Stathmin-2/STMN2 Antibody - BSA Free

Analysis of endogenous STMN2 in mouse dorsal root ganglia (DRG) neurons. A partial siRNA knockdown was used in the second lane. NBP1-49461 was used at a dilution of 1:1000. Image courtesy of Dr. Jung Eun Shin.

Staining of STMN2 in primary mouse dorsal root ganglia (DRG) neurons Image shows the expected staining of endogenous STMN2 in axons and growth cones. Tubulin is a marker of axons. NBP1-49461 was used at a dilution of 1:4000. Image courtesy of Dr. Jung Eun Shin.

Neuronal deletion of Tsc2 improves axon regeneration within the first 2 d following nerve injury. SCG10 immunostaining of sciatic nerves 1 d after crush injury in control and Tsc2 cKO mice with (conditioned) or without (sham) a conditioning injury. Red dotted line denotes the crush site while red arrowheads point to the three longest axons. Scale bar: 500 i1/4m. Image collected and cropped by Citeab from the following publication (Nociceptor Deletion of Tsc2 Enhances Axon Regeneration by Inducing a Conditioning Injury Response in Dorsal Root Ganglia. Eneuro (2019) licensed under a CC-BY license.

Staining of STMN2 in HEK293T cells transfected with GFP or a GFP-STMN2 fusion. NBP1-49461 was used at a dilution of 1:1000 (A, B) and 1:3000 (C). Image courtesy of Dr. Jung Eun Shin.

Analysis of STMN2 in HEK293T cells transfected with GFP or a GFP-STMN2 fusion. NBP1-49461 was used at a dilution of 1:4000. Image courtesy of Dr. Jung Eun Shin.

Stathmin-2/STMN2 immunoreactivity at the trigeminal root entry zone (antibody diluted 1:1000, tissue taken from a mouse with experimental autoimmune encephalomyelitis). Image from verified customer review.

• Reactivity: Hu, Mu, Rt, Bv
• Applications: WB, Func, ICC/IF, IHC, IHC, KD
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

Stathmin-2/STMN2 Antibody - BSA Free Summary

• Immunogen: C-terminal peptide of mouse STMN2. [Swiss-Prot P55821]
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: STMN2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1 - 2 ug/ml
  • Immunohistochemistry Whole-Mount reported in scientific literature (PMID 35042776)
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Frozen 1:200 - 1:500
  • Immunohistochemistry-Paraffin reported in scientific literature (PMID 31182472)
  • In vitro assay reported in scientific literature (PMID 22726832)
  • In vivo assay reported in scientific literature (PMID 22726832)
  • Knockdown Validated
  • Western Blot 1 - 2 ug/ml
• Application Notes: In Western blot a band can be seen at ~22 kDa. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Theoretical MW: 22 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID:32778834).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Stathmin-2/STMN2 Antibody - BSA Free

• FLJ34868
• FLJ50995
• neuron-specific growth-associated protein
• Protein SCG10
• SCG10
• SCG10neuronal growth-associated protein (silencer element)
• SCGN10
• SCGN10stathmin-2
• Stathmin2
• Stathmin-2
• stathmin-like 2
• STMN2
• superior cervical ganglia, neural specific 10
• Superior cervical ganglion-10 protein

Background

STMN2 (Stathmin-2 or SCG10/Scgn10) belongs to stathmin family of proteins which are known to bind tubulin for acting as a sequestering agents and for promoting microtubule disassembly. STMN2 is a membrane-associated neuronal protein expressed mainly during development and its expression correlates with neurite outgrowth. STMN2 possesses a unique N-terminal domain that is critical for membrane binding, is responsible for STMN2 localization to the Golgi complex and is important in its targeting to growth cones. STMN2 localize to perinuclear cytoplasm, axons, and growth cones of developing neurons, and exists in soluble as well as membrane-bound forms. STMN2 interacts with ITMC2, as well as MAPK8, and when phosphorylated by MAPK8, it act as regulator of microtubule stability which controls neurite length in cortical neurons. Unlike other stathmins, STMN2 acts in two ways to promote microtubule dynamics: it stabilizes microtubules at their plus end and promotes microtubule catastrophe at their minus end. In the developing brain, STMN2 negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone. Reduced STMN2 expression is associated with Down's syndrome and Alzheimer's disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Stathmin-2/STMN2 Antibody (NBP1-49461)(86)

Publications using NBP1-49461

• Hertzog N, Duman M, Bochud M et Al. Hypoxia-induced conversion of sensory Schwann cells into repair cells is regulated by HDAC8 Nat Commun 2025-01-09 [PMID: 39779705]
• Oh Y, Cho Y., et Al. Dipeptidyl peptidase 4 as an injury-responsive protein in the mouse sciatic nerve Mol Cells 2024-11-20 [PMID: 39577744]
• Deininger S, Schumacher J, Blechschmidt A et al. Nerve injury converts Schwann cells in a long-term repair-like state in human neuroma tissue. Experimental neurology 2024-10-01 [PMID: 39362479]
• Aaron D. Talsma, Jon P. Niemi, Richard E. Zigmond Neither injury induced macrophages within the nerve, nor the environment created by Wallerian degeneration is necessary for enhanced in vivo axon regeneration after peripheral nerve injury Journal of Neuroinflammation 2024-05-27 [PMID: 38802868]
• Gobrecht P, Gebel J, Leibinger M, Zeitler C et Al. Cnicin promotes functional nerve regeneration Phytomedicine 2024-05-08 [PMID: 38718639]
• Lai, JD;Berlind, JE;Fricklas, G;Lie, C;Urenda, JP;Lam, K;Sta Maria, N;Jacobs, R;Yu, V;Zhao, Z;Ichida, JK; KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury Cell stem cell 2024-04-04 [PMID: 38579683]
• Renk P, Sgodzai M, Klimas R, Blusch A et Al. Small fibre integrity and axonal pathology in the rat model of experimental autoimmune neuritis Brain Commun 2024-03-14 [PMID: 38482371]
• Matthew Grove, Hyukmin Kim, Shuhuan Pang, Jose Paz Amaya, Guoqing Hu, Jiliang Zhou, Michel Lemay, Young-Jin Son, Klaus-Armin Nave, Timothy E Behrens TEAD1 is crucial for developmental myelination, Remak bundles, and functional regeneration of peripheral nerves eLife 2024-03-08 [PMID: 38456457]
• Gobrecht P, Gebel J, Hilla A, Gisselmann G et Al. Targeting Vasohibins to Promote Axon Regeneration J Neurosci 2024-03-01 [PMID: 38429108]
• Asghari Adib E, Shadrach JL, Reilly-Jankowiak L et Al. DLK signaling in axotomized neurons triggers complement activation and loss of upstream synapses Cell Rep 2024-03-07 [PMID: 38363678]
• Au NPB, Wu T, Chen X, Gao F et Al. Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair Neuron 2023-12-12 [PMID: 38086376]
• Jone López-Erauskin, Mariana Bravo-Hernandez, Maximiliano Presa, Michael W Baughn, Ze'ev Melamed, Melinda S Beccari, Ana Rita Agra de Almeida Quadros, Olatz Arnold-Garcia, Aamir Zuberi, Karen Ling, Oleksandr Platoshyn, Elkin Niño-Jara, I Sandra Ndayambaje, Melissa McAlonis-Downes, Larissa Cabrera, Jonathan W Artates, Jennifer Ryan, Anita Hermann, John Ravits, C Frank Bennett, Paymaan Jafar-Nejad, Frank Rigo, Martin Marsala, Cathleen M Lutz, Don W Cleveland, Clotilde Lagier-Tourenne Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation. Nature neuroscience 2024-01-10 [PMID: 37996528]
• Wang Y, Halawani D, Estill M et al. Aryl hydrocarbon receptor restricts axon regeneration of DRG neurons in response to injury bioRxiv : the preprint server for biology 2023-11-05 [PMID: 37961567] (ICC/IF, Mouse)
• De Virgiliis F, Mueller F, Palmisano I et al. The circadian clock time tunes axonal regeneration Cell metabolism 2023-11-03 [PMID: 37951214]
• Chen Q, Zhang L, Zhang F, Yi S FOSL1 modulates Schwann cell responses in the wound microenvironment and regulates peripheral nerve regeneration The Journal of biological chemistry 2023-11-08 [PMID: 37949219] (IHC-Fr, Rat)
• Gupta DP, Bhusal A, Rahman MH et al. EBP50 is a key molecule for the Schwann cell-axon interaction in peripheral nerves Progress in neurobiology 2023-11-07 [PMID: 37940033] (IHC-P, Mouse)
  
  Details:
  1:500 IHC-P dilution
• Gonçalves TM, Stewart CL, Baxley SD et al. Towards a comprehensive regulatory map of Mammalian Genomes Research square 2023-09-28 [PMID: 37841836] (IHC-Fr, Chicken)
  
  Details:
  Fertilized White Leghorn chicken eggs
• Alber S, Di Matteo P, Zdradzinski MD et al. PTBP1 regulates injury responses and sensory pathways in adult peripheral neurons Science advances 2023-07-28 [PMID: 37506203] (IHC)
• Zhu Y, Luan C, Gong L et al. SnRNA-seq reveals the heterogeneity of spinal ventral horn and mechanism of motor neuron axon regeneration iScience 2023-08-18 [PMID: 37502257] (Rat)
• Schaeffer J, Vilallongue N, Decourt C et al. Customization of the translational complex regulates mRNA-specific translation to control CNS regeneration Neuron 2023-07-07 [PMID: 37442131] (IHC-Fr, Mouse)
• Chen S, Chen Q, Zhang X et al. Schwann cell-derived amphiregulin enhances nerve regeneration via supporting the proliferation and migration of Schwann cells and the elongation of axons Journal of neurochemistry 2023-07-13 [PMID: 37439370]
• Rybak-Wolf A, Wyler E, Pentimalli TM et al. Modelling viral encephalitis caused by herpes simplex virus 1 infection in cerebral organoids Nature microbiology 2023-06-22 [PMID: 37349587] (IHC-Fr, Human)
  
  Details:
  IHC-Fr (with IF detection) on human brain organoids, antibody dilution 1:1000
• Martinez-Torres S, Mesquida-Veny F, Del Rio JA, Hervera A Injury-induced activation of the endocannabinoid system promotes axon regeneration iScience 2023-06-16 [PMID: 37235048] (ICC/IF, Mouse)
• Baughn MW, Melamed Z, L�pez-Erauskin J et al. Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies Science (New York, N.Y.) 2023-03-17 [PMID: 36927019]
• Jiang C, Lu Y, Zhu R et al. Pyruvate dehydrogenase beta subunit (Pdhb) promotes peripheral axon regeneration by regulating energy supply and gene expression Experimental neurology 2023-02-28 [PMID: 36863478] (Immunohistochemistry)
• Chang YH, Dubnau J Endogenous retroviruses and TDP-43 proteinopathy form a sustaining feedback driving intercellular spread of Drosophila neurodegeneration Nature communications 2023-02-21 [PMID: 36810738] (Immunocytochemistry/ Immunofluorescence, Human)
• Linares G, Li Y, Chang W et al. SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS Cell Stem Cell 2023-02-01 [PMID: 36736291] (WB, ICC/IF, Human)
  
  Details:
  1:200 dilution used for both applications
• Yadav A, Matson KJE, Li L et al. A cellular taxonomy of the adult human spinal cord Neuron 2023-02-01 [PMID: 36731429] (IHC-Fr, Human, Mouse)
• Wang X, Yang C, Wang X et al. Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFN gamma -cGAS-STING axis Neuron 2022-11-04 [PMID: 36370710] (IHC-Fr, Mouse)
• Lee N, Nho B, Ko KR et al. Gabapentin inhibits the analgesic effects and nerve regeneration process induced by hepatocyte growth factor (HGF) in a peripheral nerve injury model: Implication for the use of VM202 and gabapentinoids for peripheral neuropathy Molecular and cellular neurosciences 2022-08-23 [PMID: 36007867] (IHC-P, Mouse)
• Talsma AD, Niemi JP, Pachter JS, Zigmond RE The primary macrophage chemokine, CCL2, is not necessary after a peripheral nerve injury for macrophage recruitment and activation or for conditioning lesion enhanced peripheral regeneration Journal of neuroinflammation 2022-07-12 [PMID: 35820932] (IHC-Fr, Mouse)
• Serger E, Luengo-Gutierrez L, Chadwick JS et al. The gut metabolite indole-3 propionate promotes nerve regeneration and repair Nature 2022-06-22 [PMID: 35732737] (IF/IHC, Mouse)
• Patel P, Buchanan CN, Zdradzinski MD et al. Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAs Nucleic acids research 2022-06-10 [PMID: 35556128] (ICC/IF, Mouse)
  
  Details:
  1:200 ICC/IF dilution
• Zhang J, Jiang C, Liu X et al. The metabolomic profiling identifies N, N-dimethylglycine as a facilitator of dorsal root ganglia neuron axon regeneration after injury FASEB journal [PMID: 35394692]
• Irune Guerra Guerra San Juan, Leslie A. Nash, Kevin S. Smith, Marcel F. Leyton-Jaimes, Menglu Qian, Joseph R. Klim et al. Loss of mouse Stmn2 function causes motor neuropathy Neuron 2022-05-01 [PMID: 35294901]
• Wang D, Zheng T, Ge X et al. Unfolded protein response-induced expression of long noncoding RNA Ngrl1 supports peripheral axon regeneration by activating the PI3K-Akt pathway Experimental neurology 2022-02-25 [PMID: 35227685]
• Niemi JP, DeFrancesco-Oranburg T, Cox A et al. The Conditioning Lesion Response in Dorsal Root Ganglion Neurons Is Inhibited in Oncomodulin Knock-Out Mice eNeuro 2022-02-24 [PMID: 35131866] (IF/IHC, Mouse)
• Lee B, Oh Y, Cho E et al. FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury The Journal of biological chemistry 2022-01-28 [PMID: 35101451]
• Meng X, Qian X, Ding X et al. Eosinophils regulate intra-adipose axonal plasticity Proceedings of the National Academy of Sciences of the United States of America 2022-01-18 [PMID: 35042776] (IHC-WhMt, Mouse)
• Nogueira-Rodrigues J, Leite SC, Pinto-Costa R et al. Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection Developmental cell 2021-12-27 [PMID: 34986324]
• Yin GN, Shin TY, Ock J et al. Pericyte derived extracellular vesicles mimetic nanovesicles improves peripheral nerve regeneration in mouse models of sciatic nerve transection International journal of molecular medicine 2022-02-01 [PMID: 34935051] (IHC-Fr, Mouse)
• Shen Y, Cheng Z, Chen S Et al. Dysregulated miR-29a-3p/PMP22 Modulates Schwann Cell Proliferation and Migration During Peripheral Nerve Regeneration Molecular neurobiology 2021-11-27 [PMID: 34837628]
• Eira J, MagalhAes J, Macedo N Et al. Transthyretin Promotes Axon Growth via Regulation of Microtubule Dynamics and Tubulin Acetylation Frontiers in cell and developmental biology 2021-11-08 [PMID: 34820375] (IHC-Fr, Mouse)
• Klimas R, Sgodzai M, Motte J Et al. Dose-dependent immunomodulatory effects of bortezomib in experimental autoimmune neuritis Brain communications 2021-10-09 [PMID: 34708206] (ICC/IF, Rat)
• Jang EH, Bae YH, Yang EM et al. Comparing axon regeneration in male and female mice after peripheral nerve injury Journal of neuroscience research 2021-09-12 [PMID: 34510521] (IF/IHC)
• Riemondy KA, Venkataraman S, Willard N et Al. Neoplastic and immune single-cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma Neuro Oncol 2022-03-22 [PMID: 34077540]
• Chen Q, Liu Q, Zhang Y et al. Leukemia inhibitory factor regulates Schwann cell proliferation and migration and affects peripheral nerve regeneration Cell death & disease 2021-04-22 [PMID: 33888681] (In Vivo, Rat)
• Wang Y, Zhang F, Zhang Y et al. Betacellulin Regulates Peripheral Nerve Regeneration by Affecting Schwann Cell Migration and Axon Elongation Research Square 2021-02-05 [PMID: 33794764] (IF/IHC, Rat)
• Nadeau JR, Arnold BM, Johnston JM et al. Acute intermittent hypoxia enhances regeneration of surgically repaired peripheral nerves in a manner akin to electrical stimulation Experimental neurology 2021-03-05 [PMID: 33684407] (IF/IHC, Rat)
• Kim H, Lee J, Cho Y PDK1 is a negative regulator of axon regeneration Molecular brain 2021-02-12 [PMID: 33579325] (IF/IHC, ICC/IF, Mouse)
• Kalinski AL, Yoon C, Huffman LD et al. Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement eLife 2020-12-02 [PMID: 33263277] (ICC/IF, Mouse)
• Franco A, Dang X, Walton EK et al. Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A Elife 2020-10-19 [PMID: 33074106]
• Jeon Y, Shin JE, Kwon M et al. In Vivo Gene Delivery of STC2 Promotes Axon Regeneration in Sciatic Nerves Mol Neurobiol 2020-10-04 [PMID: 33011858]
• Avraham O, Deng PY, Jones S, Kuruvilla R Fatty acid synthesis in satellite glial cell promotes regenerative growth in sensory neurons Nat Commun 2020-09-30 [PMID: 32994417]
• Smaila BD, Holland SD, Babaeijandaghi F et al. Systemic hypoxia mimicry enhances axonal regeneration and functional recovery following peripheral nerve injury Exp. Neurol. 2020-08-16 [PMID: 32814068] (IF/IHC, Mouse)
• Kong G, Zhou L, Serger E et al. AMPK controls the axonal regenerative ability of dorsal root ganglia sensory neurons after spinal cord injury Nat Metab 2020-08-10 [PMID: 32778834] (Mouse)
• Stratton JA, Eaton S, Rosin NL et al. Macrophages and Associated Ligands in the Aged Injured Nerve: A Defective Dynamic That Contributes to Reduced Axonal Regrowth Front Aging Neurosci 2020-06-12 [PMID: 32595489] (IF/IHC, Mouse)
• Grove M, Lee H et al. Axon-dependent expression of YAP/TAZ mediates Schwann cell remyelination but not proliferation after nerve injury. Elife 2020-05-21 [PMID: 32436841] (IF/IHC, Mouse)
• Girouard MP, Simas T, Hua L et al. Collapsin response mediator protein 4 (CRMP4) facilitates Wallerian degeneration and axon regeneration following sciatic nerve injury eNeuro 2020-01-30 [PMID: 32001550] (IF/IHC, Mouse)
• Pinto-Costa R, Castro Sousa S, Leite SC et al. Profilin1 delivery tunes cytoskeleton dynamics towards CNS axon regeneration J. Clin. Invest. 2020-01-16 [PMID: 31945017] (IF/IHC, Mouse)
• Mao S, Huang T, Chen Y et al. Circ-Spidr enhances axon regeneration after peripheral nerve injury Cell Death Dis 2019-10-17 [PMID: 31624232] (IF/IHC, Rat)
• Carlin D, Halevi AE, Ewan EE et al. Nociceptor Deletion of Tsc2 Enhances Axon Regeneration by Inducing a Conditioning Injury Response in Dorsal Root Ganglia eNeuro 2019-06-25 [PMID: 31182472] (IHC-P, Mouse)
• Holland, SD;Ramer, LM;McMahon, SB;Denk, F;Ramer, MS; An ATF3-CreERT2 Knock-In Mouse for Axotomy-Induced Genetic Editing: Proof of Principle eNeuro 2019-04-09 [PMID: 30993183] (ICC/IF, Mouse)
• Hutson TH, Kathe C, Palmisano I et al. Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models Sci Transl Med 2019-04-10 [PMID: 30971452]
• Davies AJ, Kim HW, Gonzalez-Cano R et al. Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury Cell 2019-02-07 [PMID: 30712871] (ICC/IF, Mouse)
• Melamed Z, Lopez-Erauskin J, Baughn MW et al. Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration. Nat. Neurosci. 2019-02-01 [PMID: 30643298] (WB, Human)
• Klim JR, Williams LA, Limone F et al. ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair. Nat. Neurosci. 2019-02-01 [PMID: 30643292] (WB, ICC/IF, IF/IHC, Human)
• Giovanni S, serger e, Chadwick J et al. The intermittent fasting-dependent gut microbial metabolite indole-3 propionate promotes nerve regeneration and recovery after injury Research Square 2020-12-16 (IF/IHC, Mouse)
• Avraham O, Deng PY, Jones S, Kuruvilla R Fatty acid synthesis in satellite glial cell promotes regenerative growth in sensory neurons bioRxiv (IHC-Fr, Mouse)
• Okada M. A Novel Phosphorylation site of GAP-43 is a Good Molecular Marker for Axon Regeneration after Nerve Injury. Thesis. 2016-03-23 (IF/IHC, Mouse)
• Kawasaki A, Okada M et al. Growth Cone Phosphoproteomics Reveals that GAP-43 Phosphorylated by JNK Is a Marker of Axon Growth and Regeneration. iScience 2018-06-29 [PMID: 30240740] (WB, IF/IHC, Rat)
• Frey E, Karney-Grobe S, Krolak T et al. TRPV1 Agonist, Capsaicin, Induces Axon Outgrowth after Injury via Ca2+/PKA Signaling eNeuro 2018-05-30 [PMID: 29854941] (ICC/IF, Mouse)
• Cao Y, Wang H, Zeng W. Whole-tissue 3D imaging reveals intra-adipose sympathetic plasticity regulated by NGF-TrkA signal in cold-induced beiging. Protein Cell. 2018-03-27 [PMID: 29589323] (ICC/IF, Mouse)
• Weng YL, Wang X, An R et al. Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System Neuron 2018-01-17 [PMID: 29346752] (Mouse)
• Kim KJ, Namgung U. Facilitating effects of Buyang Huanwu decoction on axonal regeneration after peripheral nerve transection J Ethnopharmacol 2017-11-02 [PMID: 29102766] (ICC/IF, Rat)
• Weng YL, An R, Cassin J et al. An Intrinsic Epigenetic Barrier for Functional Axon Regeneration. Neuron. 2017-04-19 [PMID: 28426967]
• Chadwick J, Serger E, Kong G et al. Leptin Signalling Promotes Axonal Regeneration in the Peripheral and Central Nervous System Research Square 2023-02-09 [PMID: 28091609] (IHC, Mouse)
• Rouger V, Alchini R, Kazarine A et al. Low-cost multimodal light sheet microscopy for optically cleared tissues and living specimens. J Biomed Opt. 2016-12-01 [PMID: 27999866] (IF/IHC, Human)
• Chen L, Liu Z, Zhou B et al. CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of Syntaxins. Elife 2016-06-02 [PMID: 27253061]
• Valakh V, Frey E, Babetto E et al. Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury Neurobiol. Dis. 2015-02-26 [PMID: 25726747] (ICC/IF, Mouse)
  
  Details:
  Stathmin-2/STMN2 antibody used for ICC-IF staiing on murine embryonic spot cultures and dissociated adult dorsal root ganglia / DRG neurons cultures. The assay involved - 4% paraformaldehyde-PBS fixation for 20 minutes at RT, permeablization with PBST, use of primary antibody at 1:5000 dilution with ON 4C incubation, detection using fluorochrome conjugated secondary antibody.
• Gobrecht P, Leibinger M, Andreadaki A, Fischer D. Sustained GSK3 activity markedly facilitates nerve regeneration. Nat Commun. 2014-08-01 [PMID: 25078444]
• Shin Jung Eun, Geisler Stefanie, DiAntonio Aaron. Dynamic regulation of SCG10 in regenerating axons after injury. Exp Neurol. 2014-02-01 [PMID: 24246279]
• Cho Y, Sloutsky R, Naegle KM, Cavalli V. Injury-Induced HDAC5 Nuclear Export Is Essential for Axon Regeneration. Cell. 2013-11-07 [PMID: 24209626] (IF/IHC, ICC/IF, Mouse)
• Shin JE, Cho Y, Beirowski B, Milbrandt J et al. Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration Neuron 2012-06-21 [PMID: 22726832] (ICC/IF, In Vivo, Mouse)
• Sejvar JJ, Baughman AL, Wise M, Morgan OW. et Al. Population incidence of Guillain-Barré syndrome: a systematic review and meta-analysis Neuroepidemiology 2011-03-23 [PMID: 21422765]

Reviews for Stathmin-2/STMN2 Antibody (NBP1-49461) (2)

Average Rating: 4.5

(Based on 2 reviews)

We have 2 reviews tested in 2 species: Mouse, Other.

reviewed by: Kevin Thorburn IHC-Fr Mouse 11/29/2018

Summary

• Application: Immunohistochemistry-Frozen
• Sample Tested: mouse trigeminal root entry zone,trigeminal root entry zone
• Species: Mouse
• Lot: C-7

reviewed by: Verified Customer IHC-Fr Other 08/31/2016

Summary

• Application: Immunohistochemistry-Frozen
• Sample Tested: sciatic nerve
• Species: Other
• Lot: c1

Bioinformatics

• Gene Symbol: STMN2