGB2 contain multiple serine residues which match the phosphorylation consensus sites of casein kinase II, and phosphorylation of this domain appears to be important for proper functioning of these proteins. HMGB1 and HMGB2 have been shown to facilitate the binding of various sequence-specific transcription factors to their respective DNA binding sites. HMGB1 and HMGB2 may also serve as architectural factors that recognize and mediate DNA structural changes that accompany various events such as DNA repair, transcription, and replication.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

FAQs for HMGB1/HMG-1 Peptide (NB100-2322PEP). (Showing 1 - 1 of 1 FAQ).

1. I would like to know the isotype of the HMGB1 peptide (NB100-23222PEP), the species of origin, how it was produced, and whether it can be used for immunostimulatory assays or just blocking?
   • NB100-2322PEP is a blocking peptide specific to our HMGB1 antibody, NB100-2322. This product has only been tested as a blocking peptide for that specific antibody, and we cannot guarantee any other performance. This peptide corresponds to a internal portion of the human protein and since this is the antigen, there is no specified isotype. The production method of this peptide is proprietary, and unfortunately, I do not have that information available on my end.

Bioinformatics

• Gene Symbol: HMGB1