Dopamine D2R/DRD2 Antibody - BSA Free

Immunohistochemistry-Paraffin: Dopamine D2 R/DRD2 Antibody [NLS1405] - Analysis of anti-DRD2 antibody with human brain, neurons and glia.

• Reactivity: Hu, Bt, Bv, Ca, Eq, Rb, Pm, Ma, Pm, Pm
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

Dopamine D2R/DRD2 Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human Dopamine D2R/DRD2.
• Epitope: 3rd cytoplasmic domain
• Localization: Plasma membrane
• Specificity: Human DRD2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Chimpanzee (100%), Ferret (100%), Primate (100%), Monkey (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DRD2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 10 - 20 ug/ml
• Application Notes: .

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (94%), Marmoset (81%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Dopamine D2R/DRD2 Antibody - BSA Free

• D(2) dopamine receptor
• D2DR
• D2R
• Dopamine D2 R
• Dopamine D2 receptor
• Dopamine D2R
• dopamine receptor D2 isoform
• dopamine receptor D2
• DRD2
• seven transmembrane helix receptor

Background

The DRD2 Dopamine Receptor is involved in the neuromodulation of appetitive behaviors. DRD2 may be linked to alcoholism and other substance-use disorders. Mutations in DRD2 in mice lead to the suppression of reward behavior with morphine and to the reduction of spontaneous movements, a phenotype resembling Parkinson's disease. Three alternatively spliced isoforms have been identified. DRD2 has been reported to be expressed in various regions of the brain, as well as in aorta, artery, eye, and spinal cord. ESTs have been isolated from normal pituitary and in brain, colon, lung, pancreas, and skeletal muscle cancer libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Dopamine D2R/DRD2 Antibody (NLS1405)(1)

Publication using NLS1405

• Saveanu A, Sebag F, Guillet B et al. Targeting dopamine receptors subtype 2 (D2DR) in pheochromocytomas: head-to-head comparison between in vitro and in vivo findings. J Clin Endocrinol Metab. 2013-09-05 [PMID: 24009136] (IHC-P, Human)

Bioinformatics

• Gene Symbol: DRD2
• Entrez:
  • 1813(Human)
• Uniprot:
  • P14416()