mGluR6 Antibody - BSA Free

Immunohistochemistry-Paraffin: mGluR6 Antibody [NLS4655] - Eye, Retina, Ganglion cells.

Immunohistochemistry-Paraffin: mGluR6 Antibody [NLS4655] - Analysis of anti-GRM6 / MGLUR6 antibody with human brain, glioblastoma.

Immunohistochemistry-Paraffin: mGluR6 Antibody [NLS4655] - Human eye, retina. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: mGluR6 Antibody [NLS4655] - Human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: mGluR6 Antibody [NLS4655] - Human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: mGluR6 Antibody [NLS4655] - Eye, Retina

• Reactivity: Hu, Mu, Rt, Po, Bt, Bv, Ca, Ha, Pm, Pm, Rb, Pm, Eq, Fi, Ma-Op
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

mGluR6 Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 15 amino acid peptide from N-terminal extracellular domain of human mGluR6.
• Epitope: N-Terminus extracellular domain
• Localization: Integral membrane protein.
• Specificity: Human mGluR6. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRM7 (73%), GRM4 (67%).
• Predicted Species: Equine (93%), Chimpanzee (100%), Opossum (93%), Fish (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GRM6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin 12 ug/ml
  • Western Blot 1:1000 - 1:10000
• Application Notes: Use in Immunohistochemistry-Frozen reported in scientific literature (PMID:35024589)...

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Xenopus (80%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for mGluR6 Antibody - BSA Free

• CSNB1B
• glutamate receptor, metabotropic 6
• Gm3
• GPRC1F
• GPRC1Fmetabotropic glutamate receptor 6
• GRM6
• mGlu6
• mGluR6
• MGLUR6DKFZp686H1993

Background

Metabotropic Glutamate Receptor GRM6 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7, and GRM8. Group II and Group III receptors are linked to the inhibition of the cyclic AMP signaling cascade, but differ in their agonist selectivities. GRM6 is expressed solely at the postsynaptic site of ON-bipolar cells in both rod and cone systems. Caution: GLUR6 refers to Ionotropic Glutamate Receptor 6, not to Metabotropic Glutamate Receptor 6 (mGLUR6).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for mGluR6 Antibody (NLS4655)(1)

Publication using NLS4655

• Yamasaki S, Tu H, Matsuyama T et al. A Genetic modification that reduces ON-bipolar cells in hESC-derived retinas enhances functional integration after transplantation iScience 2022-01-01 [PMID: 35024589] (IHC-Fr, Monkey)

Bioinformatics

• Gene Symbol: GRM6