NK1R Antibody Pack

Immunohistochemistry: NK1R Antibody Pack [NB100-912] - Neurokinin 1 Receptor Antibody Pack [NB100-912] - Confocal image of SPR reactivity using polyclonal anti-NK-1 Receptor (NB 300-101) in a lamina III neuron in the spinal cord of a rat.

Western Blot: NK1R Antibody Pack [NB100-912] - Analysis of Neurokinin 1 Receptor in 1: human brain lysate, 2: rat brain lysate and 3: monkey brain lysate. Neurokinin 1 Receptor Antibody [NB300-119]

Immunohistochemistry: NK1R Antibody Pack [NB100-912] - Neurokinin 1 Receptor Antibody Pack [NB100-912] - Brain, Basal Nucleus of Meynert, Neurons 40X. Neurokinin 1 Receptor Antibody [NB300-119]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ICC/IF, IHC

NK1R Antibody Pack Summary

• Description: This pack contains 1 vial each of: NB300-101 (0.1 mL) and NB300-119 (0.1 mL).
• Immunogen: See individual datasheets.
• Gene: TACR1

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: See individual datasheets of components for their validated applications

Reactivity Notes

See individual datasheets of components for their validated species

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Alternate Names for NK1R Antibody Pack

• NK1R
• NK-1R
• NK1Rneurokinin 1 receptor
• NKIR
• SPR
• SPRsubstance-P receptor
• TAC1R
• TAC1Rtachykinin 1 receptor (substance P receptor, neurokinin 1 receptor)
• tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
• tachykinin receptor 1NK-1 receptor
• TACR1

Background

We know how important it is to your research to have access to antibodies specific for your model. As it is often impossible to know which antibody will work best for a specific sample and application, we now offer SuperNovus Packs. These packs include different antibodies to the same protein to give you the ability to decide for yourself. The SuperNovus Packs are all offered at a discount price compared to purchasing each antibody individually. The tachykinins belong to an evolutionary conserved family of peptide neurotransmitters that share the c-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an established role in neurotransmission. The mammalian tachykinins include substance P, neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma. Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 which have preferential affinities for SP, NKA and NKB respectively. All three receptors share a high degree of sequence homology, have seven transmembrane spanning domains and similar signal transduction mechanisms (e.g. G-protein coupled activation of phospholipase C).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Packs are guaranteed for 1 year from date of receipt.

Publications for NK1R Antibody Pack (NB100-912)(1)

Publication using NB100-912

• Fong, AY, Potts, JT. Neurokinin-1 receptor activation in Botzinger complex evokes bradypnoea. J Physiol;575(Pt 3):869-85. 2006-09-15 [PMID: 16825299]

Bioinformatics

• Gene Symbol: TACR1