OXTR Antibody - BSA Free

Immunohistochemistry-Paraffin: OXTR Antibody - BSA Free [NBP1-02334] - Staining of human uterus, pregnant. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 40 ug/ml.

• Reactivity: Hu, Rt, Pm
• Applications: ELISA, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

OXTR Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 19 amino acid peptide from C-terminal cytoplasmic domain of human OXTR.
• Epitope: C-Terminus cytoplasmic domain
• Specificity: Human OXTR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Primate (95%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: OXTR
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry 40 ug/ml
  • Immunohistochemistry-Paraffin 40 ug/ml
• Application Notes: .

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 18755161). Predicted cross-reactivity based on sequence identity: Gorilla (95%), Gibbon (95%), Marmoset (89%), Mouse (84%), Canien (84%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for OXTR Antibody - BSA Free

• OT-R
• OXTR
• oxytocin receptor

Background

The oxytocin receptor belongs to the vasopressin/oxytocin family of GPCRs because it binds similar cyclic nonapeptide hormones. The oxytocin receptor functions primarily during labor and lactation. There is a dramatic increase in the number of oxytocin receptors just before the onset of labor causing the uterine muscles to become exceedingly sensitive to oxytocin. The activated oxytocin receptor causes an inward membrane current that results in smooth muscle contraction during labor and milk ejection during lactation. This receptor also plays a role in natriuresis, kaliuresis and may have an antistress effect.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for OXTR Antibody (NBP1-02334)(1)

Publication using NBP1-02334

• Ramos E, Castilla A, Navarro N et al. Suckling-induced oxytocin increase in the spinal cord of the rat. Brain Res. 2008-10-21 [PMID: 18755161] (IHC-P, Rat)
  
  Details:
  IHC (P): Fig 4B (rat spinal cord). Note: rat cerebellum was used as a negative control for oxytocin receptor expression.

Bioinformatics

• Gene Symbol: OXTR
• Entrez:
  • 5021(Human)
• Uniprot:
  • P30559()