Recombinant Mouse IL-1 beta/IL-1F2 Protein

Recombinant Mouse IL-1 beta /IL-1F2 (Catalog # 401-ML) stimulates cell proliferation of the D10.G4.1 mouse helper T cell line. The ED50 for this effect is 2‑10 pg/mL.

1 μg/lane of Recombinant Mouse IL1 beta /IL-1F2 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 19 kDa.

• Reactivity: Mu
• Applications: Bioactivity

Recombinant Mouse IL-1 beta/IL-1F2 Protein Summary

• Details of Functionality: Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. Symons, J.A. et al. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 272. The ED₅₀ for this effect is 2-10 pg/mL.
• Source: E. coli-derived mouse IL-1 beta/IL-1F2 protein
  Val118-Ser269, with an N-terminal Met
• Accession #: NP_032387
• N-terminal Sequence: Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: Il1b
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 17 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IL-1 beta/IL-1F2 Protein

• catabolin
• IL1 beta
• IL-1 beta
• IL-1
• IL1B
• IL-1b
• IL1-BETA
• IL-1F2
• IL1F2IL-1 beta
• interleukin 1, beta
• interleukin-1 beta
• preinterleukin 1 beta
• pro-interleukin-1-beta

Background

IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2), which are the products of distinct genes. IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 17% amino acid (aa) identity in mouse. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI (1-4). The mouse IL-1 beta cDNA encodes a 269 aa precursor. A 117 aa propeptide is cleaved intracellularly by the cysteine protease IL-1 beta -converting enzyme (Caspase-1/ICE) to generate the active cytokine (5, 6). The 17 kDa mature mouse IL-1 beta shares 90% aa sequence identity with cotton rat and rat and 65%-78% identity with canine, equine, feline, human, porcine, and rhesus IL-1 beta .

1. Allan, S.M. et al. (2005) Nat. Rev. Immunol. 5:629.
2. Boraschi, D. and A. Tagliabue (2006) Vitam. Horm. 74:229.
3. Kornman, K.S. (2006) Am. J. Clin. Nutr. 83:475S.
4. Isoda, K. and F. Ohsuzu (2006) J. Atheroscler. Thromb. 13:21.
5. Gray, P.W. et al. (1986) J. Immunol. 137:3644.
6. Martinon, F. and J. Tschopp (2007) Cell Death Differ. 14:10.

Publications for IL-1 beta/IL-1F2 (401-ML)(291)

Publications using 401-ML

• Beausoleil, S;Ariss, M;Huang, L;Ding, X;Sheth, S;Levy, T;Fisher, J;Loebelenz, J;Arlotta, K;Dixon, K;Polakiewicz, R;Kuchroo, V; InTraSeq: A Multimodal Assay that Uncovers New Single-Cell Biology and Regulatory Mechanisms Research square 2024-12-09 [PMID: 39711533] (Bioassay, Mouse)
• Xu, J;Wang, G;Hou, Y;Sun, K;Zheng, Z;Guo, Z;Hou, L;Zhang, X;Ruan, Z;Ye, Y;Guo, F; RICTOR-mediated activation of AKT/mTOR signaling and autophagy inhibition promote osteoarthritis International immunopharmacology 2024-11-25 [PMID: 39591826] (Bioassay, Mouse)
• Sun, K;Zhang, X;Hou, L;Lu, F;Liu, H;Zheng, Z;Guo, Z;Xu, J;Ruan, Z;Hou, Y;He, J;Guo, F;Yang, K; TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-?B pathway Journal of advanced research 2024-11-04 [PMID: 39505144] (Bioassay, Human, Mouse)
• Shen, Q;Murakami, K;Sotov, V;Butler, M;Ohashi, PS;Reedijk, M; Inhibition of Notch enhances efficacy of immune checkpoint blockade in triple-negative breast cancer Science advances 2024-11-01 [PMID: 39475614] (In vivo assay, Mouse)
• Liu, C;Zhang, Q;Zhou, H;Jin, L;Liu, C;Yang, M;Zhao, X;Ding, W;Xie, W;Kong, H; GLP-1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome/PFKFB3-driven glycolysis interaction and histone lactylation Journal of translational medicine 2024-10-21 [PMID: 39434134] (Bioassay, Mouse)
• Guo, H;Lv, Z;Wang, M;Li, W;Xie, Y;Liu, Z;Chen, F;Jiang, R;Liu, Y;Wu, R;Li, J;Sun, Z;Tan, G;Shi, D; CD73 alleviates osteoarthritis by maintaining anabolism and suppressing catabolism of chondrocytes extracellular matrix Journal of orthopaedic translation 2024-11-01 [PMID: 39430133] (Bioassay, Mouse)
• Faust Akl, C;Linnerbauer, M;Li, Z;Lee, HG;Clark, IC;Wheeler, MA;Quintana, FJ; Droplet-based functional CRISPR screening of cell-cell interactions by SPEAC-seq Nature protocols 2024-09-26 [PMID: 39327538] (Bioassay, Human)
• An, D;Chen, G;Cheng, WY;Mohrs, K;Adler, C;Gupta, NT;Atwal, GS;DiLillo, DJ;Daly, C;Lin, JC;Kuhnert, F; LT?R Agonism Promotes Anti-Tumor Immune Responses via Modulation of the Tumor Microenvironment Cancer research 2024-08-13 [PMID: 39137402] (Bioassay, Mouse)
• Lu, R;Qu, Y;Wang, Z;He, Z;Xu, S;Cheng, P;Lv, Z;You, H;Guo, F;Chen, A;Zhang, J;Liang, S; TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes Journal of orthopaedic translation 2024-07-01 [PMID: 39040492] (Bioassay, Mouse)
• Thakore, PI;Schnell, A;Huang, L;Zhao, M;Hou, Y;Christian, E;Zaghouani, S;Wang, C;Singh, V;Singaraju, A;Krishnan, RK;Kozoriz, D;Ma, S;Sankar, V;Notarbartolo, S;Buenrostro, JD;Sallusto, F;Patsopoulos, NA;Rozenblatt-Rosen, O;Kuchroo, VK;Regev, A; BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells Nature immunology 2024-07-15 [PMID: 39009838] (Bioassay, Mouse, Transgenic Mouse)
• Park, C;Hwang, IY;Yan, SL;Vimonpatranon, S;Wei, D;Van Ryk, D;Girard, A;Cicala, C;Arthos, J;Kehrl, JH; Murine alveolar macrophages rapidly accumulate intranasally administered SARS-CoV-2 Spike protein leading to neutrophil recruitment and damage eLife 2024-03-20 [PMID: 38507462] (In vivo assay, Mouse)
• Durand, A;Bonilla, N;Level, T;Ginestet, Z;Lombès, A;Guichard, V;Germain, M;Jacques, S;Letourneur, F;Do Cruzeiro, M;Marchiol, C;Renault, G;Le Gall, M;Charvet, C;Le Bon, A;Martin, B;Auffray, C;Lucas, B; Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice Nature communications 2024-02-26 [PMID: 38409097] (Bioassay, Mouse)
• Kulkarni, DH;Talati, K;Joyce, EL;Kousik, H;Harris, DL;Floyd, AN;Vavrinyuk, V;Barrios, B;Udayan, S;McDonald, K;John, V;Hsieh, CS;Newberry, RD; Small Intestinal Goblet Cells Control Humoral Immune Responses and Mobilization During Enteric Infection bioRxiv : the preprint server for biology 2024-01-07 [PMID: 38260555] (In vivo assay, Mouse)
• Zheng, H;Fang, J;Lu, W;Liu, Y;Chen, S;Huang, G;Zou, Y;Hu, S;Zheng, Y;Fang, H;Zhang, R; TCF12 regulates the TGF-?/Smad2/3 signaling pathway to accelerate the progression of osteoarthritis by targeting CXCR4 Journal of orthopaedic translation 2024-01-01 [PMID: 38235367] (Bioassay, Mouse)
• Nakajima, S;Demers, G;Machuca-Parra, AI;Pour, ZD;Bairamian, D;Bouyakdan, K;Fisette, A;Kabahizi, A;Robb, J;Rodaros, D;Laurent, C;Ferreira, G;Arbour, N;Alquier, T;Fulton, S; Central activation of the fatty acid sensor GPR120 suppresses microglia reactivity and alleviates sickness- and anxiety-like behaviors Journal of neuroinflammation 2023-12-19 [PMID: 38111048] (Bioassay, In vivo assay, Mouse)
• Kim, GM;Park, DR;Nguyen, TTH;Kim, J;Kim, J;Sohn, MH;Lee, WK;Lee, SY;Shim, H; Development of Anti-OSCAR Antibodies for the Treatment of Osteoarthritis Biomedicines 2023-10-19 [PMID: 37893216] (Bioassay, Mouse)
• Cheng, X;Wang, S;Li, Z;He, D;Wu, J;Ding, W; IL-1?-pretreated bone mesenchymal stem cell-derived exosomes alleviate septic endoplasmic reticulum stress via regulating SIRT1/ERK pathway Heliyon 2023-10-01 [PMID: 37771539] (Bioassay, Mouse)
• Aboushousha, R;van der Velden, J;Hamilton, N;Peng, Z;MacPherson, M;Erickson, C;White, S;Wouters, EFM;Reynaert, NL;Seward, DJ;Li, J;Janssen-Heininger, YMW; Glutaredoxin attenuates glutathione levels via deglutathionylation of Otub1 and subsequent destabilization of system xC Science advances 2023-09-15 [PMID: 37703360] (Bioassay, Mouse)
• Shearn, CT;Anderson, AL;Devereaux, MW;El Kasmi, KC;Orlicky, DJ;Sokol, RJ; Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition PloS one 2023-08-30 [PMID: 37647292] (In vivo assay, Mouse)
• Palmieri, EM;Holewinski, R;McGinity, CL;Pierri, CL;Maio, N;Weiss, JM;Tragni, V;Miranda, KM;Rouault, TA;Andresson, T;Wink, DA;McVicar, DW; Pyruvate dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic reprogramming Nature communications 2023-08-22 [PMID: 37607904] (Bioassay, Mouse)
• Chen, S;Meng, C;He, Y;Xu, H;Qu, Y;Wang, Y;Fan, Y;Huang, X;You, H; An in vitro and in vivo study: Valencene protects cartilage and alleviates the progression of osteoarthritis by anti-oxidative stress and anti-inflammatory effects International immunopharmacology 2023-08-01 [PMID: 37536183] (Bioassay, Mouse)
• Gu, W;Zhang, J;Li, Q;Zhang, Y;Lin, X;Wu, B;Yin, Q;Sun, J;Lu, Y;Sun, X;Jia, C;Li, C;Zhang, Y;Wang, M;Yin, X;Wang, S;Xu, J;Wang, R;Zhu, S;Cheng, S;Chen, S;Liu, L;Zhu, L;Yan, C;Yi, C;Li, X;Lian, Q;Lin, G;Ling, Z;Ma, L;Zhou, M;Xiao, K;Wei, H;Hu, R;Zhou, W;Ye, L;Wang, H;Li, J;Sun, B; The TRIM37 variants in Mulibrey nanism patients paralyze follicular helper T cell differentiation Cell discovery 2023-08-01 [PMID: 37528081] (Bioassay, Mouse)
• Scholz, O;Hu beta , E;Otter, S;Herebian, D;Hamacher, A;Levy, LM;Hristeva, S;Sanz, M;Ajani, H;Puentes, AR;Hoffmann, T;Hogeback, J;Unger, A;Terheyden, S;Reina do Fundo, M;Dewidar, B;Roden, M;Lammert, E; Protection of pancreatic islets from oxidative cell death by a peripherally-active morphinan with increased drug safety Molecular metabolism 2023-07-12 [PMID: 37451343] (Bioassay, Mouse)
• Lilley, RJ;Taylor, KD;Wildman, SSP;Peppiatt-Wildman, CM; Inflammatory mediators act at renal pericytes to elicit contraction of vasa recta and reduce pericyte density along the kidney medullary vascular network Frontiers in physiology 2023-06-09 [PMID: 37362447] (Bioassay, Mouse)
• Zhai, R;Lenga Ma Bonda, W;Leclaire, C;Saint-Béat, C;Theilliere, C;Belville, C;Coupet, R;Blondonnet, R;Bouvier, D;Blanchon, L;Sapin, V;Jabaudon, M; Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome Journal of translational medicine 2023-06-18 [PMID: 37331963] (Bioassay, Mouse)
• Sun, L;Zhang, X;Wu, S;Liu, Y;Guerrero-Juarez, CF;Liu, W;Huang, J;Yao, Q;Yin, M;Li, J;Ramos, R;Liao, Y;Wu, R;Xia, T;Zhang, X;Yang, Y;Li, F;Heng, S;Zhang, W;Yang, M;Tzeng, CM;Ji, C;Plikus, MV;Gallo, RL;Zhang, LJ; Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration Cell reports 2023-06-16 [PMID: 37330908]
• Li, TT;Lin, CL;Chiang, M;He, JT;Hung, CH;Hsieh, CC; Cytokine-Induced Myeloid-Derived Suppressor Cells Demonstrate Their Immunoregulatory Functions to Prolong the Survival of Diabetic Mice Cells 2023-05-29 [PMID: 37296628] (Bioassay, Mouse)
• Lu, Y;Zhang, H;Pan, H;Zhang, Z;Zeng, H;Xie, H;Yin, J;Tang, W;Lin, R;Zeng, C;Cai, D; Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages Journal of translational medicine 2023-05-22 [PMID: 37217897] (Bioassay, Mouse)
• Wayne, CR;Bremner, L;Faust, TE;Dur�n-Laforet, V;Ampatey, N;Ho, SJ;Feinberg, PA;Arvanitis, P;Ciric, B;Ruan, C;Elyaman, W;Delaney, SL;Vargas, WS;Swedo, S;Menon, V;Schafer, DP;Cutforth, T;Agalliu, D; Distinct Th17 effector cytokines differentially promote microglial and blood-brain barrier inflammatory responses during post-infectious encephalitis bioRxiv : the preprint server for biology 2023-05-09 [PMID: 37215000] (Bioassay, Mouse)
• Wan, J;Zhu, Z;He, Z;Wu, H;Chen, A;Zhu, W;Cheng, P; Stevioside protects primary articular chondrocytes against IL-1?-induced inflammation and catabolism by targeting integrin International immunopharmacology 2023-06-01 [PMID: 37167638] (Bioassay, Mouse)
• Qu, Y;Wang, Y;Wang, S;Yu, X;He, Y;Lu, R;Chen, S;Meng, C;Xu, H;Pei, W;Ni, B;Zhang, R;Huang, X;You, H; A comprehensive analysis of single-cell RNA transcriptome reveals unique SPP1+ chondrocytes in human osteoarthritis Computers in biology and medicine 2023-06-01 [PMID: 37141654] (Bioassay, Mouse)
• Slieker, RC;Donnelly, LA;Akalestou, E;Lopez-Noriega, L;Melhem, R;G�ne?, A;Abou Azar, F;Efanov, A;Georgiadou, E;Muniangi-Muhitu, H;Sheikh, M;Giordano, GN;�kerlund, M;Ahlqvist, E;Ali, A;Banasik, K;Brunak, S;Barovic, M;Bouland, GA;Burdet, F;Canouil, M;Dragan, I;Elders, PJM;Fernandez, C;Festa, A;Fitipaldi, H;Froguel, P;Gudmundsdottir, V;Gudnason, V;Gerl, MJ;van der Heijden, AA;Jennings, LL;Hansen, MK;Kim, M;Leclerc, I;Klose, C;Kuznetsov, D;Mansour Aly, D;Mehl, F;Marek, D;Melander, O;Niknejad, A;Ottosson, F;Pavo, I;Duffin, K;Syed, SK;Shaw, JL;Cabrera, O;Pullen, TJ;Simons, K;Solimena, M;Suvitaival, T;Wretlind, A;Rossing, P;Lyssenko, V;Legido Quigley, C;Groop, L;Thorens, B;Franks, PW;Lim, GE;Estall, J;Ibberson, M;Beulens, JWJ;'t Hart, LM;Pearson, ER;Rutter, GA; Identification of biomarkers for glycaemic deterioration in type 2 diabetes Nature communications 2023-05-03 [PMID: 37137910] (Bioassay, Mouse)
• Cho, MJ;Lee, HG;Yoon, JW;Kim, GR;Koo, JH;Taneja, R;Edelson, BT;Lee, YJ;Choi, JM; Steady-state memory-phenotype conventional CD4+ T cells exacerbate autoimmune neuroinflammation in a bystander manner via the Bhlhe40/GM-CSF axis Experimental & molecular medicine 2023-05-01 [PMID: 37121980] (Bioassay, Mouse)
• X Che, X Jin, NR Park, HJ Kim, HS Kyung, HJ Kim, JB Lian, JL Stein, GS Stein, JY Choi Cbfbeta Is a Novel Modulator against Osteoarthritis by Maintaining Articular Cartilage Homeostasis through TGF-beta Signaling Cells, 2023-03-31;12(7):. 2023-03-31 [PMID: 37048137] (Bioassay, Mouse)
• WS Lian, RW Wu, JY Ko, YS Chen, SY Wang, H Jahr, FS Wang Inhibition of Histone Lysine Demethylase 6A Promotes Chondrocytic Activity and Attenuates Osteoarthritis Development through Repressing H3K27me3 Enhancement of Wnt10a The international journal of biochemistry & cell biology, 2023-03-05;0(0):106394. 2023-03-05 [PMID: 36871937] (Bioassay, Mouse)
• Y Liao, L Sun, M Nie, J Li, X Huang, S Heng, W Zhang, T Xia, Z Guo, Q Zhao, LJ Zhang Modulation of Skin Inflammatory Responses by Aluminum Adjuvant Pharmaceutics, 2023-02-08;15(2):. 2023-02-08 [PMID: 36839900] (Bioassay, Mouse)
• CM Schafer, S Martin-Alm, K Kurylowicz, N Dufton, L Osuna-Alma, ML Wu, CF Johnson, AV Shah, DO Haskard, A Buxton, E Willis, K Wheeler, S Turner, M Chlebicz, RP Scott, S Kovats, A Cleuren, GM Birdsey, AM Randi, CT Griffin Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge bioRxiv : the preprint server for biology, 2023-02-11;0(0):. 2023-02-11 [PMID: 36798267] (Bioassay, Mouse)
• RK Gurram, D Wei, Q Yu, MJ Butcher, X Chen, K Cui, G Hu, M Zheng, X Zhu, J Oh, B Sun, JF Urban, K Zhao, WJ Leonard, J Zhu Crosstalk between ILC2s and Th2 cells varies among mouse models Cell Reports, 2023-02-02;42(2):112073. 2023-02-02 [PMID: 36735533] (Bioassay, Mouse)
• PA Dumesic, SE Wilensky, S Bose, JG Van Vranke, SP Gygi, BM Spiegelman RBM43 links adipose inflammation and energy expenditure through translational regulation of PGC1alpha bioRxiv : the preprint server for biology, 2023-01-07;0(0):. 2023-01-07 [PMID: 36712038] (Bioassay, Mouse)
• IC Clark, MA Wheeler, HG Lee, Z Li, LM Sanmarco, S Thaploo, CM Polonio, SW Shin, G Scalisi, AR Henry, JM Rone, F Giovannoni, M Charabati, CF Akl, DM Aleman, SEJ Zandee, A Prat, DC Douek, EA Boritz, FJ Quintana, AR Abate Identification of astrocyte regulators by nucleic acid cytometry Nature, 2023-01-04;0(0):. 2023-01-04 [PMID: 36599367] (Bioassay, Mouse)
• G Wang, E Sweren, W Andrews, Y Li, J Chen, Y Xue, E Wier, MP Alphonse, L Luo, Y Miao, R Chen, D Zeng, S Lee, A Li, E Dare, D Kim, NK Archer, SK Reddy, L Resar, Z Hu, EA Grice, MA Kane, LA Garza Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1alpha signaling and glutamine metabolism Science Advances, 2023-01-04;9(1):eabo7555. 2023-01-04 [PMID: 36598999] (Bioassay, Human, Mouse)
• CK Cheng, X Lin, Y Pu, JKY Tse, Y Wang, CL Zhang, X Cao, CW Lau, J Huang, L He, JY Luo, YT Shih, S Wan, CF Ng, L Wang, RCW Ma, JJ Chiu, TF Chan, X Yu Tian, Y Huang SOX4 is a novel phenotypic regulator of endothelial cells in atherosclerosis revealed by single-cell analysis Journal of advanced research, 2022-03-01;43(0):187-203. 2022-03-01 [PMID: 36585108] (Organ Culture, Mouse)
• Pedro P. Cunha, David Bargiela, Eleanor Minogue, Lena C.M. Krause, Laura Barbieri, Carolin Brombach et al. Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis Cancer Immunology Research 2023-03-01 [PMID: 36574610] (Bioassay, Mouse)
• S Zia, BP Hammond, M Zirngibl, A Sizov, CS Baaklini, SP Panda, MFS Ho, KV Lee, A Mainali, MK Burr, S Williams, AV Caprariell, C Power, T Simmen, BJ Kerr, JR Plemel Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance Molecular Neurodegeneration, 2022-12-13;17(1):82. 2022-12-13 [PMID: 36514132] (Bioassay, Mouse)
• YK Kim, JA Walters, ND Moss, KL Wells, R Sheridan, JG Miranda, RKP Benninger, LL Pyle, RM O'Brien, L Sussel, HW Davidson Zinc Transporter 8 Haploinsufficiency Protects Against Beta Cell Dysfunction in Type 1 Diabetes by Increasing Mitochondrial Respiration Molecular Metabolism, 2022-11-05;66(0):101632. 2022-11-05 [PMID: 36347424] (Bioassay, Mouse)
• AG Yates, E Kislitsyna, C Alfonso Ma, J Zhang, AL Sewell, A Goikolea-V, V Cai, LF Alkhader, A Skaland, B Hammond, R Dimitrova, D Batalle, C Fernandes, AD Edwards, P Gressens, C Thornton, HB Stolp Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity Journal of Neuroinflammation, 2022-10-29;19(1):265. 2022-10-29 [PMID: 36309753] (In Vivo, Mouse)
• KK Myo Min, D Rojas-Cana, D Penko, M DeNichilo, MP Cockshell, CB Ffrench, EJ Thompson, O Asplund, CJ Drogemulle, RB Prasad, L Groop, ST Grey, HE Thomas, T Loudovaris, TW Kay, MG Mahoney, CF Jessup, PT Coates, CS Bonder Desmoglein-2 is important for islet function and beta-cell survival Cell Death & Disease, 2022-10-29;13(10):911. 2022-10-29 [PMID: 36309486] (Bioassay, Mouse)
• A Filliol, Y Saito, A Nair, DH Dapito, LX Yu, A Ravichandr, S Bhattachar, S Affo, N Fujiwara, H Su, Q Sun, TM Savage, JR Wilson-Kan, JM Caviglia, L Chin, D Chen, X Wang, S Caruso, JK Kang, AD Amin, S Wallace, R Dobie, D Yin, OM Rodriguez-, C Yin, A Mehal, B Izar, RA Friedman, RG Wells, UB Pajvani, Y Hoshida, HE Remotti, N Arpaia, J Zucman-Ros, M Karin, NC Henderson, I Tabas, RF Schwabe Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis Nature, 2022-10-05;0(0):. 2022-10-05 [PMID: 36198802] (Bioassay, Mouse)
• L Rani, A Kumar, J Karhade, G Pandey, A Guha, GC Mishra, MR Wani IL-3 regulates the differentiation of pathogenic Th17 cells European Journal of Immunology, 2022-09-26;0(0):. 2022-09-26 [PMID: 36074916] (Bioassay, Mouse)
• Xintong Dong, Nathachit Limjunyawong, Elizabeth I. Sypek, Gaofeng Wang, Roger V. Ortines, Christine Youn et al. Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection Immunity 2022-09-01 [PMID: 35882236] (In vivo assay, Mouse)
• C Navarrete, A García-Mar, A Correa-Sáe, ME Prados, F Fernández, R Pineda, M Mazzone, M Álvarez-Be, MA Calzado, E Muñoz A cannabidiol aminoquinone derivative activates the PP2A/B55alpha/HIF pathway and shows protective effects in a murine model of traumatic brain injury Journal of Neuroinflammation, 2022-07-09;19(1):177. 2022-07-09 [PMID: 35810304] (Bioassay, Mouse)
• MM Tsai, JL Chen, TH Lee, H Liu, V Shanmugam, HL Hsieh Brain Protective Effect of Resveratrol via Ameliorating Interleukin-1beta-Induced MMP-9-Mediated Disruption of ZO-1 Arranged Integrity Biomedicines, 2022-05-29;10(6):. 2022-05-29 [PMID: 35740292] (Bioassay, Mouse)
• J Yin, H Zeng, K Fan, H Xie, Y Shao, Y Lu, J Zhu, Z Yao, L Liu, H Zhang, B Luo, X Wang, C Zeng, X Bai, H Zhang, D Cai Pentraxin 3 regulated by miR-224-5p modulates macrophage reprogramming and exacerbates osteoarthritis associated synovitis by targeting CD32 Cell Death & Disease, 2022-06-24;13(6):567. 2022-06-24 [PMID: 35739102] (Bioassay, Mouse)
• HZ Yu, BQ Zhu, L Zhu, S Li, LM Wang NR4A1 agonist cytosporone B attenuates neuroinflammation in a mouse model of multiple sclerosis Oncogene, 2022-12-01;17(12):2765-2770. 2022-12-01 [PMID: 35662227] (Bioassay, Mouse)
• H Kamei, T Ishii, Y Nishii Semaphorin 3A regulates alveolar bone remodeling on orthodontic tooth movement Oncogene, 2022-06-02;12(1):9243. 2022-06-02 [PMID: 35654941] (Bioassay, Mouse)
• LEA Damasceno, GCM Cebinelli, MF Fernandes, DC Nascimento, GA Públio, MAR Vinolo, SC Oliveira, T Sparwasser, TM Cunha, FQ Cunha, JC Alves-Filh STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program Cell Reports, 2022-05-24;39(8):110838. 2022-05-24 [PMID: 35613599] (Bioassay, Mouse)
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Review for IL-1 beta/IL-1F2 (401-ML) (1)

Average Rating: 5

(Based on 1 review)

reviewed by: Sweta Ghosh Stem/Immune cell maintenance or differentiation 05/10/2024

Summary

• Application: Stem/Immune cell maintenance or differentiation
• Lot: DGRM0324012

Bioinformatics

• Gene Symbol: Il1b
• Uniprot:
  • NP_032387()