Transglutaminase 1/TGM1 Antibody

Immunohistochemistry-Paraffin: Transglutaminase 1/TGM1 Antibody [NBP3-12268] - Mouse. 1:50 dilution in IHC Blocking Buffer. DAB (brown) straining and hematoxylin QS (blue) counterstain. 5x magnification. FFPE section.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

Transglutaminase 1/TGM1 Antibody Summary

• Immunogen: Synthetic peptide corresponding to unique amino acid sequence on Coagulation factor XIIIA chain precursor
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TGM1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:30000
  • Immunocytochemistry/ Immunofluorescence 1:250
  • Immunohistochemistry 1:250
  • Immunohistochemistry-Paraffin
  • Western Blot 1:450

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Contains Tris, HCl/glycine buffer (pH 7.4-7.8), 30% glycerol, 0.5% BSA, along with cryo-protective agents, and HEPES (exact storage and stabilization buffer information is proprietary).
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for Transglutaminase 1/TGM1 Antibody

• Epidermal TGase
• ICR2
• KTG
• LI
• LI1
• LI1EC 2.3.2.13
• protein-glutamine gamma-glutamyltransferase K
• protein-glutamine-gamma-glutamyltransferase)
• TG(K)
• TGASE
• TGase-1
• TGK
• TGKTGase K
• TGM1
• transglutaminase 1 (K polypeptide epidermal type I
• Transglutaminase 1
• Transglutaminase K
• transglutaminase, keratinocyte
• transglutaminase-1

Background

Tissue transglutaminase is a calcium activated enzyme which catalyzes the cross linking of proteins and the conjugation of polyamines to proteins. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD). CD, a genetic, immunologically mediated small bowel enteropathy that causes malabsorption, is one of the more common disorders in Western countries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TGM1